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The map label for this gene is elaC

Identifier: 124022243

GI number: 124022243

Start: 517230

End: 518186

Strand: Reverse

Name: elaC

Synonym: P9303_05331

Alternate gene names: 124022243

Gene position: 518186-517230 (Counterclockwise)

Preceding gene: 124022248

Following gene: 124022241

Centisome position: 19.32

GC content: 59.14

Gene sequence:

>957_bases
TTGCAGGTCACCTTTCTCGGCACCAGCTCGGGCGTACCGACACGAGCCCGCAATGTTTCTGCCGTGGCTCTGCGGCTGCC
CCAACGTGCTGAGTTGTGGCTGTTTGATTGCGGAGAAGGCACTCAGCATCAGTTCCTGCGCAGCGATCTGCGTCTGTCTC
AACTCAGACGAGTGTTCGTTAGCCACATGCATGGCGACCATGTGTTTGGCCTGCCGGGTCTGTTGGCCAGCCTCGGCCTA
TCCGGCAACAGCAACGGAGTGGATCTCTACGGCCCCGATCCACTGGAAAGCTATCTGCAAGGCGTGCTGCGCAATAGCTC
CACCAGGATCGGATACCCCCTCAAGGTTCATCGCGTGCGAGACGCAGCAGAGCAGAACCTGATTGTGTTTGAAGACAAAG
ACATCCTGGTGCGCTGCACCCCGCTCACCCATCGCGTGCCGGCCTACGCCTATCGCGTGGAGCAAAAACCCAAGCCAGGC
CATTTCAACCTTGAACGAGCCCAACGCCTCGGCATCCCGCCAGGCCCCGTCTATGCCGCCTTAAAGCGTGGTGAACAGGT
CAGCCTCGATGATGGGCGCGTGGTGGATGGCCGGGACTTCTGCGGACCAGATCGCCCAGGCGCCAGCATCGTGTTCTGCA
CCGATACGGTGTTTTCAGAAGCTGCTGTGGCCCTAGCCGCAGGCGCGGACCTGCTAATCCACGAAGCAACCTTCGCCCAT
AGCGAAGCAGAAATGGCTTATCAGAAGCAGCACTCCACCAGCACCATGGCGGCCCAAACAGCTGCCGAAGCCGGCGTCGG
GAAACTCGTATTAACCCACCTCAGTCCACGCTATGCGCCAGGCAATCCGGTTACCCCAAATGACCTGCTACGAGAAGCTC
AAGCGATCTTTTCGAACACCATCCTCGCCAAGGATTTCCTCAGTTTTGAAGTCGCTCCGCGCTGCAACAGTTCTTGA

Upstream 100 bases:

>100_bases
CCAATCAACATGTTCAACAAGGACATTCAGTGTGCCCCGATCACAACAACCAGGCCAGGCCCCAAGCCATGGCAGCATGG
TCTTTGGGGTGTTCAAGGCC

Downstream 100 bases:

>100_bases
TTACGGCCCTTAGAGCTCCCGCCCCGTGATACAAGGTGTTGTCGCTTCTGTCAGTAACTGGCGTATTCCATGGCCTCTCT
CTTTGCATCCCTGGGACGGT

Product: beta-lactamase superfamily hydrolase

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRRVFVSHMHGDHVFGLPGLLASLGL
SGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKPKPG
HFNLERAQRLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTVFSEAAVALAAGADLLIHEATFAH
SEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIFSNTILAKDFLSFEVAPRCNSS

Sequences:

>Translated_318_residues
MQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRRVFVSHMHGDHVFGLPGLLASLGL
SGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKPKPG
HFNLERAQRLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTVFSEAAVALAAGADLLIHEATFAH
SEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIFSNTILAKDFLSFEVAPRCNSS
>Mature_318_residues
MQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRRVFVSHMHGDHVFGLPGLLASLGL
SGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKPKPG
HFNLERAQRLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTVFSEAAVALAAGADLLIHEATFAH
SEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIFSNTILAKDFLSFEVAPRCNSS

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=359, Percent_Identity=32.8690807799443, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI260166619, Length=216, Percent_Identity=30.0925925925926, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI145553959, Length=109, Percent_Identity=39.4495412844037, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI260166622, Length=109, Percent_Identity=39.4495412844037, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI87082078, Length=313, Percent_Identity=42.4920127795527, Blast_Score=255, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24652403, Length=294, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_PROM3 (A2C725)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016550.1
- ProteinModelPortal:   A2C725
- SMR:   A2C725
- STRING:   A2C725
- GeneID:   4776444
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_05331
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK919698
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34613; Mature: 34613

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRRVFV
CEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
SHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVR
HHCCCCCEECHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHH
DAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKPKPGHFNLERAQRLGIPPGPVYAA
HHHHCCEEEEECCCEEEEECCCCCCCCHHEEEECCCCCCCCCCHHHHHHCCCCCCHHHHH
LKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTVFSEAAVALAAGADLLIHEATFAH
HHCCCEEECCCCEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEEHHHHHC
SEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIFSNT
HHHHHHHHHHCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ILAKDFLSFEVAPRCNSS
HHHHHHHCEEECCCCCCC
>Mature Secondary Structure
MQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRRVFV
CEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
SHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVR
HHCCCCCEECHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHH
DAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKPKPGHFNLERAQRLGIPPGPVYAA
HHHHCCEEEEECCCEEEEECCCCCCCCHHEEEECCCCCCCCCCHHHHHHCCCCCCHHHHH
LKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTVFSEAAVALAAGADLLIHEATFAH
HHCCCEEECCCCEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEEHHHHHC
SEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIFSNT
HHHHHHHHHHCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ILAKDFLSFEVAPRCNSS
HHHHHHHCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA