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The map label for this gene is lysS

Identifier: 124021897

GI number: 124021897

Start: 202932

End: 204458

Strand: Direct

Name: lysS

Synonym: P9303_01841

Alternate gene names: 124021897

Gene position: 202932-204458 (Clockwise)

Preceding gene: 124021896

Following gene: 124021898

Centisome position: 7.56

GC content: 54.09

Gene sequence:

>1527_bases
ATGGCGAGGTCAGTCCTGAGTGCCTTGTCTGAGCTGCGTGAGACTCGCCTGGAAAAGGCACAAGCCCTCAAAGAGCTGGG
GAATGGGCCTTATGCCCTGCGCTTTGAGTCAAGCCATCGCACCGCTAACTTGCAGGCGGATCATGCTGATTTGGCCAAGG
GGGAGGAGAGGCTTCTCAGTGTGTCTGTGGCTGGTCGGGTGATGGCCCGTCGTGTCATGGGCAAGTTGGCTTTCTATACC
TTGGCGGATGAGACCGGCACGATTCAGTTGTATTTGGACAAGGCCACCATTGATGCGGCTGCATCAAATGAGCTGGCTTC
AGGAACTTTTGTTCAGCTCACCACTCTTGTTGACGCGGGCGACTGGATTGGGGTCACAGGCGTGCTTCGTCGCACTGATC
GTGGTGAGCTTTCGGTGAAGGTTCAGCAGTGGCAGATCTTGAGCAAATCATTGCAACCCTTGCCGGATAAGTGGCACGGT
TTAGCTGATGTGGAGAAGCGCTATCGGCAACGCTATCTGGATCTAATCGTGTCGCCTCAGTCGCGTGAGACTTTTCGCCG
CCGGGCATTGATGGTGAGTGCAATCCGTCGATGGCTCGATGATCGCGCCTTCTTGGAAATCGAAACACCGGTGCTTCAGG
CTGAGGCCGGTGGCGCCGAAGCTAGGCCATTCATTACTCACCACAACACACTCGATCTTCCTCTTTATCTGCGTATTGCT
ACAGAGCTGCATCTCAAGAGGCTTGTGGTTGGTGGTTTTGAGCGGGTCTATGAGCTTGGGCGCATCTTTCGTAACGAGGG
GATGAGTACCCGCCACAACCCTGAATTCACTTCTGTAGAGGTCTATCAGGCCTATGCGGATTACATCGACATGATGGTCC
TTACTGAGCAGCTGATTTCCTCAGTTTGTACTCAGATCTGTGGGTCTACGAGGATCACTTATCAAGGTATAGAAATCGAC
CTAACGCCCCCTTGGCGGAGAGCCAGCATGCACGAACTGGTGCAAGAGGCGACGGGGCTTGATTTCATGGGTTTTGCTGA
CCGTGCGGTAGCGGCTTCGGCTATGGCGCGGGCAGGTCTAGAGGTTCCGTCTAAGGCCGATAGTGTGGGCCGCTTGCTTA
ATGAGGCCTTTGAACAAGCAGTGGAGGTAAGTCTGATCCAGCCAACATTTGTGCTCGATTATCCGATTGAGATCTCGCCT
CTTGCCCGACAACATCGCAGCAAACCAGGATTGGTCGAGCGCTTTGAATTGTTCATTGTGGGTCGGGAAACAGCCAATGC
TTTTAGTGAGTTAATCGATCCCCTTGATCAGCGTCAGCGGCTTGAGGCTCAGCAAGCACGTCGTCAGGCTGGGGACCTGG
AGGCTCATGGGGTTGATGAGGATTTTCTTCAGGCGCTTGAGGTGGGCATGCCCCCTACCGGCGGCTTGGGTATTGGCATC
GATCGCTTAGTGATGTTGTTCACCGATAGCCCGTCAATACGTGATGTGATTGCTTTCCCTCTGCTTCGACCGGAGCTCAA
AACTTAA

Upstream 100 bases:

>100_bases
GCTTCTGCTCCTGCTTCTGCTCCTGCTTCTGCTTCGGTTGCCGTTGCGAGTTGATTAAGTCGATGGGGTGAGTAGAGCAA
CGACTCCATCGACCGGCAAG

Downstream 100 bases:

>100_bases
TCTTCAACGTCGGGAACCGCCGCAGTGGATAATTAACTCAATGGCATGGTCCTATTTCTATGAGTGGCGAGCGCGTAGGT
TTCCGCTTCAAACACGCCGA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MARSVLSALSELRETRLEKAQALKELGNGPYALRFESSHRTANLQADHADLAKGEERLLSVSVAGRVMARRVMGKLAFYT
LADETGTIQLYLDKATIDAAASNELASGTFVQLTTLVDAGDWIGVTGVLRRTDRGELSVKVQQWQILSKSLQPLPDKWHG
LADVEKRYRQRYLDLIVSPQSRETFRRRALMVSAIRRWLDDRAFLEIETPVLQAEAGGAEARPFITHHNTLDLPLYLRIA
TELHLKRLVVGGFERVYELGRIFRNEGMSTRHNPEFTSVEVYQAYADYIDMMVLTEQLISSVCTQICGSTRITYQGIEID
LTPPWRRASMHELVQEATGLDFMGFADRAVAASAMARAGLEVPSKADSVGRLLNEAFEQAVEVSLIQPTFVLDYPIEISP
LARQHRSKPGLVERFELFIVGRETANAFSELIDPLDQRQRLEAQQARRQAGDLEAHGVDEDFLQALEVGMPPTGGLGIGI
DRLVMLFTDSPSIRDVIAFPLLRPELKT

Sequences:

>Translated_508_residues
MARSVLSALSELRETRLEKAQALKELGNGPYALRFESSHRTANLQADHADLAKGEERLLSVSVAGRVMARRVMGKLAFYT
LADETGTIQLYLDKATIDAAASNELASGTFVQLTTLVDAGDWIGVTGVLRRTDRGELSVKVQQWQILSKSLQPLPDKWHG
LADVEKRYRQRYLDLIVSPQSRETFRRRALMVSAIRRWLDDRAFLEIETPVLQAEAGGAEARPFITHHNTLDLPLYLRIA
TELHLKRLVVGGFERVYELGRIFRNEGMSTRHNPEFTSVEVYQAYADYIDMMVLTEQLISSVCTQICGSTRITYQGIEID
LTPPWRRASMHELVQEATGLDFMGFADRAVAASAMARAGLEVPSKADSVGRLLNEAFEQAVEVSLIQPTFVLDYPIEISP
LARQHRSKPGLVERFELFIVGRETANAFSELIDPLDQRQRLEAQQARRQAGDLEAHGVDEDFLQALEVGMPPTGGLGIGI
DRLVMLFTDSPSIRDVIAFPLLRPELKT
>Mature_507_residues
ARSVLSALSELRETRLEKAQALKELGNGPYALRFESSHRTANLQADHADLAKGEERLLSVSVAGRVMARRVMGKLAFYTL
ADETGTIQLYLDKATIDAAASNELASGTFVQLTTLVDAGDWIGVTGVLRRTDRGELSVKVQQWQILSKSLQPLPDKWHGL
ADVEKRYRQRYLDLIVSPQSRETFRRRALMVSAIRRWLDDRAFLEIETPVLQAEAGGAEARPFITHHNTLDLPLYLRIAT
ELHLKRLVVGGFERVYELGRIFRNEGMSTRHNPEFTSVEVYQAYADYIDMMVLTEQLISSVCTQICGSTRITYQGIEIDL
TPPWRRASMHELVQEATGLDFMGFADRAVAASAMARAGLEVPSKADSVGRLLNEAFEQAVEVSLIQPTFVLDYPIEISPL
ARQHRSKPGLVERFELFIVGRETANAFSELIDPLDQRQRLEAQQARRQAGDLEAHGVDEDFLQALEVGMPPTGGLGIGID
RLVMLFTDSPSIRDVIAFPLLRPELKT

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=507, Percent_Identity=42.4063116370809, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI194272210, Length=507, Percent_Identity=42.4063116370809, Blast_Score=398, Evalue=1e-111,
Organism=Escherichia coli, GI1789256, Length=508, Percent_Identity=48.6220472440945, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1790571, Length=506, Percent_Identity=47.8260869565217, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI87082379, Length=329, Percent_Identity=33.7386018237082, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788173, Length=250, Percent_Identity=28.8, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17535925, Length=512, Percent_Identity=42.3828125, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535927, Length=512, Percent_Identity=42.3828125, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71994340, Length=507, Percent_Identity=42.603550295858, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17551876, Length=480, Percent_Identity=22.2916666666667, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32566633, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320242, Length=522, Percent_Identity=41.3793103448276, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=30.1255230125523, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323011, Length=527, Percent_Identity=24.2884250474383, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24640849, Length=493, Percent_Identity=44.421906693712, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640851, Length=493, Percent_Identity=44.421906693712, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17136276, Length=470, Percent_Identity=23.1914893617021, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYK_PROM3 (A2C629)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016204.1
- ProteinModelPortal:   A2C629
- SMR:   A2C629
- STRING:   A2C629
- GeneID:   4777121
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_01841
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- ProtClustDB:   PRK00484
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 56845; Mature: 56714

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSVLSALSELRETRLEKAQALKELGNGPYALRFESSHRTANLQADHADLAKGEERLLS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCHHHHHCCHHHHHH
VSVAGRVMARRVMGKLAFYTLADETGTIQLYLDKATIDAAASNELASGTFVQLTTLVDAG
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECCHHCHHCCCCCCCCCEEEEEEEECCC
DWIGVTGVLRRTDRGELSVKVQQWQILSKSLQPLPDKWHGLADVEKRYRQRYLDLIVSPQ
CCCCHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHCCCC
SRETFRRRALMVSAIRRWLDDRAFLEIETPVLQAEAGGAEARPFITHHNTLDLPLYLRIA
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCCCEEEECCCCCCCCHHHHH
TELHLKRLVVGGFERVYELGRIFRNEGMSTRHNPEFTSVEVYQAYADYIDMMVLTEQLIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SVCTQICGSTRITYQGIEIDLTPPWRRASMHELVQEATGLDFMGFADRAVAASAMARAGL
HHHHHHHCCCEEEEECEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
EVPSKADSVGRLLNEAFEQAVEVSLIQPTFVLDYPIEISPLARQHRSKPGLVERFELFIV
CCCCCHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCCHHHHHCCCCCCHHEEEEEEEE
GRETANAFSELIDPLDQRQRLEAQQARRQAGDLEAHGVDEDFLQALEVGMPPTGGLGIGI
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCH
DRLVMLFTDSPSIRDVIAFPLLRPELKT
HHEEEEECCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ARSVLSALSELRETRLEKAQALKELGNGPYALRFESSHRTANLQADHADLAKGEERLLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCHHHHHCCHHHHHH
VSVAGRVMARRVMGKLAFYTLADETGTIQLYLDKATIDAAASNELASGTFVQLTTLVDAG
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECCHHCHHCCCCCCCCCEEEEEEEECCC
DWIGVTGVLRRTDRGELSVKVQQWQILSKSLQPLPDKWHGLADVEKRYRQRYLDLIVSPQ
CCCCHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHCCCC
SRETFRRRALMVSAIRRWLDDRAFLEIETPVLQAEAGGAEARPFITHHNTLDLPLYLRIA
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCCCEEEECCCCCCCCHHHHH
TELHLKRLVVGGFERVYELGRIFRNEGMSTRHNPEFTSVEVYQAYADYIDMMVLTEQLIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SVCTQICGSTRITYQGIEIDLTPPWRRASMHELVQEATGLDFMGFADRAVAASAMARAGL
HHHHHHHCCCEEEEECEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
EVPSKADSVGRLLNEAFEQAVEVSLIQPTFVLDYPIEISPLARQHRSKPGLVERFELFIV
CCCCCHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCCHHHHHCCCCCCHHEEEEEEEE
GRETANAFSELIDPLDQRQRLEAQQARRQAGDLEAHGVDEDFLQALEVGMPPTGGLGIGI
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCH
DRLVMLFTDSPSIRDVIAFPLLRPELKT
HHEEEEECCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA