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The map label for this gene is guaA

Identifier: 124021760

GI number: 124021760

Start: 44874

End: 46460

Strand: Direct

Name: guaA

Synonym: P9303_00451

Alternate gene names: 124021760

Gene position: 44874-46460 (Clockwise)

Preceding gene: 124021759

Following gene: 124021761

Centisome position: 1.67

GC content: 49.15

Gene sequence:

>1587_bases
ATGTCCAATTCCCAGTCTGAAGGTCAGCGCCAGCCGGCAATCGTCATTCTCGATTTTGGCTCTCAGTATTCAGAGCTGAT
TGCCCGTCGGGTGCGAGAAACAGAGGTCTACTCATTGGTGATGAGCTATAGCACCTCAGCGGATGAGCTTCGCCAGCTTG
CCCCGAAGGGCATCATTTTGAGTGGCGGACCTAGCTCTGTGTATGCCGAGAGAGCGCCGCTGTGTGATCCGAACATTTGG
GATTTGGGTATTCCTGTGCTGGGGGTTTGTTATGGCATGCAATTGATGGTGCAGCAGTTGGGTGGTCGGGTGGAAATGGC
AACGGGCAAGGCCGAATACGGCAAGGCTCCTCTTGAAATTGATGACCCGACGGATCTGCTCACCAATGTTGAGAATGGAT
CCACCATGTGGATGAGCCATGGTGATTCAGTGCGCGCCTTACCTGAGGGGTTTGTGCGACTTGCTCATACAGCGAATACA
CCAGATGCGGCTGTGGCTTACCACACGCGTTCTCTTTATGGCGTGCAATTTCATCCTGAGGTGGTTCATTCCACTGATGG
AATGTCGTTGATTAGAAATTTTGTTTATCACATTTGTGGCTGTGAACCGGATTGGACTACGACCGCATTTATTGAAGAAG
CCGTTAGCCAGGTTCGTTCTCAAGTCGGAGATAAACGGGTGTTGCTTGCTTTGTCTGGTGGTGTTGATTCTTCCACTCTT
GCCTTTCTTTTAAAAAAGGCCATTGGAGATCAGCTCACGTGCATGTTTATTGATCAGGGGTTTATGCGTAAAGGTGAACC
TGAGTTTTTGATGGATTTCTTTGATCGTAAGTTCAATATTAATGTTGAATATATCAATGCAAGACAACGGTTTATTTCTA
AGTTGAATGGCATTGTTGATCCGGAAGAGAAACGTAAAATTATTGGTACCGAATTCATCAGGGTGTTTGAGGAGGAAAGC
AATCGTCTCGGTCCCTTTGATTATCTTGCGCAGGGCACTCTTTATCCGGATGTGATCGAGAGTGCTGGTACCAACATCGA
TCCGAAAACCGGAGAGCGGGTGGCGGTAAAGATCAAGAGCCACCACAATGTGGGCGGTCTTCCTAAAGATCTGCAGTTCA
AATTGGTGGAGCCGCTTAGGCGATTGTTTAAAGACGAGGTGCGAAAAGTAGGTCGTTCTTTGGGCTTGCCGGAAGAGATT
GTCCGCCGTCACCCTTTCCCTGGTCCAGGTCTGGCGATTCGCATTCTTGGTGAAGTGACCGACGAGAAGTTGAATTGTTT
GCGTGATGCCGATTTGATTGTTCGCGAAGAAATTCGTGAAGCTGGTTTGTATCACGAGATTTGGCAGGCTTTTGCCGTCT
TACTGCCGGTGCGCTCCGTCGGGGTAATGGGGGATCAGCGCACTTACGCTTGGCCGATTGTTTTGCGATGTGTCTCCAGT
GAGGACGGCATGACAGCGGATTGGTCGCGTTTACCTGATGAACTTTTGGAGCGTATCTCCAATCGAATTGTCAATGAAGT
GAGAGGTGTCAACCGTGTTGTGCTTGACATCACCAGCAAGCCTCCTGGAACGATTGAGTGGGAATAG

Upstream 100 bases:

>100_bases
CAGTTGGCTGTCTTGGGAGTGACCCCTGAGGATTCACCGATAAGCCTTTCTCTACCCTGAACGTTCTGTTGGTTGACTCC
AGAGGAGCTTTTTCGCTGAT

Downstream 100 bases:

>100_bases
ATATGCAGAGTTTGATTACGAAGTTACGAACATCTCTTTGTTGAGACCAATTTTTTAGCAATTATATCATATTTTGCTGA
ATATGCATACTGCTAAGCGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSNSQSEGQRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYSTSADELRQLAPKGIILSGGPSSVYAERAPLCDPNIW
DLGIPVLGVCYGMQLMVQQLGGRVEMATGKAEYGKAPLEIDDPTDLLTNVENGSTMWMSHGDSVRALPEGFVRLAHTANT
PDAAVAYHTRSLYGVQFHPEVVHSTDGMSLIRNFVYHICGCEPDWTTTAFIEEAVSQVRSQVGDKRVLLALSGGVDSSTL
AFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNINVEYINARQRFISKLNGIVDPEEKRKIIGTEFIRVFEEES
NRLGPFDYLAQGTLYPDVIESAGTNIDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRSLGLPEEI
VRRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSS
EDGMTADWSRLPDELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE

Sequences:

>Translated_528_residues
MSNSQSEGQRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYSTSADELRQLAPKGIILSGGPSSVYAERAPLCDPNIW
DLGIPVLGVCYGMQLMVQQLGGRVEMATGKAEYGKAPLEIDDPTDLLTNVENGSTMWMSHGDSVRALPEGFVRLAHTANT
PDAAVAYHTRSLYGVQFHPEVVHSTDGMSLIRNFVYHICGCEPDWTTTAFIEEAVSQVRSQVGDKRVLLALSGGVDSSTL
AFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNINVEYINARQRFISKLNGIVDPEEKRKIIGTEFIRVFEEES
NRLGPFDYLAQGTLYPDVIESAGTNIDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRSLGLPEEI
VRRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSS
EDGMTADWSRLPDELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE
>Mature_527_residues
SNSQSEGQRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYSTSADELRQLAPKGIILSGGPSSVYAERAPLCDPNIWD
LGIPVLGVCYGMQLMVQQLGGRVEMATGKAEYGKAPLEIDDPTDLLTNVENGSTMWMSHGDSVRALPEGFVRLAHTANTP
DAAVAYHTRSLYGVQFHPEVVHSTDGMSLIRNFVYHICGCEPDWTTTAFIEEAVSQVRSQVGDKRVLLALSGGVDSSTLA
FLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNINVEYINARQRFISKLNGIVDPEEKRKIIGTEFIRVFEEESN
RLGPFDYLAQGTLYPDVIESAGTNIDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRSLGLPEEIV
RRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSSE
DGMTADWSRLPDELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=38.3363471971067, Blast_Score=316, Evalue=3e-86,
Organism=Escherichia coli, GI1788854, Length=531, Percent_Identity=51.4124293785311, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=36.6148531951641, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=36.6148531951641, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=36.6148531951641, Blast_Score=308, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=49.0421455938697, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI281365319, Length=557, Percent_Identity=36.983842010772, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_PROM3 (A2C5P2)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016067.1
- ProteinModelPortal:   A2C5P2
- SMR:   A2C5P2
- STRING:   A2C5P2
- GeneID:   4778458
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00451
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   QDICGCE
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C

EC number: =6.3.5.2

Molecular weight: Translated: 59069; Mature: 58938

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 90-90 ACT_SITE 178-178 ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSQSEGQRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYSTSADELRQLAPKGIIL
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEE
SGGPSSVYAERAPLCDPNIWDLGIPVLGVCYGMQLMVQQLGGRVEMATGKAEYGKAPLEI
ECCCCCHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCC
DDPTDLLTNVENGSTMWMSHGDSVRALPEGFVRLAHTANTPDAAVAYHTRSLYGVQFHPE
CCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHEEEEHHHEEEEEECCH
VVHSTDGMSLIRNFVYHICGCEPDWTTTAFIEEAVSQVRSQVGDKRVLLALSGGVDSSTL
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
AFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNINVEYINARQRFISKLNGIVD
HHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHCCEEEEEEEEECHHHHHHHHHCCCCC
PEEKRKIIGTEFIRVFEEESNRLGPFDYLAQGTLYPDVIESAGTNIDPKTGERVAVKIKS
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
HHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRSLGLPEEIVRRHPFPGPGLAIRILGEVT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEEHHHH
DEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSS
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHEEECC
EDGMTADWSRLPDELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE
CCCCCCCHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SNSQSEGQRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYSTSADELRQLAPKGIIL
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEE
SGGPSSVYAERAPLCDPNIWDLGIPVLGVCYGMQLMVQQLGGRVEMATGKAEYGKAPLEI
ECCCCCHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCC
DDPTDLLTNVENGSTMWMSHGDSVRALPEGFVRLAHTANTPDAAVAYHTRSLYGVQFHPE
CCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHEEEEHHHEEEEEECCH
VVHSTDGMSLIRNFVYHICGCEPDWTTTAFIEEAVSQVRSQVGDKRVLLALSGGVDSSTL
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
AFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNINVEYINARQRFISKLNGIVD
HHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHCCEEEEEEEEECHHHHHHHHHCCCCC
PEEKRKIIGTEFIRVFEEESNRLGPFDYLAQGTLYPDVIESAGTNIDPKTGERVAVKIKS
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
HHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRSLGLPEEIVRRHPFPGPGLAIRILGEVT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEEHHHH
DEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSS
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHEEECC
EDGMTADWSRLPDELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE
CCCCCCCHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA