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The map label for this gene is csd [H]

Identifier: 124022016

GI number: 124022016

Start: 320023

End: 321327

Strand: Direct

Name: csd [H]

Synonym: P9303_03051

Alternate gene names: 124022016

Gene position: 320023-321327 (Clockwise)

Preceding gene: 124022015

Following gene: 124022019

Centisome position: 11.93

GC content: 54.1

Gene sequence:

>1305_bases
ATGACCTCTTCCGTTAGTTCAGATCAGAGCATGCCGTTGGCGATGGCTGCTGTAGAAGCTTCAGCCAACCTGGCAGATCT
CACGCGAGCGGATTTCCCGCTACTAGGCCAGACCGCCTGCTTAGGTCAGCCCTTGATTTACATGGACCATGCGGCGACAA
GTCAGAAGCCACGGCAGGTGCTGGATGCCTTACAGCATTACTACGACCATGACAACGCCAATGTGCACCGTGGTGCCCAT
CAGTTGAGTGTTCGGGCTACCGAGGATTTTGAACGAGCACGTCAGAAGGTGGCTGATTTCATCGCTGCCTCAAGCGCGCG
GGAAATCGTTTTCACCAGGAATGCAAGTGAGGCGATCAACCTGGTGGCTCGCAGTTGGGGTGATGCCAACCTCCATGAAG
GTGACGAGGTGCTGCTTACCTTGATGGAGCATCACAGCAACATTGTCCCTTGGCAGATGCTTGCCAAGCGAACAGGTTGC
GTGCTGCGCTTTGTCGACCTCACCGATTGCGGGGAGCTTGATTTAAATGATCTTCGGCAAAAGCTCTCAGAGCGCACTCG
TTTGGTCAGTCTGGCTCACTTGAGCAATGTGCTGGGCTGTTTTAACCCTATCTCTGAGGTCACTGCAGAGGCTCATCGCT
TCGGTGCTCTGGTGTTGCTGGATGCTTGCCAGAGCTTGCCACATATGCCTGTTGATGTGTCCCGGCTTGGATGTGACTTT
CTCGTGGGTTCTTCCCACAAATTGTGTGGTCCTACCGGGATGGGTTTTCTTTGGGCTCGAGAGGAGTTGCTTGATGCCAT
GCCGCCTTTCCTCGGCGGTGGCGAAATGATTCAGGATGTCTATCTCGACCACAGCAGCTGGGCTGATCTGCCTTACAAGT
TTGAAGCAGGTACCCCTGCTATTGGGGAAGCTATTGGTATGGGCGTTGCTCTCGACTACCTGAACCAGGTTGGCTTAGAT
CGTATTCACGCTTGGGAGCAGCAGCTCACGCTGCAATTGTTTGATCGCCTCCAAGGCATCGATGGGTTGACGATTCTGGG
CCCAACTCCTCAGCAGGAGCCTGATCGGGCGGTCCTGGCGGCTTTCACAGTGGATGGCTTGCATCCCAATGATATTGGTG
CCTTGCTTGATTCAGCAGGGATCTGTATTCGTAGTGGCCACCACTGCACCCAGCCTTTGCATCGTCACTATGGGATCCCT
GGATCAGCTCGTGCCAGCTTGAGCTTCACCAATACACCAGAAGAAGTCGATCGTTTTGCTGAGGAATTGGTTTCGACGAT
CGGCTTCTTAAGAGAGCACAGCTAG

Upstream 100 bases:

>100_bases
TTACTGCGCGCGTTTTGTGATGAGGTGATTTGCATGCTCCCATCAACTGCACAGGCCTGGCGGCCGTTGACTCGATTGTT
GGATGGGGTTTGAGCCGATC

Downstream 100 bases:

>100_bases
AGCTTTAGGTGGCGGCGGAAGAATTGCTCAGTTGCTTCTAAGACTTTGATCTTGACAGCACTGTCGCGAAAGCCGTGGCC
TTCCTGCTCAAAAATGTGTA

Product: cysteine desulfurase or selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTSSVSSDQSMPLAMAAVEASANLADLTRADFPLLGQTACLGQPLIYMDHAATSQKPRQVLDALQHYYDHDNANVHRGAH
QLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAINLVARSWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGC
VLRFVDLTDCGELDLNDLRQKLSERTRLVSLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPAIGEAIGMGVALDYLNQVGLD
RIHAWEQQLTLQLFDRLQGIDGLTILGPTPQQEPDRAVLAAFTVDGLHPNDIGALLDSAGICIRSGHHCTQPLHRHYGIP
GSARASLSFTNTPEEVDRFAEELVSTIGFLREHS

Sequences:

>Translated_434_residues
MTSSVSSDQSMPLAMAAVEASANLADLTRADFPLLGQTACLGQPLIYMDHAATSQKPRQVLDALQHYYDHDNANVHRGAH
QLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAINLVARSWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGC
VLRFVDLTDCGELDLNDLRQKLSERTRLVSLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPAIGEAIGMGVALDYLNQVGLD
RIHAWEQQLTLQLFDRLQGIDGLTILGPTPQQEPDRAVLAAFTVDGLHPNDIGALLDSAGICIRSGHHCTQPLHRHYGIP
GSARASLSFTNTPEEVDRFAEELVSTIGFLREHS
>Mature_433_residues
TSSVSSDQSMPLAMAAVEASANLADLTRADFPLLGQTACLGQPLIYMDHAATSQKPRQVLDALQHYYDHDNANVHRGAHQ
LSVRATEDFERARQKVADFIAASSAREIVFTRNASEAINLVARSWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGCV
LRFVDLTDCGELDLNDLRQKLSERTRLVSLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDFL
VGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPAIGEAIGMGVALDYLNQVGLDR
IHAWEQQLTLQLFDRLQGIDGLTILGPTPQQEPDRAVLAAFTVDGLHPNDIGALLDSAGICIRSGHHCTQPLHRHYGIPG
SARASLSFTNTPEEVDRFAEELVSTIGFLREHS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=405, Percent_Identity=25.679012345679, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156713448, Length=448, Percent_Identity=24.5535714285714, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=47.3684210526316, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1789175, Length=389, Percent_Identity=36.5038560411311, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI48994898, Length=405, Percent_Identity=25.9259259259259, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=218, Percent_Identity=30.2752293577982, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=373, Percent_Identity=24.3967828418231, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=405, Percent_Identity=26.6666666666667, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20129463, Length=409, Percent_Identity=26.8948655256724, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47487; Mature: 47356

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSVSSDQSMPLAMAAVEASANLADLTRADFPLLGQTACLGQPLIYMDHAATSQKPRQV
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCCCHHHH
LDALQHYYDHDNANVHRGAHQLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAIN
HHHHHHHHCCCCCCHHCCHHHEEEECHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
LVARSWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGCVLRFVDLTDCGELDLNDLRQ
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHHH
KLSERTRLVSLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHH
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPA
EECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCH
IGEAIGMGVALDYLNQVGLDRIHAWEQQLTLQLFDRLQGIDGLTILGPTPQQEPDRAVLA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEE
AFTVDGLHPNDIGALLDSAGICIRSGHHCTQPLHRHYGIPGSARASLSFTNTPEEVDRFA
EEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHH
EELVSTIGFLREHS
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSVSSDQSMPLAMAAVEASANLADLTRADFPLLGQTACLGQPLIYMDHAATSQKPRQV
CCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCCCHHHH
LDALQHYYDHDNANVHRGAHQLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAIN
HHHHHHHHCCCCCCHHCCHHHEEEECHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
LVARSWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGCVLRFVDLTDCGELDLNDLRQ
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHHH
KLSERTRLVSLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHH
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPA
EECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCH
IGEAIGMGVALDYLNQVGLDRIHAWEQQLTLQLFDRLQGIDGLTILGPTPQQEPDRAVLA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEE
AFTVDGLHPNDIGALLDSAGICIRSGHHCTQPLHRHYGIPGSARASLSFTNTPEEVDRFA
EEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHH
EELVSTIGFLREHS
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]