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The map label for this gene is pkwA [H]

Identifier: 124026613

GI number: 124026613

Start: 1570425

End: 1571501

Strand: Direct

Name: pkwA [H]

Synonym: NATL1_19081

Alternate gene names: 124026613

Gene position: 1570425-1571501 (Clockwise)

Preceding gene: 124026612

Following gene: 124026614

Centisome position: 84.22

GC content: 44.66

Gene sequence:

>1077_bases
ATGCCTGGTATAGAAGCATTTAGTCCCAAGGGAATGCTTCATGAAAGTTGGTCTGCTCAAGCTAACGACTACGCAATTGT
CTGCGGCTGGGCACTACAAGGTAAAACTTTTTTAGTAGGTGATGTCGCTGGTGGGCTTTATGCATTTGAGGGAATATCTG
GAAAGCTCATTTGGCAAATAAAAGACATACATAAAGGTGGCTTACTCGCAATGTCTATACATCCAAATGGAAAGACTTTT
GCAACTGCTGGCCAAGATGGACATGTAAATATATGGGAAAGCCAAAAGGGTACGTCAACTAAAACTTTGGAACTTGGGAA
AGGATGGGTTGAGCACATCAAGTGGTCCCCAGACGGAAAATTTTTAGCTGTAGTTTTTACTAAATACGTCTATGTTTTTG
ATGATAAAGGTCAAGAACATTGGCGATCAGATGAGCATCCCAGCACTGTCAGCGCGATTGCTTGGTCTAATTCAAATGAA
TTAGCAACAGCATGCTATGGCCAAGTCACTTTTTTTGATGTAGTAAACGACAAGATCAATCAAAAGTTGGAATGGCGAGG
CTCGCTAGTATCGATGGTGCTTAGTCCAGATGGAGACATAGTGGCATGCGGCAGCCAAGATAATTCTGTTCATTTCTGGC
GTCGTTCAACTGATCAAGATTCAGAGATGACAGGCTACCCAGGTAAACCAAGCCACCTAGCTTTTGATCAAACCGGCACA
GTCCTTGCTACTGGGGGTAGTGATCGCGTGACGGTTTGGAGTTTTCAAGGCGATGGTCCTGAGGGAACTGTACCAGGAGA
GTTAATGCTTCATACGGAACCCATTTCATGTCTTGCTTTTTCACACAGCGGGATGCTTCTTTTAGCTTCTGGCGCGAGAG
ATGGTTCAGTTTTTTCTTGGTTTCTCCAAAAAGATGGTCAGGGTGATCCAGTTGGTGGTGCATTTGCCGGTGACCTTGTA
AGCCAAATCGCTTGGCACCCTGATGACACTGCTTTGGCTGCAATAAATGCAAACGGAGGAATTACGGTTTGGGAGTTTAA
GGTTCGGACGAAAACGTCAGCTCAAGGATTCGGATAA

Upstream 100 bases:

>100_bases
CACAACCTGATAAAGAATGGGGCAATGAACCTCGCCGTAACCAACTCGTCTTTATCGGTAGAAATCTTGATGAAGCAGAA
ATGATCAAGGAGTTTGATAA

Downstream 100 bases:

>100_bases
GGTCAAAATTTCTTATTTCCAATAGATTCTCGAGAGCTACTCGATTGCTATTAGCTAGAAAATTAAAAACCCAACAAGGG
GAGTTTTTACTGATGTATAA

Product: WD-40 repeat-containing G-protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MPGIEAFSPKGMLHESWSAQANDYAIVCGWALQGKTFLVGDVAGGLYAFEGISGKLIWQIKDIHKGGLLAMSIHPNGKTF
ATAGQDGHVNIWESQKGTSTKTLELGKGWVEHIKWSPDGKFLAVVFTKYVYVFDDKGQEHWRSDEHPSTVSAIAWSNSNE
LATACYGQVTFFDVVNDKINQKLEWRGSLVSMVLSPDGDIVACGSQDNSVHFWRRSTDQDSEMTGYPGKPSHLAFDQTGT
VLATGGSDRVTVWSFQGDGPEGTVPGELMLHTEPISCLAFSHSGMLLLASGARDGSVFSWFLQKDGQGDPVGGAFAGDLV
SQIAWHPDDTALAAINANGGITVWEFKVRTKTSAQGFG

Sequences:

>Translated_358_residues
MPGIEAFSPKGMLHESWSAQANDYAIVCGWALQGKTFLVGDVAGGLYAFEGISGKLIWQIKDIHKGGLLAMSIHPNGKTF
ATAGQDGHVNIWESQKGTSTKTLELGKGWVEHIKWSPDGKFLAVVFTKYVYVFDDKGQEHWRSDEHPSTVSAIAWSNSNE
LATACYGQVTFFDVVNDKINQKLEWRGSLVSMVLSPDGDIVACGSQDNSVHFWRRSTDQDSEMTGYPGKPSHLAFDQTGT
VLATGGSDRVTVWSFQGDGPEGTVPGELMLHTEPISCLAFSHSGMLLLASGARDGSVFSWFLQKDGQGDPVGGAFAGDLV
SQIAWHPDDTALAAINANGGITVWEFKVRTKTSAQGFG
>Mature_357_residues
PGIEAFSPKGMLHESWSAQANDYAIVCGWALQGKTFLVGDVAGGLYAFEGISGKLIWQIKDIHKGGLLAMSIHPNGKTFA
TAGQDGHVNIWESQKGTSTKTLELGKGWVEHIKWSPDGKFLAVVFTKYVYVFDDKGQEHWRSDEHPSTVSAIAWSNSNEL
ATACYGQVTFFDVVNDKINQKLEWRGSLVSMVLSPDGDIVACGSQDNSVHFWRRSTDQDSEMTGYPGKPSHLAFDQTGTV
LATGGSDRVTVWSFQGDGPEGTVPGELMLHTEPISCLAFSHSGMLLLASGARDGSVFSWFLQKDGQGDPVGGAFAGDLVS
QIAWHPDDTALAAINANGGITVWEFKVRTKTSAQGFG

Specific function: May play a regulatory role during the complex growth cycle and in secondary metabolite production [H]

COG id: COG2319

COG function: function code R; FOG: WD40 repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 WD repeats [H]

Homologues:

Organism=Homo sapiens, GI113865883, Length=271, Percent_Identity=27.3062730627306, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71982263, Length=311, Percent_Identity=26.0450160771704, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020472
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR015943
- InterPro:   IPR001680
- InterPro:   IPR011046
- InterPro:   IPR019782
- InterPro:   IPR019775
- InterPro:   IPR017986
- InterPro:   IPR019781 [H]

Pfam domain/function: PF00069 Pkinase; PF00400 WD40 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 38623; Mature: 38492

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00678 WD_REPEATS_1 ; PS50082 WD_REPEATS_2 ; PS50294 WD_REPEATS_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGIEAFSPKGMLHESWSAQANDYAIVCGWALQGKTFLVGDVAGGLYAFEGISGKLIWQI
CCCCCCCCCCCCEECCCCCCCCCEEEEEEEEECCCEEEEEECCCCEEEECCCCCEEEEEE
KDIHKGGLLAMSIHPNGKTFATAGQDGHVNIWESQKGTSTKTLELGKGWVEHIKWSPDGK
EECCCCCEEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEECCCCHHHHEEECCCCC
FLAVVFTKYVYVFDDKGQEHWRSDEHPSTVSAIAWSNSNELATACYGQVTFFDVVNDKIN
EEEEEEEEEEEEEECCCHHHCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEEHHHHHC
QKLEWRGSLVSMVLSPDGDIVACGSQDNSVHFWRRSTDQDSEMTGYPGKPSHLAFDQTGT
CEEEECCCEEEEEECCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCE
VLATGGSDRVTVWSFQGDGPEGTVPGELMLHTEPISCLAFSHSGMLLLASGARDGSVFSW
EEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCCCEEEEECCCCCCCEEEE
FLQKDGQGDPVGGAFAGDLVSQIAWHPDDTALAAINANGGITVWEFKVRTKTSAQGFG
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
PGIEAFSPKGMLHESWSAQANDYAIVCGWALQGKTFLVGDVAGGLYAFEGISGKLIWQI
CCCCCCCCCCCEECCCCCCCCCEEEEEEEEECCCEEEEEECCCCEEEECCCCCEEEEEE
KDIHKGGLLAMSIHPNGKTFATAGQDGHVNIWESQKGTSTKTLELGKGWVEHIKWSPDGK
EECCCCCEEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEECCCCHHHHEEECCCCC
FLAVVFTKYVYVFDDKGQEHWRSDEHPSTVSAIAWSNSNELATACYGQVTFFDVVNDKIN
EEEEEEEEEEEEEECCCHHHCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEEHHHHHC
QKLEWRGSLVSMVLSPDGDIVACGSQDNSVHFWRRSTDQDSEMTGYPGKPSHLAFDQTGT
CEEEECCCEEEEEECCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCE
VLATGGSDRVTVWSFQGDGPEGTVPGELMLHTEPISCLAFSHSGMLLLASGARDGSVFSW
EEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCCCEEEEECCCCCCCEEEE
FLQKDGQGDPVGGAFAGDLVSQIAWHPDDTALAAINANGGITVWEFKVRTKTSAQGFG
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631732 [H]