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The map label for this gene is fur [H]

Identifier: 124023044

GI number: 124023044

Start: 1145740

End: 1146300

Strand: Reverse

Name: fur [H]

Synonym: P9303_13391

Alternate gene names: 124023044

Gene position: 1146300-1145740 (Counterclockwise)

Preceding gene: 124023045

Following gene: 124023040

Centisome position: 42.73

GC content: 49.73

Gene sequence:

>561_bases
TTGCTTGCAGGAATCTCAAGCCATCAATTGCGCCAATCACTCTCATTAGCGGTTACTGTTGAGAAATGCATTGCAGAGGT
GGCCTTGCCTACTTCTTCGTCCCTGGCCCGTATCCATGGACAACTTGAGGTTGGCTTGCATCAGGGTGGTCGACGTTTAA
CGCCTCAAAGACGCCGCGTTCTTGATCTCTTTGAAAGTATTGGTTCTGGCATTCACCTCAGTGCTGAAGAAGTCCATCAG
CAACTTCTAGAAGCAAACTCGAAGGTGTCTCTAGCAACGATCTACCGCACGCTGCGCTTGCTTGTCGAGATGGGTTTTCT
ACACGAGTTGGAAATAAGCGATGGCGGACATCGCTTTGAATTAGCAAGTCACGACCATCCTGATCATCACCATTTGGTAT
GCGTGCGTTGTGGTCGTACTGAGGAGTTTGAGAGCAAGCCAGTACTGGAAGCTGGACGCTCTGCTGCTGAGCGGATCGGG
TTCCAACTGATCGAGTCAACATTGAATGTAAGGGCTCTATGTCCGTCTTGTCAGAGACCCTCTACAACCAATGTCCATTG
A

Upstream 100 bases:

>100_bases
TAGTAGCGCTATCACGCCTTGCCACAAAGGCAGAACATCAACGATTGGCTTGGCTCAAACAACTTTAAAGAAACAACGCG
ATCTACCTTGAGATGCTGCC

Downstream 100 bases:

>100_bases
TGGCTGATGACAAACATCAGTGTTGAGAATGCTGATCACACGGCATCCAATGGGTTCCCATCTGGTGAGCGCCTTTGCAT
CCCAACTCACGTGCCTTCGC

Product: hypothetical protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MLAGISSHQLRQSLSLAVTVEKCIAEVALPTSSSLARIHGQLEVGLHQGGRRLTPQRRRVLDLFESIGSGIHLSAEEVHQ
QLLEANSKVSLATIYRTLRLLVEMGFLHELEISDGGHRFELASHDHPDHHHLVCVRCGRTEEFESKPVLEAGRSAAERIG
FQLIESTLNVRALCPSCQRPSTTNVH

Sequences:

>Translated_186_residues
MLAGISSHQLRQSLSLAVTVEKCIAEVALPTSSSLARIHGQLEVGLHQGGRRLTPQRRRVLDLFESIGSGIHLSAEEVHQ
QLLEANSKVSLATIYRTLRLLVEMGFLHELEISDGGHRFELASHDHPDHHHLVCVRCGRTEEFESKPVLEAGRSAAERIG
FQLIESTLNVRALCPSCQRPSTTNVH
>Mature_186_residues
MLAGISSHQLRQSLSLAVTVEKCIAEVALPTSSSLARIHGQLEVGLHQGGRRLTPQRRRVLDLFESIGSGIHLSAEEVHQ
QLLEANSKVSLATIYRTLRLLVEMGFLHELEISDGGHRFELASHDHPDHHHLVCVRCGRTEEFESKPVLEAGRSAAERIG
FQLIESTLNVRALCPSCQRPSTTNVH

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates genes involved in iron scavenging or photosynthetic electron transport [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=131, Percent_Identity=27.4809160305344, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI87082363, Length=143, Percent_Identity=32.8671328671329, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 20575; Mature: 20575

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAGISSHQLRQSLSLAVTVEKCIAEVALPTSSSLARIHGQLEVGLHQGGRRLTPQRRRV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEECHHCCCCCCCHHHHHH
LDLFESIGSGIHLSAEEVHQQLLEANSKVSLATIYRTLRLLVEMGFLHELEISDGGHRFE
HHHHHHHCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHEEEECCCCCEEE
LASHDHPDHHHLVCVRCGRTEEFESKPVLEAGRSAAERIGFQLIESTLNVRALCPSCQRP
ECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
STTNVH
CCCCCC
>Mature Secondary Structure
MLAGISSHQLRQSLSLAVTVEKCIAEVALPTSSSLARIHGQLEVGLHQGGRRLTPQRRRV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEECHHCCCCCCCHHHHHH
LDLFESIGSGIHLSAEEVHQQLLEANSKVSLATIYRTLRLLVEMGFLHELEISDGGHRFE
HHHHHHHCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHEEEECCCCCEEE
LASHDHPDHHHLVCVRCGRTEEFESKPVLEAGRSAAERIGFQLIESTLNVRALCPSCQRP
ECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
STTNVH
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8704986 [H]