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The map label for this gene is umuC [H]

Identifier: 124023298

GI number: 124023298

Start: 1402082

End: 1403356

Strand: Reverse

Name: umuC [H]

Synonym: P9303_15961

Alternate gene names: 124023298

Gene position: 1403356-1402082 (Counterclockwise)

Preceding gene: 124023302

Following gene: 124023295

Centisome position: 52.31

GC content: 56.31

Gene sequence:

>1275_bases
ATGTCTCGGGTCACGGCCCTGATCGACGGCAACAATTTCTATGCCTCCTGTGAGCAAAGCCTTGACGCCTCGCTAATCGG
TCGTCCTCTGGTCGTGCTCTCCAACAACGATGGCTGCATTGTTGCTCGCAGCTCCGAAGCGCGTGCTCTCGGTATCAGCA
TGGGCACGCCCTATTTCAAGGTCCGTCACAAATTGGACCGACTTGGCGTTGTCGTGCGCAGCTCCAACTACGCCCTCTAC
GGCGATATGAGCCAACGACTGATGAGCTTGCTGGAAGCCCATTGTGAGGAGCTGGAGATCTACTCCATTGATGAAGCCTT
TGCTTATGTCAATGGTCCCTCTGATGACAACCTAAAGCCCTGGGCCCGTCAACTACGGGCCCAGGTGCATCGCAACCTGG
GCCTGCCGATAGCAATCGGACTTGGCGCCAGTAAAGGTCAGGCGAAACTCGCCAACCACCTAGCCAAGGCCATACCGGCT
CACGCTGGAGTGTTCAACCTACTCACCGCTAGTGATCCAGATACATGGCTCGAGAGCGTCGCTATCGAAAATGTATGGGG
CATCGGCCGCAAGTTAGCCCACTGGTGCCGACTTAGAGGCGTAACCAATGCCCGGCAATTGCGCGATATGCCACGTAGCC
AACTTCATGCCCGCTGTGGCGTTGTAGGCATACGCCTACAACGCGAATTACAAGGTCATGCCTGCCTTCCTCTAGCCCTA
GCCCCAACATCAAAACAGGAAACCTGCGTTAGCCGCAGTTTTAGCCGACCAATCGCCAATCCAGAGGAATTACGCCAGGC
AATCGCAACCTACGTGGTGCGCGCCAGTGAAAAACTGCGACGACAACAGCAACGGGCCGGGACCCTTACCGTATTCACAC
GTACCAGCCCATTTGCGCCAGCGTTTTACAGCCAAGCCGCTACCATCCAACTGGATCTGCCAAGCAACGACACTGCAATC
TTGCTAGCAGCAGCCCTGCCACTAGTAGAGCGAATCTACCGGCCCCATTGCCGCTTAAACAAAGCTGGGGTGCTGATGCA
AAACCTACAGAGTGCAGACCATCTGCAACAACACCTGTTGGTAGCAGTTCATGCCGATGAGCAGCATCGCCGCGATCGAC
TAATGAACACCATCGACCGACTCAATCACCGTTACGGCAGCGGAACCGTGGGTTGGGCAGTTTGTGGCATGCAGCCAGGA
TGGAGCATGCGTCGTCATCAACTCAGCCGCGCGGCCACAACTCGCCTTAATGACGTGCCGTTGGTGCTGGCCTGA

Upstream 100 bases:

>100_bases
GCGACTGGCTGTCGCAGCAAAGCACGATCTCGCTATCAGGCAGAAGCTAGTGCGTCTGTACTAGCATGAGACATTCTTTC
GCTCGCTTTCCTCCAGTGCC

Downstream 100 bases:

>100_bases
AACTTAGAATTGAATGTCAACAGATCTCATTAGTTAGGGGATTGGGCTGGATTTGATTTGCTCGGTTCCATCCACATCTC
CAATCCATAAAGAATGCGCC

Product: UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFKVRHKLDRLGVVVRSSNYALY
GDMSQRLMSLLEAHCEELEIYSIDEAFAYVNGPSDDNLKPWARQLRAQVHRNLGLPIAIGLGASKGQAKLANHLAKAIPA
HAGVFNLLTASDPDTWLESVAIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGHACLPLAL
APTSKQETCVSRSFSRPIANPEELRQAIATYVVRASEKLRRQQQRAGTLTVFTRTSPFAPAFYSQAATIQLDLPSNDTAI
LLAAALPLVERIYRPHCRLNKAGVLMQNLQSADHLQQHLLVAVHADEQHRRDRLMNTIDRLNHRYGSGTVGWAVCGMQPG
WSMRRHQLSRAATTRLNDVPLVLA

Sequences:

>Translated_424_residues
MSRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFKVRHKLDRLGVVVRSSNYALY
GDMSQRLMSLLEAHCEELEIYSIDEAFAYVNGPSDDNLKPWARQLRAQVHRNLGLPIAIGLGASKGQAKLANHLAKAIPA
HAGVFNLLTASDPDTWLESVAIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGHACLPLAL
APTSKQETCVSRSFSRPIANPEELRQAIATYVVRASEKLRRQQQRAGTLTVFTRTSPFAPAFYSQAATIQLDLPSNDTAI
LLAAALPLVERIYRPHCRLNKAGVLMQNLQSADHLQQHLLVAVHADEQHRRDRLMNTIDRLNHRYGSGTVGWAVCGMQPG
WSMRRHQLSRAATTRLNDVPLVLA
>Mature_423_residues
SRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFKVRHKLDRLGVVVRSSNYALYG
DMSQRLMSLLEAHCEELEIYSIDEAFAYVNGPSDDNLKPWARQLRAQVHRNLGLPIAIGLGASKGQAKLANHLAKAIPAH
AGVFNLLTASDPDTWLESVAIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGHACLPLALA
PTSKQETCVSRSFSRPIANPEELRQAIATYVVRASEKLRRQQQRAGTLTVFTRTSPFAPAFYSQAATIQLDLPSNDTAIL
LAAALPLVERIYRPHCRLNKAGVLMQNLQSADHLQQHLLVAVHADEQHRRDRLMNTIDRLNHRYGSGTVGWAVCGMQPGW
SMRRHQLSRAATTRLNDVPLVLA

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=421, Percent_Identity=38.9548693586698, Blast_Score=276, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 46947; Mature: 46815

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFK
CCCEEEEEECCCEEEHHHHCCCHHHCCCCEEEEECCCCEEEEECCCCCEEEEECCCCHHH
VRHKLDRLGVVVRSSNYALYGDMSQRLMSLLEAHCEELEIYSIDEAFAYVNGPSDDNLKP
HHHHHHHHCEEEECCCEEEECCHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCCCCCCH
WARQLRAQVHRNLGLPIAIGLGASKGQAKLANHLAKAIPAHAGVFNLLTASDPDTWLESV
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHCCHHHEEECCCHHHHHHHH
AIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGHACLPLAL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHCEEEEEEHHHCCCCCEEEEEE
APTSKQETCVSRSFSRPIANPEELRQAIATYVVRASEKLRRQQQRAGTLTVFTRTSPFAP
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
AFYSQAATIQLDLPSNDTAILLAAALPLVERIYRPHCRLNKAGVLMQNLQSADHLQQHLL
HHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEE
VAVHADEQHRRDRLMNTIDRLNHRYGSGTVGWAVCGMQPGWSMRRHQLSRAATTRLNDVP
EEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LVLA
EEEC
>Mature Secondary Structure 
SRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFK
CCEEEEEECCCEEEHHHHCCCHHHCCCCEEEEECCCCEEEEECCCCCEEEEECCCCHHH
VRHKLDRLGVVVRSSNYALYGDMSQRLMSLLEAHCEELEIYSIDEAFAYVNGPSDDNLKP
HHHHHHHHCEEEECCCEEEECCHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCCCCCCH
WARQLRAQVHRNLGLPIAIGLGASKGQAKLANHLAKAIPAHAGVFNLLTASDPDTWLESV
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHCCHHHEEECCCHHHHHHHH
AIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGHACLPLAL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHCEEEEEEHHHCCCCCEEEEEE
APTSKQETCVSRSFSRPIANPEELRQAIATYVVRASEKLRRQQQRAGTLTVFTRTSPFAP
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
AFYSQAATIQLDLPSNDTAILLAAALPLVERIYRPHCRLNKAGVLMQNLQSADHLQQHLL
HHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEE
VAVHADEQHRRDRLMNTIDRLNHRYGSGTVGWAVCGMQPGWSMRRHQLSRAATTRLNDVP
EEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LVLA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]