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The map label for this gene is aspS [H]

Identifier: 124026867

GI number: 124026867

Start: 1818274

End: 1820112

Strand: Direct

Name: aspS [H]

Synonym: NATL1_21621

Alternate gene names: 124026867

Gene position: 1818274-1820112 (Clockwise)

Preceding gene: 124026866

Following gene: 124026868

Centisome position: 97.51

GC content: 37.36

Gene sequence:

>1839_bases
ATGATGATTGAGAATTTTATGCGCAATAAGACTTGTGGAGAACTACGTGCTTCCGCAATTAGCGCAAATGTTCAACTATG
TGGTTGGGTTGATCGCAGAAGGGATCATGGCGGAGTAATTTTTATTGATCTAAGAGACCGTTCTGGAACAATTCAAATCA
CAGTTGATCCAGATCAAGGTCAGGATCTTTTTAGCATCGCTGAGAGTCTTAGAAATGAGACTGTTCTTCAGATCAATGGA
TTAGTAAGAGCAAGACCTGACGAAGCTATTAATACAAAAATCCCAACCGGTGAAGTAGAAGTCTTAGCTAAAAATATAAA
AATTCTCAATACTGTCACTAGTACACTTCCTTTCTCAGTGTCAATTCATGATGAGGAGAGTGTTAAAGAAGAAATCAGAC
TAAGGCATAGATATTTAGATCTCAGAAGAGAGAGAATGAATAATAATCTTCGATTGAGACATAACACGGTCAAAGCGGCT
AGAAGTTTTCTTGAAAACGAAGGATTTATAGAAGTTGAAACACCAATTTTGACTCGCTCAACTCCTGAAGGAGCCAGAGA
TTACTTAGTACCCTCACGTGTATGTGGTGGCGAGTTTTTTGCTTTACCGCAATCCCCACAATTATTCAAACAATTGTTGA
TGGTTGGTGGAGTTGAACGTTATTACCAAGTCGCTCGTTGTTTTCGTGATGAAGATTTACGCGCAGACAGGCAACCAGAA
TTTACTCAATTAGATATTGAAATGAGTTTTATGGAGGAAAAAGAGATCATCGAATTAAATGAAAAATTAATTGTAAGTAT
ATGGAAAAAAATTAAAGGGATTGATCTCCAAACTCCATTTCCGAGAATGACTTGGCAAGAATCTATGGATCGTTTTGGAA
CTGACAGACCTGATACTCGATATGGAATGGAACTTGTCAACACAAGTGATTTATTTTCCAAAAGTGGATTTAAAGTTTTT
TCAAATGCTATTTCTTCTGGTGGATGCGTTAAGTGCATCACCATTGAGGATGGAAATAATTTGATTAGTAATGTAAGAAT
AAAACCGGGTGGAGATATTTTTAGCGAAGCCCAAAAGGCTGGTGCTGGTGGACTAGCATTTATCAGGGTTCGAGATGATC
AAGAAGTCGATACAATTGGAGCCATAAAAGATAATTTAACTACCTCGCAAATAAAAGAACTCCTATTAAAAACCCAAGCT
AAACCTGGTGATCTAATACTTTTTGGTGCTGGGCCCACAAACATTGTTAATAGAACCTTAGATAGAGTTCGTCAATTTAT
TGCGAAAGATCTAAAGATAATCTCAGACAACGAATTAAAAACTCAGTGGAATTTTCTTTGGGTCACTGATTTTCCTATGT
TTGAATTCAATTCTGATGAAAATCGTCTTGAAGCAATTCATCATCCTTTCTGTGCTCCTAAGCCTGAAGATATTGGTGAA
TCAGAAAGCCTATGGAAAGACAAATTACCCAATTCAAATGCTCAAGCGTATGATCTAGTTCTTAATGGATTAGAAATTGG
CGGGGGATCTTTAAGAATTCACAACTCAGAACTTCAAAAAACCGTACTAGAAGTAATTGGTCTATCAAAAAATGAAGCAG
AAGAGCAGTTTGGTTTTTTAATTGATGCCCTTGCCATGGGTGCTCCACCACATGGTGGGATTGCATTTGGACTGGACAGA
ATAGTTATGCTCTTAGCCAATGAAGATTCAATTAGAGATACTATTGCTTTTCCAAAAACACAACAAGCTCGTTGTTCTAT
GGCTAAAGCGCCTGCAAACGTGGAAAACAAACAATTAGAAGACCTCCACATAGCTTCTACTTGGATAGATCCTGATTGA

Upstream 100 bases:

>100_bases
CTGCAATAATCGTAAAAAGACCATTCTATCGAAAAGGTTTTTGAGCAAGTAGAAACTGTGTTGTGCATAAAAGCCGGTCT
TTGTGGGAAACTCATTATTC

Downstream 100 bases:

>100_bases
ATTACTAGAAATTAGCGGTAAAAACATTATCCTAAAGAGAAAATATGTAAATTTCTTGGCGTTTACCTAGATCAAGGTAG
CTTAAAGAATGATTGAAAAG

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MMIENFMRNKTCGELRASAISANVQLCGWVDRRRDHGGVIFIDLRDRSGTIQITVDPDQGQDLFSIAESLRNETVLQING
LVRARPDEAINTKIPTGEVEVLAKNIKILNTVTSTLPFSVSIHDEESVKEEIRLRHRYLDLRRERMNNNLRLRHNTVKAA
RSFLENEGFIEVETPILTRSTPEGARDYLVPSRVCGGEFFALPQSPQLFKQLLMVGGVERYYQVARCFRDEDLRADRQPE
FTQLDIEMSFMEEKEIIELNEKLIVSIWKKIKGIDLQTPFPRMTWQESMDRFGTDRPDTRYGMELVNTSDLFSKSGFKVF
SNAISSGGCVKCITIEDGNNLISNVRIKPGGDIFSEAQKAGAGGLAFIRVRDDQEVDTIGAIKDNLTTSQIKELLLKTQA
KPGDLILFGAGPTNIVNRTLDRVRQFIAKDLKIISDNELKTQWNFLWVTDFPMFEFNSDENRLEAIHHPFCAPKPEDIGE
SESLWKDKLPNSNAQAYDLVLNGLEIGGGSLRIHNSELQKTVLEVIGLSKNEAEEQFGFLIDALAMGAPPHGGIAFGLDR
IVMLLANEDSIRDTIAFPKTQQARCSMAKAPANVENKQLEDLHIASTWIDPD

Sequences:

>Translated_612_residues
MMIENFMRNKTCGELRASAISANVQLCGWVDRRRDHGGVIFIDLRDRSGTIQITVDPDQGQDLFSIAESLRNETVLQING
LVRARPDEAINTKIPTGEVEVLAKNIKILNTVTSTLPFSVSIHDEESVKEEIRLRHRYLDLRRERMNNNLRLRHNTVKAA
RSFLENEGFIEVETPILTRSTPEGARDYLVPSRVCGGEFFALPQSPQLFKQLLMVGGVERYYQVARCFRDEDLRADRQPE
FTQLDIEMSFMEEKEIIELNEKLIVSIWKKIKGIDLQTPFPRMTWQESMDRFGTDRPDTRYGMELVNTSDLFSKSGFKVF
SNAISSGGCVKCITIEDGNNLISNVRIKPGGDIFSEAQKAGAGGLAFIRVRDDQEVDTIGAIKDNLTTSQIKELLLKTQA
KPGDLILFGAGPTNIVNRTLDRVRQFIAKDLKIISDNELKTQWNFLWVTDFPMFEFNSDENRLEAIHHPFCAPKPEDIGE
SESLWKDKLPNSNAQAYDLVLNGLEIGGGSLRIHNSELQKTVLEVIGLSKNEAEEQFGFLIDALAMGAPPHGGIAFGLDR
IVMLLANEDSIRDTIAFPKTQQARCSMAKAPANVENKQLEDLHIASTWIDPD
>Mature_612_residues
MMIENFMRNKTCGELRASAISANVQLCGWVDRRRDHGGVIFIDLRDRSGTIQITVDPDQGQDLFSIAESLRNETVLQING
LVRARPDEAINTKIPTGEVEVLAKNIKILNTVTSTLPFSVSIHDEESVKEEIRLRHRYLDLRRERMNNNLRLRHNTVKAA
RSFLENEGFIEVETPILTRSTPEGARDYLVPSRVCGGEFFALPQSPQLFKQLLMVGGVERYYQVARCFRDEDLRADRQPE
FTQLDIEMSFMEEKEIIELNEKLIVSIWKKIKGIDLQTPFPRMTWQESMDRFGTDRPDTRYGMELVNTSDLFSKSGFKVF
SNAISSGGCVKCITIEDGNNLISNVRIKPGGDIFSEAQKAGAGGLAFIRVRDDQEVDTIGAIKDNLTTSQIKELLLKTQA
KPGDLILFGAGPTNIVNRTLDRVRQFIAKDLKIISDNELKTQWNFLWVTDFPMFEFNSDENRLEAIHHPFCAPKPEDIGE
SESLWKDKLPNSNAQAYDLVLNGLEIGGGSLRIHNSELQKTVLEVIGLSKNEAEEQFGFLIDALAMGAPPHGGIAFGLDR
IVMLLANEDSIRDTIAFPKTQQARCSMAKAPANVENKQLEDLHIASTWIDPD

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=610, Percent_Identity=40.327868852459, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI5031815, Length=306, Percent_Identity=25.4901960784314, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI194272210, Length=306, Percent_Identity=25.4901960784314, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI45439306, Length=265, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI226491502, Length=258, Percent_Identity=24.8062015503876, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1788173, Length=602, Percent_Identity=46.5116279069767, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1789256, Length=320, Percent_Identity=28.125, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790571, Length=296, Percent_Identity=27.3648648648649, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32566633, Length=614, Percent_Identity=34.6905537459283, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI71994340, Length=301, Percent_Identity=26.578073089701, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17535925, Length=301, Percent_Identity=26.578073089701, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17535927, Length=301, Percent_Identity=26.578073089701, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17551876, Length=290, Percent_Identity=25.1724137931034, Blast_Score=93, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325153, Length=658, Percent_Identity=30.5471124620061, Blast_Score=257, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6323011, Length=263, Percent_Identity=27.3764258555133, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=261, Percent_Identity=24.904214559387, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321807, Length=252, Percent_Identity=26.5873015873016, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324256, Length=173, Percent_Identity=25.4335260115607, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24584738, Length=608, Percent_Identity=38.9802631578947, Blast_Score=394, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640849, Length=299, Percent_Identity=26.7558528428094, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640851, Length=299, Percent_Identity=26.7558528428094, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136276, Length=277, Percent_Identity=26.7148014440433, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921528, Length=286, Percent_Identity=25.1748251748252, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 68945; Mature: 68945

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIENFMRNKTCGELRASAISANVQLCGWVDRRRDHGGVIFIDLRDRSGTIQITVDPDQG
CCCHHHHCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCCEEEEEEECCCCEEEEEECCCCC
QDLFSIAESLRNETVLQINGLVRARPDEAINTKIPTGEVEVLAKNIKILNTVTSTLPFSV
CHHHHHHHHHCCCEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
SIHDEESVKEEIRLRHRYLDLRRERMNNNLRLRHNTVKAARSFLENEGFIEVETPILTRS
EECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCEEEECCCEEECC
TPEGARDYLVPSRVCGGEFFALPQSPQLFKQLLMVGGVERYYQVARCFRDEDLRADRQPE
CCCCCHHCCCCCHHCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
FTQLDIEMSFMEEKEIIELNEKLIVSIWKKIKGIDLQTPFPRMTWQESMDRFGTDRPDTR
CEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCH
YGMELVNTSDLFSKSGFKVFSNAISSGGCVKCITIEDGNNLISNVRIKPGGDIFSEAQKA
HHHEEECCHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCEEHCCEECCCCHHHHHHHHC
GAGGLAFIRVRDDQEVDTIGAIKDNLTTSQIKELLLKTQAKPGDLILFGAGPTNIVNRTL
CCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
DRVRQFIAKDLKIISDNELKTQWNFLWVTDFPMFEFNSDENRLEAIHHPFCAPKPEDIGE
HHHHHHHHHHHEEECCCCCEEEEEEEEEECCCEEEECCCCHHHHHHHCCCCCCCCCCCCC
SESLWKDKLPNSNAQAYDLVLNGLEIGGGSLRIHNSELQKTVLEVIGLSKNEAEEQFGFL
CHHHHHHCCCCCCCCEEEEEEECEEECCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHH
IDALAMGAPPHGGIAFGLDRIVMLLANEDSIRDTIAFPKTQQARCSMAKAPANVENKQLE
HHHHHHCCCCCCCHHHHHHHHEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC
DLHIASTWIDPD
CEEEEEECCCCC
>Mature Secondary Structure
MMIENFMRNKTCGELRASAISANVQLCGWVDRRRDHGGVIFIDLRDRSGTIQITVDPDQG
CCCHHHHCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCCEEEEEEECCCCEEEEEECCCCC
QDLFSIAESLRNETVLQINGLVRARPDEAINTKIPTGEVEVLAKNIKILNTVTSTLPFSV
CHHHHHHHHHCCCEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
SIHDEESVKEEIRLRHRYLDLRRERMNNNLRLRHNTVKAARSFLENEGFIEVETPILTRS
EECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCEEEECCCEEECC
TPEGARDYLVPSRVCGGEFFALPQSPQLFKQLLMVGGVERYYQVARCFRDEDLRADRQPE
CCCCCHHCCCCCHHCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
FTQLDIEMSFMEEKEIIELNEKLIVSIWKKIKGIDLQTPFPRMTWQESMDRFGTDRPDTR
CEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCH
YGMELVNTSDLFSKSGFKVFSNAISSGGCVKCITIEDGNNLISNVRIKPGGDIFSEAQKA
HHHEEECCHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCEEHCCEECCCCHHHHHHHHC
GAGGLAFIRVRDDQEVDTIGAIKDNLTTSQIKELLLKTQAKPGDLILFGAGPTNIVNRTL
CCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
DRVRQFIAKDLKIISDNELKTQWNFLWVTDFPMFEFNSDENRLEAIHHPFCAPKPEDIGE
HHHHHHHHHHHEEECCCCCEEEEEEEEEECCCEEEECCCCHHHHHHHCCCCCCCCCCCCC
SESLWKDKLPNSNAQAYDLVLNGLEIGGGSLRIHNSELQKTVLEVIGLSKNEAEEQFGFL
CHHHHHHCCCCCCCCEEEEEEECEEECCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHH
IDALAMGAPPHGGIAFGLDRIVMLLANEDSIRDTIAFPKTQQARCSMAKAPANVENKQLE
HHHHHHCCCCCCCHHHHHHHHEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC
DLHIASTWIDPD
CEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA