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The map label for this gene is ptxD [H]

Identifier: 124022834

GI number: 124022834

Start: 1007702

End: 1008703

Strand: Reverse

Name: ptxD [H]

Synonym: P9303_11271

Alternate gene names: 124022834

Gene position: 1008703-1007702 (Counterclockwise)

Preceding gene: 124022835

Following gene: 124022833

Centisome position: 37.6

GC content: 57.98

Gene sequence:

>1002_bases
ATGACCCTCACAGCCTCTCCCGATCCAAGACCCCATCTAGTAATCACCAACTATGTGCAGGAAGAGGTGATTGACCTCCT
TTCCACTTTCGCGCGGGTCACCGCCAATCGCAGTCAAGCTCCCTGGAGCCGCAGTGATTTGCTCGAAGCCGCACGGTATG
CCGATGGGCTGCTGATGTTCATGCCCGATTATGTGGATGCGCAGTTTCTTGATCAGTGCCCGCGCCTGCGTTCGATTGCT
GGCGCCCTGCGTGGTTTCGACAATTTCGACCTTGCGGCGTGTGAGGCGCGGGGTGTTCGTTACCGCTTTATTCCCAATCT
GTTGGCAGCCCCCACCGCTGAACTCACCGTGGCAATGTTGATCAGCCTGGCGCGATCCATGCCAGCGGGGGATGCCTTTG
TGCGATCGGGGCGTTTCCATGGATGGCGGCCAAAGTTTTATTCCAAAGGGGTGATCAACAGCACTGTTGGCATCCTGGGG
ATGGGCCAACTCGGCCTGGAATTCGCCAAGCGAATGCAGGGCTTTGGGGCAACGCTGCTTTACAGCGACCCGGTTCCTTT
GGATCGCACATGCGAGCAACGCCTTGAACTCGCGCATGTGGAATTCAACGAACTGCTTGAACGCAGTGATCATCTGGTGC
TGATGGTCCCGCTCGACAACGACACGCAGCATCTGATCAACAGCGACGTGTTGACCCGATGCAAGCCGGGAGCCGTGCTG
ATCAATCCCTGCCGCGGATCGGTTGTTGATGAACTTGCCGTGGTGGAGGCTCTTCAGTCGGGCCATCTGGCTGGATATGG
AGCTGATGTCTTCGAAATGGAGGACTGGGCCCGACGGGACCACCCCGAGTCGATTCCCCAAGCCTTGCTCGATCAACCCG
ATCGCACCCTGCTCACCCCGCATATCGGTTCGGCCGTCCAAACAATCCGTGAAGACATCGCGATGACTGCTGCCCTAAAT
CTCAAGGCGCTTGTTCTGACCACCCTGTCGCCGATCGCATGA

Upstream 100 bases:

>100_bases
TCATGGAATACCAGCAAGTTTCTGCCTTGCTTTTAGTGGTGCTTGTGGTGGTCACGGCCCTCGATTCGATGAGCAATGCC
CTGCGTCACTGGATGGTGCA

Downstream 100 bases:

>100_bases
ACAACGTCACGATGCATTCGGATCCCAAGGATCTCCTTCAACTCAAAGAGCGTTATGAACAAGACGGTGTCGTCCATGTG
CCTGGGTTGGTTTCAACCGA

Product: lactate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent phosphite dehydrogenase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTLTASPDPRPHLVITNYVQEEVIDLLSTFARVTANRSQAPWSRSDLLEAARYADGLLMFMPDYVDAQFLDQCPRLRSIA
GALRGFDNFDLAACEARGVRYRFIPNLLAAPTAELTVAMLISLARSMPAGDAFVRSGRFHGWRPKFYSKGVINSTVGILG
MGQLGLEFAKRMQGFGATLLYSDPVPLDRTCEQRLELAHVEFNELLERSDHLVLMVPLDNDTQHLINSDVLTRCKPGAVL
INPCRGSVVDELAVVEALQSGHLAGYGADVFEMEDWARRDHPESIPQALLDQPDRTLLTPHIGSAVQTIREDIAMTAALN
LKALVLTTLSPIA

Sequences:

>Translated_333_residues
MTLTASPDPRPHLVITNYVQEEVIDLLSTFARVTANRSQAPWSRSDLLEAARYADGLLMFMPDYVDAQFLDQCPRLRSIA
GALRGFDNFDLAACEARGVRYRFIPNLLAAPTAELTVAMLISLARSMPAGDAFVRSGRFHGWRPKFYSKGVINSTVGILG
MGQLGLEFAKRMQGFGATLLYSDPVPLDRTCEQRLELAHVEFNELLERSDHLVLMVPLDNDTQHLINSDVLTRCKPGAVL
INPCRGSVVDELAVVEALQSGHLAGYGADVFEMEDWARRDHPESIPQALLDQPDRTLLTPHIGSAVQTIREDIAMTAALN
LKALVLTTLSPIA
>Mature_332_residues
TLTASPDPRPHLVITNYVQEEVIDLLSTFARVTANRSQAPWSRSDLLEAARYADGLLMFMPDYVDAQFLDQCPRLRSIAG
ALRGFDNFDLAACEARGVRYRFIPNLLAAPTAELTVAMLISLARSMPAGDAFVRSGRFHGWRPKFYSKGVINSTVGILGM
GQLGLEFAKRMQGFGATLLYSDPVPLDRTCEQRLELAHVEFNELLERSDHLVLMVPLDNDTQHLINSDVLTRCKPGAVLI
NPCRGSVVDELAVVEALQSGHLAGYGADVFEMEDWARRDHPESIPQALLDQPDRTLLTPHIGSAVQTIREDIAMTAALNL
KALVLTTLSPIA

Specific function: Catalyzes phosphite (phosphonate) oxidation [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=293, Percent_Identity=32.7645051194539, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI23308577, Length=289, Percent_Identity=30.7958477508651, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=30.3149606299213, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=30.3149606299213, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI87082289, Length=270, Percent_Identity=33.7037037037037, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1789279, Length=280, Percent_Identity=29.2857142857143, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787645, Length=213, Percent_Identity=28.169014084507, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788660, Length=254, Percent_Identity=29.1338582677165, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=300, Percent_Identity=29.6666666666667, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=24.8175182481752, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=29.8449612403101, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=312, Percent_Identity=25.3205128205128, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=285, Percent_Identity=25.2631578947368, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=265, Percent_Identity=26.4150943396226, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=171, Percent_Identity=30.9941520467836, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=168, Percent_Identity=29.1666666666667, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=159, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45551003, Length=312, Percent_Identity=30.1282051282051, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24585514, Length=312, Percent_Identity=30.1282051282051, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574282, Length=312, Percent_Identity=30.1282051282051, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574284, Length=312, Percent_Identity=30.1282051282051, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=30.6709265175719, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=31.5112540192926, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=328, Percent_Identity=29.8780487804878, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI19921140, Length=255, Percent_Identity=31.3725490196078, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=24.8366013071895, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=28.740157480315, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=28.740157480315, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=28.740157480315, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=28.740157480315, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=28.740157480315, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.20.1.1 [H]

Molecular weight: Translated: 36697; Mature: 36565

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTASPDPRPHLVITNYVQEEVIDLLSTFARVTANRSQAPWSRSDLLEAARYADGLLMF
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEE
MPDYVDAQFLDQCPRLRSIAGALRGFDNFDLAACEARGVRYRFIPNLLAAPTAELTVAML
CCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCHHHHCCHHHHHHHHH
ISLARSMPAGDAFVRSGRFHGWRPKFYSKGVINSTVGILGMGQLGLEFAKRMQGFGATLL
HHHHHCCCCCHHHHHCCCCCCCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEE
YSDPVPLDRTCEQRLELAHVEFNELLERSDHLVLMVPLDNDTQHLINSDVLTRCKPGAVL
ECCCCCCCHHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEE
INPCRGSVVDELAVVEALQSGHLAGYGADVFEMEDWARRDHPESIPQALLDQPDRTLLTP
EECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEECC
HIGSAVQTIREDIAMTAALNLKALVLTTLSPIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLTASPDPRPHLVITNYVQEEVIDLLSTFARVTANRSQAPWSRSDLLEAARYADGLLMF
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEE
MPDYVDAQFLDQCPRLRSIAGALRGFDNFDLAACEARGVRYRFIPNLLAAPTAELTVAML
CCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCHHHHCCHHHHHHHHH
ISLARSMPAGDAFVRSGRFHGWRPKFYSKGVINSTVGILGMGQLGLEFAKRMQGFGATLL
HHHHHCCCCCHHHHHCCCCCCCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEE
YSDPVPLDRTCEQRLELAHVEFNELLERSDHLVLMVPLDNDTQHLINSDVLTRCKPGAVL
ECCCCCCCHHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEE
INPCRGSVVDELAVVEALQSGHLAGYGADVFEMEDWARRDHPESIPQALLDQPDRTLLTP
EECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEECC
HIGSAVQTIREDIAMTAALNLKALVLTTLSPIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9791102; 11278981 [H]