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The map label for this gene is mutY [H]

Identifier: 124021885

GI number: 124021885

Start: 192340

End: 193542

Strand: Direct

Name: mutY [H]

Synonym: P9303_01721

Alternate gene names: 124021885

Gene position: 192340-193542 (Clockwise)

Preceding gene: 124021883

Following gene: 124021886

Centisome position: 7.17

GC content: 55.78

Gene sequence:

>1203_bases
TTGTTGATTCATTTTGGCGACTTTATGGCTCAGGGGTTAGAAGGTTCGAGTCAACAGTGCCGAGAGTTGCTCGATAAACG
TTGGCCCGAGATGCGTCAGCAGCTTTTGGCTTGGTGGCAAGTCCATGGCCGTAAGCACGTTGCCATTAAGCCGTGGATGC
TCACATCAGATGGGCGTTGGCCCGAACCACACGAAGCCCTCTCGCCCTATGGCATCTGGATCGCGGAGGTGATGCTTCAA
CAAACCCAGTTGAAGGTGATGCGTCCTTACTGGCAGCAGTGGATGGTGGTGTTGCCAACGGTGCAGCATTTGGCTGCTGC
TGAAGAGCGCCAAGTGTTGTTGCTGTGGCAGGGCCTTGGCTATTACTCCCGTGCCCGCCGGCTGCATCAGGCGGCGCGTC
AATTGGCAGCTTCCCCTCTGCCCTCTTCTCTTGAGGCTTGGCAGGCTTTCCCGGGTATTGGTCGTACCACGGCAGGGAGC
ATCCTTTCCAGTGCATTGAATAGGCCAGTACCAATCCTTGATGGCAATGTGCGTCGTGTGCTGGCCAGACTTCATGCTTG
TCTGGAGCCCCCGCACAGAGCTCAGGCAAGCTTTTGGCAGTGGAGTGAAGCTCTTCTCGATCCTTTGCGGCCAAGAGATT
TCAATCAGGCCTTGATGGATTTGGGTGCTTTGGTGTGTACTCCTAGGACCCCAAGTTGCCAGTTATGCCCTTGGCAAAGC
AGTTGTGCTGCCTACGCTGCTGGAGAGCCAAGCCACTTCCCCGTGAAGGATGCGAGCAAGCCCATTCCCTTCCAGGTGAT
TGGTGTGGGGGTCGTACTGAACGAAGCGGGTGAGGTCTTAATTGATCAGAGGCTTAATGAGGGCTTACTCGGTGGTTTGT
GGGAATTCCCTGGTGGCAAGCAGGAGCCAGGTGAAGCCATCGAAGCCACCATTGCTCGCGAGCTCAGGGAGGAATTGGCG
ATTGAAGTGCAGGTGGGTGAGCAGCTGATTGCGCTTGACCATGCCTACAGCCATAAGAAGCTTCGCTTTGTTGTTTATCT
CTGCCGCTGGATCTCAGGAGAGCCCAAGCCTTTGGCGAGTCAGCAGGTGTGCTGGGTGAAGCCTGAAGATCTTTCTGACT
ATCCCTTCCCGGCAGCCAATGCGCGCATGATTGCCGCGTTGATTGATCATCTTCGCGCAGACACGCTTGGCCAGCGTTCC
TAG

Upstream 100 bases:

>100_bases
GAATCGTTTGGTTCAAGCAATGGCCTGGTTGAACGAACGCTGCAATAGTGCCTTAAAAACTTGTTGCAGCCCAGTTGGCT
CTTGAGAGGTTGGTGGTCAG

Downstream 100 bases:

>100_bases
CTTCAACTCAGTAGCTGCTAACTGATGACGGGGACCAATCCGGTTCACAGCAACGAGCCTGAGGTGATTTGCTTGGGCGA
GGCGTTGGTGGATCGTCTTG

Product: adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLIHFGDFMAQGLEGSSQQCRELLDKRWPEMRQQLLAWWQVHGRKHVAIKPWMLTSDGRWPEPHEALSPYGIWIAEVMLQ
QTQLKVMRPYWQQWMVVLPTVQHLAAAEERQVLLLWQGLGYYSRARRLHQAARQLAASPLPSSLEAWQAFPGIGRTTAGS
ILSSALNRPVPILDGNVRRVLARLHACLEPPHRAQASFWQWSEALLDPLRPRDFNQALMDLGALVCTPRTPSCQLCPWQS
SCAAYAAGEPSHFPVKDASKPIPFQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATIARELREELA
IEVQVGEQLIALDHAYSHKKLRFVVYLCRWISGEPKPLASQQVCWVKPEDLSDYPFPAANARMIAALIDHLRADTLGQRS

Sequences:

>Translated_400_residues
MLIHFGDFMAQGLEGSSQQCRELLDKRWPEMRQQLLAWWQVHGRKHVAIKPWMLTSDGRWPEPHEALSPYGIWIAEVMLQ
QTQLKVMRPYWQQWMVVLPTVQHLAAAEERQVLLLWQGLGYYSRARRLHQAARQLAASPLPSSLEAWQAFPGIGRTTAGS
ILSSALNRPVPILDGNVRRVLARLHACLEPPHRAQASFWQWSEALLDPLRPRDFNQALMDLGALVCTPRTPSCQLCPWQS
SCAAYAAGEPSHFPVKDASKPIPFQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATIARELREELA
IEVQVGEQLIALDHAYSHKKLRFVVYLCRWISGEPKPLASQQVCWVKPEDLSDYPFPAANARMIAALIDHLRADTLGQRS
>Mature_400_residues
MLIHFGDFMAQGLEGSSQQCRELLDKRWPEMRQQLLAWWQVHGRKHVAIKPWMLTSDGRWPEPHEALSPYGIWIAEVMLQ
QTQLKVMRPYWQQWMVVLPTVQHLAAAEERQVLLLWQGLGYYSRARRLHQAARQLAASPLPSSLEAWQAFPGIGRTTAGS
ILSSALNRPVPILDGNVRRVLARLHACLEPPHRAQASFWQWSEALLDPLRPRDFNQALMDLGALVCTPRTPSCQLCPWQS
SCAAYAAGEPSHFPVKDASKPIPFQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGKQEPGEAIEATIARELREELA
IEVQVGEQLIALDHAYSHKKLRFVVYLCRWISGEPKPLASQQVCWVKPEDLSDYPFPAANARMIAALIDHLRADTLGQRS

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=376, Percent_Identity=35.1063829787234, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298652, Length=376, Percent_Identity=35.1063829787234, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298648, Length=376, Percent_Identity=35.1063829787234, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298650, Length=376, Percent_Identity=35.1063829787234, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI6912520, Length=376, Percent_Identity=35.1063829787234, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI190358497, Length=376, Percent_Identity=35.1063829787234, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789331, Length=323, Percent_Identity=39.6284829721362, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788056, Length=120, Percent_Identity=31.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786288, Length=121, Percent_Identity=33.0578512396694, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 45033; Mature: 45033

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIHFGDFMAQGLEGSSQQCRELLDKRWPEMRQQLLAWWQVHGRKHVAIKPWMLTSDGRW
CEEECHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECEEEECCCCC
PEPHEALSPYGIWIAEVMLQQTQLKVMRPYWQQWMVVLPTVQHLAAAEERQVLLLWQGLG
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
YYSRARRLHQAARQLAASPLPSSLEAWQAFPGIGRTTAGSILSSALNRPVPILDGNVRRV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
LARLHACLEPPHRAQASFWQWSEALLDPLRPRDFNQALMDLGALVCTPRTPSCQLCPWQS
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCC
SCAAYAAGEPSHFPVKDASKPIPFQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGK
CCCHHCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCHHHHHHHHHCCCHHCCHHCCCCCC
QEPGEAIEATIARELREELAIEVQVGEQLIALDHAYSHKKLRFVVYLCRWISGEPKPLAS
CCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCC
QQVCWVKPEDLSDYPFPAANARMIAALIDHLRADTLGQRS
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLIHFGDFMAQGLEGSSQQCRELLDKRWPEMRQQLLAWWQVHGRKHVAIKPWMLTSDGRW
CEEECHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECEEEECCCCC
PEPHEALSPYGIWIAEVMLQQTQLKVMRPYWQQWMVVLPTVQHLAAAEERQVLLLWQGLG
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
YYSRARRLHQAARQLAASPLPSSLEAWQAFPGIGRTTAGSILSSALNRPVPILDGNVRRV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
LARLHACLEPPHRAQASFWQWSEALLDPLRPRDFNQALMDLGALVCTPRTPSCQLCPWQS
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCC
SCAAYAAGEPSHFPVKDASKPIPFQVIGVGVVLNEAGEVLIDQRLNEGLLGGLWEFPGGK
CCCHHCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCHHHHHHHHHCCCHHCCHHCCCCCC
QEPGEAIEATIARELREELAIEVQVGEQLIALDHAYSHKKLRFVVYLCRWISGEPKPLAS
CCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCC
QQVCWVKPEDLSDYPFPAANARMIAALIDHLRADTLGQRS
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]