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The map label for this gene is dapL

Identifier: 124026646

GI number: 124026646

Start: 1593215

End: 1594441

Strand: Reverse

Name: dapL

Synonym: NATL1_19411

Alternate gene names: 124026646

Gene position: 1594441-1593215 (Counterclockwise)

Preceding gene: 124026649

Following gene: 124026645

Centisome position: 85.51

GC content: 37.9

Gene sequence:

>1227_bases
GTGGTAAAAGTTAATGCTGATTACCTGAAGTTAAAAGCAGGCTATCTTTTCCCAGAGATTTCTCGGAGAATTACAGAATT
TAGTTCTAAGAATCCTAATGCTAATTTGATCCGCCTAGGAATTGGTGATGTTACTGAACCTCTACCTTTGGCTTGTCGTG
AAGCAATGAAAGCGGCAATTGAGGAAATGGGAACAGAAGATGGATTTAGGGGCTATGGCCCAGAACAGGGGTATAAATGG
CTTCGAGAGATTATCTCTGAGAATGATTATATATCTCGTGGTTGTGAGATTTCAGCTGAAGAAATCTTTGTTTCAGATGG
CTCTAAATGCGATAGCAGTAATATTTTAGATATTCTTGGCAAGGAAAATAAAATAGCCGTAACTGATCCTGTTTATCCTG
TATACGTTGACACTAATGTGATGACAGGTAGGACTGGAGAAGCTAACTCAGTAGGAGAGTATACAGGTTTGAGTTACATC
CCAATTAATTCAGAGAATGGATTTGAGGCATCTATTCCAAAAGATAAATTTGATTTGATTTATCTTTGTTTTCCTAATAA
TCCTACGGGGGCTGTGGCAACTAAAGAGCAACTGGTTTCTTGGGTGAAATATGCAAAAGAAAATAATTCTTTGATTCTTT
TTGATGCTGCATACGAGGCTTTCATTAAAGATGAATCGATTCCTCATTCGATTTTTGAAATTGAGGGAGCTAGAGATTGT
GCAATTGAGTTTCGTTCGTTTTCGAAAAATGCAGGCTTCACAGGCACAAGATGTGCTTTTACAGTTATTCCCAAATCTTT
AAAAGGTAAAGCAGGGATAGAAACAGTCGATTTGTGGTCCTTATGGAATAGGAGACAAAGTACGAAATTCAACGGTGTAA
GCTATGTTGTACAGAGAGGGGCTGAAGCTGTTTACTCAAAAGAGGGGAAAATACAAATCAAAAAATTAGTAAGTTTTTAT
ATGGACAATGCTGAAATAATTAAATCAAATTTGACTGCTGCAGGATTTGAAGTTTTTGGCGCGGTAAATGCCCCTTATGC
ATGGATAAAAACACCGAAAAATATGAGCTCATGGGACTTCTTCGATTTCTTGCTTGAAAAAGCAAATGTTGTTGGTACAC
CTGGCAGTGGATTTGGGGCTGCGGGAGAAGGCTATTTTAGATTGTCTGCCTTCAACAGCAGAGAAAATGTCGAAAAAGCT
ATGGAAAGGATCGTAAAACTTAAATGA

Upstream 100 bases:

>100_bases
CTTCTATTAAAAATCAGTTTTTAATTATGGAATCATCAATGTTTAAAGATTTAAAGGTGTTTTAGGGATTATCCTTAAAA
TAAATTTTGTCGATTTTTAA

Downstream 100 bases:

>100_bases
GTAATATCATGGTAAGTTCCTTGTTAAAAAGTGCTATTCATCTCGACAGTTTAATTATGGTTGATTCTGCAAATCAAACT
GATGGAGATACTGCTGTTAT

Product: L,L-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MVKVNADYLKLKAGYLFPEISRRITEFSSKNPNANLIRLGIGDVTEPLPLACREAMKAAIEEMGTEDGFRGYGPEQGYKW
LREIISENDYISRGCEISAEEIFVSDGSKCDSSNILDILGKENKIAVTDPVYPVYVDTNVMTGRTGEANSVGEYTGLSYI
PINSENGFEASIPKDKFDLIYLCFPNNPTGAVATKEQLVSWVKYAKENNSLILFDAAYEAFIKDESIPHSIFEIEGARDC
AIEFRSFSKNAGFTGTRCAFTVIPKSLKGKAGIETVDLWSLWNRRQSTKFNGVSYVVQRGAEAVYSKEGKIQIKKLVSFY
MDNAEIIKSNLTAAGFEVFGAVNAPYAWIKTPKNMSSWDFFDFLLEKANVVGTPGSGFGAAGEGYFRLSAFNSRENVEKA
MERIVKLK

Sequences:

>Translated_408_residues
MVKVNADYLKLKAGYLFPEISRRITEFSSKNPNANLIRLGIGDVTEPLPLACREAMKAAIEEMGTEDGFRGYGPEQGYKW
LREIISENDYISRGCEISAEEIFVSDGSKCDSSNILDILGKENKIAVTDPVYPVYVDTNVMTGRTGEANSVGEYTGLSYI
PINSENGFEASIPKDKFDLIYLCFPNNPTGAVATKEQLVSWVKYAKENNSLILFDAAYEAFIKDESIPHSIFEIEGARDC
AIEFRSFSKNAGFTGTRCAFTVIPKSLKGKAGIETVDLWSLWNRRQSTKFNGVSYVVQRGAEAVYSKEGKIQIKKLVSFY
MDNAEIIKSNLTAAGFEVFGAVNAPYAWIKTPKNMSSWDFFDFLLEKANVVGTPGSGFGAAGEGYFRLSAFNSRENVEKA
MERIVKLK
>Mature_408_residues
MVKVNADYLKLKAGYLFPEISRRITEFSSKNPNANLIRLGIGDVTEPLPLACREAMKAAIEEMGTEDGFRGYGPEQGYKW
LREIISENDYISRGCEISAEEIFVSDGSKCDSSNILDILGKENKIAVTDPVYPVYVDTNVMTGRTGEANSVGEYTGLSYI
PINSENGFEASIPKDKFDLIYLCFPNNPTGAVATKEQLVSWVKYAKENNSLILFDAAYEAFIKDESIPHSIFEIEGARDC
AIEFRSFSKNAGFTGTRCAFTVIPKSLKGKAGIETVDLWSLWNRRQSTKFNGVSYVVQRGAEAVYSKEGKIQIKKLVSFY
MDNAEIIKSNLTAAGFEVFGAVNAPYAWIKTPKNMSSWDFFDFLLEKANVVGTPGSGFGAAGEGYFRLSAFNSRENVEKA
MERIVKLK

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788722, Length=341, Percent_Identity=28.7390029325513, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_PROM1 (A2C4T7)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015761.1
- ProteinModelPortal:   A2C4T7
- SMR:   A2C4T7
- STRING:   A2C4T7
- GeneID:   4779504
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_19411
- eggNOG:   COG0436
- HOGENOM:   HBG645860
- OMA:   VDLIYLC
- ProtClustDB:   PRK07590
- BioCyc:   PMAR167555:NATL1_19411-MONOMER
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR019942
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03542

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 45274; Mature: 45274

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 42-42 BINDING 72-72 BINDING 75-75 BINDING 109-109 BINDING 132-132 BINDING 187-187 BINDING 187-187 BINDING 215-215 BINDING 218-218 BINDING 246-246 BINDING 248-248 BINDING 257-257 BINDING 291-291 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVNADYLKLKAGYLFPEISRRITEFSSKNPNANLIRLGIGDVTEPLPLACREAMKAAI
CEEECCHHEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
EEMGTEDGFRGYGPEQGYKWLREIISENDYISRGCEISAEEIFVSDGSKCDSSNILDILG
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCHHEEEECCCCCCCCCCHHHHHC
KENKIAVTDPVYPVYVDTNVMTGRTGEANSVGEYTGLSYIPINSENGFEASIPKDKFDLI
CCCCEEEECCCEEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEE
YLCFPNNPTGAVATKEQLVSWVKYAKENNSLILFDAAYEAFIKDESIPHSIFEIEGARDC
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCHHEEECCCHHH
AIEFRSFSKNAGFTGTRCAFTVIPKSLKGKAGIETVDLWSLWNRRQSTKFNGVSYVVQRG
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHCCCCCCCCCHHHHHHHHC
AEAVYSKEGKIQIKKLVSFYMDNAEIIKSNLTAAGFEVFGAVNAPYAWIKTPKNMSSWDF
HHHHHCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCHHHEECCCCCEEEEECCCCCCCHHH
FDFLLEKANVVGTPGSGFGAAGEGYFRLSAFNSRENVEKAMERIVKLK
HHHHHHHCCEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVKVNADYLKLKAGYLFPEISRRITEFSSKNPNANLIRLGIGDVTEPLPLACREAMKAAI
CEEECCHHEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
EEMGTEDGFRGYGPEQGYKWLREIISENDYISRGCEISAEEIFVSDGSKCDSSNILDILG
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCHHEEEECCCCCCCCCCHHHHHC
KENKIAVTDPVYPVYVDTNVMTGRTGEANSVGEYTGLSYIPINSENGFEASIPKDKFDLI
CCCCEEEECCCEEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEE
YLCFPNNPTGAVATKEQLVSWVKYAKENNSLILFDAAYEAFIKDESIPHSIFEIEGARDC
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCHHEEECCCHHH
AIEFRSFSKNAGFTGTRCAFTVIPKSLKGKAGIETVDLWSLWNRRQSTKFNGVSYVVQRG
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHCCCCCCCCCHHHHHHHHC
AEAVYSKEGKIQIKKLVSFYMDNAEIIKSNLTAAGFEVFGAVNAPYAWIKTPKNMSSWDF
HHHHHCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCHHHEECCCCCEEEEECCCCCCCHHH
FDFLLEKANVVGTPGSGFGAAGEGYFRLSAFNSRENVEKAMERIVKLK
HHHHHHHCCEECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA