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The map label for this gene is obgE

Identifier: 124022104

GI number: 124022104

Start: 397937

End: 398926

Strand: Direct

Name: obgE

Synonym: P9303_03941

Alternate gene names: 124022104

Gene position: 397937-398926 (Clockwise)

Preceding gene: 124022099

Following gene: 124022105

Centisome position: 14.83

GC content: 53.64

Gene sequence:

>990_bases
ATGCAGTTCATAGATCAGGCACGTATCACCGTTAGAGCAGGGCGCGGCGGCGATGGGATCATGGCTTTTAGGCGGGAGAA
GTATGTGCCGGCTGGCGGTCCCTCTGGTGGGGATGGTGGTGAAGGCGGCAACGTCGTTCTGGAAGCGGATGGCAACCTTC
AGACCCTGCTCGATTTTAAGTACAACAGACTCTTTCCAGCGCCTGATGGTCGGCGGGGTGGTCCGAATCGCTGTACCGGT
GCCTCAGGTAAAGACTTGATCATCAAGGTGCCATGTGGCACTGAAGTGCGTCATCTCTCCACGGGCATCCTTCTTGGTGA
CCTCACTCGATCTGACGATCTACTTGTGGTGGCTTTTGGAGGGCGTGGAGGGCTGGGTAATGCCCATTACCTGAGTAATC
GCAACCGTGCTCCTGAAAAATTTACGGAAGGGCGCGATGGGGAGGAATGGTTCCTTCAATTGGAACTCAAGCTATTAGCA
GAGGTGGGGATCATTGGTTTGCCGAATGCAGGCAAGAGCACTTTGATTTCTGTGCTTTCGGCAGCTCGGCCCAAGATTGC
TGATTATCCCTTCACTACATTGGTGCCCAATCTCGGTGTTGTGCGTCGACCCAGTGGAGATGGCACAGTTTTTGCTGATA
TCCCTGGTCTGATTGCCGGTGCAGCACAAGGAGCAGGCCTAGGGCATGATTTCCTTCGCCACATCGAACGCACCAGGTTG
TTGATTCATGTGTTGGATGGTGGCGCAGAAGATCCAGTTGAAGACTTGCTGGTGGTTGAAAAGGAGCTGGTTGCTTATGG
CCATGACTTGGTTGAAAGGCCACGGCTGTTGGTGCTCAATAAACAGGAGTTATTGGATGAACAGCATCAAGATCAGCTGG
TTGATGCCCTTCAGGCAGCGAGTGGTCGACGCTTGATTTTGATTTCTGCGGCTATGGGTCTAGGCCTTGAGGGGCTGTTG
GCGCAGGTATGGAAGGAACTTGGCGTCTGA

Upstream 100 bases:

>100_bases
ACTGTCTAATTTTTTATTGCAAATGCTTCTCGTTATGCCATCCTCGATTCGCTCCTGATGAATTTATTCCCCTTAAATCC
ATTGGTATTACTGGAATAGG

Downstream 100 bases:

>100_bases
GGTGTTCAGGTCAGGTCTGCGAGACCACATCCAGACTTGTCTGTTCGCTTGTCATTGGCCATAACTGGAGTGAAAACATT
GATGACATGACCTTTTACAG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQFIDQARITVRAGRGGDGIMAFRREKYVPAGGPSGGDGGEGGNVVLEADGNLQTLLDFKYNRLFPAPDGRRGGPNRCTG
ASGKDLIIKVPCGTEVRHLSTGILLGDLTRSDDLLVVAFGGRGGLGNAHYLSNRNRAPEKFTEGRDGEEWFLQLELKLLA
EVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRL
LIHVLDGGAEDPVEDLLVVEKELVAYGHDLVERPRLLVLNKQELLDEQHQDQLVDALQAASGRRLILISAAMGLGLEGLL
AQVWKELGV

Sequences:

>Translated_329_residues
MQFIDQARITVRAGRGGDGIMAFRREKYVPAGGPSGGDGGEGGNVVLEADGNLQTLLDFKYNRLFPAPDGRRGGPNRCTG
ASGKDLIIKVPCGTEVRHLSTGILLGDLTRSDDLLVVAFGGRGGLGNAHYLSNRNRAPEKFTEGRDGEEWFLQLELKLLA
EVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRL
LIHVLDGGAEDPVEDLLVVEKELVAYGHDLVERPRLLVLNKQELLDEQHQDQLVDALQAASGRRLILISAAMGLGLEGLL
AQVWKELGV
>Mature_329_residues
MQFIDQARITVRAGRGGDGIMAFRREKYVPAGGPSGGDGGEGGNVVLEADGNLQTLLDFKYNRLFPAPDGRRGGPNRCTG
ASGKDLIIKVPCGTEVRHLSTGILLGDLTRSDDLLVVAFGGRGGLGNAHYLSNRNRAPEKFTEGRDGEEWFLQLELKLLA
EVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRL
LIHVLDGGAEDPVEDLLVVEKELVAYGHDLVERPRLLVLNKQELLDEQHQDQLVDALQAASGRRLILISAAMGLGLEGLL
AQVWKELGV

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=319, Percent_Identity=42.3197492163009, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI111955139, Length=352, Percent_Identity=35.2272727272727, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI111955063, Length=188, Percent_Identity=37.7659574468085, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI58761500, Length=137, Percent_Identity=29.9270072992701, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1789574, Length=328, Percent_Identity=51.5243902439024, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1787454, Length=139, Percent_Identity=35.2517985611511, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17508313, Length=324, Percent_Identity=36.4197530864198, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=327, Percent_Identity=27.5229357798165, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17509631, Length=158, Percent_Identity=32.2784810126582, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=125, Percent_Identity=32.8, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=173, Percent_Identity=41.0404624277457, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319281, Length=125, Percent_Identity=36.8, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321773, Length=172, Percent_Identity=30.8139534883721, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129375, Length=322, Percent_Identity=39.1304347826087, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24585318, Length=290, Percent_Identity=34.4827586206897, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356473, Length=124, Percent_Identity=35.4838709677419, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_PROM3 (A2C6N6)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016411.1
- ProteinModelPortal:   A2C6N6
- SMR:   A2C6N6
- STRING:   A2C6N6
- GeneID:   4778001
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_03941
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 35139; Mature: 35139

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFIDQARITVRAGRGGDGIMAFRREKYVPAGGPSGGDGGEGGNVVLEADGNLQTLLDFK
CCCCCCCEEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECH
YNRLFPAPDGRRGGPNRCTGASGKDLIIKVPCGTEVRHLSTGILLGDLTRSDDLLVVAFG
HHEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCEEEECCCCCCCEEEEEEC
GRGGLGNAHYLSNRNRAPEKFTEGRDGEEWFLQLELKLLAEVGIIGLPNAGKSTLISVLS
CCCCCCCCCCCCCCCCCCHHHHCCCCCHHHEEHHHHHHHHHCCEEECCCCCHHHHHHHHH
AARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRL
HCCCCCCCCCHHHHCCCCCEEECCCCCCEEEECCCHHHHHCCCCCCCCHHHHHHHHHHEE
LIHVLDGGAEDPVEDLLVVEKELVAYGHDLVERPRLLVLNKQELLDEQHQDQLVDALQAA
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHC
SGRRLILISAAMGLGLEGLLAQVWKELGV
CCCEEEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQFIDQARITVRAGRGGDGIMAFRREKYVPAGGPSGGDGGEGGNVVLEADGNLQTLLDFK
CCCCCCCEEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECH
YNRLFPAPDGRRGGPNRCTGASGKDLIIKVPCGTEVRHLSTGILLGDLTRSDDLLVVAFG
HHEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCEEEECCCCCCCEEEEEEC
GRGGLGNAHYLSNRNRAPEKFTEGRDGEEWFLQLELKLLAEVGIIGLPNAGKSTLISVLS
CCCCCCCCCCCCCCCCCCHHHHCCCCCHHHEEHHHHHHHHHCCEEECCCCCHHHHHHHHH
AARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRL
HCCCCCCCCCHHHHCCCCCEEECCCCCCEEEECCCHHHHHCCCCCCCCHHHHHHHHHHEE
LIHVLDGGAEDPVEDLLVVEKELVAYGHDLVERPRLLVLNKQELLDEQHQDQLVDALQAA
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHC
SGRRLILISAAMGLGLEGLLAQVWKELGV
CCCEEEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA