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The map label for this gene is thrA [H]

Identifier: 124022597

GI number: 124022597

Start: 805183

End: 806499

Strand: Reverse

Name: thrA [H]

Synonym: P9303_08881

Alternate gene names: 124022597

Gene position: 806499-805183 (Counterclockwise)

Preceding gene: 124022598

Following gene: 124022596

Centisome position: 30.06

GC content: 55.81

Gene sequence:

>1317_bases
ATGGGCAAGAAGATAGGAGTTGGTCTCCTGGGGCTTGGAACAGTAGGCGCCGGTGTTGCAGGCATCCTCCAAGCCCCCGA
AGGGCGGCATCCTCTGGTGGCAGAGCTTGAACTGGTGCGTGTAGCGGTTCGAAATCTGCAACGACCTCGCTCGATTGAAC
TTCCCGCATCCTTGCTGACCAACAACCCACAGGCTGTTGTTGATGATCCCTCTGTGCAAGTGGTTGTTGAAGTCATGGGA
GGGATCGAACCAGCCCGAACCCTGATCATGCGAGCCATTGCCGCCGGCAAAGCAGTTGTTACAGCTAACAAAGCCGTAAT
TGCAAGACATGGCGAAGAGATTGCAGCTGCTGCAGCTGCTGCAGGGGTATACGTACTGATCGAAGCTGCCGTCGGCGGAG
GCATCCCGATCATCGAGCCACTTAAGCAATCACTAGGTGGCAACCGGATCGAACGCGTGAGCGGCATCATCAACGGCACC
ACCAACTACATCCTCAGTCGCATGGCACAGGAAGGGGTGGCCTATGACGACGTGCTCAAGACCGCCCAGGATCTTGGCTA
TGCAGAGGCAGATCCAGCGGCCGACGTTGAGGGCTTCGATGCAGCAGACAAGATTGCCATCCTCAGTGGACTGGCCTTCG
GTGGACCTGTCAACCGTGACTCAATTCCCACCCAAGGCATCAACAAGCTTCAAAGCCGCGATGTGGACTACGCCAAACAG
CTTGGCTACAGGGTGAAATTATTGGCTGTCGCCGAACGTCTCAACTCAGACGCTCAGACCAGTCAGTCCTTGCCCTTAGC
TGTAAGGGTGCAACCAACAATGGTGCCTCTAGACCACCCGCTTGCAGGAGTAAATGGCGTGAACAACGCCATCCTGGTTG
AGGGCGATCCGATCGGCCGCGTGATGTTTTATGGCCCAGGAGCAGGTTCTGGACCCACCGCCTCTGCTGTGGTAGCTGAC
ATCCTCAACATCGCTGGCATACGCCAACTAGGTGAAGTCCACGGCAGCCTCGATCCCCTTCTCGCCGCAAGCAGTTGGCG
TTCCTGTCACCTCGTTGATCCAAGTGCCATCCGTCAGCGCAACTATGTGCGCTTCAATGCAGAGGACACACCAGGCGTGA
TCGGTCGGATCGGTAGCTGCTTCGGCGATCGTGCAATTTCAATTCAATCAATCGTGCAATTCGATGCCTCCGATGCCGGC
GCAGAAATCGTTGTAATTACCCATGAAATAAGTCAAGGCCAGATGCAAGATGCCCTTACTGCAATCACCTCTATGGCTGA
GGTCAAAGGACTTGCCGCCCATCTCAGCTGCCTTTAA

Upstream 100 bases:

>100_bases
CTCCTCAATATGAAGGCCCAGGCCCAGCAGCTTGCAAGGGTTTCGTCTTCCACAACTTCCTAGAGTCCTACCAGCTAGTA
CAAGACTGGACACAGCTGCC

Downstream 100 bases:

>100_bases
CAGCCAGCAACCCCCTGACGAAGAGACCCCGCCATACGCAAGAGTTGCAAAACAAGTTGAGAGACAAGTCTGCAGACGCT
GACCTGTGCCCCCAAAGGTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MGKKIGVGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRNLQRPRSIELPASLLTNNPQAVVDDPSVQVVVEVMG
GIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIAAAAAAAGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGT
TNYILSRMAQEGVAYDDVLKTAQDLGYAEADPAADVEGFDAADKIAILSGLAFGGPVNRDSIPTQGINKLQSRDVDYAKQ
LGYRVKLLAVAERLNSDAQTSQSLPLAVRVQPTMVPLDHPLAGVNGVNNAILVEGDPIGRVMFYGPGAGSGPTASAVVAD
ILNIAGIRQLGEVHGSLDPLLAASSWRSCHLVDPSAIRQRNYVRFNAEDTPGVIGRIGSCFGDRAISIQSIVQFDASDAG
AEIVVITHEISQGQMQDALTAITSMAEVKGLAAHLSCL

Sequences:

>Translated_438_residues
MGKKIGVGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRNLQRPRSIELPASLLTNNPQAVVDDPSVQVVVEVMG
GIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIAAAAAAAGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGT
TNYILSRMAQEGVAYDDVLKTAQDLGYAEADPAADVEGFDAADKIAILSGLAFGGPVNRDSIPTQGINKLQSRDVDYAKQ
LGYRVKLLAVAERLNSDAQTSQSLPLAVRVQPTMVPLDHPLAGVNGVNNAILVEGDPIGRVMFYGPGAGSGPTASAVVAD
ILNIAGIRQLGEVHGSLDPLLAASSWRSCHLVDPSAIRQRNYVRFNAEDTPGVIGRIGSCFGDRAISIQSIVQFDASDAG
AEIVVITHEISQGQMQDALTAITSMAEVKGLAAHLSCL
>Mature_437_residues
GKKIGVGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRNLQRPRSIELPASLLTNNPQAVVDDPSVQVVVEVMGG
IEPARTLIMRAIAAGKAVVTANKAVIARHGEEIAAAAAAAGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGTT
NYILSRMAQEGVAYDDVLKTAQDLGYAEADPAADVEGFDAADKIAILSGLAFGGPVNRDSIPTQGINKLQSRDVDYAKQL
GYRVKLLAVAERLNSDAQTSQSLPLAVRVQPTMVPLDHPLAGVNGVNNAILVEGDPIGRVMFYGPGAGSGPTASAVVADI
LNIAGIRQLGEVHGSLDPLLAASSWRSCHLVDPSAIRQRNYVRFNAEDTPGVIGRIGSCFGDRAISIQSIVQFDASDAGA
EIVVITHEISQGQMQDALTAITSMAEVKGLAAHLSCL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=118, Percent_Identity=33.0508474576271, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45429; Mature: 45297

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKIGVGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRNLQRPRSIELPASLLT
CCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
NNPQAVVDDPSVQVVVEVMGGIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIAAAAAA
CCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCHHEECCCHHHHHHHHH
AGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGTTNYILSRMAQEGVAYDDVLK
CCCEEEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
TAQDLGYAEADPAADVEGFDAADKIAILSGLAFGGPVNRDSIPTQGINKLQSRDVDYAKQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHH
LGYRVKLLAVAERLNSDAQTSQSLPLAVRVQPTMVPLDHPLAGVNGVNNAILVEGDPIGR
CCCHHHHHHHHHHHCCCHHHCCCCCEEEEECCEEECCCCCCCCCCCCCCEEEEECCCCCE
VMFYGPGAGSGPTASAVVADILNIAGIRQLGEVHGSLDPLLAASSWRSCHLVDPSAIRQR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECHHHHHCC
NYVRFNAEDTPGVIGRIGSCFGDRAISIQSIVQFDASDAGAEIVVITHEISQGQMQDALT
CCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHH
AITSMAEVKGLAAHLSCL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKKIGVGLLGLGTVGAGVAGILQAPEGRHPLVAELELVRVAVRNLQRPRSIELPASLLT
CCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
NNPQAVVDDPSVQVVVEVMGGIEPARTLIMRAIAAGKAVVTANKAVIARHGEEIAAAAAA
CCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCHHEECCCHHHHHHHHH
AGVYVLIEAAVGGGIPIIEPLKQSLGGNRIERVSGIINGTTNYILSRMAQEGVAYDDVLK
CCCEEEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
TAQDLGYAEADPAADVEGFDAADKIAILSGLAFGGPVNRDSIPTQGINKLQSRDVDYAKQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHH
LGYRVKLLAVAERLNSDAQTSQSLPLAVRVQPTMVPLDHPLAGVNGVNNAILVEGDPIGR
CCCHHHHHHHHHHHCCCHHHCCCCCEEEEECCEEECCCCCCCCCCCCCCEEEEECCCCCE
VMFYGPGAGSGPTASAVVADILNIAGIRQLGEVHGSLDPLLAASSWRSCHLVDPSAIRQR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECHHHHHCC
NYVRFNAEDTPGVIGRIGSCFGDRAISIQSIVQFDASDAGAEIVVITHEISQGQMQDALT
CCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHH
AITSMAEVKGLAAHLSCL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]