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The map label for this gene is lpxD [H]

Identifier: 124023435

GI number: 124023435

Start: 1518107

End: 1519150

Strand: Reverse

Name: lpxD [H]

Synonym: P9303_17351

Alternate gene names: 124023435

Gene position: 1519150-1518107 (Counterclockwise)

Preceding gene: 124023436

Following gene: 124023434

Centisome position: 56.63

GC content: 55.84

Gene sequence:

>1044_bases
ATGCGCTTCAGCCAGTTGATCGCCTCCCTCCAACAAGGAAGCGCTGGGCTGCAGGACCACCAGCTAGCTGAAGATCCTGA
ACTGCTTAGCTGCGCATCTCTCGATCAAGCAAAGGCCAATCAGCTCAGTTTTCTGGAACAGGGCAATGCACTAACCACAC
AGCTAAGCCACAGCAAGGTTGGGGCCGTATTGATTCCACCTCAGGATGATCTACGTGTCATTGCTGAACAAAGAGGGCTG
GCCTTTGCGGTGTTGCGAGATCCTCGTCTGGCATTCGCTGAAGCCTTGGAACAATTGCATCCACGCTCGCGGCCCAAGGC
AGGTGTTCACCCCACAGCCGTGATCGGAGATCAAGTGCATCTTGGCCAAGGGATCTCAATCGGTGCGCACGTCGTCATCG
GTGATGGCAGCCGTATCGGTGCCTATAGCGTGGTCCATCCAGGCGTAGTGATTTACGAAGATGTGGTGGTGGGGGAAGCT
AATGAACTTCATGCCAATGCTGTTCTTCAGCCTGGTTCCAGGCTAGGTCTGAACTGCGTTGTGCACTCCAATGCCGTTGT
GGGATCAGAGGGTTTCGGCTTCGTACCTACCGCCAATGGATGGCGAAAGATGCCTCAAACCGGTTTAGTGGTTCTTGAAG
ACGGTGTTGAAGTGGGCTGCGGGTCGACCATCGACCGTCCCTCGGTGGGTGAGACTCGCATCGGCGCTGGTACCAAAATT
GACAACCTCGTGCAAATCGGCCACGGGGTGGTTACAGGCCAAGGATGTGCCCTTGCCTCACAGGTGGGGATTGCCGGCGG
TGCTCGCCTGGGTGACGGTGTAATCCTCGCCGGTCAGGTTGGAGTCGCTAATCGCGCTGTAATCGGCGATCGTGCCATCG
CTAGCTCGAAAAGCGGTATTCATGGCGAAGTTGAAGCGGGGGAAGTTGTCAGCGGCTATCCCGCGATTCCAAATCGCCTC
TGGTTGCGCTGTTCCGCCAGCTTCAGCAAATTACCGGAGATGGCCAAAATGTTGAGGAAGCTGACAAGAGATACACCTCA
GTAA

Upstream 100 bases:

>100_bases
CGGTCGTGGTGCATAGGGACGTGTTGGTTCTCCGCAACGCGTGACTTGAGTGAACATCAACAACACATCACGCCTACGAT
CCGCCGAAAAGTGATTTGAC

Downstream 100 bases:

>100_bases
CCTCACAGGAGGCACAAGCCATTTTGGAGTCCTCCACATGCGCCAGCACCGCATCGTTCTGCTGCCTGGTGATGGTATCG
GTCCTGAAATCACTGCTGTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRFSQLIASLQQGSAGLQDHQLAEDPELLSCASLDQAKANQLSFLEQGNALTTQLSHSKVGAVLIPPQDDLRVIAEQRGL
AFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVHLGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEA
NELHANAVLQPGSRLGLNCVVHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
DNLVQIGHGVVTGQGCALASQVGIAGGARLGDGVILAGQVGVANRAVIGDRAIASSKSGIHGEVEAGEVVSGYPAIPNRL
WLRCSASFSKLPEMAKMLRKLTRDTPQ

Sequences:

>Translated_347_residues
MRFSQLIASLQQGSAGLQDHQLAEDPELLSCASLDQAKANQLSFLEQGNALTTQLSHSKVGAVLIPPQDDLRVIAEQRGL
AFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVHLGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEA
NELHANAVLQPGSRLGLNCVVHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
DNLVQIGHGVVTGQGCALASQVGIAGGARLGDGVILAGQVGVANRAVIGDRAIASSKSGIHGEVEAGEVVSGYPAIPNRL
WLRCSASFSKLPEMAKMLRKLTRDTPQ
>Mature_347_residues
MRFSQLIASLQQGSAGLQDHQLAEDPELLSCASLDQAKANQLSFLEQGNALTTQLSHSKVGAVLIPPQDDLRVIAEQRGL
AFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVHLGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEA
NELHANAVLQPGSRLGLNCVVHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
DNLVQIGHGVVTGQGCALASQVGIAGGARLGDGVILAGQVGVANRAVIGDRAIASSKSGIHGEVEAGEVVSGYPAIPNRL
WLRCSASFSKLPEMAKMLRKLTRDTPQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=324, Percent_Identity=30.5555555555556, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36082; Mature: 36082

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSQLIASLQQGSAGLQDHQLAEDPELLSCASLDQAKANQLSFLEQGNALTTQLSHSKV
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCC
GAVLIPPQDDLRVIAEQRGLAFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVH
CEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEE
LGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEANELHANAVLQPGSRLGLNCV
CCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEEEECCCCHHCCCEEECCCCCCCEEEE
VHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
EECCEEECCCCCCCCCCCCCHHHCCCCCEEEEECCCEECCCCCCCCCCCCCCCCCCCCCH
DNLVQIGHGVVTGQGCALASQVGIAGGARLGDGVILAGQVGVANRAVIGDRAIASSKSGI
HHHHHHCCCEEECCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHCCCCCC
HGEVEAGEVVSGYPAIPNRLWLRCSASFSKLPEMAKMLRKLTRDTPQ
CCCCCCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRFSQLIASLQQGSAGLQDHQLAEDPELLSCASLDQAKANQLSFLEQGNALTTQLSHSKV
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCC
GAVLIPPQDDLRVIAEQRGLAFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVH
CEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEE
LGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEANELHANAVLQPGSRLGLNCV
CCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEEEECCCCHHCCCEEECCCCCCCEEEE
VHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
EECCEEECCCCCCCCCCCCCHHHCCCCCEEEEECCCEECCCCCCCCCCCCCCCCCCCCCH
DNLVQIGHGVVTGQGCALASQVGIAGGARLGDGVILAGQVGVANRAVIGDRAIASSKSGI
HHHHHHCCCEEECCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHCCCCCC
HGEVEAGEVVSGYPAIPNRLWLRCSASFSKLPEMAKMLRKLTRDTPQ
CCCCCCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]