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The map label for this gene is aroA

Identifier: 124023589

GI number: 124023589

Start: 1650365

End: 1651690

Strand: Reverse

Name: aroA

Synonym: P9303_18891

Alternate gene names: 124023589

Gene position: 1651690-1650365 (Counterclockwise)

Preceding gene: 124023590

Following gene: 124023588

Centisome position: 61.57

GC content: 56.11

Gene sequence:

>1326_bases
TTGAGCGTTACAAGCACTGCCTCATCGTCACGTGAGCTTCGAGCAGGTGGTGGGCTTTCTGGAACGGTGCGAGTCCCTGG
AGATAAATCGATTTCCCATCGAGCGCTGTTATTTGGAGCTATCGCAGAAGGGATCACCACCATCGAGGGCCTTTTACCTG
CTGAAGATCCCATGAGTACCGCCGCCTGTCTTCGAGCGATGGGAGCCACGATCAGCCCGATTCATGCCGGGCAAATAGTT
CGCGTTGAAGGCGTTGGTCTTGATGGACTTCAAGAACCGCAAGATGTACTCGACTGCGGTAACTCCGGCACAACAATTCG
GCTGATGCTAGGGCTGTTGGCAGCAAGCAAGGGCCGCCATTTCGTGCTTAGCGGTGATTCCTCTTTGCGCCGTAGGCCCA
TGAATCGGGTTGGCCAGCCATTAACAATGATGGGAGCCAAAATTAAAGGACGATCCAACGGCGACTTCGCACCACTTGCC
GTGAGTGGTCAGAAACTTCGTGGTGGTGTCATCGGTACACCTGTAGCAAGTGCCCAGGTGAAGTCAGCCCTGCTGCTGGC
AGCCCTTACCGCCGATGGGGCAACGACTGTGATCGAACCAGCCCATTCTAGAGACCACAGCGAACGCATGTTGCGGGCAT
TCGGCGCTGATCTCGAAGTGGGAGGAGAGATGGGTCGCCATATCAGAGTGAGCCCAGGACAAAAGCTTTATGGCCAAAAT
ATTGTCGTGCCAGGTGATATCAGTTCCGCTGCTTTTTGGCTTGTCGCAGGAGTGCTTGTGCCTGGAGCTGAGCTCGTGGT
GGAAAACGTTGGTTTAAACCCCACCCGTACCGGCATCCTGGAAGTGTTGCAGCAAATGGAAGCTCGCATTGAGGTGCTCA
ACCGCCATGAAGTCGCCGGTGAACCGGTTGGAGACCTACGGGTGAGGCAAGGACCGTTAAAGCCGTTCAGCATCAATGGG
GACATCATTCCTCGCCTGGTCGACGAGGTGCCGATCTTGGCGGTGGCTGCTTGTTTCTGTGATGGTGAAAGCAAAATTAC
TGACGCCAGTGAACTGCGCGTCAAGGAAACCGATCGGCTCGCTGTGATGACCAGGCAGCTCACGGCTATGGGAGCAGATA
TCGACGAACATGCCGATGGGCTTACCATCCGCGGTGGCCGAACACTGCGAGGCACAGAACTCGATAGTGAAACGGATCAT
CGTGTCGCCATGAGCCTGGCGGTGGCTGCGTTGTTGGCGGAGGGCAATTCTCGCTTGACGGGTAGCGAAGCTGCGGCTGT
TTCCTACCCCAACTTCTGGGACGACCTTGAGCGGCTGCATCGCTGA

Upstream 100 bases:

>100_bases
TTGAGATGGTTCAAAAGAGACAAATTACACAACACAAAAACAAATTGGAAATAAGCTCAAACGCTTGCCCATAAGATCGA
TCTGATCCGGGCCACACCCA

Downstream 100 bases:

>100_bases
GTCGCTTCCTCTCGGAACGCTGTCTGCTTATGCAACAGCTGACGGCAGTTTCAGCCTGTACAGCAGTCATTTTAACGAGG
CCTTTCATAGTTCAGCTGGA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSVTSTASSSRELRAGGGLSGTVRVPGDKSISHRALLFGAIAEGITTIEGLLPAEDPMSTAACLRAMGATISPIHAGQIV
RVEGVGLDGLQEPQDVLDCGNSGTTIRLMLGLLAASKGRHFVLSGDSSLRRRPMNRVGQPLTMMGAKIKGRSNGDFAPLA
VSGQKLRGGVIGTPVASAQVKSALLLAALTADGATTVIEPAHSRDHSERMLRAFGADLEVGGEMGRHIRVSPGQKLYGQN
IVVPGDISSAAFWLVAGVLVPGAELVVENVGLNPTRTGILEVLQQMEARIEVLNRHEVAGEPVGDLRVRQGPLKPFSING
DIIPRLVDEVPILAVAACFCDGESKITDASELRVKETDRLAVMTRQLTAMGADIDEHADGLTIRGGRTLRGTELDSETDH
RVAMSLAVAALLAEGNSRLTGSEAAAVSYPNFWDDLERLHR

Sequences:

>Translated_441_residues
MSVTSTASSSRELRAGGGLSGTVRVPGDKSISHRALLFGAIAEGITTIEGLLPAEDPMSTAACLRAMGATISPIHAGQIV
RVEGVGLDGLQEPQDVLDCGNSGTTIRLMLGLLAASKGRHFVLSGDSSLRRRPMNRVGQPLTMMGAKIKGRSNGDFAPLA
VSGQKLRGGVIGTPVASAQVKSALLLAALTADGATTVIEPAHSRDHSERMLRAFGADLEVGGEMGRHIRVSPGQKLYGQN
IVVPGDISSAAFWLVAGVLVPGAELVVENVGLNPTRTGILEVLQQMEARIEVLNRHEVAGEPVGDLRVRQGPLKPFSING
DIIPRLVDEVPILAVAACFCDGESKITDASELRVKETDRLAVMTRQLTAMGADIDEHADGLTIRGGRTLRGTELDSETDH
RVAMSLAVAALLAEGNSRLTGSEAAAVSYPNFWDDLERLHR
>Mature_440_residues
SVTSTASSSRELRAGGGLSGTVRVPGDKSISHRALLFGAIAEGITTIEGLLPAEDPMSTAACLRAMGATISPIHAGQIVR
VEGVGLDGLQEPQDVLDCGNSGTTIRLMLGLLAASKGRHFVLSGDSSLRRRPMNRVGQPLTMMGAKIKGRSNGDFAPLAV
SGQKLRGGVIGTPVASAQVKSALLLAALTADGATTVIEPAHSRDHSERMLRAFGADLEVGGEMGRHIRVSPGQKLYGQNI
VVPGDISSAAFWLVAGVLVPGAELVVENVGLNPTRTGILEVLQQMEARIEVLNRHEVAGEPVGDLRVRQGPLKPFSINGD
IIPRLVDEVPILAVAACFCDGESKITDASELRVKETDRLAVMTRQLTAMGADIDEHADGLTIRGGRTLRGTELDSETDHR
VAMSLAVAALLAEGNSRLTGSEAAAVSYPNFWDDLERLHR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=433, Percent_Identity=27.4826789838337, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320332, Length=453, Percent_Identity=27.1523178807947, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_PROM3 (A2CAX1)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017896.1
- ProteinModelPortal:   A2CAX1
- SMR:   A2CAX1
- STRING:   A2CAX1
- GeneID:   4778688
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_18891
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   PAPSRDH
- ProtClustDB:   PRK02427
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46396; Mature: 46265

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTSTASSSRELRAGGGLSGTVRVPGDKSISHRALLFGAIAEGITTIEGLLPAEDPMST
CCCCCCCCCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AACLRAMGATISPIHAGQIVRVEGVGLDGLQEPQDVLDCGNSGTTIRLMLGLLAASKGRH
HHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCE
FVLSGDSSLRRRPMNRVGQPLTMMGAKIKGRSNGDFAPLAVSGQKLRGGVIGTPVASAQV
EEEECCHHHHHCCHHHHCCCHHHHCCEEECCCCCCCCEEEECCCHHCCCCCCCCCHHHHH
KSALLLAALTADGATTVIEPAHSRDHSERMLRAFGADLEVGGEMGRHIRVSPGQKLYGQN
HHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCEECCCCCCEEEECCCCHHCCCC
IVVPGDISSAAFWLVAGVLVPGAELVVENVGLNPTRTGILEVLQQMEARIEVLNRHEVAG
EEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EPVGDLRVRQGPLKPFSINGDIIPRLVDEVPILAVAACFCDGESKITDASELRVKETDRL
CCCCCCEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCEECCCHHH
AVMTRQLTAMGADIDEHADGLTIRGGRTLRGTELDSETDHRVAMSLAVAALLAEGNSRLT
HHHHHHHHHHCCCHHHCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
GSEAAAVSYPNFWDDLERLHR
CCCCCEECCCCHHHHHHHHCC
>Mature Secondary Structure 
SVTSTASSSRELRAGGGLSGTVRVPGDKSISHRALLFGAIAEGITTIEGLLPAEDPMST
CCCCCCCCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AACLRAMGATISPIHAGQIVRVEGVGLDGLQEPQDVLDCGNSGTTIRLMLGLLAASKGRH
HHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCE
FVLSGDSSLRRRPMNRVGQPLTMMGAKIKGRSNGDFAPLAVSGQKLRGGVIGTPVASAQV
EEEECCHHHHHCCHHHHCCCHHHHCCEEECCCCCCCCEEEECCCHHCCCCCCCCCHHHHH
KSALLLAALTADGATTVIEPAHSRDHSERMLRAFGADLEVGGEMGRHIRVSPGQKLYGQN
HHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCEECCCCCCEEEECCCCHHCCCC
IVVPGDISSAAFWLVAGVLVPGAELVVENVGLNPTRTGILEVLQQMEARIEVLNRHEVAG
EEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EPVGDLRVRQGPLKPFSINGDIIPRLVDEVPILAVAACFCDGESKITDASELRVKETDRL
CCCCCCEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCEECCCHHH
AVMTRQLTAMGADIDEHADGLTIRGGRTLRGTELDSETDHRVAMSLAVAALLAEGNSRLT
HHHHHHHHHHCCCHHHCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
GSEAAAVSYPNFWDDLERLHR
CCCCCEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA