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The map label for this gene is yciC [H]

Identifier: 124026612

GI number: 124026612

Start: 1569055

End: 1570437

Strand: Direct

Name: yciC [H]

Synonym: NATL1_19071

Alternate gene names: 124026612

Gene position: 1569055-1570437 (Clockwise)

Preceding gene: 124026611

Following gene: 124026613

Centisome position: 84.14

GC content: 42.15

Gene sequence:

>1383_bases
ATGAGCAACACGCTAAAAGTACCGGTTACAATATTGACTGGTTTTCTAGGATCTGGCAAAACAACCCTACTCAATCGAAT
CCTGAGCGAAGAGCACGGTAAAAAAATAGCTGTTATTGAGAATGAATATGGTGAAGTTGGCATTGATCAAGGATTAGTCA
TTAATGCTGATGAAGAGGTCTTCGAGATGTCCAATGGTTGCATTTGCTGCACCGTTCGGGGTGATCTTATTCGTGTACTT
GGAAACCTCATGAAGAGGCGAGACAAATTTGACTATGTATTAGTTGAAACTACTGGCCTTGCTGATCCTGGTCCTGTCGC
TCAGACATTCTTTATGGACGATGAAATCCGTGAGGAGTTTTCACTTGATGGAATAGTCACACTTGTTGATGCAGCCCATA
TAGAGCAACAACTTGGTCGAAGTGATGAGAGTTCGGAGCAAGTTGCCTTTGCTGACGTCCTTGTCCTAAATAAAACCGAT
CTAGTTTCAGATGAATCACTCGACAACTTAGAATCACGGCTACGCGATATGAATCGTATGGCTCGTGTCATACGTAGTAA
ACAAGCAGACGTCTCAATTGATACTGTGCTAAATCTAAGTGCTTTTGATCTAGATCAAGTACTTAAGCGTCGTCCAACTT
TTCTTGAACCAGAATACCCATTTGAGTGGACAGGTGTTTTTTCACTTGAAAAAGGTCGCTATGAACTTACGCTCGAAGAA
GGTCCAGACCCCACAATGTCTCTCGTCCAGTTATTAGACCAAGGTAAAGACGAGACAGCTCTTAACACAGGTGCTGAATC
ATGCGTGAGACTCTACGCAGAACAAGAACAACTTATGAATCCAGGGGATTTGGTTCCAGTCGGCAAGCATGTGAGCCTTC
AACTTCAATCCGAAGGGACTAAGTCCTTCTTCATAGATGTTGATAAGGCAAGGGATATAGGTCTATTCACGCAACATACA
GCCGAAGAATTTAATATGAAATTAACGAAAGTAAATACTCCTTCTACAGACGAGATAGATAATGATCATAACATCTCTAC
AATTTCTCCAATAGCTGAGAGGGTTTGGGTAGCTGAACACGAACACGATGACGAAGTAGGTTCATTCGCTATCGAGCGAG
AGGGTGATGTAGATCCGGAGAAACTCAATAGATGGCTAAGTCGACTTTTGTCTGAGAAAGGTGTGGATATATTTCGCACT
AAAGGTTTCATTAGTTATGCGGGTGAATCTAAGCGAATAGTTTTTCAAGGAGTACACATGCTCTTCACAGCACAACCTGA
TAAAGAATGGGGCAATGAACCTCGCCGTAACCAACTCGTCTTTATCGGTAGAAATCTTGATGAAGCAGAAATGATCAAGG
AGTTTGATAAATGCCTGGTATAG

Upstream 100 bases:

>100_bases
CTTTGAATTAAAATCACTTGAATTGTTGGGTATCCAAAAGAATTGGCTAACTGATATTTCTCTTGATAGCACTCATTGTT
CCCATCGTTAATTAAAGAAA

Downstream 100 bases:

>100_bases
AAGCATTTAGTCCCAAGGGAATGCTTCATGAAAGTTGGTCTGCTCAAGCTAACGACTACGCAATTGTCTGCGGCTGGGCA
CTACAAGGTAAAACTTTTTT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSNTLKVPVTILTGFLGSGKTTLLNRILSEEHGKKIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIREEFSLDGIVTLVDAAHIEQQLGRSDESSEQVAFADVLVLNKTD
LVSDESLDNLESRLRDMNRMARVIRSKQADVSIDTVLNLSAFDLDQVLKRRPTFLEPEYPFEWTGVFSLEKGRYELTLEE
GPDPTMSLVQLLDQGKDETALNTGAESCVRLYAEQEQLMNPGDLVPVGKHVSLQLQSEGTKSFFIDVDKARDIGLFTQHT
AEEFNMKLTKVNTPSTDEIDNDHNISTISPIAERVWVAEHEHDDEVGSFAIEREGDVDPEKLNRWLSRLLSEKGVDIFRT
KGFISYAGESKRIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLDEAEMIKEFDKCLV

Sequences:

>Translated_460_residues
MSNTLKVPVTILTGFLGSGKTTLLNRILSEEHGKKIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIREEFSLDGIVTLVDAAHIEQQLGRSDESSEQVAFADVLVLNKTD
LVSDESLDNLESRLRDMNRMARVIRSKQADVSIDTVLNLSAFDLDQVLKRRPTFLEPEYPFEWTGVFSLEKGRYELTLEE
GPDPTMSLVQLLDQGKDETALNTGAESCVRLYAEQEQLMNPGDLVPVGKHVSLQLQSEGTKSFFIDVDKARDIGLFTQHT
AEEFNMKLTKVNTPSTDEIDNDHNISTISPIAERVWVAEHEHDDEVGSFAIEREGDVDPEKLNRWLSRLLSEKGVDIFRT
KGFISYAGESKRIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLDEAEMIKEFDKCLV
>Mature_459_residues
SNTLKVPVTILTGFLGSGKTTLLNRILSEEHGKKIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVLG
NLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIREEFSLDGIVTLVDAAHIEQQLGRSDESSEQVAFADVLVLNKTDL
VSDESLDNLESRLRDMNRMARVIRSKQADVSIDTVLNLSAFDLDQVLKRRPTFLEPEYPFEWTGVFSLEKGRYELTLEEG
PDPTMSLVQLLDQGKDETALNTGAESCVRLYAEQEQLMNPGDLVPVGKHVSLQLQSEGTKSFFIDVDKARDIGLFTQHTA
EEFNMKLTKVNTPSTDEIDNDHNISTISPIAERVWVAEHEHDDEVGSFAIEREGDVDPEKLNRWLSRLLSEKGVDIFRTK
GFISYAGESKRIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLDEAEMIKEFDKCLV

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=209, Percent_Identity=44.4976076555024, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI126722884, Length=209, Percent_Identity=44.4976076555024, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI146231952, Length=209, Percent_Identity=44.4976076555024, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI148727351, Length=209, Percent_Identity=44.0191387559809, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI223941779, Length=197, Percent_Identity=43.6548223350254, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI223941776, Length=198, Percent_Identity=42.9292929292929, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI119120938, Length=133, Percent_Identity=49.6240601503759, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI87082430, Length=213, Percent_Identity=40.8450704225352, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1788499, Length=184, Percent_Identity=32.6086956521739, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=223, Percent_Identity=34.0807174887892, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 51803; Mature: 51672

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTLKVPVTILTGFLGSGKTTLLNRILSEEHGKKIAVIENEYGEVGIDQGLVINADEEV
CCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIREEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHEEECCHHHHHHH
SLDGIVTLVDAAHIEQQLGRSDESSEQVAFADVLVLNKTDLVSDESLDNLESRLRDMNRM
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
ARVIRSKQADVSIDTVLNLSAFDLDQVLKRRPTFLEPEYPFEWTGVFSLEKGRYELTLEE
HHHHHHCCCCCCHHHEECCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEEEEECC
GPDPTMSLVQLLDQGKDETALNTGAESCVRLYAEQEQLMNPGDLVPVGKHVSLQLQSEGT
CCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCC
KSFFIDVDKARDIGLFTQHTAEEFNMKLTKVNTPSTDEIDNDHNISTISPIAERVWVAEH
CEEEEEECCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
EHDDEVGSFAIEREGDVDPEKLNRWLSRLLSEKGVDIFRTKGFISYAGESKRIVFQGVHM
CCCCCHHCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEE
LFTAQPDKEWGNEPRRNQLVFIGRNLDEAEMIKEFDKCLV
EEECCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTLKVPVTILTGFLGSGKTTLLNRILSEEHGKKIAVIENEYGEVGIDQGLVINADEEV
CCCEEEHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDDEIREEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHEEECCHHHHHHH
SLDGIVTLVDAAHIEQQLGRSDESSEQVAFADVLVLNKTDLVSDESLDNLESRLRDMNRM
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
ARVIRSKQADVSIDTVLNLSAFDLDQVLKRRPTFLEPEYPFEWTGVFSLEKGRYELTLEE
HHHHHHCCCCCCHHHEECCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEEEEECC
GPDPTMSLVQLLDQGKDETALNTGAESCVRLYAEQEQLMNPGDLVPVGKHVSLQLQSEGT
CCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCC
KSFFIDVDKARDIGLFTQHTAEEFNMKLTKVNTPSTDEIDNDHNISTISPIAERVWVAEH
CEEEEEECCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
EHDDEVGSFAIEREGDVDPEKLNRWLSRLLSEKGVDIFRTKGFISYAGESKRIVFQGVHM
CCCCCHHCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEE
LFTAQPDKEWGNEPRRNQLVFIGRNLDEAEMIKEFDKCLV
EEECCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]