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The map label for this gene is zwf [H]

Identifier: 124022649

GI number: 124022649

Start: 853055

End: 854578

Strand: Reverse

Name: zwf [H]

Synonym: P9303_09401

Alternate gene names: 124022649

Gene position: 854578-853055 (Counterclockwise)

Preceding gene: 124022650

Following gene: 124022648

Centisome position: 31.86

GC content: 53.54

Gene sequence:

>1524_bases
ATGAGCACCACGATCACAAACCCTTTACGAGTTGGACTACGTCAAGAGCGGGTTATTGCACCGCAGTGCCTAGTCATCTT
TGGAGCAAGTGGCGACCTGACCCACCGCAAATTGGTTCCAGCCCTTTTCGAGCTATACAAACAACGACGGCTACCGAGTG
AATTCGCCTTACTTGGCTGCGCGCGACGTCCTTGGAGCAACGAAATATTTCGCCAAAAAATGGCTGAAGCCCTCGGCGAG
ACTATCAACGAAAACCAGCTTGCTTGGGATCAATTCGCCGCAGGTCTTTTTTACGAACCTGTCGATCTACAGAAGCCAGA
AGACCTCATCAAACTCAGCCATCGGCTGGAAGAGATTGATCGACTCCGCGCCACCCGTAGCAATCGCACCTTCTATCTTT
CGGTGTCACCAAAGTTCTACGGTAGTGGCTGCAAAGCTCTTGCTAATGCCGGTCTTCTAAGCGACCCCAAACGCAGTCGA
GTGGTCATCGAAAAACCATTCGGGCGGGATTACGCCAGTGCTCAGTCTTTAAATCAAATCGTCCAAAGCTGTGGCCAAGA
GAATCAAATCTTCCGCATCGACCACTACCTCGGCAAAGAAACAGTCCAGAACATCCTTGTACTGCGATTTGCCAATACCA
TCTTTGAACCAATCTGGAACAGGAATTACATCTCCAGCGTTCAAATCACGGCCGCTGAAACCGTAGGTGTTGAAGAACGA
GCCAACTACTACGAATCTTCAGGTGCCCTGCGAGACATGGTGCAAAACCATCTCACCCAGATGCTGGCCATCACCACGAT
GGAACCGCCAGGGCGCTTTGACCCTGAGGCAATCCGCAATGAAAAAGCCAAGGTTTTGCTAGCGGCTCGCCTAGCGGATG
AGTTGGAACCTTGGAACTGCTGCATCCGTGGCCAGTACGCACCTGGCGGCACCAAGGAAGCTCCGATAGCAGGCTATCGA
CAGGAGCCGGGTGTCGATCCCAGCAGCACCACCGAGACCTATGTAGCGATGAAACTTTTCATCGACAACTGGCGCTGGCA
GGGAGTGCCCTTTTACGTTCGTACTGGCAAACGACTGGCAAAGCGTCTTAGTGAAGTGGTGCTCACCTTTCGAGAAGCAC
CCGTGCACCTTTTCGATGCCGCTGGGGGCAGCCCTACAGCGAACCAACTCATCCTGCGAATCCAACCGGATGAAGGTGCC
GAGTGGCGCTTTGAGGTGAAGTCACCTGGTTCAGGCATGCGCAGCCGACCAGTAGAGATGGAATTCTCCTATGACGAATC
CTTCGGTGAGCCATCCGATGAGGGATACGTCCGACTTTTGGCCGATGCCATGCTCAGTGACCCAACTTTATTTACCCGCA
GTGATGAGGTTGAAGCAGCGTGGCGCCTTTACACCCCTCTACTGGAACTGATTGAAGACAGCCCATGGCAATTGCCCATT
CATCCCTATGAATCACGTACCTGGGGGCCCGCTGCTGCCGATACCCTGCTTGCCAATGACGGATTGCTCTGGCGCCGACC
CTGA

Upstream 100 bases:

>100_bases
CAAATTTTTTTGGGCATACGACGACAAAGCATGCCGGGATGGTCTGGAGCACTTTGAATTCACAGATCCTTGGTTACCCG
TCAGAAGAGGTCCGTGTTCC

Downstream 100 bases:

>100_bases
TCCCGCCTGGCTTATCTCATCTTGATTACTCAGCTCTAGCCATGTCCCCCCAGCTCACGCTTCAGAGCCCTCTGCAACTC
CCTCCTAGTGAGGTCCCTAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSTTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGCARRPWSNEIFRQKMAEALGE
TINENQLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEIDRLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSR
VVIEKPFGRDYASAQSLNQIVQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNCCIRGQYAPGGTKEAPIAGYR
QEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGA
EWRFEVKSPGSGMRSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
HPYESRTWGPAAADTLLANDGLLWRRP

Sequences:

>Translated_507_residues
MSTTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGCARRPWSNEIFRQKMAEALGE
TINENQLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEIDRLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSR
VVIEKPFGRDYASAQSLNQIVQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNCCIRGQYAPGGTKEAPIAGYR
QEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGA
EWRFEVKSPGSGMRSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
HPYESRTWGPAAADTLLANDGLLWRRP
>Mature_506_residues
STTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGCARRPWSNEIFRQKMAEALGET
INENQLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEIDRLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSRV
VIEKPFGRDYASAQSLNQIVQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEERA
NYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNCCIRGQYAPGGTKEAPIAGYRQ
EPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGAE
WRFEVKSPGSGMRSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPIH
PYESRTWGPAAADTLLANDGLLWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=495, Percent_Identity=35.7575757575758, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=35.9342915811088, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI52145310, Length=488, Percent_Identity=29.3032786885246, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788158, Length=496, Percent_Identity=39.1129032258064, Blast_Score=348, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17538218, Length=510, Percent_Identity=33.5294117647059, Blast_Score=296, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=477, Percent_Identity=34.5911949685535, Blast_Score=269, Evalue=8e-73,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=35.9081419624217, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=35.9081419624217, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=28.781512605042, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57440; Mature: 57309

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGC
CCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHC
ARRPWSNEIFRQKMAEALGETINENQLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEID
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
RLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSRVVIEKPFGRDYASAQSLNQI
HHHHHCCCCEEEEEECCCHHCCCHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
VQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
HHHCCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCHHHH
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNC
HHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCE
CIRGQYAPGGTKEAPIAGYRQEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLA
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCEEECCHHHHH
KRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGAEWRFEVKSPGSGMRSRPVEM
HHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
EECCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECC
HPYESRTWGPAAADTLLANDGLLWRRP
CCCCCCCCCCHHHHHHEECCCEEECCC
>Mature Secondary Structure 
STTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGC
CCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHC
ARRPWSNEIFRQKMAEALGETINENQLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEID
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
RLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSRVVIEKPFGRDYASAQSLNQI
HHHHHCCCCEEEEEECCCHHCCCHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
VQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
HHHCCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCHHHH
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNC
HHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCE
CIRGQYAPGGTKEAPIAGYRQEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLA
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCEEECCHHHHH
KRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGAEWRFEVKSPGSGMRSRPVEM
HHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
EECCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECC
HPYESRTWGPAAADTLLANDGLLWRRP
CCCCCCCCCCHHHHHHEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]