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The map label for this gene is cya1 [H]

Identifier: 124022050

GI number: 124022050

Start: 347511

End: 349448

Strand: Direct

Name: cya1 [H]

Synonym: P9303_03401

Alternate gene names: 124022050

Gene position: 347511-349448 (Clockwise)

Preceding gene: 124022049

Following gene: 124022052

Centisome position: 12.95

GC content: 61.87

Gene sequence:

>1938_bases
TTGAAGCTCAGCCAGCGCATCCGCGACGGTCTCGTTCAAGCCGGGCTGATCGGCGCCGCGGCCCTGTTCCTGGGGGGACT
GTCGACAACGGGAATCAGTGCATCGATCGATTGGCTGCTGTACGACAGCGTCATCACCCTGCGTTCGCGCGATTCCGCCC
AACGACATCCGGTGACGATCGTCGGAATCGACGAAGACGACATCAGCCACTACGGATGGCCGATCGACGATGCCGTGCTC
TGTCGTGCCCTTCGGAACGCCCTGCAAGCCAACGCCAGTGCTATCGGCCTGGATCTCTACCGCGACCAGGGAATTGGTCC
GCAGCAGAGCTGTCTGCCGGAGCTGATCCGGCAAAACTCCGAGATCGTGGCCATCTTCAACGCTGCCGAGGGCATCACCG
CTCCACCGGGGACACCTGCCGCCCAGCAGGCCTTCAATGACCTGGTGGTCGATGCCGATGGCGTAATCCGTCGGGACCTG
ATCCATGTCAGCGGTCAGGACGCCGCCACCGTGAGCCTGCCGGTCCGACTGATCGAGACATCCGGTCTGCAGCCCGGCCT
GCTCGATCTGCTGAAGAAGCCAGACAGAGCAGAACAACTCGGACCATGGCTGCTGCCCCATTCCGGGGGATACCGCGACC
TCGATGCTGCCGGTTACCAGCGACTGCTGCCGTTTCATCAACCCGGGAGCTTCCGCACCATCAGCCTGCGTACGCTGGCT
GATGGCAAATGGGCTGCAGAGGCCCTGCAGCAGGGAGACATTGTGCTGCTCGGGAGCACCGCGCCCAGCCTGAAAGATCT
GTTCGAAATCCCGCACAGCCGTTTCAGCCAAAGCAACAAATTCCTCATGCCCGGGGTGGAAGTGCATGCTCTGCGCGTCG
CCGCCCTGCTGAATGGTCTGGATCAGCCATGGACGCTCCGAACACTGCCGCCCTGGAACGAGCAGGGCCTGGAGCTGATC
GCCATCCTCGTCGGGATCAGCCTTGGTGCCAGCTGCAGCAAGCTGCAACGCAGCATCACGATCACCACAGTGCTAACGGT
CGTTCTGGCGGGCTGCGGTGCCGCTTTGCTCTGGACGCAAGGACTTTGGATTGGCCTCACCCTGCCGGTGATCTCCCTAC
CCGTGATGGCTGGGGTGGGTTGGCTGCGCCGCGGAGCGCTCCTGCAACGTCAAAAACAACAAATCGAACGCCTGCTGGGC
CAAACCACCTCCCCTGCCGTGGCACAACAGTTGTGGGAACAACGCGACTCCCTCCTGCGGGATGGCCAGTTCGAAGGGAA
GCAGGTCACCGCAACAGTGTTGTTCACCGACACCCAAGACTTCACCAGCATTTCCGAACAGCTGTCACCCTCCGAGCTGC
TGACATGGCTCAACCGTGGCATGAGCCTGTTGGTGCAGGAGATCACCAACCACGGCGGCATCATCAATAAATTCACCGGT
GATGGACTTCTGGCGGTTTTTGGAGCACCGATCAGCCAGGGAATGGCCGTGGATGCAGGCCATGCGATTGATGCGTCTTT
GGCGATTACGGCTCGGCTAGCCGAGCTCAATCAAGCATTGAAACTGGAGCAGGCGCCAGCCATGCGCATGCGGATCGGCA
TTCATTCCGGTCCGGTGATCGCCGGCTCGATGGGAAGCAGCGCGCGGCTGGAATTCACGGTGATGGGGGACACGGTGAAT
TGCGCGTCGCGGTTGGAAAGCCTGGCCAGGGTTCCAGCCGACGACAGCTGCCGCACCCTCTTCAGCCAAGAGACCCTGAT
GCGGTGTGAGCGCGACGACCTGCTCTGGCATTCGGTGGGGCGATTGCAGGTGAAAGGGCGTCAGCAAGAGCTGGACGTTC
TCGAACTCAAGGGCACCAAACCAGCCGCCAATGTCAGAACAGGCAGCGCACCGGCAGACGATCGGGCCAGGAGCGCAGAT
CAAGAGCTGCCAGGTTGA

Upstream 100 bases:

>100_bases
TGGCGGCAATGACCGCGGAACTCACCGCCTCCAGCGTGCTGGGAGTGCCTCTTTCACCGGAGAATGACGCTTTGCTCAAC
AGCTTTCACTGGAGCCGGTT

Downstream 100 bases:

>100_bases
AGTCATTGATCAGATGTTGTTTGGACACAGAGCTGGCACACCGATCGACCAGGGCATTCAGGCGCTCCTGATGACCACGG
TCGACCGCCGTTGGTTCCGC

Product: hypothetical protein

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MKLSQRIRDGLVQAGLIGAAALFLGGLSTTGISASIDWLLYDSVITLRSRDSAQRHPVTIVGIDEDDISHYGWPIDDAVL
CRALRNALQANASAIGLDLYRDQGIGPQQSCLPELIRQNSEIVAIFNAAEGITAPPGTPAAQQAFNDLVVDADGVIRRDL
IHVSGQDAATVSLPVRLIETSGLQPGLLDLLKKPDRAEQLGPWLLPHSGGYRDLDAAGYQRLLPFHQPGSFRTISLRTLA
DGKWAAEALQQGDIVLLGSTAPSLKDLFEIPHSRFSQSNKFLMPGVEVHALRVAALLNGLDQPWTLRTLPPWNEQGLELI
AILVGISLGASCSKLQRSITITTVLTVVLAGCGAALLWTQGLWIGLTLPVISLPVMAGVGWLRRGALLQRQKQQIERLLG
QTTSPAVAQQLWEQRDSLLRDGQFEGKQVTATVLFTDTQDFTSISEQLSPSELLTWLNRGMSLLVQEITNHGGIINKFTG
DGLLAVFGAPISQGMAVDAGHAIDASLAITARLAELNQALKLEQAPAMRMRIGIHSGPVIAGSMGSSARLEFTVMGDTVN
CASRLESLARVPADDSCRTLFSQETLMRCERDDLLWHSVGRLQVKGRQQELDVLELKGTKPAANVRTGSAPADDRARSAD
QELPG

Sequences:

>Translated_645_residues
MKLSQRIRDGLVQAGLIGAAALFLGGLSTTGISASIDWLLYDSVITLRSRDSAQRHPVTIVGIDEDDISHYGWPIDDAVL
CRALRNALQANASAIGLDLYRDQGIGPQQSCLPELIRQNSEIVAIFNAAEGITAPPGTPAAQQAFNDLVVDADGVIRRDL
IHVSGQDAATVSLPVRLIETSGLQPGLLDLLKKPDRAEQLGPWLLPHSGGYRDLDAAGYQRLLPFHQPGSFRTISLRTLA
DGKWAAEALQQGDIVLLGSTAPSLKDLFEIPHSRFSQSNKFLMPGVEVHALRVAALLNGLDQPWTLRTLPPWNEQGLELI
AILVGISLGASCSKLQRSITITTVLTVVLAGCGAALLWTQGLWIGLTLPVISLPVMAGVGWLRRGALLQRQKQQIERLLG
QTTSPAVAQQLWEQRDSLLRDGQFEGKQVTATVLFTDTQDFTSISEQLSPSELLTWLNRGMSLLVQEITNHGGIINKFTG
DGLLAVFGAPISQGMAVDAGHAIDASLAITARLAELNQALKLEQAPAMRMRIGIHSGPVIAGSMGSSARLEFTVMGDTVN
CASRLESLARVPADDSCRTLFSQETLMRCERDDLLWHSVGRLQVKGRQQELDVLELKGTKPAANVRTGSAPADDRARSAD
QELPG
>Mature_645_residues
MKLSQRIRDGLVQAGLIGAAALFLGGLSTTGISASIDWLLYDSVITLRSRDSAQRHPVTIVGIDEDDISHYGWPIDDAVL
CRALRNALQANASAIGLDLYRDQGIGPQQSCLPELIRQNSEIVAIFNAAEGITAPPGTPAAQQAFNDLVVDADGVIRRDL
IHVSGQDAATVSLPVRLIETSGLQPGLLDLLKKPDRAEQLGPWLLPHSGGYRDLDAAGYQRLLPFHQPGSFRTISLRTLA
DGKWAAEALQQGDIVLLGSTAPSLKDLFEIPHSRFSQSNKFLMPGVEVHALRVAALLNGLDQPWTLRTLPPWNEQGLELI
AILVGISLGASCSKLQRSITITTVLTVVLAGCGAALLWTQGLWIGLTLPVISLPVMAGVGWLRRGALLQRQKQQIERLLG
QTTSPAVAQQLWEQRDSLLRDGQFEGKQVTATVLFTDTQDFTSISEQLSPSELLTWLNRGMSLLVQEITNHGGIINKFTG
DGLLAVFGAPISQGMAVDAGHAIDASLAITARLAELNQALKLEQAPAMRMRIGIHSGPVIAGSMGSSARLEFTVMGDTVN
CASRLESLARVPADDSCRTLFSQETLMRCERDDLLWHSVGRLQVKGRQQELDVLELKGTKPAANVRTGSAPADDRARSAD
QELPG

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI134152694, Length=186, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI167830411, Length=179, Percent_Identity=31.2849162011173, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI4504217, Length=176, Percent_Identity=32.3863636363636, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4580422, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=140, Percent_Identity=36.4285714285714, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17568383, Length=193, Percent_Identity=32.6424870466321, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71982300, Length=186, Percent_Identity=31.1827956989247, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534651, Length=186, Percent_Identity=34.4086021505376, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17534659, Length=229, Percent_Identity=28.3842794759825, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534649, Length=189, Percent_Identity=31.7460317460317, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193206632, Length=243, Percent_Identity=28.8065843621399, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534653, Length=190, Percent_Identity=31.0526315789474, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=186, Percent_Identity=30.1075268817204, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71989805, Length=180, Percent_Identity=31.1111111111111, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=180, Percent_Identity=31.1111111111111, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508769, Length=180, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86564713, Length=223, Percent_Identity=27.8026905829596, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71985505, Length=202, Percent_Identity=28.7128712871287, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193205840, Length=185, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193206054, Length=251, Percent_Identity=27.0916334661355, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574512, Length=205, Percent_Identity=32.1951219512195, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161076872, Length=205, Percent_Identity=32.1951219512195, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI85725044, Length=188, Percent_Identity=27.6595744680851, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24663843, Length=193, Percent_Identity=30.5699481865285, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24663839, Length=193, Percent_Identity=30.5699481865285, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI62484298, Length=185, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62484477, Length=185, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116008008, Length=185, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366459, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366457, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366455, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI56292422, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI56292424, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666940, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 69476; Mature: 69476

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSQRIRDGLVQAGLIGAAALFLGGLSTTGISASIDWLLYDSVITLRSRDSAQRHPVTI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHEEHHHHHEECCCCCCCCCCEEE
VGIDEDDISHYGWPIDDAVLCRALRNALQANASAIGLDLYRDQGIGPQQSCLPELIRQNS
EECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEEEHHCCCCCCHHHHHHHHHHCCC
EIVAIFNAAEGITAPPGTPAAQQAFNDLVVDADGVIRRDLIHVSGQDAATVSLPVRLIET
CEEEEEECCCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHEEECCCCCEEEEEEEEEEEC
SGLQPGLLDLLKKPDRAEQLGPWLLPHSGGYRDLDAAGYQRLLPFHQPGSFRTISLRTLA
CCCCCCHHHHHCCCCCHHHCCCEECCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEEEC
DGKWAAEALQQGDIVLLGSTAPSLKDLFEIPHSRFSQSNKFLMPGVEVHALRVAALLNGL
CCHHHHHHHCCCCEEEEECCCCHHHHHHHCCHHHHCCCCCEECCCCHHHHHHHHHHHCCC
DQPWTLRTLPPWNEQGLELIAILVGISLGASCSKLQRSITITTVLTVVLAGCGAALLWTQ
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
GLWIGLTLPVISLPVMAGVGWLRRGALLQRQKQQIERLLGQTTSPAVAQQLWEQRDSLLR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DGQFEGKQVTATVLFTDTQDFTSISEQLSPSELLTWLNRGMSLLVQEITNHGGIINKFTG
CCCCCCCEEEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
DGLLAVFGAPISQGMAVDAGHAIDASLAITARLAELNQALKLEQAPAMRMRIGIHSGPVI
CCEEEEECCCHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
AGSMGSSARLEFTVMGDTVNCASRLESLARVPADDSCRTLFSQETLMRCERDDLLWHSVG
EECCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC
RLQVKGRQQELDVLELKGTKPAANVRTGSAPADDRARSADQELPG
CEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MKLSQRIRDGLVQAGLIGAAALFLGGLSTTGISASIDWLLYDSVITLRSRDSAQRHPVTI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHEEHHHHHEECCCCCCCCCCEEE
VGIDEDDISHYGWPIDDAVLCRALRNALQANASAIGLDLYRDQGIGPQQSCLPELIRQNS
EECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEEEHHCCCCCCHHHHHHHHHHCCC
EIVAIFNAAEGITAPPGTPAAQQAFNDLVVDADGVIRRDLIHVSGQDAATVSLPVRLIET
CEEEEEECCCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHEEECCCCCEEEEEEEEEEEC
SGLQPGLLDLLKKPDRAEQLGPWLLPHSGGYRDLDAAGYQRLLPFHQPGSFRTISLRTLA
CCCCCCHHHHHCCCCCHHHCCCEECCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEEEC
DGKWAAEALQQGDIVLLGSTAPSLKDLFEIPHSRFSQSNKFLMPGVEVHALRVAALLNGL
CCHHHHHHHCCCCEEEEECCCCHHHHHHHCCHHHHCCCCCEECCCCHHHHHHHHHHHCCC
DQPWTLRTLPPWNEQGLELIAILVGISLGASCSKLQRSITITTVLTVVLAGCGAALLWTQ
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
GLWIGLTLPVISLPVMAGVGWLRRGALLQRQKQQIERLLGQTTSPAVAQQLWEQRDSLLR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DGQFEGKQVTATVLFTDTQDFTSISEQLSPSELLTWLNRGMSLLVQEITNHGGIINKFTG
CCCCCCCEEEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
DGLLAVFGAPISQGMAVDAGHAIDASLAITARLAELNQALKLEQAPAMRMRIGIHSGPVI
CCEEEEECCCHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
AGSMGSSARLEFTVMGDTVNCASRLESLARVPADDSCRTLFSQETLMRCERDDLLWHSVG
EECCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC
RLQVKGRQQELDVLELKGTKPAANVRTGSAPADDRARSADQELPG
CEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]