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The map label for this gene is proA

Identifier: 124023545

GI number: 124023545

Start: 1607044

End: 1608360

Strand: Direct

Name: proA

Synonym: P9303_18451

Alternate gene names: 124023545

Gene position: 1607044-1608360 (Clockwise)

Preceding gene: 124023544

Following gene: 124023546

Centisome position: 59.9

GC content: 53.91

Gene sequence:

>1317_bases
ATGACAACTTCTCCTGGAGTTCCTGAGCCTTCCGCCCAGTTGCTGCGACTTGCAGCAGAGGTGCGGCAAGCAGCCATGGC
TCTTGGACAAAGTGATGACAACCAGCGGCGTAAAGCCCTGATAGCAATGGCCAATGCTTTGCTGTCAAGCTCTGAGCAGA
TCGTGAGGGCTAATCGACTCGATTTAGAGAAGGCTCGAACTGAGGGACTTGCTGCTGCCCTGATGGCGCGGCTCAAGCTT
GATGAAAGCAAACTCAATTCGGCTATCGAGGGGCTCAGGCAGTTGGCTCAGTTATCTGATCCCCTTGGTTTGCGTCAGTT
GCATCGTGAACTGGATCAAGACCTAGTGCTGGAGCGCATCACCGTTCCTCTTGGAGTCCTGGGGGTAATCTTTGAGGCGC
GCCCAGATGCCGTGATTCAGATCGCTTCACTGGCGATTCGCTCTGGCAATGGCGCACTTCTCAAGGGCGGCAGCGAAGCA
AGCCATACCAATCAGGCCATCATTGAGGCGTTGAAGAATGGTCTGGCTGAAACAGAGATCGATCCCGAGGCAATTGCCTT
ACTCACGACCCGTCAGGAAAGCCTTGCCCTACTTCGCCTTGATGGCCTAGTGGATTTGATCATCCCTCGCGGCAGCAACG
AACTGGTGCGTTTCATTCAGGACAACACACGAATTCCGGTTCTTGGTCATGCAGACGGAATCTGTCATCTCTATCTCGAT
GCCGCAGCGGATCTGAAGCAGGCCCTCCAGATTGCAATCGACAGCAAGACCCAGTACCCCGCAGCATGCAACGCTATTGA
AACTCTGCTCATTCATCAGTCCATTGCACCGTCGTTTTTAGAACTTGCAATTCCTGCCTTTCGTCAGGCCAGGGTTCGTC
TGCTTGGCGATTCAGCTAGCCGGGCTTTAGGAGTAGAAGAGTCAGCAAGTGAAGAGGATTGGGCTACGGAATATCTCGAT
CTGATTCTGTCAGTGAAAGTGGTGCCTGATCTAGAGGGAGCCCTGGATCACATCCGTCGCTATAGCTCCCGTCACACGGA
GGCGATTGTCAGCAATGATCAGGAGACGGCTGAGCGTTTTCTCCAAGTTGTCGATAGTGCCGGTGTTTTTCACAATTGCT
CCACGCGTTTTGCCGATGGATTCCGTTATGGCTTTGGAGCCGAGGTTGGAATCAGTACTCAAACACTGCCTCCAAGGGGG
CCGGTTGGCTTGGAAGGGCTGGTGACCTATCGCTATCGGTTGCGTGGACAAGGCCAGATTGTGGCGGACTATGCCAATGG
TGAATGCATGTTCACGCACCGGGACCTACCGCTGTGA

Upstream 100 bases:

>100_bases
GCTGGTCGCCTGGGGGCAGCTCGACTTGCCCTTCAACGTCTCTTAAGTGTCGGCAATGCCCCTTGAGGCGTAATGATGAG
CACAGCTGTGCCGCGCTGTG

Downstream 100 bases:

>100_bases
TCAATCGCCTCCCTTTAGGAGCCATTCATGTTAACGATGTGCGCTTGTGGGCTCACGTGGGTGTGCTTGACCATGAAAGA
CGTGAAGGTCAGTGGTTCAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALIAMANALLSSSEQIVRANRLDLEKARTEGLAAALMARLKL
DESKLNSAIEGLRQLAQLSDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQIASLAIRSGNGALLKGGSEA
SHTNQAIIEALKNGLAETEIDPEAIALLTTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
AAADLKQALQIAIDSKTQYPAACNAIETLLIHQSIAPSFLELAIPAFRQARVRLLGDSASRALGVEESASEEDWATEYLD
LILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQVVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYRYRLRGQGQIVADYANGECMFTHRDLPL

Sequences:

>Translated_438_residues
MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALIAMANALLSSSEQIVRANRLDLEKARTEGLAAALMARLKL
DESKLNSAIEGLRQLAQLSDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQIASLAIRSGNGALLKGGSEA
SHTNQAIIEALKNGLAETEIDPEAIALLTTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
AAADLKQALQIAIDSKTQYPAACNAIETLLIHQSIAPSFLELAIPAFRQARVRLLGDSASRALGVEESASEEDWATEYLD
LILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQVVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYRYRLRGQGQIVADYANGECMFTHRDLPL
>Mature_437_residues
TTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALIAMANALLSSSEQIVRANRLDLEKARTEGLAAALMARLKLD
ESKLNSAIEGLRQLAQLSDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQIASLAIRSGNGALLKGGSEAS
HTNQAIIEALKNGLAETEIDPEAIALLTTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLDA
AADLKQALQIAIDSKTQYPAACNAIETLLIHQSIAPSFLELAIPAFRQARVRLLGDSASRALGVEESASEEDWATEYLDL
ILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQVVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGP
VGLEGLVTYRYRLRGQGQIVADYANGECMFTHRDLPL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=424, Percent_Identity=46.4622641509434, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI62912457, Length=424, Percent_Identity=46.4622641509434, Blast_Score=341, Evalue=7e-94,
Organism=Escherichia coli, GI1786438, Length=398, Percent_Identity=37.9396984924623, Blast_Score=286, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17569967, Length=408, Percent_Identity=43.8725490196078, Blast_Score=327, Evalue=8e-90,
Organism=Caenorhabditis elegans, GI17569969, Length=408, Percent_Identity=43.8725490196078, Blast_Score=327, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6324899, Length=446, Percent_Identity=42.6008968609865, Blast_Score=358, Evalue=1e-100,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=46.2102689486553, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PROM3 (A2CAS7)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017852.1
- ProteinModelPortal:   A2CAS7
- SMR:   A2CAS7
- STRING:   A2CAS7
- GeneID:   4775996
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_18451
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 47569; Mature: 47438

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALIAMANALLSSSEQIVRANRL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLEKARTEGLAAALMARLKLDESKLNSAIEGLRQLAQLSDPLGLRQLHRELDQDLVLERI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TVPLGVLGVIFEARPDAVIQIASLAIRSGNGALLKGGSEASHTNQAIIEALKNGLAETEI
HHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCC
DPEAIALLTTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
CHHHEEEEEECHHHHHHHEECCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEHH
AAADLKQALQIAIDSKTQYPAACNAIETLLIHQSIAPSFLELAIPAFRQARVRLLGDSAS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHH
RALGVEESASEEDWATEYLDLILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERF
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQVVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYRLRGQGQI
HHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCEE
VADYANGECMFTHRDLPL
EEEECCCEEEEECCCCCC
>Mature Secondary Structure 
TTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALIAMANALLSSSEQIVRANRL
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLEKARTEGLAAALMARLKLDESKLNSAIEGLRQLAQLSDPLGLRQLHRELDQDLVLERI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TVPLGVLGVIFEARPDAVIQIASLAIRSGNGALLKGGSEASHTNQAIIEALKNGLAETEI
HHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCC
DPEAIALLTTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
CHHHEEEEEECHHHHHHHEECCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEHH
AAADLKQALQIAIDSKTQYPAACNAIETLLIHQSIAPSFLELAIPAFRQARVRLLGDSAS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHH
RALGVEESASEEDWATEYLDLILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERF
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQVVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYRLRGQGQI
HHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCEE
VADYANGECMFTHRDLPL
EEEECCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA