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The map label for this gene is icd [H]

Identifier: 124026750

GI number: 124026750

Start: 1687498

End: 1688922

Strand: Direct

Name: icd [H]

Synonym: NATL1_20451

Alternate gene names: 124026750

Gene position: 1687498-1688922 (Clockwise)

Preceding gene: 124026745

Following gene: 124026756

Centisome position: 90.5

GC content: 38.46

Gene sequence:

>1425_bases
ATGGCAAATTTTGAAAAGCTTACTGCACCATCAGAAGGCCAAAGAATTACTTTTTCTGATGGGAACCCAGTAGTCCCAGA
CCATCCAATTATTCCATTTATCAGAGGTGATGGAACAGGGATTGATATTTGGCCAGCTACACAATTAGTCATCGATAAAG
CTATTGAAAAAGCTTATGGAAAAAATCGATCCATTGAATGGTTCAAAATCTATGCAGGTGATGAAGCTTGCGAGTTATAC
GGAACTTATCAATATTTACCAAACGATACCCTCGAAGCGATCCGAACTTACGGGATAGCTATCAAAGGACCTTTAACAAC
TCCTGTAGGTGGTGGGATTAGATCTTTAAACGTATCTCTAAGACAGATTTTTGATCTATATTCATGTGTTAGGCCTTGCA
AATATTACGAAGGGACTCCAAGCCCTCATAAAAAGCCTCAGGATTTAGATGTAATTGTTTATAGAGAAAATACTGAAGAT
ATTTATATGGGTATTGAATGGGAATCTGATGATCCTGAATGCATCAAATTGATTGACCAAATCAATAATGAAATAATTCC
AGCCAGCCAAAAACTAAAAAACAGGAAAATTCCAAGCGGATCAGGAATAGGCATTAAACCAGTTAGTAAAAGTGGTAGTC
AAAGACATATCAGACGTGCAATTAAACATGCACTCACCCTGGAAGGGAGCAAAAGACATGTGACCTTGGTTCACAAGGGA
AACATCATGAAATTCACTGAAGGAGCTTTCAGAGATTGGGGATACGAATTAGCAACCACAGAATTTAGGAATGAATGCGT
TACCGAGAGAGAAAGTTGGATTTTAGATAATGTAGAAAAAAATCCTCATATCTCCTATGAGGAGAATGCTGAGTTAATTG
ATCCAGGTTATTCGTCTTTAACAGAAGAGAAAAAGAAAGCTATTTGTGATGAGGTTTGTTCCGTTCTTTCAATCATTGGC
AGTAGTCATGGCAGTGGTAAATGGAAAGATATGGTGATGGTTGATGACCGAATAGCAGATAGTATTTTTCAACAAATTCA
AACTCGTCCTCAAGAGTATTCCATACTTGCAACTCTCAATCTTAATGGTGACTACATATCGGATGCGGCCGCTGCAATTG
TTGGTGGACTGGGGATGGCACCAGGTGCAAACATTGGAGATAAAGCGGCTATTTTCGAAGCCACCCATGGAACAGCTCCT
AAACATGCAGGTTTGGACAGAATAAATCCAGGTTCAGTAATACTAAGTGGAGTAATGATGCTGGAATATTTGGGTTGGAA
TGAGGCAGCAAAATTAATTACAAATGGATTGAGCAAATCTATTTCAGACAAACAAGTTACTTACGATCTAGCACGATTAA
TGGAACCACGCGTAGAGCCTCTTAGTTGTAGTGATTTTGCGAACTCAATTGTTGAAAGATTTTAA

Upstream 100 bases:

>100_bases
CCTAGCGAAGGCTAGTGCCATGAGTTCAAAATCATTTAATCAAAACTTACCACTTAGACATAAGCTCAACATTAGATGAC
TTAATCGTTGAATAAAAATC

Downstream 100 bases:

>100_bases
CTAATTTTATCTAGAGTCTTTACAAATTAAGAAATTGAATCCATCAATTTTAATACTTCTAGTAGTGTTTTCTCATTTCC
AAGATTGCCTGGGAAAGTAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MANFEKLTAPSEGQRITFSDGNPVVPDHPIIPFIRGDGTGIDIWPATQLVIDKAIEKAYGKNRSIEWFKIYAGDEACELY
GTYQYLPNDTLEAIRTYGIAIKGPLTTPVGGGIRSLNVSLRQIFDLYSCVRPCKYYEGTPSPHKKPQDLDVIVYRENTED
IYMGIEWESDDPECIKLIDQINNEIIPASQKLKNRKIPSGSGIGIKPVSKSGSQRHIRRAIKHALTLEGSKRHVTLVHKG
NIMKFTEGAFRDWGYELATTEFRNECVTERESWILDNVEKNPHISYEENAELIDPGYSSLTEEKKKAICDEVCSVLSIIG
SSHGSGKWKDMVMVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDKAAIFEATHGTAP
KHAGLDRINPGSVILSGVMMLEYLGWNEAAKLITNGLSKSISDKQVTYDLARLMEPRVEPLSCSDFANSIVERF

Sequences:

>Translated_474_residues
MANFEKLTAPSEGQRITFSDGNPVVPDHPIIPFIRGDGTGIDIWPATQLVIDKAIEKAYGKNRSIEWFKIYAGDEACELY
GTYQYLPNDTLEAIRTYGIAIKGPLTTPVGGGIRSLNVSLRQIFDLYSCVRPCKYYEGTPSPHKKPQDLDVIVYRENTED
IYMGIEWESDDPECIKLIDQINNEIIPASQKLKNRKIPSGSGIGIKPVSKSGSQRHIRRAIKHALTLEGSKRHVTLVHKG
NIMKFTEGAFRDWGYELATTEFRNECVTERESWILDNVEKNPHISYEENAELIDPGYSSLTEEKKKAICDEVCSVLSIIG
SSHGSGKWKDMVMVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDKAAIFEATHGTAP
KHAGLDRINPGSVILSGVMMLEYLGWNEAAKLITNGLSKSISDKQVTYDLARLMEPRVEPLSCSDFANSIVERF
>Mature_473_residues
ANFEKLTAPSEGQRITFSDGNPVVPDHPIIPFIRGDGTGIDIWPATQLVIDKAIEKAYGKNRSIEWFKIYAGDEACELYG
TYQYLPNDTLEAIRTYGIAIKGPLTTPVGGGIRSLNVSLRQIFDLYSCVRPCKYYEGTPSPHKKPQDLDVIVYRENTEDI
YMGIEWESDDPECIKLIDQINNEIIPASQKLKNRKIPSGSGIGIKPVSKSGSQRHIRRAIKHALTLEGSKRHVTLVHKGN
IMKFTEGAFRDWGYELATTEFRNECVTERESWILDNVEKNPHISYEENAELIDPGYSSLTEEKKKAICDEVCSVLSIIGS
SHGSGKWKDMVMVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDKAAIFEATHGTAPK
HAGLDRINPGSVILSGVMMLEYLGWNEAAKLITNGLSKSISDKQVTYDLARLMEPRVEPLSCSDFANSIVERF

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=136, Percent_Identity=38.9705882352941, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI28178838, Length=133, Percent_Identity=30.8270676691729, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4758582, Length=116, Percent_Identity=30.1724137931034, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787381, Length=469, Percent_Identity=47.7611940298507, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI87081683, Length=115, Percent_Identity=33.9130434782609, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788101, Length=113, Percent_Identity=31.858407079646, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71986051, Length=474, Percent_Identity=29.1139240506329, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144293, Length=110, Percent_Identity=37.2727272727273, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17505779, Length=123, Percent_Identity=35.7723577235772, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324709, Length=454, Percent_Identity=27.7533039647577, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322097, Length=429, Percent_Identity=27.5058275058275, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324291, Length=147, Percent_Identity=31.2925170068027, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24643270, Length=451, Percent_Identity=30.3769401330377, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24643268, Length=451, Percent_Identity=30.3769401330377, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24661184, Length=390, Percent_Identity=28.974358974359, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52521; Mature: 52390

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANFEKLTAPSEGQRITFSDGNPVVPDHPIIPFIRGDGTGIDIWPATQLVIDKAIEKAYG
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHC
KNRSIEWFKIYAGDEACELYGTYQYLPNDTLEAIRTYGIAIKGPLTTPVGGGIRSLNVSL
CCCCEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCKYYEGTPSPHKKPQDLDVIVYRENTEDIYMGIEWESDDPECIKLIDQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHH
INNEIIPASQKLKNRKIPSGSGIGIKPVSKSGSQRHIRRAIKHALTLEGSKRHVTLVHKG
HCCCCCCCHHHHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
NIMKFTEGAFRDWGYELATTEFRNECVTERESWILDNVEKNPHISYEENAELIDPGYSSL
CEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHH
TEEKKKAICDEVCSVLSIIGSSHGSGKWKDMVMVDDRIADSIFQQIQTRPQEYSILATLN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDAAAAIVGGLGMAPGANIGDKAAIFEATHGTAPKHAGLDRINPGSVILSGVMM
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEYLGWNEAAKLITNGLSKSISDKQVTYDLARLMEPRVEPLSCSDFANSIVERF
HHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
ANFEKLTAPSEGQRITFSDGNPVVPDHPIIPFIRGDGTGIDIWPATQLVIDKAIEKAYG
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHC
KNRSIEWFKIYAGDEACELYGTYQYLPNDTLEAIRTYGIAIKGPLTTPVGGGIRSLNVSL
CCCCEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCKYYEGTPSPHKKPQDLDVIVYRENTEDIYMGIEWESDDPECIKLIDQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHH
INNEIIPASQKLKNRKIPSGSGIGIKPVSKSGSQRHIRRAIKHALTLEGSKRHVTLVHKG
HCCCCCCCHHHHHCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECC
NIMKFTEGAFRDWGYELATTEFRNECVTERESWILDNVEKNPHISYEENAELIDPGYSSL
CEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHH
TEEKKKAICDEVCSVLSIIGSSHGSGKWKDMVMVDDRIADSIFQQIQTRPQEYSILATLN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYISDAAAAIVGGLGMAPGANIGDKAAIFEATHGTAPKHAGLDRINPGSVILSGVMM
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEYLGWNEAAKLITNGLSKSISDKQVTYDLARLMEPRVEPLSCSDFANSIVERF
HHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169222; 11759840 [H]