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The map label for this gene is sam1

Identifier: 124021888

GI number: 124021888

Start: 195100

End: 196530

Strand: Direct

Name: sam1

Synonym: P9303_01751

Alternate gene names: 124021888

Gene position: 195100-196530 (Clockwise)

Preceding gene: 124021886

Following gene: 124021890

Centisome position: 7.27

GC content: 51.08

Gene sequence:

>1431_bases
ATGGTGGCAGTGCCCACATCAATGGCCTCGTTGCAGGCCCCCCCTCAATACGTCGTAGCAGACATCGACCTAGCGGATTT
TGGCCGTAAGGAATTGAGCATTGCTGAAACTGAGATGCCAGGTTTGATGGCCCTCAGGGTCAAGCACGGCAGCGAAAAAC
CTCTCAAGGGGGCTCGCATTGCTGGCAGTCTGCACATGACCATTCAGACGGGTGTGTTGATTGAGACGCTCGTGGCCCTC
GGTGCTGACGTGCGCTGGGCTTCATGCAACATTTTTTCTACTCAAGATCACGCTGCTGCTGCTATTGCCGCTAGCGGCGT
GCCTGTCTTTGCAACCAAAGGCGAGACTCTTGATGAGTATTGGGCCTATACCCATCGCATTCTCGAGTGGGGTGATGGTG
GCACTCCCAACATGATCTTGGATGACGGTGGTGATGCAACTGGCTTGGTGATGCTTGGCAGCAAGGCCGAGAGCGATAGT
TCTGTACTGGATAACCCTGGCAACGAGGAAGAGACGGCATTGTTTGCCTCGATTCGTACCAAGTTGGCCCAGGATTCCAG
TTTTTATTCCCGCATCAAGAGCAATATTCAGGGGGTGACAGAAGAGACAACTACGGGTGTTGCGCGTCTGTATCAGATGC
AAAAGAGTGGTGAATTGCCTTTCCCTGCGATCAATGTCAATGACTCGGTGACTAAGAGCAAGTTCGACAATCTTTATGGA
TGCCGTGAATCCTTGGTGGATGGCATTAAGCGGGCCACTGATGTGATGGTCGCTGGCAAGGTGGCTTTGGTGATGGGCTA
TGGCGATGTGGGTAAGGGTTCAGCTCAATCGCTACGGGGCCTTGGTGCCACAGTGATGATTGCTGAAATTGACCCTATCT
GTGCTCTTCAGGCAGCGATGGAGGGCTATCGGGTGGTGCGTCTGGATGAGGTGGTTCAGGATGTCGATATCTTTGTGACC
TCCACAGGCAACTTTCAGGTGATTCGCCATGAACATCTGATCCGTATGAAGGATGAGGCCATTGTTTGCAATATCGGCCA
CTTTGATAATGAGATTGATGTTGCATCTTTAAAGGATTATTCCTGGGAGAACATCAAGCCTCAGGTTGATCACATCACTC
TTCCCAGCGGAAATAAGATCATTCTTCTGGCTGAAGGGCGTTTGGTGAACCTTGGTTGTGCTACTGGTCACCCCAGCTTT
GTGATGAGCAATTCCTTTACCAATCAGGTCTTAGCTCAAATTGAGTTGTTTTCGAAAGGTGATAAGTATGCCGATCAGGT
GTATGTGTTGCCTAAGCACCTCGATGAGATGGTGGCTCGCCTTCACTTGGAGAAGATCGGTGCGAGGCTTACTGAGCTCA
CCAAGCAGCAGGCCGATTACATCAGTGTGCCTATTGAAGGTCCGTATAAGCCCGACCATTATCGCTACTGA

Upstream 100 bases:

>100_bases
AATCCATGAGTCATCTGTAGATTGCCCCCTAAGCGATCCCGAAGTCTCGGCGACTTCGCTGAGATTTCCGTACACAATTC
CCCCAAGGGAGCTTTTAACC

Downstream 100 bases:

>100_bases
TTGTTTCCAGGCAGGCAAGCTTATTTTTTACAATTAGGCTTGTCTGCCTGGCAAGAAGATGACTCAATAGTTGTTATAGA
TTGAGTGGTAAAAAGAGATC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MVAVPTSMASLQAPPQYVVADIDLADFGRKELSIAETEMPGLMALRVKHGSEKPLKGARIAGSLHMTIQTGVLIETLVAL
GADVRWASCNIFSTQDHAAAAIAASGVPVFATKGETLDEYWAYTHRILEWGDGGTPNMILDDGGDATGLVMLGSKAESDS
SVLDNPGNEEETALFASIRTKLAQDSSFYSRIKSNIQGVTEETTTGVARLYQMQKSGELPFPAINVNDSVTKSKFDNLYG
CRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLDEVVQDVDIFVT
STGNFQVIRHEHLIRMKDEAIVCNIGHFDNEIDVASLKDYSWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSF
VMSNSFTNQVLAQIELFSKGDKYADQVYVLPKHLDEMVARLHLEKIGARLTELTKQQADYISVPIEGPYKPDHYRY

Sequences:

>Translated_476_residues
MVAVPTSMASLQAPPQYVVADIDLADFGRKELSIAETEMPGLMALRVKHGSEKPLKGARIAGSLHMTIQTGVLIETLVAL
GADVRWASCNIFSTQDHAAAAIAASGVPVFATKGETLDEYWAYTHRILEWGDGGTPNMILDDGGDATGLVMLGSKAESDS
SVLDNPGNEEETALFASIRTKLAQDSSFYSRIKSNIQGVTEETTTGVARLYQMQKSGELPFPAINVNDSVTKSKFDNLYG
CRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLDEVVQDVDIFVT
STGNFQVIRHEHLIRMKDEAIVCNIGHFDNEIDVASLKDYSWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSF
VMSNSFTNQVLAQIELFSKGDKYADQVYVLPKHLDEMVARLHLEKIGARLTELTKQQADYISVPIEGPYKPDHYRY
>Mature_476_residues
MVAVPTSMASLQAPPQYVVADIDLADFGRKELSIAETEMPGLMALRVKHGSEKPLKGARIAGSLHMTIQTGVLIETLVAL
GADVRWASCNIFSTQDHAAAAIAASGVPVFATKGETLDEYWAYTHRILEWGDGGTPNMILDDGGDATGLVMLGSKAESDS
SVLDNPGNEEETALFASIRTKLAQDSSFYSRIKSNIQGVTEETTTGVARLYQMQKSGELPFPAINVNDSVTKSKFDNLYG
CRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLDEVVQDVDIFVT
STGNFQVIRHEHLIRMKDEAIVCNIGHFDNEIDVASLKDYSWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSF
VMSNSFTNQVLAQIELFSKGDKYADQVYVLPKHLDEMVARLHLEKIGARLTELTKQQADYISVPIEGPYKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=61.2554112554113, Blast_Score=534, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=60.9090909090909, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI298286489, Length=463, Percent_Identity=50.5399568034557, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI24308043, Length=463, Percent_Identity=50.5399568034557, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI195539337, Length=463, Percent_Identity=50.5399568034557, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI195539349, Length=463, Percent_Identity=50.5399568034557, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI21361647, Length=463, Percent_Identity=50.3239740820734, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506425, Length=470, Percent_Identity=59.1489361702128, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320882, Length=484, Percent_Identity=59.0909090909091, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=62.0171673819742, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24656245, Length=453, Percent_Identity=51.2141280353201, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45553387, Length=462, Percent_Identity=50.4329004329004, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=461, Percent_Identity=50.3253796095445, Blast_Score=446, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_PROM3 (A2C620)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016195.1
- ProteinModelPortal:   A2C620
- SMR:   A2C620
- STRING:   A2C620
- GeneID:   4776917
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_01751
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51771; Mature: 51771

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 67-67 BINDING 142-142 BINDING 202-202 BINDING 232-232 BINDING 236-236 BINDING 237-237 BINDING 289-289 BINDING 324-324 BINDING 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVPTSMASLQAPPQYVVADIDLADFGRKELSIAETEMPGLMALRVKHGSEKPLKGARI
CEECCCCHHHCCCCCCEEEEECCHHHCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCEE
AGSLHMTIQTGVLIETLVALGADVRWASCNIFSTQDHAAAAIAASGVPVFATKGETLDEY
ECEEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHEECCCEEEEECCCCHHHH
WAYTHRILEWGDGGTPNMILDDGGDATGLVMLGSKAESDSSVLDNPGNEEETALFASIRT
HHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHH
KLAQDSSFYSRIKSNIQGVTEETTTGVARLYQMQKSGELPFPAINVNDSVTKSKFDNLYG
HHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHH
CRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAM
HHHHHHHHHHHHHHEEEECEEEEEEECCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHH
EGYRVVRLDEVVQDVDIFVTSTGNFQVIRHEHLIRMKDEAIVCNIGHFDNEIDVASLKDY
CCCEEEEHHHHHCCEEEEEECCCCEEEEEECCEEEECCCEEEEECCCCCCCCCEEECCCC
SWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFSKG
CCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCC
DKYADQVYVLPKHLDEMVARLHLEKIGARLTELTKQQADYISVPIEGPYKPDHYRY
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MVAVPTSMASLQAPPQYVVADIDLADFGRKELSIAETEMPGLMALRVKHGSEKPLKGARI
CEECCCCHHHCCCCCCEEEEECCHHHCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCEE
AGSLHMTIQTGVLIETLVALGADVRWASCNIFSTQDHAAAAIAASGVPVFATKGETLDEY
ECEEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHEECCCEEEEECCCCHHHH
WAYTHRILEWGDGGTPNMILDDGGDATGLVMLGSKAESDSSVLDNPGNEEETALFASIRT
HHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHH
KLAQDSSFYSRIKSNIQGVTEETTTGVARLYQMQKSGELPFPAINVNDSVTKSKFDNLYG
HHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHH
CRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAM
HHHHHHHHHHHHHHEEEECEEEEEEECCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHH
EGYRVVRLDEVVQDVDIFVTSTGNFQVIRHEHLIRMKDEAIVCNIGHFDNEIDVASLKDY
CCCEEEEHHHHHCCEEEEEECCCCEEEEEECCEEEECCCEEEEECCCCCCCCCEEECCCC
SWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFSKG
CCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCC
DKYADQVYVLPKHLDEMVARLHLEKIGARLTELTKQQADYISVPIEGPYKPDHYRY
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA