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The map label for this gene is algA [H]

Identifier: 124022673

GI number: 124022673

Start: 876619

End: 877002

Strand: Direct

Name: algA [H]

Synonym: P9303_09641

Alternate gene names: 124022673

Gene position: 876619-877002 (Clockwise)

Preceding gene: 124022672

Following gene: 124022674

Centisome position: 32.68

GC content: 52.08

Gene sequence:

>384_bases
ATGCTGAACGCAACTGCTAGCAGAGGCATGAGCAAGGCCCCCCAGAGAGTTGAGCGTCCTTGGGGTTGGTATGAAGATCT
GCTCGAAGGAGAGGGTTATAAGGTCAAGCGTTTTTTGGTCTTTGCTGGTCAACAGCTCAGCCTTCAGCGCCATCAACATC
GCAGTGAAAATTGGACTGTGGTCTCAGGCCAGGGGCAGCTTTTCTGTAAAAACACTTGGCACGATGCTCAAGCTGGCACC
ACGTTGTATATCCCTCTGGGAGTGCTTCACCGAGCTCGTGGAGGCCAAAGCGATTTGGTGGTCGTTGAGGTTCAGCATGG
TCAGCTTTTGCAGGAATCAGATATTGAACGCCTCGAGGATGACTACGGACGGGTGATAAGTTAG

Upstream 100 bases:

>100_bases
AGGAAACTTCTCTACACTGCTATCACGCGCGCGCGACAGCGAGTGGATCTCGTTACTGCAATGGCATCTGGTCGTAGTGA
CGGCTGAGGCTGACGCCGCC

Downstream 100 bases:

>100_bases
GCAATCAACCTTTGAAGAAAAGGCGAGGCAGCACAACGCGGGTATCCGCGTATGGGGCGTTGTCTGCCTGATTTAAAGGA
TCAATCAGGCAGACAACGCC

Product: sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MLNATASRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTVVSGQGQLFCKNTWHDAQAGT
TLYIPLGVLHRARGGQSDLVVVEVQHGQLLQESDIERLEDDYGRVIS

Sequences:

>Translated_127_residues
MLNATASRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTVVSGQGQLFCKNTWHDAQAGT
TLYIPLGVLHRARGGQSDLVVVEVQHGQLLQESDIERLEDDYGRVIS
>Mature_127_residues
MLNATASRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTVVSGQGQLFCKNTWHDAQAGT
TLYIPLGVLHRARGGQSDLVVVEVQHGQLLQESDIERLEDDYGRVIS

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0662

COG function: function code G; Mannose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=112, Percent_Identity=39.2857142857143, Blast_Score=86, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 14462; Mature: 14462

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNATASRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTV
CCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCEEE
VSGQGQLFCKNTWHDAQAGTTLYIPLGVLHRARGGQSDLVVVEVQHGQLLQESDIERLED
ECCCCCEEECCCCCCCCCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHH
DYGRVIS
HHCCCCC
>Mature Secondary Structure
MLNATASRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTV
CCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCEEE
VSGQGQLFCKNTWHDAQAGTTLYIPLGVLHRARGGQSDLVVVEVQHGQLLQESDIERLED
ECCCCCEEECCCCCCCCCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHH
DYGRVIS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]