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The map label for this gene is wzb [C]

Identifier: 124026746

GI number: 124026746

Start: 1684545

End: 1685018

Strand: Reverse

Name: wzb [C]

Synonym: NATL1_20411

Alternate gene names: 124026746

Gene position: 1685018-1684545 (Counterclockwise)

Preceding gene: 124026747

Following gene: 124026744

Centisome position: 90.36

GC content: 33.12

Gene sequence:

>474_bases
ATGGTAAAAAAAATTCTCTTTGTTTGCTTGGGCAATATTTGTCGTTCGCCTGCCGCTGAAGGCATTTTTAATCACAAAAT
TAAAGAGAGAGATTTAGAAAAATTTTTTGTAGTTGATTCCGCAGGAACAGGAAGTTGGCATGTTGGAAATCTTCCTGATA
AAAGAATGCGAGCAACAGCTTTATCAAGGGGGATAGAACTGACCAGTAGGTCGAGACAAATCGAAGAAAATGATTTATAT
GAATTTGATCAGATTCTTGTTATGGATAAAGATAATCTCGATGCTGTTAAATCATTAACTAAAGATCAAAATAATCCTGT
AAATTCTAAAATAAAGCTTATTCTAAGTTACTCAAAAAACTTTCAATTAGATGAAGTCCCTGACCCTTATTATGGTGGAC
AAAATGGATTCGACAAAGTTATAGATTTACTTGATGATGCTATGGATGGATTAATAGATAGTCTCACGAATTAG

Upstream 100 bases:

>100_bases
TGCAAGAGGCATGTTGCGAAGCTTTTTTGGAGAGGTATGGACTGAAAGCTATATAAATAATATCCTTTTTGACTTAAAAT
AAAATAAAGACATTAGAAAA

Downstream 100 bases:

>100_bases
GCGTTGGCCAGACTTCCTCTGGAATCTTTGATCTGAAAATATCAATTAGCTCTTTTAATACATCTTCAATATTCATACCA
TCTGTTACAAGCTCTATGGC

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MVKKILFVCLGNICRSPAAEGIFNHKIKERDLEKFFVVDSAGTGSWHVGNLPDKRMRATALSRGIELTSRSRQIEENDLY
EFDQILVMDKDNLDAVKSLTKDQNNPVNSKIKLILSYSKNFQLDEVPDPYYGGQNGFDKVIDLLDDAMDGLIDSLTN

Sequences:

>Translated_157_residues
MVKKILFVCLGNICRSPAAEGIFNHKIKERDLEKFFVVDSAGTGSWHVGNLPDKRMRATALSRGIELTSRSRQIEENDLY
EFDQILVMDKDNLDAVKSLTKDQNNPVNSKIKLILSYSKNFQLDEVPDPYYGGQNGFDKVIDLLDDAMDGLIDSLTN
>Mature_157_residues
MVKKILFVCLGNICRSPAAEGIFNHKIKERDLEKFFVVDSAGTGSWHVGNLPDKRMRATALSRGIELTSRSRQIEENDLY
EFDQILVMDKDNLDAVKSLTKDQNNPVNSKIKLILSYSKNFQLDEVPDPYYGGQNGFDKVIDLLDDAMDGLIDSLTN

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=139, Percent_Identity=38.8489208633094, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4757714, Length=139, Percent_Identity=39.568345323741, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI96304457, Length=105, Percent_Identity=36.1904761904762, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6325330, Length=133, Percent_Identity=36.0902255639098, Blast_Score=91, Evalue=8e-20,
Organism=Drosophila melanogaster, GI78711846, Length=136, Percent_Identity=37.5, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI78706766, Length=143, Percent_Identity=39.8601398601399, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI78706768, Length=143, Percent_Identity=39.8601398601399, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI78706764, Length=135, Percent_Identity=40, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI78706770, Length=139, Percent_Identity=33.0935251798561, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78706772, Length=139, Percent_Identity=33.0935251798561, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648069, Length=118, Percent_Identity=33.8983050847458, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17714; Mature: 17714

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKILFVCLGNICRSPAAEGIFNHKIKERDLEKFFVVDSAGTGSWHVGNLPDKRMRATA
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCEECCCCCHHHHHHHH
LSRGIELTSRSRQIEENDLYEFDQILVMDKDNLDAVKSLTKDQNNPVNSKIKLILSYSKN
HHHCCHHHHHHCCCCCCCHHHHHHEEEECCCCHHHHHHHHHCCCCCCCHHEEEEEECCCC
FQLDEVPDPYYGGQNGFDKVIDLLDDAMDGLIDSLTN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVKKILFVCLGNICRSPAAEGIFNHKIKERDLEKFFVVDSAGTGSWHVGNLPDKRMRATA
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCEECCCCCHHHHHHHH
LSRGIELTSRSRQIEENDLYEFDQILVMDKDNLDAVKSLTKDQNNPVNSKIKLILSYSKN
HHHCCHHHHHHCCCCCCCHHHHHHEEEECCCCHHHHHHHHHCCCCCCCHHEEEEEECCCC
FQLDEVPDPYYGGQNGFDKVIDLLDDAMDGLIDSLTN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]