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The map label for this gene is cmk

Identifier: 124026745

GI number: 124026745

Start: 1683005

End: 1684555

Strand: Direct

Name: cmk

Synonym: NATL1_20401

Alternate gene names: 124026745

Gene position: 1683005-1684555 (Clockwise)

Preceding gene: 124026742

Following gene: 124026750

Centisome position: 90.25

GC content: 33.4

Gene sequence:

>1551_bases
GTGGTACGAAAAATCTTCCAAACTAATGCTGAATTAAAAGATTGGCTTAGTGAACAAAATTCAGCAATAATTTTTATCCC
TACTATGGGAGGACTTCACCCTGGGCACCAATATTTAATTCAGAAAGCCAAAGAAAGAAAAACAAACACAAACCAAATTA
TTCTTGTAAGTATTTTTGTAAATCCATTGCAATTTAGCAAGGGTGAAGACTTCAAAAAATATCCCAGAAATATAAACAGA
GATGCTGAATTAGCTTTTAGTGCAGGAGCAGACGCGATTTGGGCTCCAGATTATGATGAAGTTTTTCCCGGAGGCGCAGA
TTCACATTTTAAAATTGAAGTTCCTAAAACATTGCATAATCAATTATGTGGTGCTGAAAGGAAAGGACATTTTGATGGAG
TCGCAACCGTTATTATTCGATTGATAAAAATTATCAAACCAAAGAAACTTGTTCTGGGAGAGAAAGATTGGCAACAATTA
ATTATAATTAGAAAACTCTTTCAAGAACTATCAATACCTGTAAAAATTGAATCCTATTCCACACAAAGAGACCAAAGTGG
ATTTGCTTATAGTTCAAGAAATTCTTATCTTAGTGATTCTGAAAGAGTAAATGCTCAATCATTACCTAATGCAATCAAAG
AAGCAAAAACAGAATTTGATAAAGGGAAAGTAATAAATCTCACAAAAATAGCTTCGATATTTAAAGAAAATAATTTAAAA
ATTGAATATCTCAAAATTGTAGATCCATTTTCATTAAAAGAAACAGAAAATATCAATAGACTATGCCTTTTGGCAGTAGC
AGTAAAATGTGGGTCTACGAGGCTAATTGATCACACTTTTCTTATGCACAGAAAACCAATTATTGCGATTGATGGTCCTG
CTGGTGCAGGGAAAAGCACAGTAACTAAAGCATTTGCCAAGAAACTTGGTTTTATTTATTTAGATACTGGCGCAATGTAT
CGAGCAGTGACTTGGTTAATCATAAGCAATTCTATTGATCCAAATGATCAAGTGGAAATCAAAAATATCTTGAAAGATTC
AAAATTAGAATTTAAAAGCTCAAGCTTTGTTGAGCAAAAAATCTTCATAAATAATATTGACGTAACAGAGAAGATACGAT
CCCCTAAAGTGACTTCAATGGTATCCGAAATTGCCAAACAACAATTTGTAAGAGAATTATTGACGCGAAAACAACAAGTA
ATTGGAAATAATGGGGGCTTAGTTGCAGAAGGAAGAGACATAGGCACAGCTGTATTTCCAGATGCAGACCTAAAAATTTT
TCTTACTGCCTCTCCAACAGAAAGAGCAAAAAGAAGAGCCCTTGACTTACACAAAAGAGGTTATGAATTCTCCAGCATTG
AAGATCTTGAAAAAGAAATTAAAGAAAGAGATAAAAAAGATAGTGAACGAAAAATAGCCCCTTTAAAAAAAGCTCAAGAT
GCCATAGAGCTTGTAACAGATGGTATGAATATTGAAGATGTATTAAAAGAGCTAATTGATATTTTCAGATCAAAGATTCC
AGAGGAAGTCTGGCCAACGCCTAATTCGTGA

Upstream 100 bases:

>100_bases
TGAACCCTAATATGAAATCCATATGGGATCAGTATCAGTATGCAATCAACTTATTTCATTTCAATCATAAGTTGATGAAA
TTAATTTGTTTACCAACATA

Downstream 100 bases:

>100_bases
GACTATCTATTAATCCATCCATAGCATCATCAAGTAAATCTATAACTTTGTCGAATCCATTTTGTCCACCATAATAAGGG
TCAGGGACTTCATCTAATTG

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantothenate synthetase; PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MVRKIFQTNAELKDWLSEQNSAIIFIPTMGGLHPGHQYLIQKAKERKTNTNQIILVSIFVNPLQFSKGEDFKKYPRNINR
DAELAFSAGADAIWAPDYDEVFPGGADSHFKIEVPKTLHNQLCGAERKGHFDGVATVIIRLIKIIKPKKLVLGEKDWQQL
IIIRKLFQELSIPVKIESYSTQRDQSGFAYSSRNSYLSDSERVNAQSLPNAIKEAKTEFDKGKVINLTKIASIFKENNLK
IEYLKIVDPFSLKETENINRLCLLAVAVKCGSTRLIDHTFLMHRKPIIAIDGPAGAGKSTVTKAFAKKLGFIYLDTGAMY
RAVTWLIISNSIDPNDQVEIKNILKDSKLEFKSSSFVEQKIFINNIDVTEKIRSPKVTSMVSEIAKQQFVRELLTRKQQV
IGNNGGLVAEGRDIGTAVFPDADLKIFLTASPTERAKRRALDLHKRGYEFSSIEDLEKEIKERDKKDSERKIAPLKKAQD
AIELVTDGMNIEDVLKELIDIFRSKIPEEVWPTPNS

Sequences:

>Translated_516_residues
MVRKIFQTNAELKDWLSEQNSAIIFIPTMGGLHPGHQYLIQKAKERKTNTNQIILVSIFVNPLQFSKGEDFKKYPRNINR
DAELAFSAGADAIWAPDYDEVFPGGADSHFKIEVPKTLHNQLCGAERKGHFDGVATVIIRLIKIIKPKKLVLGEKDWQQL
IIIRKLFQELSIPVKIESYSTQRDQSGFAYSSRNSYLSDSERVNAQSLPNAIKEAKTEFDKGKVINLTKIASIFKENNLK
IEYLKIVDPFSLKETENINRLCLLAVAVKCGSTRLIDHTFLMHRKPIIAIDGPAGAGKSTVTKAFAKKLGFIYLDTGAMY
RAVTWLIISNSIDPNDQVEIKNILKDSKLEFKSSSFVEQKIFINNIDVTEKIRSPKVTSMVSEIAKQQFVRELLTRKQQV
IGNNGGLVAEGRDIGTAVFPDADLKIFLTASPTERAKRRALDLHKRGYEFSSIEDLEKEIKERDKKDSERKIAPLKKAQD
AIELVTDGMNIEDVLKELIDIFRSKIPEEVWPTPNS
>Mature_516_residues
MVRKIFQTNAELKDWLSEQNSAIIFIPTMGGLHPGHQYLIQKAKERKTNTNQIILVSIFVNPLQFSKGEDFKKYPRNINR
DAELAFSAGADAIWAPDYDEVFPGGADSHFKIEVPKTLHNQLCGAERKGHFDGVATVIIRLIKIIKPKKLVLGEKDWQQL
IIIRKLFQELSIPVKIESYSTQRDQSGFAYSSRNSYLSDSERVNAQSLPNAIKEAKTEFDKGKVINLTKIASIFKENNLK
IEYLKIVDPFSLKETENINRLCLLAVAVKCGSTRLIDHTFLMHRKPIIAIDGPAGAGKSTVTKAFAKKLGFIYLDTGAMY
RAVTWLIISNSIDPNDQVEIKNILKDSKLEFKSSSFVEQKIFINNIDVTEKIRSPKVTSMVSEIAKQQFVRELLTRKQQV
IGNNGGLVAEGRDIGTAVFPDADLKIFLTASPTERAKRRALDLHKRGYEFSSIEDLEKEIKERDKKDSERKIAPLKKAQD
AIELVTDGMNIEDVLKELIDIFRSKIPEEVWPTPNS

Specific function: Displays a CMP kinase activity

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786325, Length=270, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787139, Length=221, Percent_Identity=38.9140271493213, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322046, Length=279, Percent_Identity=31.1827956989247, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANCY_PROM1 (A2C536)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015860.1
- ProteinModelPortal:   A2C536
- STRING:   A2C536
- GeneID:   4779871
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_20401
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   LGEKDWQ
- ProtClustDB:   PRK13477
- BioCyc:   PMAR167555:NATL1_20401-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01349
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00017
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase

EC number: =6.3.2.1; =2.7.4.14

Molecular weight: Translated: 58349; Mature: 58349

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: ACT_SITE 36-36 BINDING 64-64 BINDING 64-64 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKIFQTNAELKDWLSEQNSAIIFIPTMGGLHPGHQYLIQKAKERKTNTNQIILVSIFV
CCCHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEE
NPLQFSKGEDFKKYPRNINRDAELAFSAGADAIWAPDYDEVFPGGADSHFKIEVPKTLHN
CCHHCCCCCCHHHHCCCCCCCCCEEEECCCCCEECCCHHHHCCCCCCCEEEEECCHHHHH
QLCGAERKGHFDGVATVIIRLIKIIKPKKLVLGEKDWQQLIIIRKLFQELSIPVKIESYS
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHCCCCEEEECCC
TQRDQSGFAYSSRNSYLSDSERVNAQSLPNAIKEAKTEFDKGKVINLTKIASIFKENNLK
CCCCCCCCEECCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCE
IEYLKIVDPFSLKETENINRLCLLAVAVKCGSTRLIDHTFLMHRKPIIAIDGPAGAGKST
EEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCEEEEECCCCCCHHH
VTKAFAKKLGFIYLDTGAMYRAVTWLIISNSIDPNDQVEIKNILKDSKLEFKSSSFVEQK
HHHHHHHHCCEEEEECCHHHHHHEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
IFINNIDVTEKIRSPKVTSMVSEIAKQQFVRELLTRKQQVIGNNGGLVAEGRDIGTAVFP
HEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEECC
DADLKIFLTASPTERAKRRALDLHKRGYEFSSIEDLEKEIKERDKKDSERKIAPLKKAQD
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AIELVTDGMNIEDVLKELIDIFRSKIPEEVWPTPNS
HHHHHHCCCCHHHHHHHHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure
MVRKIFQTNAELKDWLSEQNSAIIFIPTMGGLHPGHQYLIQKAKERKTNTNQIILVSIFV
CCCHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEE
NPLQFSKGEDFKKYPRNINRDAELAFSAGADAIWAPDYDEVFPGGADSHFKIEVPKTLHN
CCHHCCCCCCHHHHCCCCCCCCCEEEECCCCCEECCCHHHHCCCCCCCEEEEECCHHHHH
QLCGAERKGHFDGVATVIIRLIKIIKPKKLVLGEKDWQQLIIIRKLFQELSIPVKIESYS
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHCCCCEEEECCC
TQRDQSGFAYSSRNSYLSDSERVNAQSLPNAIKEAKTEFDKGKVINLTKIASIFKENNLK
CCCCCCCCEECCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCE
IEYLKIVDPFSLKETENINRLCLLAVAVKCGSTRLIDHTFLMHRKPIIAIDGPAGAGKST
EEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCEEEEECCCCCCHHH
VTKAFAKKLGFIYLDTGAMYRAVTWLIISNSIDPNDQVEIKNILKDSKLEFKSSSFVEQK
HHHHHHHHCCEEEEECCHHHHHHEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
IFINNIDVTEKIRSPKVTSMVSEIAKQQFVRELLTRKQQVIGNNGGLVAEGRDIGTAVFP
HEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEECC
DADLKIFLTASPTERAKRRALDLHKRGYEFSSIEDLEKEIKERDKKDSERKIAPLKKAQD
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AIELVTDGMNIEDVLKELIDIFRSKIPEEVWPTPNS
HHHHHHCCCCHHHHHHHHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA