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The map label for this gene is proC [H]

Identifier: 124023839

GI number: 124023839

Start: 1909252

End: 1910094

Strand: Reverse

Name: proC [H]

Synonym: P9303_21461

Alternate gene names: 124023839

Gene position: 1910094-1909252 (Counterclockwise)

Preceding gene: 124023840

Following gene: 124023833

Centisome position: 71.2

GC content: 58.36

Gene sequence:

>843_bases
GTGGCCTCTAATCACTCCATGCCCTGCTCTTTGGGGGTAATCGGCCTGGGCCGAATGGCTCAGGCTCTTGTTTTGCCGCT
GTTGAAGCAGGGAGAGCTTGCTCCGCAGCAGGTTGTTGCGCTAGTGGGCCGTGGCGCAAGTGTCGAACGTCTCGCAGACC
AACTGCCAATAGGTCTGCGTTTGAAAGCTGCAGATGATCCCACTGCGGCAGAGGCATGGATGGCGCCCATTCAATTGCTA
GCGGTGAAACCGCAGCAGCTTGATCAGATAGCAGCTTCAGCAGCTCGTCTTAAGCAAACTGCAGCTGGGCCGCAGCTGTT
GATTTCTGTGCTTGCTGGCGTGAGCTTGGCTCGTTTGCAGCAGGCTTTTCCCGCTCATGCCTGTGTGCGTGCCGTTCCAA
ATACCCCTGCCTTGGTAGGCGCTGGGCTCACTGGATTGTCTTGGGGAGAGGGAGTCACGGCAGAGCAACGCCTAGCGGTT
GAGCGATTGTTTTTGCCGGTGAGCGAGGTGCTGGAATTGCCGGAGTCGCAGCTGGATGCTTTTTTGGCGTTGACGTCATC
CGGCCCTGCCTATGTGGCACTGGTGGCTGAGGCGATGGCTGATGGTGCGGTAGCGGCAGGCCTGCCGAGATCCTTGGCCC
ATCATCTTGCCCATCGCACCCTTGCTGGCACAGCAGCCTTGCTTAAGGAGCAGAAACTGCATCCTGCGGAACTTAAGGAC
ATGGTGACCTCTCCTGGTGGCACCACGATTGCCGCACTGCGCAAGCTTGAGCAGGCTGGGGTTCGTTCTGCTTTGATTGA
GGCGGTTGTTGCAGCTGCTCAACGTAGCCGTGAACTGGCTTGA

Upstream 100 bases:

>100_bases
TCTGCACCATCGATGGTGAGTCAGGATCACGATTCAGTACCGTCATCGTCTCAACAAACTGGTGCGGCGCCTGTTCCGGC
CTGGGAGGTCACCCGCGCTG

Downstream 100 bases:

>100_bases
GTTAGGCCGCCATCTTTGTCGCCCCTAATAAGCCGCGGTAGAGCGTTTCCAGGTCGTCGATGTTGCGGGTGATGGTGTAT
CGCTCCAGCACGCGCATACG

Product: delta 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MASNHSMPCSLGVIGLGRMAQALVLPLLKQGELAPQQVVALVGRGASVERLADQLPIGLRLKAADDPTAAEAWMAPIQLL
AVKPQQLDQIAASAARLKQTAAGPQLLISVLAGVSLARLQQAFPAHACVRAVPNTPALVGAGLTGLSWGEGVTAEQRLAV
ERLFLPVSEVLELPESQLDAFLALTSSGPAYVALVAEAMADGAVAAGLPRSLAHHLAHRTLAGTAALLKEQKLHPAELKD
MVTSPGGTTIAALRKLEQAGVRSALIEAVVAAAQRSRELA

Sequences:

>Translated_280_residues
MASNHSMPCSLGVIGLGRMAQALVLPLLKQGELAPQQVVALVGRGASVERLADQLPIGLRLKAADDPTAAEAWMAPIQLL
AVKPQQLDQIAASAARLKQTAAGPQLLISVLAGVSLARLQQAFPAHACVRAVPNTPALVGAGLTGLSWGEGVTAEQRLAV
ERLFLPVSEVLELPESQLDAFLALTSSGPAYVALVAEAMADGAVAAGLPRSLAHHLAHRTLAGTAALLKEQKLHPAELKD
MVTSPGGTTIAALRKLEQAGVRSALIEAVVAAAQRSRELA
>Mature_279_residues
ASNHSMPCSLGVIGLGRMAQALVLPLLKQGELAPQQVVALVGRGASVERLADQLPIGLRLKAADDPTAAEAWMAPIQLLA
VKPQQLDQIAASAARLKQTAAGPQLLISVLAGVSLARLQQAFPAHACVRAVPNTPALVGAGLTGLSWGEGVTAEQRLAVE
RLFLPVSEVLELPESQLDAFLALTSSGPAYVALVAEAMADGAVAAGLPRSLAHHLAHRTLAGTAALLKEQKLHPAELKDM
VTSPGGTTIAALRKLEQAGVRSALIEAVVAAAQRSRELA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=282, Percent_Identity=35.1063829787234, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI21361454, Length=286, Percent_Identity=36.013986013986, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=35.2517985611511, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797095, Length=278, Percent_Identity=35.2517985611511, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786585, Length=280, Percent_Identity=36.0714285714286, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=35.0746268656716, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17540664, Length=294, Percent_Identity=30.952380952381, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320861, Length=294, Percent_Identity=30.2721088435374, Blast_Score=126, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=33.9483394833948, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=33.5740072202166, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=40.2366863905325, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28885; Mature: 28754

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNHSMPCSLGVIGLGRMAQALVLPLLKQGELAPQQVVALVGRGASVERLADQLPIGLR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCEE
LKAADDPTAAEAWMAPIQLLAVKPQQLDQIAASAARLKQTAAGPQLLISVLAGVSLARLQ
EECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QAFPAHACVRAVPNTPALVGAGLTGLSWGEGVTAEQRLAVERLFLPVSEVLELPESQLDA
HHCCHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHH
FLALTSSGPAYVALVAEAMADGAVAAGLPRSLAHHLAHRTLAGTAALLKEQKLHPAELKD
HHHCCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MVTSPGGTTIAALRKLEQAGVRSALIEAVVAAAQRSRELA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASNHSMPCSLGVIGLGRMAQALVLPLLKQGELAPQQVVALVGRGASVERLADQLPIGLR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCEE
LKAADDPTAAEAWMAPIQLLAVKPQQLDQIAASAARLKQTAAGPQLLISVLAGVSLARLQ
EECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QAFPAHACVRAVPNTPALVGAGLTGLSWGEGVTAEQRLAVERLFLPVSEVLELPESQLDA
HHCCHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHH
FLALTSSGPAYVALVAEAMADGAVAAGLPRSLAHHLAHRTLAGTAALLKEQKLHPAELKD
HHHCCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MVTSPGGTTIAALRKLEQAGVRSALIEAVVAAAQRSRELA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]