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The map label for this gene is umuD [H]

Identifier: 124023302

GI number: 124023302

Start: 1404473

End: 1404949

Strand: Reverse

Name: umuD [H]

Synonym: P9303_16001

Alternate gene names: 124023302

Gene position: 1404949-1404473 (Counterclockwise)

Preceding gene: 124023303

Following gene: 124023298

Centisome position: 52.37

GC content: 55.56

Gene sequence:

>477_bases
ATGGAGTTCAGCGAGCCTCTTCTTCATTTGCGCTCCGAGCGGAAGCAGCAGATCCTGCCATTAGCGAGTGAGCACGTGGC
GGCAGGCTTCCCCTCCCCTGCTGAGGACTATATCGAGATCGGCATCGACCTCAACGAACAATTGATTCGTCATCCAGCTA
GCACCTTCTTCCTGCGTGTTAGCGGTCACTCAATGACAGGTGTTGGCATCCACAATGGCGACCTCTTAGTTGTCGACCGC
AGCCTAGATGCACGCCCCGGTCACATCGTGGTGGCGATTCTTGATGGTGCCTTCACTCTCAAACAACTTGTCCGCCACCG
TGGCGTACTGCGTCTAGAGGCCGCCCATTCCAATTACCCACCGCTGGATCTGGCTCGCTTCGGTGACGTGCAAATCTGGG
GTGTGGCAGTGCATTCCATTCATAGCCTCAATCCTGCGCAGCAAACATCCCACTCAACACAACGCCTAGATGAATAG

Upstream 100 bases:

>100_bases
TAAAGAGGTTGCTACCGCCTGGGGCACGCCCCTATCAAGCCAAATCAGAAAACCGTCCCGAGTGGAACAGGTGTACTATC
AGGGTGATGCCGATGTTGCA

Downstream 100 bases:

>100_bases
GCTCAAAATAGGCAAGACGATGAATCAGGCTGCCCGGTATAGCAATAGTGTTGTTGCTCATCTTTAAAGATATTACCTTT
AAATCGTATATAGAGATAGG

Product: SOS mutagenesis protein UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MEFSEPLLHLRSERKQQILPLASEHVAAGFPSPAEDYIEIGIDLNEQLIRHPASTFFLRVSGHSMTGVGIHNGDLLVVDR
SLDARPGHIVVAILDGAFTLKQLVRHRGVLRLEAAHSNYPPLDLARFGDVQIWGVAVHSIHSLNPAQQTSHSTQRLDE

Sequences:

>Translated_158_residues
MEFSEPLLHLRSERKQQILPLASEHVAAGFPSPAEDYIEIGIDLNEQLIRHPASTFFLRVSGHSMTGVGIHNGDLLVVDR
SLDARPGHIVVAILDGAFTLKQLVRHRGVLRLEAAHSNYPPLDLARFGDVQIWGVAVHSIHSLNPAQQTSHSTQRLDE
>Mature_158_residues
MEFSEPLLHLRSERKQQILPLASEHVAAGFPSPAEDYIEIGIDLNEQLIRHPASTFFLRVSGHSMTGVGIHNGDLLVVDR
SLDARPGHIVVAILDGAFTLKQLVRHRGVLRLEAAHSNYPPLDLARFGDVQIWGVAVHSIHSLNPAQQTSHSTQRLDE

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=130, Percent_Identity=42.3076923076923, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1790476, Length=132, Percent_Identity=37.1212121212121, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 17486; Mature: 17486

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSEPLLHLRSERKQQILPLASEHVAAGFPSPAEDYIEIGIDLNEQLIRHPASTFFLRV
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEECCCCCHHHHHCCCCEEEEEE
SGHSMTGVGIHNGDLLVVDRSLDARPGHIVVAILDGAFTLKQLVRHRGVLRLEAAHSNYP
CCCCEEEEEEECCCEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHCCEEEEEECCCCCC
PLDLARFGDVQIWGVAVHSIHSLNPAQQTSHSTQRLDE
CCCHHHCCCEEEEEEEEHHHHCCCCHHHHCCHHHHCCC
>Mature Secondary Structure
MEFSEPLLHLRSERKQQILPLASEHVAAGFPSPAEDYIEIGIDLNEQLIRHPASTFFLRV
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEECCCCCHHHHHCCCCEEEEEE
SGHSMTGVGIHNGDLLVVDRSLDARPGHIVVAILDGAFTLKQLVRHRGVLRLEAAHSNYP
CCCCEEEEEEECCCEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHCCEEEEEECCCCCC
PLDLARFGDVQIWGVAVHSIHSLNPAQQTSHSTQRLDE
CCCHHHCCCEEEEEEEEHHHHCCCCHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]