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The map label for this gene is pntB [H]

Identifier: 124022571

GI number: 124022571

Start: 779093

End: 780532

Strand: Direct

Name: pntB [H]

Synonym: P9303_08621

Alternate gene names: 124022571

Gene position: 779093-780532 (Clockwise)

Preceding gene: 124022570

Following gene: 124022572

Centisome position: 29.04

GC content: 55.56

Gene sequence:

>1440_bases
ATGAATATTGCTGAGATCCTTAAGTTCGCGATTGATCTGGTCGCGGTTTTACTGCTTGCCCTTGGGATCAAGGGCCTTTC
GAAGGTGCGCTCTGCTCGTGAGGCCAATCGCCTTGCCGCTGTTGCCATGGCACTTGCCGTAGTGGGCTTGATCGTGAACT
ATCTCGGCACCACCGGCATCGCTGCTGAAGCCTGGATTTGGATCATCTTCGGCACGGTGGTCGGTGGATGTCTCGGTGCG
ATCACAGCGCAGCGTGTGCCGATGACCTCAATGCCGGAGACCGTTGCTCTGTTTAACGGCTGCGGAGGCATGTCGTCGTT
GTTGGTGGCTCTCGGTGTTGCAATCTTCCCGACAGCCGCTGGTGCTGGCGAAGCAGGCAGCGGAGTGGTTGAAGACATCT
CGATTGTGGTGTCTGTTTTTGTTGGCTCGATCACCTTCTCAGGATCCATAGTGGCGATGGCAAAGCTGCAGGGCTGGCTG
TCAACACCACCTTGGATGCAGAGCAGGGTTCGACATGCCGTGAACATTGCGCTTGCTGTGATGTCTTTAGTGGCTGCCAT
CGAACTTGGCCGCCATGGCGACAACGTCAGTGCGCTGTGGTTGCTGGTGATCGGGTCTGGTTTGTTGGGAATCGGCGTAA
CGCTACCGATTGGCGGCGCCGATATGCCAGTGGTGATCTCACTTTTGAACAGTTATTCAGGTGTTGCGGCGGCGGCGGCA
GGTTTCGTTGTCGGTAGTCAGTTGCTGATTGTGGCTGGCGCCATGGTTGGAGCTGCTGGTCTGATCCTTACTCAGGTGAT
GTGCAACGGCATGAATCGCTCGTTGGTATCCGTGTTGTTTGGTGGAGCGTTAGGAGCAAGCGCTGCTGCTGGCGGAGGTG
GCGAATATAAAAACATCACCAGTTGCAGCGCTGAGGAGTGTGCGCTCACCCTTGAGGCCGCAGAGCGGGTTGTCATCGTT
CCCGGTTACGGCCTGGCTGTAGCACAGGCCCAGCACACGCTTAGGGAAGTCACCCGTGCTTTGGAGGCAGCTGGAATTGA
GGTCACCTATGCCATCCATCCGGTTGCTGGACGGATGCCAGGCCATATGAACGTTCTCCTTGCAGAAGCCGATGTGCCTT
ACGAGCAGCTCAAGGAGATGGATGTGATTAATCCTGAGTTCCCAGCTACTGACGTGGTGCTGGTGCTAGGGGCGAACGAC
GTTGTGAATCCTCAGGCCAAGACCGATACAAGTTCACCTCTCTATGGCATGCCTGTGTTGGATGTGCAGGAAGCTCGAAC
GGTGTTCGTGGTGAAGCGGGGCATGAGTGCGGGCTACTCAGGGATTAAGAATGATCTGTTTGAACTTGCCAATACTTCCA
TGGTGTTTGGTGATGCCAAGAAGGTGTTGGGTGATCTTTTGGTTGAACTAAAGGAGCTTGGTGTTGGCAAGAAGGGGTGA

Upstream 100 bases:

>100_bases
TTGGTTTCGCCTTGTTCAACGTGATTGGCGGATTTCTCGTTACCGATCGGATGCTGGCCATGTTCAGCCGCAAGTCATCT
CGCCGCAGGGACAACCACTG

Downstream 100 bases:

>100_bases
ACCCCATCCCGAGCTGCTTCAGCAGCTCGGGATGTCTTCTTTTAGACAGAGATTGCCTTGGCTGGGCGGTGATTTGCAGA
CCCTCAGGGACACCCTGAGA

Product: nicotinamide nucleotide transhydrogenase, subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNIAEILKFAIDLVAVLLLALGIKGLSKVRSAREANRLAAVAMALAVVGLIVNYLGTTGIAAEAWIWIIFGTVVGGCLGA
ITAQRVPMTSMPETVALFNGCGGMSSLLVALGVAIFPTAAGAGEAGSGVVEDISIVVSVFVGSITFSGSIVAMAKLQGWL
STPPWMQSRVRHAVNIALAVMSLVAAIELGRHGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAAAGGGGEYKNITSCSAEECALTLEAAERVVIV
PGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGAND
VVNPQAKTDTSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG

Sequences:

>Translated_479_residues
MNIAEILKFAIDLVAVLLLALGIKGLSKVRSAREANRLAAVAMALAVVGLIVNYLGTTGIAAEAWIWIIFGTVVGGCLGA
ITAQRVPMTSMPETVALFNGCGGMSSLLVALGVAIFPTAAGAGEAGSGVVEDISIVVSVFVGSITFSGSIVAMAKLQGWL
STPPWMQSRVRHAVNIALAVMSLVAAIELGRHGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAAAGGGGEYKNITSCSAEECALTLEAAERVVIV
PGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGAND
VVNPQAKTDTSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG
>Mature_479_residues
MNIAEILKFAIDLVAVLLLALGIKGLSKVRSAREANRLAAVAMALAVVGLIVNYLGTTGIAAEAWIWIIFGTVVGGCLGA
ITAQRVPMTSMPETVALFNGCGGMSSLLVALGVAIFPTAAGAGEAGSGVVEDISIVVSVFVGSITFSGSIVAMAKLQGWL
STPPWMQSRVRHAVNIALAVMSLVAAIELGRHGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAAAGGGGEYKNITSCSAEECALTLEAAERVVIV
PGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGAND
VVNPQAKTDTSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=479, Percent_Identity=37.5782881002088, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI122939153, Length=479, Percent_Identity=37.5782881002088, Blast_Score=285, Evalue=6e-77,
Organism=Escherichia coli, GI1787886, Length=456, Percent_Identity=44.9561403508772, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17550456, Length=406, Percent_Identity=41.1330049261084, Blast_Score=284, Evalue=9e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48994; Mature: 48994

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAEILKFAIDLVAVLLLALGIKGLSKVRSAREANRLAAVAMALAVVGLIVNYLGTTGI
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAEAWIWIIFGTVVGGCLGAITAQRVPMTSMPETVALFNGCGGMSSLLVALGVAIFPTAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC
GAGEAGSGVVEDISIVVSVFVGSITFSGSIVAMAKLQGWLSTPPWMQSRVRHAVNIALAV
CCCCCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MSLVAAIELGRHGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHH
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAAAGGGGEYKNIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SCSAEECALTLEAAERVVIVPGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMP
CCCHHHHHEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
GHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVVNPQAKTDTSSPLYGMPVL
CCCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG
CHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNIAEILKFAIDLVAVLLLALGIKGLSKVRSAREANRLAAVAMALAVVGLIVNYLGTTGI
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAEAWIWIIFGTVVGGCLGAITAQRVPMTSMPETVALFNGCGGMSSLLVALGVAIFPTAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC
GAGEAGSGVVEDISIVVSVFVGSITFSGSIVAMAKLQGWLSTPPWMQSRVRHAVNIALAV
CCCCCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
MSLVAAIELGRHGDNVSALWLLVIGSGLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAA
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHH
GFVVGSQLLIVAGAMVGAAGLILTQVMCNGMNRSLVSVLFGGALGASAAAGGGGEYKNIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SCSAEECALTLEAAERVVIVPGYGLAVAQAQHTLREVTRALEAAGIEVTYAIHPVAGRMP
CCCHHHHHEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
GHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVVNPQAKTDTSSPLYGMPVL
CCCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DVQEARTVFVVKRGMSAGYSGIKNDLFELANTSMVFGDAKKVLGDLLVELKELGVGKKG
CHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]