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The map label for this gene is mprA [H]

Identifier: 124022336

GI number: 124022336

Start: 590201

End: 590923

Strand: Reverse

Name: mprA [H]

Synonym: P9303_06261

Alternate gene names: 124022336

Gene position: 590923-590201 (Counterclockwise)

Preceding gene: 124022337

Following gene: 124022334

Centisome position: 22.03

GC content: 47.44

Gene sequence:

>723_bases
ATGACTAACGCATCATCACCGAGAACCAGAGTCCTATTGGTGGATGATGAACCGAGGCTGACAGAACTTCTACGCCTAGA
ACTTGATGTTGAGGGTTATGAGGTCAGCGTGGCGGAGGACGGCGCCTCAGGGTTGATCAAAGCTCGAAGTGATCCGTCAC
CAAACCTAATCATTCTTGATTGGAACCTTCCTGATTTCACAGGTGTCGATATCTGTCAACGTATTCGTTCCAGTGGCATT
AAGACACCGATCTTGATGCTCACAGGTCATGACGATGTCACCGATCGCGTCAAGGCACTGGATGCTGGAGTTGATGACTA
TCTAACCAAACCCTTCTCCATTGAAGAGCTCATGGCCAGATTACGAGCCATGCAACGCAGAGCAGAGCAATTCTCAGGAG
ACTCTGGCAACGAGCATCAACCAGAGACCATACAAGTAGCGGACTTAAAGATGAACACCAGCACAAGGGATGTAACGCGC
GACAATCGCACGATTCAACTTTCCGTAAAAGAATATGAGCTACTACATTTCCTAATGGTTGGCGCAGGAAAAGTTCACGA
ACGTGACGCCATTATGAAAGCTGTATGGGGAGAGGATTTCTTCGGAGATGACAATCTTCTAGACGTTTACATCCGCTATC
TACGCCAAAAGATTGAACAAAAAGGTGCTGCTACTATGATTCACACAGTTCGCGGGGTTGGCTTTATCCTTCGAGCAGAA
TAA

Upstream 100 bases:

>100_bases
TGGATCCACACCCTGAAGGAGGGGCCCACGCATAACCATTGATTGCACAAGGTCTCGATCCAGACAAACTGCTTAAGTAG
ACACCAGGTTTATTGCATGA

Downstream 100 bases:

>100_bases
TACATACAAATTACCTTCGGCTTTTATAATGAAAATGCCTGAAGCTATATTCTCATGAAGAAGGACCTCTTCCCCCAGCG
CATTTCCACAAAGGTATTTT

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTNASSPRTRVLLVDDEPRLTELLRLELDVEGYEVSVAEDGASGLIKARSDPSPNLIILDWNLPDFTGVDICQRIRSSGI
KTPILMLTGHDDVTDRVKALDAGVDDYLTKPFSIEELMARLRAMQRRAEQFSGDSGNEHQPETIQVADLKMNTSTRDVTR
DNRTIQLSVKEYELLHFLMVGAGKVHERDAIMKAVWGEDFFGDDNLLDVYIRYLRQKIEQKGAATMIHTVRGVGFILRAE

Sequences:

>Translated_240_residues
MTNASSPRTRVLLVDDEPRLTELLRLELDVEGYEVSVAEDGASGLIKARSDPSPNLIILDWNLPDFTGVDICQRIRSSGI
KTPILMLTGHDDVTDRVKALDAGVDDYLTKPFSIEELMARLRAMQRRAEQFSGDSGNEHQPETIQVADLKMNTSTRDVTR
DNRTIQLSVKEYELLHFLMVGAGKVHERDAIMKAVWGEDFFGDDNLLDVYIRYLRQKIEQKGAATMIHTVRGVGFILRAE
>Mature_239_residues
TNASSPRTRVLLVDDEPRLTELLRLELDVEGYEVSVAEDGASGLIKARSDPSPNLIILDWNLPDFTGVDICQRIRSSGIK
TPILMLTGHDDVTDRVKALDAGVDDYLTKPFSIEELMARLRAMQRRAEQFSGDSGNEHQPETIQVADLKMNTSTRDVTRD
NRTIQLSVKEYELLHFLMVGAGKVHERDAIMKAVWGEDFFGDDNLLDVYIRYLRQKIEQKGAATMIHTVRGVGFILRAE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=38.0530973451327, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=39.4736842105263, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=34.6491228070175, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=33.0472103004292, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=35.6223175965665, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=33.7662337662338, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.0434782608696, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=32.0175438596491, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787229, Length=235, Percent_Identity=31.9148936170213, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.3859649122807, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI145693140, Length=190, Percent_Identity=33.6842105263158, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788550, Length=162, Percent_Identity=27.1604938271605, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=160, Percent_Identity=27.5, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788521, Length=126, Percent_Identity=34.9206349206349, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27046; Mature: 26915

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNASSPRTRVLLVDDEPRLTELLRLELDVEGYEVSVAEDGASGLIKARSDPSPNLIILD
CCCCCCCCEEEEEECCCCHHHHHHHHEECCCCEEEEEECCCCCCEEEECCCCCCCEEEEE
WNLPDFTGVDICQRIRSSGIKTPILMLTGHDDVTDRVKALDAGVDDYLTKPFSIEELMAR
CCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCHHHHHCCCCCHHHHHHH
LRAMQRRAEQFSGDSGNEHQPETIQVADLKMNTSTRDVTRDNRTIQLSVKEYELLHFLMV
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHH
GAGKVHERDAIMKAVWGEDFFGDDNLLDVYIRYLRQKIEQKGAATMIHTVRGVGFILRAE
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECC
>Mature Secondary Structure 
TNASSPRTRVLLVDDEPRLTELLRLELDVEGYEVSVAEDGASGLIKARSDPSPNLIILD
CCCCCCCEEEEEECCCCHHHHHHHHEECCCCEEEEEECCCCCCEEEECCCCCCCEEEEE
WNLPDFTGVDICQRIRSSGIKTPILMLTGHDDVTDRVKALDAGVDDYLTKPFSIEELMAR
CCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCHHHHHCCCCCHHHHHHH
LRAMQRRAEQFSGDSGNEHQPETIQVADLKMNTSTRDVTRDNRTIQLSVKEYELLHFLMV
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHH
GAGKVHERDAIMKAVWGEDFFGDDNLLDVYIRYLRQKIEQKGAATMIHTVRGVGFILRAE
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA