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The map label for this gene is purU [H]

Identifier: 124026889

GI number: 124026889

Start: 1844418

End: 1845272

Strand: Reverse

Name: purU [H]

Synonym: NATL1_21841

Alternate gene names: 124026889

Gene position: 1845272-1844418 (Counterclockwise)

Preceding gene: 124026891

Following gene: 124026888

Centisome position: 98.96

GC content: 35.09

Gene sequence:

>855_bases
GTGAGCATCAAAACAGTTATTTTGCAGTTCATTTGTCCTGATAAGCCAGGACTTGTAAGTGATTTGGCAAGTTGGATAGC
GAGTAAAAATGGCAATATTAGACATGCTGATCACCATACAGATGCAGATGCAAAATTGTTTCTAAGTCGCATTGAGTGGG
ATTTAGATGGATTTCTGCTTGATAAAAACGAAATCACCTCTGAGGTAAATTTACTGGAGCAAAGATTGAATGGGAAAGCG
GCCTTGAGCTTCTCTGATGATTTTCCTAATGTTGCAATCTTTGTTAGTAAGCAGAGTCATTGTTTAGTTGATCTTTTATG
GAGAGTTAAGGCAGGCGAATTATGTATGAATGTACCTTTAGTTATCTCAAATCATTCAGATTTAGAGGAAATTTGCTCGA
GTTTTTCCATTCCTTTTAAGCTTATAGAAGTAAATAAAAACAATAAAGCAGATTCCGAAAGTAAAATTTTAGATTTACTA
CATGACTACAACATTGATTTAGGCGTTTTGGCTAAATATATGCAAATTTTAAGTAGTTCATTTTTAGAGCAGTTTCCAAA
TCTCATTAATATTCATCATTCTTTCCTTCCTGCTTTTAAAGGGGCTCAACCATATCATCAAGCTTGGGATAGAGGAGTAA
AATTAATTGGTGCAACAGCGCATTATGTCACTAAGGATCTTGATGCTGGTCCCATAATTGAACAGACTATATCTAACGTG
AGTCATCGTGATGAAGTATCAGATTTAATAAGAAAGGGTAGAGATTTGGAGCGAGTCGCTTTAGCAAGAGCTTTAAGATT
GCATTTAAAAAGACAAGTTATTGTTTATAGAGGCAGAACGGCTGTATTTACATGA

Upstream 100 bases:

>100_bases
TCTGTTTTTTGGCTATTCATTTGCATAGATGCTATGAAATTTGCTTGTTAATTTTCAATGTGTGGTCTAAAAAAGAGAAT
AGTTTAAGGATATAGCTATA

Downstream 100 bases:

>100_bases
TTAAAAATGTTTATTTCCTAAATTTAAAAAATAATTTTTCAGACAATGTTGGCTGGACTTGTTTTCAGTTAGGTGTATTT
TGTTTGCCGTCCAGCGCGTT

Product: formyltetrahydrofolate deformylase

Products: NA

Alternate protein names: Formyl-FH(4) hydrolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSIKTVILQFICPDKPGLVSDLASWIASKNGNIRHADHHTDADAKLFLSRIEWDLDGFLLDKNEITSEVNLLEQRLNGKA
ALSFSDDFPNVAIFVSKQSHCLVDLLWRVKAGELCMNVPLVISNHSDLEEICSSFSIPFKLIEVNKNNKADSESKILDLL
HDYNIDLGVLAKYMQILSSSFLEQFPNLINIHHSFLPAFKGAQPYHQAWDRGVKLIGATAHYVTKDLDAGPIIEQTISNV
SHRDEVSDLIRKGRDLERVALARALRLHLKRQVIVYRGRTAVFT

Sequences:

>Translated_284_residues
MSIKTVILQFICPDKPGLVSDLASWIASKNGNIRHADHHTDADAKLFLSRIEWDLDGFLLDKNEITSEVNLLEQRLNGKA
ALSFSDDFPNVAIFVSKQSHCLVDLLWRVKAGELCMNVPLVISNHSDLEEICSSFSIPFKLIEVNKNNKADSESKILDLL
HDYNIDLGVLAKYMQILSSSFLEQFPNLINIHHSFLPAFKGAQPYHQAWDRGVKLIGATAHYVTKDLDAGPIIEQTISNV
SHRDEVSDLIRKGRDLERVALARALRLHLKRQVIVYRGRTAVFT
>Mature_283_residues
SIKTVILQFICPDKPGLVSDLASWIASKNGNIRHADHHTDADAKLFLSRIEWDLDGFLLDKNEITSEVNLLEQRLNGKAA
LSFSDDFPNVAIFVSKQSHCLVDLLWRVKAGELCMNVPLVISNHSDLEEICSSFSIPFKLIEVNKNNKADSESKILDLLH
DYNIDLGVLAKYMQILSSSFLEQFPNLINIHHSFLPAFKGAQPYHQAWDRGVKLIGATAHYVTKDLDAGPIIEQTISNVS
HRDEVSDLIRKGRDLERVALARALRLHLKRQVIVYRGRTAVFT

Specific function: Produces Formate From Formyl-Tetrahydrofolate. Provides The Major Source Of Formate For The Purt-Dependent Synthesis Of 5'-Phosphoribosyl-N-Formylglycinamide (Fgar) During Aerobic Growth. Has A Role In Regulating The One-Carbon Pool. [C]

COG id: COG0788

COG function: function code F; Formyltetrahydrofolate hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=190, Percent_Identity=31.0526315789474, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI209869995, Length=190, Percent_Identity=31.0526315789474, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI209869993, Length=190, Percent_Identity=31.0526315789474, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1787483, Length=287, Percent_Identity=38.3275261324042, Blast_Score=200, Evalue=8e-53,
Organism=Escherichia coli, GI1788846, Length=167, Percent_Identity=28.1437125748503, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17567511, Length=165, Percent_Identity=35.1515151515151, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR002376
- InterPro:   IPR004810 [H]

Pfam domain/function: PF01842 ACT; PF00551 Formyl_trans_N [H]

EC number: =3.5.1.10 [H]

Molecular weight: Translated: 32023; Mature: 31892

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKTVILQFICPDKPGLVSDLASWIASKNGNIRHADHHTDADAKLFLSRIEWDLDGFLL
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEE
DKNEITSEVNLLEQRLNGKAALSFSDDFPNVAIFVSKQSHCLVDLLWRVKAGELCMNVPL
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCE
VISNHSDLEEICSSFSIPFKLIEVNKNNKADSESKILDLLHDYNIDLGVLAKYMQILSSS
EEECCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FLEQFPNLINIHHSFLPAFKGAQPYHQAWDRGVKLIGATAHYVTKDLDAGPIIEQTISNV
HHHHCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHHHCCCCCCCHHHHHHHHC
SHRDEVSDLIRKGRDLERVALARALRLHLKRQVIVYRGRTAVFT
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCEECCC
>Mature Secondary Structure 
SIKTVILQFICPDKPGLVSDLASWIASKNGNIRHADHHTDADAKLFLSRIEWDLDGFLL
CHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEE
DKNEITSEVNLLEQRLNGKAALSFSDDFPNVAIFVSKQSHCLVDLLWRVKAGELCMNVPL
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCE
VISNHSDLEEICSSFSIPFKLIEVNKNNKADSESKILDLLHDYNIDLGVLAKYMQILSSS
EEECCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FLEQFPNLINIHHSFLPAFKGAQPYHQAWDRGVKLIGATAHYVTKDLDAGPIIEQTISNV
HHHHCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHHHCCCCCCCHHHHHHHHC
SHRDEVSDLIRKGRDLERVALARALRLHLKRQVIVYRGRTAVFT
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]