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The map label for this gene is mrdA [H]

Identifier: 124021764

GI number: 124021764

Start: 48830

End: 50632

Strand: Direct

Name: mrdA [H]

Synonym: P9303_00491

Alternate gene names: 124021764

Gene position: 48830-50632 (Clockwise)

Preceding gene: 124021763

Following gene: 124021769

Centisome position: 1.82

GC content: 53.63

Gene sequence:

>1803_bases
ATGAGTGGATCGCGGCCTTTGGGACGTGCCAATCAGCGGCACAGTGGTTTAGGCCAGCAGCCCAAGGTCTTGCTTGCTCT
GGTGCTTTTGTTTTGTGGCGCCATGGTGGCGCGGTTGACCTGGTTACAGCTGTTGGAAGGGGCTCGATACCGAGAGTTGG
CAGATGAAAATCGGATTCGCTTGGTACCCCGTTCACCGATTCGTGGTCGGCTGCTCGATCGTCAAGGACGTGTACTTGCC
TCAAGCAAGCTCAGCTACAACCTTTATTTGCAGCCTCGATTGCTTAGTGATGGTAATTGGCCTGGGCTTCGTGACAGTCT
TTCTCAGTTGCTCAATCTTCCTAAGCAGGATTTAGATCAACGCAGGCGACAGGGGGTTGGCACGGATGGCTATCGCATCA
CTTTGGCAACTGATTTGAAACCTGAGCAGGTGCTGCGTTTTCGAGAGCAGGCTCGCAGTTTTGAAGCGGCCCAGGTCGAT
GTGGATGTACTACGTCACTACCCGTACGGCACTTTGGCCGCCCATGTCTTGGGTTATACCCAGCCAATTACTGAAAAGGA
GTTTAAGACTCTCGCTGATCAGGGTTATGAGATTAGAGATCGCATTGGCCGAATTGGAGTGGAGGCGGCCTATGAGCCTC
ATTTACGAGGGAAGTGGGGTGGTCAGATGCTTGAAGTCAACGCTATGGGAGAGGTGCAGCGCAGTCTTGGTGACAAGCCT
TCACAGGCGGGTAAAGATCTCCTCCTCACACTTGACCTTGATTTGCAGTTGGCTGCTGAAAAGGCTCTTGAAGATAAGCC
TGGCGGTGCAGTTGTAGCACTCGATCCTCGTAACGGTGCTATTCGCGCCATGGCTAGTCGCCCTGCCTTTGATCCCAACT
TTTTCTCAAAACTCTTCACCACGCAGAAGGAGTACGACAAGCTTTTTGCTTCGTCGAGCAAGCCATTGCTCAGTCGGGCC
ATGAATGCCTATGACCCGGGGAGTACTTGGAAACCTGTTACAAGTATGGCGGGCATGGAGAGTGGCAAGTTTCTGCCTGA
TGTGCGTTTAAAGACGGCGGCATGCATCACTTATGGGGGGCATTGCTTCCCTGACCACAACGGTGTCGGATTTGGCACGA
TCGGTTATGAGGATGCGCTGCGCTTTTCCAGCAATACCTTCTTTTATCAGGTGGGTGTGGGTGTGGGTTCTAAGGCGCTT
TATGAGGCCGCCATCAAGCTTGGTTTCGATGCCCGTACTGGGATTGAGATTGGCTATGAGGAGAGCAAGGGCTTGGTGGG
CCATCAGGCCTGGGCGGCTAAAGGTCGGGGTTGGGCTGAAGCTGGAACGACTCCTTGGATTCCCGAGGACATGGCCAGCG
CCTCGATTGGTCAATCTGTAGTTCAGATCACTCCTTTGCAACTTGCTCGCGCTTATGCAGTATTTGCCAATGGGGGGTTT
TTGGTCACTCCTCATCTGGCAGATGGTGCGATTGACTGGACTTCATCACTGCGACGCATCAAGGTCGATATCAAGCCATC
CACATTGGCGACGATTAGGCGTGGTTTGCGCAAGGTTGTGCAGGATGGGACTGGTTCAGGTCTCAATTTGCCCAACTTTC
CGCAAGTGGCCGGCAAGACGGGCACTGCCGAGGACAGTACCGGTGGCTCTGATCACGCATGGTTTGCATGTTTTGCGCCA
TATCAGTCAGCAGAAATCGTCGTTGTTGCTTTTGCCCAGAACACTCCTGGTGGCGGTTCGGTCCATGCGTTGCCTATGGC
ACGGCAGGTGCTTCAGGCTTGGAATCGCACACGCTCTAGTTGA

Upstream 100 bases:

>100_bases
TGGCCAGGATTGAGGGACGGCTTGATGCTCTTCAGCTTCACCTGCAGACAGATGTTGGCGATTTTTCGCCAACATCAGGC
GTGGAACAAAGCTGACGTTG

Downstream 100 bases:

>100_bases
ACTCACTGACTCTCAGAACACACTGATGTTTGGTCTCAGGCGGCCAGGTTGAGGGGTTGGCCGAGGATTGTTCTGTAGTA
GCTCCGCAGTTGTTGCGTGG

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSGSRPLGRANQRHSGLGQQPKVLLALVLLFCGAMVARLTWLQLLEGARYRELADENRIRLVPRSPIRGRLLDRQGRVLA
SSKLSYNLYLQPRLLSDGNWPGLRDSLSQLLNLPKQDLDQRRRQGVGTDGYRITLATDLKPEQVLRFREQARSFEAAQVD
VDVLRHYPYGTLAAHVLGYTQPITEKEFKTLADQGYEIRDRIGRIGVEAAYEPHLRGKWGGQMLEVNAMGEVQRSLGDKP
SQAGKDLLLTLDLDLQLAAEKALEDKPGGAVVALDPRNGAIRAMASRPAFDPNFFSKLFTTQKEYDKLFASSSKPLLSRA
MNAYDPGSTWKPVTSMAGMESGKFLPDVRLKTAACITYGGHCFPDHNGVGFGTIGYEDALRFSSNTFFYQVGVGVGSKAL
YEAAIKLGFDARTGIEIGYEESKGLVGHQAWAAKGRGWAEAGTTPWIPEDMASASIGQSVVQITPLQLARAYAVFANGGF
LVTPHLADGAIDWTSSLRRIKVDIKPSTLATIRRGLRKVVQDGTGSGLNLPNFPQVAGKTGTAEDSTGGSDHAWFACFAP
YQSAEIVVVAFAQNTPGGGSVHALPMARQVLQAWNRTRSS

Sequences:

>Translated_600_residues
MSGSRPLGRANQRHSGLGQQPKVLLALVLLFCGAMVARLTWLQLLEGARYRELADENRIRLVPRSPIRGRLLDRQGRVLA
SSKLSYNLYLQPRLLSDGNWPGLRDSLSQLLNLPKQDLDQRRRQGVGTDGYRITLATDLKPEQVLRFREQARSFEAAQVD
VDVLRHYPYGTLAAHVLGYTQPITEKEFKTLADQGYEIRDRIGRIGVEAAYEPHLRGKWGGQMLEVNAMGEVQRSLGDKP
SQAGKDLLLTLDLDLQLAAEKALEDKPGGAVVALDPRNGAIRAMASRPAFDPNFFSKLFTTQKEYDKLFASSSKPLLSRA
MNAYDPGSTWKPVTSMAGMESGKFLPDVRLKTAACITYGGHCFPDHNGVGFGTIGYEDALRFSSNTFFYQVGVGVGSKAL
YEAAIKLGFDARTGIEIGYEESKGLVGHQAWAAKGRGWAEAGTTPWIPEDMASASIGQSVVQITPLQLARAYAVFANGGF
LVTPHLADGAIDWTSSLRRIKVDIKPSTLATIRRGLRKVVQDGTGSGLNLPNFPQVAGKTGTAEDSTGGSDHAWFACFAP
YQSAEIVVVAFAQNTPGGGSVHALPMARQVLQAWNRTRSS
>Mature_599_residues
SGSRPLGRANQRHSGLGQQPKVLLALVLLFCGAMVARLTWLQLLEGARYRELADENRIRLVPRSPIRGRLLDRQGRVLAS
SKLSYNLYLQPRLLSDGNWPGLRDSLSQLLNLPKQDLDQRRRQGVGTDGYRITLATDLKPEQVLRFREQARSFEAAQVDV
DVLRHYPYGTLAAHVLGYTQPITEKEFKTLADQGYEIRDRIGRIGVEAAYEPHLRGKWGGQMLEVNAMGEVQRSLGDKPS
QAGKDLLLTLDLDLQLAAEKALEDKPGGAVVALDPRNGAIRAMASRPAFDPNFFSKLFTTQKEYDKLFASSSKPLLSRAM
NAYDPGSTWKPVTSMAGMESGKFLPDVRLKTAACITYGGHCFPDHNGVGFGTIGYEDALRFSSNTFFYQVGVGVGSKALY
EAAIKLGFDARTGIEIGYEESKGLVGHQAWAAKGRGWAEAGTTPWIPEDMASASIGQSVVQITPLQLARAYAVFANGGFL
VTPHLADGAIDWTSSLRRIKVDIKPSTLATIRRGLRKVVQDGTGSGLNLPNFPQVAGKTGTAEDSTGGSDHAWFACFAPY
QSAEIVVVAFAQNTPGGGSVHALPMARQVLQAWNRTRSS

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=596, Percent_Identity=30.3691275167785, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1786272, Length=483, Percent_Identity=26.0869565217391, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65433; Mature: 65302

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSRPLGRANQRHSGLGQQPKVLLALVLLFCGAMVARLTWLQLLEGARYRELADENRIR
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEE
LVPRSPIRGRLLDRQGRVLASSKLSYNLYLQPRLLSDGNWPGLRDSLSQLLNLPKQDLDQ
EECCCCCCCCHHCCCCCEEEECCCEEEEEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
RRRQGVGTDGYRITLATDLKPEQVLRFREQARSFEAAQVDVDVLRHYPYGTLAAHVLGYT
HHHCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCC
QPITEKEFKTLADQGYEIRDRIGRIGVEAAYEPHLRGKWGGQMLEVNAMGEVQRSLGDKP
CCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCC
SQAGKDLLLTLDLDLQLAAEKALEDKPGGAVVALDPRNGAIRAMASRPAFDPNFFSKLFT
CCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHH
TQKEYDKLFASSSKPLLSRAMNAYDPGSTWKPVTSMAGMESGKFLPDVRLKTAACITYGG
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHEEEEEECC
HCFPDHNGVGFGTIGYEDALRFSSNTFFYQVGVGVGSKALYEAAIKLGFDARTGIEIGYE
EECCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCC
ESKGLVGHQAWAAKGRGWAEAGTTPWIPEDMASASIGQSVVQITPLQLARAYAVFANGGF
CCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHEECHHHHHHHHEEEECCCE
LVTPHLADGAIDWTSSLRRIKVDIKPSTLATIRRGLRKVVQDGTGSGLNLPNFPQVAGKT
EEECCCCCCCCHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCC
GTAEDSTGGSDHAWFACFAPYQSAEIVVVAFAQNTPGGGSVHALPMARQVLQAWNRTRSS
CCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGSRPLGRANQRHSGLGQQPKVLLALVLLFCGAMVARLTWLQLLEGARYRELADENRIR
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEE
LVPRSPIRGRLLDRQGRVLASSKLSYNLYLQPRLLSDGNWPGLRDSLSQLLNLPKQDLDQ
EECCCCCCCCHHCCCCCEEEECCCEEEEEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
RRRQGVGTDGYRITLATDLKPEQVLRFREQARSFEAAQVDVDVLRHYPYGTLAAHVLGYT
HHHCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCC
QPITEKEFKTLADQGYEIRDRIGRIGVEAAYEPHLRGKWGGQMLEVNAMGEVQRSLGDKP
CCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCC
SQAGKDLLLTLDLDLQLAAEKALEDKPGGAVVALDPRNGAIRAMASRPAFDPNFFSKLFT
CCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHH
TQKEYDKLFASSSKPLLSRAMNAYDPGSTWKPVTSMAGMESGKFLPDVRLKTAACITYGG
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHEEEEEECC
HCFPDHNGVGFGTIGYEDALRFSSNTFFYQVGVGVGSKALYEAAIKLGFDARTGIEIGYE
EECCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCC
ESKGLVGHQAWAAKGRGWAEAGTTPWIPEDMASASIGQSVVQITPLQLARAYAVFANGGF
CCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHEECHHHHHHHHEEEECCCE
LVTPHLADGAIDWTSSLRRIKVDIKPSTLATIRRGLRKVVQDGTGSGLNLPNFPQVAGKT
EEECCCCCCCCHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCC
GTAEDSTGGSDHAWFACFAPYQSAEIVVVAFAQNTPGGGSVHALPMARQVLQAWNRTRSS
CCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]