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The map label for this gene is gor [H]

Identifier: 124023509

GI number: 124023509

Start: 1575503

End: 1576864

Strand: Direct

Name: gor [H]

Synonym: P9303_18091

Alternate gene names: 124023509

Gene position: 1575503-1576864 (Clockwise)

Preceding gene: 124023505

Following gene: 124023510

Centisome position: 58.73

GC content: 53.82

Gene sequence:

>1362_bases
TTGGAGCATCCTTTTGATCTGATCGTGCTTGGCGCTGGCTCTGGTGGACTAGCCGCTGCTAAGCGAGCCGCAAGCCATGG
TGCCAAGGTCGCCATCGTTGAAGGTGACCGTGTTGGAGGGACCTGCGTCATTCGCGGCTGTGTACCGAAGAAACTGTTGG
TCTACGGATCTCTTTATCGAGAACAGCTTGAAGTTGCCCCCAGTTTTGGAGTTGAGTTGAGTGATGCACGGATCAATGCG
GGGGTGTTGCTAGCCAATGTGCGTCAGGAAGTGGATCGTCTCAATGCTCTTCACATTGACCTGCTAGCCAAAAACGGTGT
TGAGCTTGTGACGGGATGGGGGAGTTTTACGAGCCCAAACAGCGTGGCTGTCTCAAGGAACGGAGCCATCGATGCTTCAC
AGGAACTTCACGGCGATCACATTCTGATCGCGGTCGGTGGGCGTCCCCATCGTCCTGATATCCCAGGTGCGGAGTTGGGC
TGGGTTAGCGATGACATGTTCATGCAAAGCAGCTTCCCCGACCGAGTGGTGGTGGTGGGGGCTGGATTTATTGCCTGTGA
ATTTGCCTGCATCCTCCATGGCCTTGGCGTCGAGGTCATCCAACTGGTGCGAGGGGATCACTTGCTGCGTGGCTTTGATC
GGGAACTCTCCACTGCAGTACAGGATGGAATGCAGGGGAAGGGCATTGATCTTCGTTTTGGAGAAAACCCAGCCGCTCTA
AAAGGCCAACCTGGCGATCTCGTCTTGTCAACCCAGAGTGGGGAACGCTTCTCTTGTGGGGGGGTTCTTCTTGCTACAGG
ACGACGACCCTTTTTGCAAGGACTCAACCTTGACGCTGCTGGGGTTGTTTTAGAAGGTCGACGTATTTCAGTGGATGCCA
ACCAATCCACAAATATCCCTCACATCTTTGCTGTTGGTGATGTAACAGACCGCATCAACCTCACCCCTGTGGCAATCGAT
GAGGGCAGGGCATTCGCCGACAGTGTTTTTGGGCAGAAACCCCGCCAGGTCAATCATGACCTCGTTGCCAGTGCTGTCTT
CAGCCAACCAGAGCTAGCCACGGTTGGGCTCACTGAAGAGCAGTCGATTGATCGCTATGGCAAAGATCAGGTCAAGGTCT
ACCGCGCCCGCTTCCGATCCATGGCTCAGGCCTTGCCAAAGCGAGGACCACGTTGTCTTCTCAAGTTAATTGTGGATCGC
AACACTGATCGAATCCTTGGTTGTCACATGGTGGGGGAACATGCTGCCGAAATTATTCAGATGGCATCAATCGCACTAGC
AATGGGTGCTACAAAGGCAGACTTTGATCGCACCATGGCATTACATCCCACGGTTTCTGAGGAGTTTGTCACCATGACTT
AG

Upstream 100 bases:

>100_bases
GAGTCATGACAGGTTTACTGATCATTGTCGTCACGATCCCTGAGTAATCCTGGCGTTGCTTTCTTAAGGAGTTGACAATG
GATGCAGTGATCCTCGTCTC

Downstream 100 bases:

>100_bases
GGAGTATTTCTGAAGATAAATTCCATACATCCTTTTAGTCGATCACTTGCGCCATTTGAGTGGTCCAGGCAAGGTCTTAG
GGGGATGCTATAAGGGCTCG

Product: glutathione reductase (NADPH)

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MEHPFDLIVLGAGSGGLAAAKRAASHGAKVAIVEGDRVGGTCVIRGCVPKKLLVYGSLYREQLEVAPSFGVELSDARINA
GVLLANVRQEVDRLNALHIDLLAKNGVELVTGWGSFTSPNSVAVSRNGAIDASQELHGDHILIAVGGRPHRPDIPGAELG
WVSDDMFMQSSFPDRVVVVGAGFIACEFACILHGLGVEVIQLVRGDHLLRGFDRELSTAVQDGMQGKGIDLRFGENPAAL
KGQPGDLVLSTQSGERFSCGGVLLATGRRPFLQGLNLDAAGVVLEGRRISVDANQSTNIPHIFAVGDVTDRINLTPVAID
EGRAFADSVFGQKPRQVNHDLVASAVFSQPELATVGLTEEQSIDRYGKDQVKVYRARFRSMAQALPKRGPRCLLKLIVDR
NTDRILGCHMVGEHAAEIIQMASIALAMGATKADFDRTMALHPTVSEEFVTMT

Sequences:

>Translated_453_residues
MEHPFDLIVLGAGSGGLAAAKRAASHGAKVAIVEGDRVGGTCVIRGCVPKKLLVYGSLYREQLEVAPSFGVELSDARINA
GVLLANVRQEVDRLNALHIDLLAKNGVELVTGWGSFTSPNSVAVSRNGAIDASQELHGDHILIAVGGRPHRPDIPGAELG
WVSDDMFMQSSFPDRVVVVGAGFIACEFACILHGLGVEVIQLVRGDHLLRGFDRELSTAVQDGMQGKGIDLRFGENPAAL
KGQPGDLVLSTQSGERFSCGGVLLATGRRPFLQGLNLDAAGVVLEGRRISVDANQSTNIPHIFAVGDVTDRINLTPVAID
EGRAFADSVFGQKPRQVNHDLVASAVFSQPELATVGLTEEQSIDRYGKDQVKVYRARFRSMAQALPKRGPRCLLKLIVDR
NTDRILGCHMVGEHAAEIIQMASIALAMGATKADFDRTMALHPTVSEEFVTMT
>Mature_453_residues
MEHPFDLIVLGAGSGGLAAAKRAASHGAKVAIVEGDRVGGTCVIRGCVPKKLLVYGSLYREQLEVAPSFGVELSDARINA
GVLLANVRQEVDRLNALHIDLLAKNGVELVTGWGSFTSPNSVAVSRNGAIDASQELHGDHILIAVGGRPHRPDIPGAELG
WVSDDMFMQSSFPDRVVVVGAGFIACEFACILHGLGVEVIQLVRGDHLLRGFDRELSTAVQDGMQGKGIDLRFGENPAAL
KGQPGDLVLSTQSGERFSCGGVLLATGRRPFLQGLNLDAAGVVLEGRRISVDANQSTNIPHIFAVGDVTDRINLTPVAID
EGRAFADSVFGQKPRQVNHDLVASAVFSQPELATVGLTEEQSIDRYGKDQVKVYRARFRSMAQALPKRGPRCLLKLIVDR
NTDRILGCHMVGEHAAEIIQMASIALAMGATKADFDRTMALHPTVSEEFVTMT

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=37.8494623655914, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI22035672, Length=460, Percent_Identity=34.7826086956522, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=30.3687635574837, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=30.3687635574837, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=30.3687635574837, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=30.3687635574837, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=30.3687635574837, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291045266, Length=462, Percent_Identity=31.6017316017316, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=30.7359307359307, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI291045268, Length=461, Percent_Identity=29.7180043383948, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=39.9082568807339, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=28.0087527352298, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=27.8145695364238, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=24.7787610619469, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=453, Percent_Identity=38.1898454746137, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71983419, Length=453, Percent_Identity=38.1898454746137, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17557007, Length=471, Percent_Identity=34.1825902335456, Blast_Score=257, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=32.6446280991736, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=31.8082788671024, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=36.4224137931034, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=29.5503211991435, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=27.3504273504274, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=37.1308016877637, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=35.1694915254237, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=35.1694915254237, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=35.3813559322034, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=31.5334773218143, Blast_Score=191, Evalue=7e-49,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48407; Mature: 48407

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHPFDLIVLGAGSGGLAAAKRAASHGAKVAIVEGDRVGGTCVIRGCVPKKLLVYGSLYR
CCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHH
EQLEVAPSFGVELSDARINAGVLLANVRQEVDRLNALHIDLLAKNGVELVTGWGSFTSPN
HHHHCCCCCCCEEECCEECCCEEEHHHHHHHHHHCEEEEEEEECCCEEEEECCCCCCCCC
SVAVSRNGAIDASQELHGDHILIAVGGRPHRPDIPGAELGWVSDDMFMQSSFPDRVVVVG
CEEEECCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEEE
AGFIACEFACILHGLGVEVIQLVRGDHLLRGFDRELSTAVQDGMQGKGIDLRFGENPAAL
CCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
KGQPGDLVLSTQSGERFSCGGVLLATGRRPFLQGLNLDAAGVVLEGRRISVDANQSTNIP
CCCCCCEEEECCCCCEEECCEEEEECCCCHHHHCCCCCCCCEEEECEEEEEECCCCCCCC
HIFAVGDVTDRINLTPVAIDEGRAFADSVFGQKPRQVNHDLVASAVFSQPELATVGLTEE
EEEEECCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCCH
QSIDRYGKDQVKVYRARFRSMAQALPKRGPRCLLKLIVDRNTDRILGCHMVGEHAAEIIQ
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHH
MASIALAMGATKADFDRTMALHPTVSEEFVTMT
HHHHHHHHCCCCCCCCCEEEECCCCCCCEEECC
>Mature Secondary Structure
MEHPFDLIVLGAGSGGLAAAKRAASHGAKVAIVEGDRVGGTCVIRGCVPKKLLVYGSLYR
CCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHH
EQLEVAPSFGVELSDARINAGVLLANVRQEVDRLNALHIDLLAKNGVELVTGWGSFTSPN
HHHHCCCCCCCEEECCEECCCEEEHHHHHHHHHHCEEEEEEEECCCEEEEECCCCCCCCC
SVAVSRNGAIDASQELHGDHILIAVGGRPHRPDIPGAELGWVSDDMFMQSSFPDRVVVVG
CEEEECCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEEE
AGFIACEFACILHGLGVEVIQLVRGDHLLRGFDRELSTAVQDGMQGKGIDLRFGENPAAL
CCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
KGQPGDLVLSTQSGERFSCGGVLLATGRRPFLQGLNLDAAGVVLEGRRISVDANQSTNIP
CCCCCCEEEECCCCCEEECCEEEEECCCCHHHHCCCCCCCCEEEECEEEEEECCCCCCCC
HIFAVGDVTDRINLTPVAIDEGRAFADSVFGQKPRQVNHDLVASAVFSQPELATVGLTEE
EEEEECCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCCH
QSIDRYGKDQVKVYRARFRSMAQALPKRGPRCLLKLIVDRNTDRILGCHMVGEHAAEIIQ
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHH
MASIALAMGATKADFDRTMALHPTVSEEFVTMT
HHHHHHHHCCCCCCCCCEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]