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The map label for this gene is purM

Identifier: 124026744

GI number: 124026744

Start: 1681835

End: 1682875

Strand: Reverse

Name: purM

Synonym: NATL1_20391

Alternate gene names: 124026744

Gene position: 1682875-1681835 (Counterclockwise)

Preceding gene: 124026746

Following gene: 124026743

Centisome position: 90.25

GC content: 37.18

Gene sequence:

>1041_bases
ATGGATTACAAAACTGCGGGAGTTGATGTTACTGCTGGAAGAGCTTTTGTGGAGAGAATTAAATCATGCGTTGAAAAAAC
TCACAAAAGTGAGGTCATAGGAGGGTTAGGAGGTTTTGGAGGATGTATAAGAATTCCAAAAGGATTTGAAAGTCCAGTCT
TGGTCTCTGGGACAGATGGTGTTGGTACAAAATTAGAATTAGCTCAGCAATATGGTTGTCATTTTGGAGTCGGAATAGAT
TTGGTTGCAATGTGTGTAAATGATGTAATAACTAATGGGGCTCGACCTTTATTTTTTCTTGATTACATAGCAAGCGGAAC
TTTGACTCCTGATGCTTTGGCTGAAGTGATAGAGGGCATTGCAGCAGGTTGTTGTCAATCGGATTGTTCTCTCTTGGGAG
GCGAAACAGCTGAAATGCCAGGTTTTTATCCCAGTGGAAGATATGACCTGGCAGGTTTCTGTGTTGGGATCGTTGAAAAT
CATCACTTAATAGACGGCACGAAAATTAATTGTGGAGATCAGATCATTGGGATTAAAAGTAACGGTGTTCATAGCAATGG
TTTTAGTCTTGTTCGTAAAGTTCTTTCTATGGCGAATGTAGATGAAAACACTCTTTATGGGAAAGACAAAAGGAACTTGA
TCCAATCTTTGCTGGAACCAACAGCAATTTATGTTCAACTTGTTGAGAAATTGTTGAGAGAAAATTTACCAATTCATGGA
ATGACGCATATTACAGGTGGAGGATTGCCAGAGAATCTTCCTAGGATTTTCCCTTCTGGATTGTTACCACATATAGATAT
AACTACTTGGGAAATAACTGAAATCTTTAATTGGTTACAAAATGCTGGAGATATTCCTGAAATTGATCTTTGGAATACTT
TTAATATGGGTATTGGTTTTTGTCTAATTGTTCCTAAAAATGAGGTGAATTCTGCTTTAGAAATATGTATGAAAAATGAT
TTTGAAGCTTGGAATATAGGTCAAGTTGTTGAAAGTCAGAACAATTCAAAACATAGCGGTATTTTAGGAATACCTAGCTG
A

Upstream 100 bases:

>100_bases
CTTATGATTGAAATGAAATAAGTTGATTGCATACTGATACTGATCCCATATGGATTTCATATTAGGGTTCATATCTTTTG
AATAAGAAAGCTTTTTACTG

Downstream 100 bases:

>100_bases
GCATATAAGCGAAGTTTTATAAAATCTCCAGTACAGTATCTGAACAAATTAAATGAAGGTTAAAAAAGATTTTCTATAAC
GGTAAAAAAACAGTAAGATG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MDYKTAGVDVTAGRAFVERIKSCVEKTHKSEVIGGLGGFGGCIRIPKGFESPVLVSGTDGVGTKLELAQQYGCHFGVGID
LVAMCVNDVITNGARPLFFLDYIASGTLTPDALAEVIEGIAAGCCQSDCSLLGGETAEMPGFYPSGRYDLAGFCVGIVEN
HHLIDGTKINCGDQIIGIKSNGVHSNGFSLVRKVLSMANVDENTLYGKDKRNLIQSLLEPTAIYVQLVEKLLRENLPIHG
MTHITGGGLPENLPRIFPSGLLPHIDITTWEITEIFNWLQNAGDIPEIDLWNTFNMGIGFCLIVPKNEVNSALEICMKND
FEAWNIGQVVESQNNSKHSGILGIPS

Sequences:

>Translated_346_residues
MDYKTAGVDVTAGRAFVERIKSCVEKTHKSEVIGGLGGFGGCIRIPKGFESPVLVSGTDGVGTKLELAQQYGCHFGVGID
LVAMCVNDVITNGARPLFFLDYIASGTLTPDALAEVIEGIAAGCCQSDCSLLGGETAEMPGFYPSGRYDLAGFCVGIVEN
HHLIDGTKINCGDQIIGIKSNGVHSNGFSLVRKVLSMANVDENTLYGKDKRNLIQSLLEPTAIYVQLVEKLLRENLPIHG
MTHITGGGLPENLPRIFPSGLLPHIDITTWEITEIFNWLQNAGDIPEIDLWNTFNMGIGFCLIVPKNEVNSALEICMKND
FEAWNIGQVVESQNNSKHSGILGIPS
>Mature_346_residues
MDYKTAGVDVTAGRAFVERIKSCVEKTHKSEVIGGLGGFGGCIRIPKGFESPVLVSGTDGVGTKLELAQQYGCHFGVGID
LVAMCVNDVITNGARPLFFLDYIASGTLTPDALAEVIEGIAAGCCQSDCSLLGGETAEMPGFYPSGRYDLAGFCVGIVEN
HHLIDGTKINCGDQIIGIKSNGVHSNGFSLVRKVLSMANVDENTLYGKDKRNLIQSLLEPTAIYVQLVEKLLRENLPIHG
MTHITGGGLPENLPRIFPSGLLPHIDITTWEITEIFNWLQNAGDIPEIDLWNTFNMGIGFCLIVPKNEVNSALEICMKND
FEAWNIGQVVESQNNSKHSGILGIPS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=44.1176470588235, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=44.1176470588235, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=44.1176470588235, Blast_Score=278, Evalue=5e-75,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=50.4451038575668, Blast_Score=341, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17567511, Length=341, Percent_Identity=41.0557184750733, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=42.9824561403509, Blast_Score=271, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24582400, Length=298, Percent_Identity=40.6040268456376, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_PROM1 (A2C535)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015859.1
- ProteinModelPortal:   A2C535
- SMR:   A2C535
- STRING:   A2C535
- GeneID:   4779866
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_20391
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   PMAR167555:NATL1_20391-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37255; Mature: 37255

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTAGVDVTAGRAFVERIKSCVEKTHKSEVIGGLGGFGGCIRIPKGFESPVLVSGTDG
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCC
VGTKLELAQQYGCHFGVGIDLVAMCVNDVITNGARPLFFLDYIASGTLTPDALAEVIEGI
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
AAGCCQSDCSLLGGETAEMPGFYPSGRYDLAGFCVGIVENHHLIDGTKINCGDQIIGIKS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCEECCCCEEEEEEC
NGVHSNGFSLVRKVLSMANVDENTLYGKDKRNLIQSLLEPTAIYVQLVEKLLRENLPIHG
CCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MTHITGGGLPENLPRIFPSGLLPHIDITTWEITEIFNWLQNAGDIPEIDLWNTFNMGIGF
EEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEE
CLIVPKNEVNSALEICMKNDFEAWNIGQVVESQNNSKHSGILGIPS
EEEECCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCEECCCC
>Mature Secondary Structure
MDYKTAGVDVTAGRAFVERIKSCVEKTHKSEVIGGLGGFGGCIRIPKGFESPVLVSGTDG
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCC
VGTKLELAQQYGCHFGVGIDLVAMCVNDVITNGARPLFFLDYIASGTLTPDALAEVIEGI
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
AAGCCQSDCSLLGGETAEMPGFYPSGRYDLAGFCVGIVENHHLIDGTKINCGDQIIGIKS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCEECCCCEEEEEEC
NGVHSNGFSLVRKVLSMANVDENTLYGKDKRNLIQSLLEPTAIYVQLVEKLLRENLPIHG
CCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MTHITGGGLPENLPRIFPSGLLPHIDITTWEITEIFNWLQNAGDIPEIDLWNTFNMGIGF
EEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEE
CLIVPKNEVNSALEICMKNDFEAWNIGQVVESQNNSKHSGILGIPS
EEEECCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA