Click here to switch to the map view.

The map label for this gene is mutSB [H]

Identifier: 124022099

GI number: 124022099

Start: 391408

End: 393894

Strand: Direct

Name: mutSB [H]

Synonym: P9303_03891

Alternate gene names: 124022099

Gene position: 391408-393894 (Clockwise)

Preceding gene: 124022098

Following gene: 124022104

Centisome position: 14.59

GC content: 57.7

Gene sequence:

>2487_bases
ATGCAGCCGCTTGGTTACGGCAGGGATGATTGGCTTCTTTCAAGTTCAGTGGGGCGCAACAGCGTTGAAATGAGCGCTGT
AGTCATGAGCTCTGAGGTCTCGACTGCTTCGCTTGCCTTTCAGGACACACTCAAACAGCTTGAATGGCCACGCTTATGTG
AACACCTCGCTGGATTTGCCAGCACCTTGCAGGGCCGGCGTCATTGCCAGACTTTGTCGCTGCCTGCCGATTTGTCTGAC
AGCCGTTTGCGCTTGGCAGAAACTCTTGAGATCGGTGCTTTGGATGGTCTGATTGATGGAGGCCTCAGCTTTCAGGGTGT
CCATGACCTTGGCCATATCCTGGCTCGCTGTACAAAAGGTGGTGTGGCTTCTGGGGAAGAGCTTTTAGCTGTTGCCGACA
CCCTTGCAGCAGCGCGCCGCTTGCGCCGCCAGATTAATGATCCAGAGCTTCGTCCCACGATCTCGGCGTTGTTGCTGGAT
GTCGCAACGATGCCGGAGCTGGAACGGCGACTCAAATTTGCATTGGAAGAGGGTGGTCGGGTGGCTGATCGCGTCAGCTC
CAAGCTCGCTGGCTTGCGACGACAGTGGCAAGGTTTGCGTCAGGAACGTCGCGATTGCCTACAGGAGGTGATCAGGCGTC
ATGCGGCCATGTTGCAGGACACTGTGATCGCTGATCGCCATGGCCGGCCAGTGCTAGCGGTGAAGGCCGCTGCAGTGTCT
CAACTCCCCGGCCTGGTCCACGACAGCTCAGCATCTGGCAGCACAGTCTTTGTTGAGCCTCAGGTTGTGATCACCCTGAG
TAATCGTCTTGCTGAATTGGATGGTCATATCCGAGAGCAGCAGCAGCTCGTCTTGGCAGAGTTGAGTGCGGCGGTGGCTG
AGTCCGGCGTATCGATTAGTCGCCTGGGAGAGGTTCTGCTTCAACTCGACTTGGCTCTGGCTCGTGGCCGTTATGGTCAA
TGGCTTGGTGGGGTCCCCCCTGCGTTGCATGCAGAGGCTGCAGCTCCTTTCAGCCTTCAGGAGCTGCGACATCCCTTGCT
GGTTTGGCAGCATCGCCGTGAGCATGGCGAAGCTGTGGTGCCGATCAGCGTTGAGGTCTCCTCCACCCTGAAAGTGGTCG
CGATTACAGGACCCAACACCGGTGGAAAGACTGTCACGCTTAAGAGTGTTGGCCTGGCCTTGCTGATGGCTCGGGCGGGT
CTCTTGTTGCCTTGCACAGGGAGTCCATCAATGCCCTGGTGTGCACAGGTGCTTGCTGATATCGGTGATGAACAGTCACT
ACAACAGAATCTCTCCACCTTTAGTGGCCATGTGAAGCGCATTGGCCGCATTCTTGAAGCCTTGATCGAGGGGCCTGGTC
CAGCTTTGGTGCTTCTTGATGAGGTCGGGGCGGGGACTGATCCCAGTGAAGGGACGGCCCTGGCCACAGCCCTGCTGCGC
ACGCTTGCCGACCGGGCTCGTCTGACCATCGCGACAACTCATTTCGGCAAACTCAAGGCCCTCAAATATGGCGATTCTCG
CTTTGAAAACGCTTCTGTGGCCTTTGATAGCGAGACGATGTTGCCCACCTATCGACTGCAATGGGGAATCCCTGGTCGCA
GTAATGCCCTCAGCATCGCGATGCGGCTTGGCCTAGACGACGCAGTGATTGCTCAGGCGCAAGAGCTGCTGGGACCTTGT
GGTGATGGAGAGGTGAATGAGGTGATCCGTGGTCTTGAAGAGCAACGCAGCCTTCAACAGGCAGCTGCTGAAGATGCCGC
GGCTCTGCTGGCACGTACGGAATTGCTGCATGAGGAACTTCTCAGTCGCTGGCAGAAGCAGCGCAAGCAATCTGCAGATT
TGCAGGAACAAGGCCGCCAGAAGCTGGAGAGCTCCATTCGAGAGGGGCAGAAGGAAGTCCGTCAGTTGATTCGCCGGTTG
CGCGAGGGTCGTGCCGATGGTGAGTCCGCACGACGTGCAGGTCAGCGCTTGCGTCGCATTCAGGCTGACCATCGGATTCA
GCCTCAACGCAAACAGCACATTGGCTGGCGTCCTGAGGTGGGAGAGCGCATTCGGCTGTTGGCCCTTGGCAAGGCGGCAG
AAGTGATTGCTATCTCTGAAGATGGCAAACAACTGACAGTGCGTTGTGGAGTCATGCGCAGCACTGTGGAGTTGTCAGGG
GTGGAAAGCCTTGATGGCCTGAAGCCAAGTCCTCCAGAGTTGGTGGTGAAGGTGAAGGTCCGTTCAGGTCTGGGCCGTGG
CACGGAGGTACGCACGACCCGCAACACCGTGGATGTTCGCGGACTGCGGGTGCATGAAGCCGAGGTTGCTGTTGAGGAGC
ACTTGCGCAGTAGCACTGGTCCGATATGGGTCATTCATGGCATCGGCAGCGGCAAACTCAAGCGAGGGCTCCGCCAGTGG
CTTGAGACCGTTCCTTATGTGGAACGCGTAAACGATGCCGATCAGAGTGATGGTGGAGCGGGTTGCAGTGTGATTTGGCT
GCATTAG

Upstream 100 bases:

>100_bases
GCTGAAAGGGGTTGGCTTGATGAGCGGGCGGTGGTCTTAGAAACCTTGTTGAGTTTCAAGCGAGCTGGTGCCGATTTGAT
CCTCACCTACCACGCTTGTG

Downstream 100 bases:

>100_bases
CCCAGAATGGGCAAGTGGAGTTTGCGGTCGTTTGGGTCTTGTTCAGTGTTGTCTTGAGCTGTCATTGCGATGGCTTCCCC
GTCGGCACCAAACAGTCGCC

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 828; Mature: 828

Protein sequence:

>828_residues
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFASTLQGRRHCQTLSLPADLSD
SRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCTKGGVASGEELLAVADTLAAARRLRRQINDPELRPTISALLLD
VATMPELERRLKFALEEGGRVADRVSSKLAGLRRQWQGLRQERRDCLQEVIRRHAAMLQDTVIADRHGRPVLAVKAAAVS
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGHIREQQQLVLAELSAAVAESGVSISRLGEVLLQLDLALARGRYGQ
WLGGVPPALHAEAAAPFSLQELRHPLLVWQHRREHGEAVVPISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAG
LLLPCTGSPSMPWCAQVLADIGDEQSLQQNLSTFSGHVKRIGRILEALIEGPGPALVLLDEVGAGTDPSEGTALATALLR
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDSETMLPTYRLQWGIPGRSNALSIAMRLGLDDAVIAQAQELLGPC
GDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEELLSRWQKQRKQSADLQEQGRQKLESSIREGQKEVRQLIRRL
REGRADGESARRAGQRLRRIQADHRIQPQRKQHIGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
VESLDGLKPSPPELVVKVKVRSGLGRGTEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTGPIWVIHGIGSGKLKRGLRQW
LETVPYVERVNDADQSDGGAGCSVIWLH

Sequences:

>Translated_828_residues
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFASTLQGRRHCQTLSLPADLSD
SRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCTKGGVASGEELLAVADTLAAARRLRRQINDPELRPTISALLLD
VATMPELERRLKFALEEGGRVADRVSSKLAGLRRQWQGLRQERRDCLQEVIRRHAAMLQDTVIADRHGRPVLAVKAAAVS
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGHIREQQQLVLAELSAAVAESGVSISRLGEVLLQLDLALARGRYGQ
WLGGVPPALHAEAAAPFSLQELRHPLLVWQHRREHGEAVVPISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAG
LLLPCTGSPSMPWCAQVLADIGDEQSLQQNLSTFSGHVKRIGRILEALIEGPGPALVLLDEVGAGTDPSEGTALATALLR
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDSETMLPTYRLQWGIPGRSNALSIAMRLGLDDAVIAQAQELLGPC
GDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEELLSRWQKQRKQSADLQEQGRQKLESSIREGQKEVRQLIRRL
REGRADGESARRAGQRLRRIQADHRIQPQRKQHIGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
VESLDGLKPSPPELVVKVKVRSGLGRGTEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTGPIWVIHGIGSGKLKRGLRQW
LETVPYVERVNDADQSDGGAGCSVIWLH
>Mature_828_residues
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFASTLQGRRHCQTLSLPADLSD
SRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCTKGGVASGEELLAVADTLAAARRLRRQINDPELRPTISALLLD
VATMPELERRLKFALEEGGRVADRVSSKLAGLRRQWQGLRQERRDCLQEVIRRHAAMLQDTVIADRHGRPVLAVKAAAVS
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGHIREQQQLVLAELSAAVAESGVSISRLGEVLLQLDLALARGRYGQ
WLGGVPPALHAEAAAPFSLQELRHPLLVWQHRREHGEAVVPISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAG
LLLPCTGSPSMPWCAQVLADIGDEQSLQQNLSTFSGHVKRIGRILEALIEGPGPALVLLDEVGAGTDPSEGTALATALLR
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDSETMLPTYRLQWGIPGRSNALSIAMRLGLDDAVIAQAQELLGPC
GDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEELLSRWQKQRKQSADLQEQGRQKLESSIREGQKEVRQLIRRL
REGRADGESARRAGQRLRRIQADHRIQPQRKQHIGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
VESLDGLKPSPPELVVKVKVRSGLGRGTEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTGPIWVIHGIGSGKLKRGLRQW
LETVPYVERVNDADQSDGGAGCSVIWLH

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=405, Percent_Identity=24.6913580246914, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI26638666, Length=295, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4505253, Length=295, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI26638664, Length=295, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4557761, Length=266, Percent_Identity=27.0676691729323, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI262231786, Length=212, Percent_Identity=29.7169811320755, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI4504191, Length=276, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789089, Length=225, Percent_Identity=28.4444444444444, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=271, Percent_Identity=26.5682656826568, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17534743, Length=292, Percent_Identity=21.9178082191781, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539736, Length=379, Percent_Identity=23.4828496042216, Blast_Score=66, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324482, Length=425, Percent_Identity=22.3529411764706, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=196, Percent_Identity=26.0204081632653, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319935, Length=205, Percent_Identity=28.780487804878, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584320, Length=294, Percent_Identity=26.530612244898, Blast_Score=98, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24664545, Length=299, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 90023; Mature: 90023

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFA
CCCCCCCCCCCEEECCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
STLQGRRHCQTLSLPADLSDSRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCTKG
HHHHHHHHHCEECCCCCCCCCHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHCC
GVASGEELLAVADTLAAARRLRRQINDPELRPTISALLLDVATMPELERRLKFALEEGGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
VADRVSSKLAGLRRQWQGLRQERRDCLQEVIRRHAAMLQDTVIADRHGRPVLAVKAAAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGHIREQQQLVLAELSAAVAESGVSIS
HCCCCEECCCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RLGEVLLQLDLALARGRYGQWLGGVPPALHAEAAAPFSLQELRHPLLVWQHRREHGEAVV
HHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHCCCCCCCHHHHCCHHHHHHHHHHCCCEEE
PISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAGLLLPCTGSPSMPWCAQVLAD
EEEEEECCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHH
IGDEQSLQQNLSTFSGHVKRIGRILEALIEGPGPALVLLDEVGAGTDPSEGTALATALLR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDSETMLPTYRLQWGIPGRSNALSIA
HHHHHCEEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHH
MRLGLDDAVIAQAQELLGPCGDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEEL
HHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRWQKQRKQSADLQEQGRQKLESSIREGQKEVRQLIRRLREGRADGESARRAGQRLRRI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QADHRIQPQRKQHIGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
HHHCCCCCHHHHCCCCCCCHHHHEEEEEECCCCEEEEECCCCCEEEEEEHHHHHHHHHCC
VESLDGLKPSPPELVVKVKVRSGLGRGTEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTG
CHHHCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEECCEEEHHHHHHHHHHHHCCCC
PIWVIHGIGSGKLKRGLRQWLETVPYVERVNDADQSDGGAGCSVIWLH
CEEEEECCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFA
CCCCCCCCCCCEEECCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
STLQGRRHCQTLSLPADLSDSRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCTKG
HHHHHHHHHCEECCCCCCCCCHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHCC
GVASGEELLAVADTLAAARRLRRQINDPELRPTISALLLDVATMPELERRLKFALEEGGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
VADRVSSKLAGLRRQWQGLRQERRDCLQEVIRRHAAMLQDTVIADRHGRPVLAVKAAAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGHIREQQQLVLAELSAAVAESGVSIS
HCCCCEECCCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RLGEVLLQLDLALARGRYGQWLGGVPPALHAEAAAPFSLQELRHPLLVWQHRREHGEAVV
HHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHCCCCCCCHHHHCCHHHHHHHHHHCCCEEE
PISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAGLLLPCTGSPSMPWCAQVLAD
EEEEEECCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHH
IGDEQSLQQNLSTFSGHVKRIGRILEALIEGPGPALVLLDEVGAGTDPSEGTALATALLR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDSETMLPTYRLQWGIPGRSNALSIA
HHHHHCEEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHH
MRLGLDDAVIAQAQELLGPCGDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEEL
HHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRWQKQRKQSADLQEQGRQKLESSIREGQKEVRQLIRRLREGRADGESARRAGQRLRRI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QADHRIQPQRKQHIGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
HHHCCCCCHHHHCCCCCCCHHHHEEEEEECCCCEEEEECCCCCEEEEEEHHHHHHHHHCC
VESLDGLKPSPPELVVKVKVRSGLGRGTEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTG
CHHHCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEECCEEEHHHHHHHHHHHHCCCC
PIWVIHGIGSGKLKRGLRQWLETVPYVERVNDADQSDGGAGCSVIWLH
CEEEEECCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]