Click here to switch to the map view.

The map label for this gene is ilvC

Identifier: 124023705

GI number: 124023705

Start: 1763977

End: 1764972

Strand: Direct

Name: ilvC

Synonym: P9303_20051

Alternate gene names: 124023705

Gene position: 1763977-1764972 (Clockwise)

Preceding gene: 124023704

Following gene: 124023706

Centisome position: 65.75

GC content: 55.82

Gene sequence:

>996_bases
ATGGCTCAGCTTTTCTACGACTCCGATGCCGATCTCAGTCTGCTGAACGGAAAGACCGTGGCAATTGTCGGCTATGGCTC
CCAGGGCCATGCCCATGCCCTCAACCTCAAGGACAGCGGCGTAGATGTGGTAGTGGGCCTATATGAAGGCAGCCGCTCCG
CCGAGAAAGCCCGCACCGATGGGCTGGAAGTGCTCAGCGTCGCTGAAGCCTCCGCCAAAGCGGACTGGATCATGGTGCTA
CTACCGGATGAATTCCAAAAAGATGTTTATGCAAAAGAGATCGCCCCTCATCTGAGTTCAGGCAAAGTGTTGAGCTTCGC
TCACGGCTTCAACATCCGCTTCGGGTTAATTCAGCCGCCAGCTGATGTCGACGTGGTAATGATTGCTCCCAAGGGACCCG
GCCATACCGTGCGCTGGGAATATCAGAATGGGCAGGGCGTTCCAGCCCTATTCGCAATTGAACAAGATGCCTCCGGCCAA
GCACGTGCACTGGCCATGGCCTACGCCAAGGGCATCGGCGGCACCCGAGCGGGCATCCTCGAAACCAACTTCAAGGAAGA
AACCGAAACCGACTTATTCGGAGAACAGGCCGTGCTCTGCGGCGGGCTCTCAGAGCTCGTCAAAGCAGGCTTTGAAACCC
TTGTAGAAGCTGGCTACCAGCCTGAGCTGGCCTACTTCGAATGCCTTCACGAGGTGAAGTTGATCGTGGATCTGATGGTG
AAGGGCGGCCTCACTGCCATGCGTGATTCAATCTCCAACACGGCTGAATACGGCGACTACGTGAGTGGGCCAAGACTGAT
CAACGCTGATACCAAAGCTGAGATGAAGCGCATCCTCGCTGACATCCAAGACGGCACCTTCGCTAAAAACTTTGTTGCCG
AATGCGAATCAGGCAAACCTGAGATGAAGAAGATTCGCGATCGCGATGCCGCCCATCCAATTGAGCAGGTCGGCAAAGGT
CTCCGCGCCATGTTCAGCTGGTTGAAAACAGCCTGA

Upstream 100 bases:

>100_bases
GAGTCAGAGGCGGTCTGGAGGCATCCAGATGGACCGGAAACTTACGACCAAGGCCAATTACGTAAGGTGAAGAGATACCC
AGATCAACGATCACGCCAGG

Downstream 100 bases:

>100_bases
CCCTGGCCATTCTGCTAGTCATCACTGCAGCAGGTCTCGACCTGCTGATCGGTGATCCGCGCTGGTGTCCACATCCCGTT
GAGTTGATGGGATCTGTGAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAQLFYDSDADLSLLNGKTVAIVGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARTDGLEVLSVAEASAKADWIMVL
LPDEFQKDVYAKEIAPHLSSGKVLSFAHGFNIRFGLIQPPADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQ
ARALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKPEMKKIRDRDAAHPIEQVGKG
LRAMFSWLKTA

Sequences:

>Translated_331_residues
MAQLFYDSDADLSLLNGKTVAIVGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARTDGLEVLSVAEASAKADWIMVL
LPDEFQKDVYAKEIAPHLSSGKVLSFAHGFNIRFGLIQPPADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQ
ARALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKPEMKKIRDRDAAHPIEQVGKG
LRAMFSWLKTA
>Mature_330_residues
AQLFYDSDADLSLLNGKTVAIVGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARTDGLEVLSVAEASAKADWIMVLL
PDEFQKDVYAKEIAPHLSSGKVLSFAHGFNIRFGLIQPPADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQA
RALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMVK
GGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKPEMKKIRDRDAAHPIEQVGKGL
RAMFSWLKTA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=292, Percent_Identity=38.3561643835616, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=327, Percent_Identity=32.4159021406728, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PROM3 (A2CB87)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018012.1
- ProteinModelPortal:   A2CB87
- SMR:   A2CB87
- STRING:   A2CB87
- GeneID:   4777779
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_20051
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 35706; Mature: 35575

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLFYDSDADLSLLNGKTVAIVGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARTD
CCEEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHC
GLEVLSVAEASAKADWIMVLLPDEFQKDVYAKEIAPHLSSGKVLSFAHGFNIRFGLIQPP
CHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCC
ADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQARALAMAYAKGIGGTRAGIL
CCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKP
HCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
EMKKIRDRDAAHPIEQVGKGLRAMFSWLKTA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQLFYDSDADLSLLNGKTVAIVGYGSQGHAHALNLKDSGVDVVVGLYEGSRSAEKARTD
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHC
GLEVLSVAEASAKADWIMVLLPDEFQKDVYAKEIAPHLSSGKVLSFAHGFNIRFGLIQPP
CHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCC
ADVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGQARALAMAYAKGIGGTRAGIL
CCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLTAMRDSISNTAEYGDYVSGPRLINADTKAEMKRILADIQDGTFAKNFVAECESGKP
HCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
EMKKIRDRDAAHPIEQVGKGLRAMFSWLKTA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA