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The map label for this gene is mutM [H]

Identifier: 124023869

GI number: 124023869

Start: 1932445

End: 1933320

Strand: Direct

Name: mutM [H]

Synonym: P9303_21761

Alternate gene names: 124023869

Gene position: 1932445-1933320 (Clockwise)

Preceding gene: 124023868

Following gene: 124023870

Centisome position: 72.03

GC content: 53.42

Gene sequence:

>876_bases
TTGCCGGAATTACCTGAAGTTGAGACGGTCCGCCGCGGATTGGCAGACCGTCTTATTGATTTTCAGATCGACCAGGTTGA
GGTTTGCCGAGAACGAGCAATAGCAAGCCCTGGCGGTTCTGCCCTATTCATCAAGATGCTTTGCGGCATGCACGTGGGCT
CATGGTTAAGACGCGGCAAGTACTTGATGGCGTCTTTACATCATGATTTTGCCCAGCCATCAGCTGATTCAGAACCAGAT
CCTGATGGTGGATGGTGGGGCGTTCACCTGCGCATGACAGGGCAGTTTCAATGGCATGAAGCCATCAGTTCACCCTGCCC
GCATACACGCGTACGCATCTGGAACAAAAAAGATGAGGAACTGCGCTTCGTTGACACCCGCAGCTTCGGACAAATGTGGT
GGGTTCCACCTGGCAACGCCCCGGAAACAATCATCACAGGGCTGCAAAAACTTGGGCCAGAGCCATTCAGCAGCGCCTTC
AATTCCTCTTACCTAAGCAAACGCTTGAAGGGTTCGAAACGACCAATCAAGTCAGCGCTTTTGGATCAATCCATCGTGGC
AGGGGCAGGCAACATCTATACCGATGAAAGCCTTTTTGCCGCCAGAATCCTTCCCCACACTCCATCAGGTCAATTAAAAA
AGGTTGAACTTGAACGCTTATGCGACTGCCTCACGGAGGTCCTCAGAGTGAGCATCGGTGCTGGAGGAACAACCTTCAGC
GACTTCAGAGATCTTGAAGGCATGAACGGCAACTACGGTGGTCAAGCCTGGGTGTATCGCAGAGGAGGCCAAGCCTGCCG
GATATGCAGCACGCCAATCCGCCGTGAAAGCCTCTGCGGTCGTGGCACCCACTGGTGCCCCAATTGCCAAAGATGA

Upstream 100 bases:

>100_bases
TTCGCTTCGAGAAAACGAACTACTTCGGCATGCAAGGTACCGATAACGGCAACCTCACCAACAGCTTTGCTGAATCAGAG
CTCGATCGCGCCTAAGGCGC

Downstream 100 bases:

>100_bases
ATCCTGGCAAAAATGTTCGATTCACAGCAACAGCGGCAAGCTCTAAGCAACACCATTCGCGATTTCCATCAACGCGGTTG
GTGTGATGGAACTGGCGGTA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPELPEVETVRRGLADRLIDFQIDQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGKYLMASLHHDFAQPSADSEPD
PDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKDEELRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAF
NSSYLSKRLKGSKRPIKSALLDQSIVAGAGNIYTDESLFAARILPHTPSGQLKKVELERLCDCLTEVLRVSIGAGGTTFS
DFRDLEGMNGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR

Sequences:

>Translated_291_residues
MPELPEVETVRRGLADRLIDFQIDQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGKYLMASLHHDFAQPSADSEPD
PDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKDEELRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAF
NSSYLSKRLKGSKRPIKSALLDQSIVAGAGNIYTDESLFAARILPHTPSGQLKKVELERLCDCLTEVLRVSIGAGGTTFS
DFRDLEGMNGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR
>Mature_290_residues
PELPEVETVRRGLADRLIDFQIDQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGKYLMASLHHDFAQPSADSEPDP
DGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKDEELRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAFN
SSYLSKRLKGSKRPIKSALLDQSIVAGAGNIYTDESLFAARILPHTPSGQLKKVELERLCDCLTEVLRVSIGAGGTTFSD
FRDLEGMNGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=291, Percent_Identity=35.7388316151203, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786932, Length=251, Percent_Identity=23.5059760956175, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 32546; Mature: 32415

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLADRLIDFQIDQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGK
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLMASLHHDFAQPSADSEPDPDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKDEE
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHCCCCCCCEEEEECCCCCC
LRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAFNSSYLSKRLKGSKRPIKSAL
EEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LDQSIVAGAGNIYTDESLFAARILPHTPSGQLKKVELERLCDCLTEVLRVSIGAGGTTFS
HHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DFRDLEGMNGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR
HHHHCCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLADRLIDFQIDQVEVCRERAIASPGGSALFIKMLCGMHVGSWLRRGK
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLMASLHHDFAQPSADSEPDPDGGWWGVHLRMTGQFQWHEAISSPCPHTRVRIWNKKDEE
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHCCCCCCCEEEEECCCCCC
LRFVDTRSFGQMWWVPPGNAPETIITGLQKLGPEPFSSAFNSSYLSKRLKGSKRPIKSAL
EEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LDQSIVAGAGNIYTDESLFAARILPHTPSGQLKKVELERLCDCLTEVLRVSIGAGGTTFS
HHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DFRDLEGMNGNYGGQAWVYRRGGQACRICSTPIRRESLCGRGTHWCPNCQR
HHHHCCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]