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The map label for this gene is purC

Identifier: 124026471

GI number: 124026471

Start: 1447445

End: 1448188

Strand: Reverse

Name: purC

Synonym: NATL1_17661

Alternate gene names: 124026471

Gene position: 1448188-1447445 (Counterclockwise)

Preceding gene: 124026474

Following gene: 124026470

Centisome position: 77.66

GC content: 33.6

Gene sequence:

>744_bases
ATGAATCATATCCAAGGATCACTAATTTATGAAGGCAAAGCAAAAAGAGTTTTTGCGTGTGAAAATCCAAATAGGGTTTT
AATAGAATTCAAAAATGATGCTACAGCTTTTAATGCAAAAAAACGATCAGAGATTGACGGGAAAGGGCGCTTAAATTGCA
AAATTTCTGCGGCACTTTTTAAATTGCTTGAATTGAATGGAATCCCAACACACTTTTTAGAACTTCAATCGGAAACATTC
ATGATTGCGGATAAAATCAATGTGATCCCTCTAGAAGTTGTTATTCGCAATATTGCTACAGGGTCACTATGTAGAGAAAC
ACCGATCAATCAAGGAACAATATTAAACCCTCCACTCCTCGATTATTATTATAAAGATGATGAATTAGGAGATCCTATAC
TTACAGAAAGAAGATTGAAACTGCTAGATTTGATAAGTACTTCGCAGATAGAAAAAATAGAGACAATTACTAAAACTGTA
AATAAAATTTTAAAAGAATATTTTGATGATCTCGATTTATTATTGGTTGACTTTAAATTAGAGTTCGGTTTTAATTCGTT
AGGCGAAATTGTGATTGCTGATGAAATAAGTCCAGATAATTGTAGGTTTTGGGATAAAACAAATTCTGACCCTAAGGGAC
GTATCCTTGACAAAGACCGCTTTCGGCAAGATCTTGGAGGGGTGATAGATGCTTATGGGGAGATTTTGAAACGAATAGAG
AGAGATTCTTCTAATTCTTCTTAA

Upstream 100 bases:

>100_bases
TATTTATTTGTTTGGAGTTTAGGTTTCAAATCAATTTATTTTGATTGAGGTGATTTTTGTAGCATTGTCTATTTATACTA
ATCAGATATCAGAGGTATTA

Downstream 100 bases:

>100_bases
GCAAATTGTTCTTAGCCAAAGATTCCTTCACTTAATTGAATTGCTTTGAAACTTATGTTCAAAAGACACACAAGTTCTAA
TAGAAAATTAATAGGCAGAG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MNHIQGSLIYEGKAKRVFACENPNRVLIEFKNDATAFNAKKRSEIDGKGRLNCKISAALFKLLELNGIPTHFLELQSETF
MIADKINVIPLEVVIRNIATGSLCRETPINQGTILNPPLLDYYYKDDELGDPILTERRLKLLDLISTSQIEKIETITKTV
NKILKEYFDDLDLLLVDFKLEFGFNSLGEIVIADEISPDNCRFWDKTNSDPKGRILDKDRFRQDLGGVIDAYGEILKRIE
RDSSNSS

Sequences:

>Translated_247_residues
MNHIQGSLIYEGKAKRVFACENPNRVLIEFKNDATAFNAKKRSEIDGKGRLNCKISAALFKLLELNGIPTHFLELQSETF
MIADKINVIPLEVVIRNIATGSLCRETPINQGTILNPPLLDYYYKDDELGDPILTERRLKLLDLISTSQIEKIETITKTV
NKILKEYFDDLDLLLVDFKLEFGFNSLGEIVIADEISPDNCRFWDKTNSDPKGRILDKDRFRQDLGGVIDAYGEILKRIE
RDSSNSS
>Mature_247_residues
MNHIQGSLIYEGKAKRVFACENPNRVLIEFKNDATAFNAKKRSEIDGKGRLNCKISAALFKLLELNGIPTHFLELQSETF
MIADKINVIPLEVVIRNIATGSLCRETPINQGTILNPPLLDYYYKDDELGDPILTERRLKLLDLISTSQIEKIETITKTV
NKILKEYFDDLDLLLVDFKLEFGFNSLGEIVIADEISPDNCRFWDKTNSDPKGRILDKDRFRQDLGGVIDAYGEILKRIE
RDSSNSS

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=33.6283185840708, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=33.6283185840708, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI119220559, Length=233, Percent_Identity=32.618025751073, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1788820, Length=231, Percent_Identity=40.6926406926407, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=34.9775784753363, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18860083, Length=225, Percent_Identity=30.6666666666667, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=28.0193236714976, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PROM1 (A2C4B2)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015586.1
- ProteinModelPortal:   A2C4B2
- SMR:   A2C4B2
- STRING:   A2C4B2
- GeneID:   4779753
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_17661
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   PMAR167555:NATL1_17661-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28102; Mature: 28102

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHIQGSLIYEGKAKRVFACENPNRVLIEFKNDATAFNAKKRSEIDGKGRLNCKISAALF
CCCCCCEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCCHHCCCCCCCEEEEEHHHHHH
KLLELNGIPTHFLELQSETFMIADKINVIPLEVVIRNIATGSLCRETPINQGTILNPPLL
HHHHCCCCCHHHHHHCCCEEEEECCCCEEEHHHHHHHHCCCCHHHCCCCCCCEECCCCHH
DYYYKDDELGDPILTERRLKLLDLISTSQIEKIETITKTVNKILKEYFDDLDLLLVDFKL
HEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
EFGFNSLGEIVIADEISPDNCRFWDKTNSDPKGRILDKDRFRQDLGGVIDAYGEILKRIE
ECCCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RDSSNSS
CCCCCCC
>Mature Secondary Structure
MNHIQGSLIYEGKAKRVFACENPNRVLIEFKNDATAFNAKKRSEIDGKGRLNCKISAALF
CCCCCCEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCCHHCCCCCCCEEEEEHHHHHH
KLLELNGIPTHFLELQSETFMIADKINVIPLEVVIRNIATGSLCRETPINQGTILNPPLL
HHHHCCCCCHHHHHHCCCEEEEECCCCEEEHHHHHHHHCCCCHHHCCCCCCCEECCCCHH
DYYYKDDELGDPILTERRLKLLDLISTSQIEKIETITKTVNKILKEYFDDLDLLLVDFKL
HEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
EFGFNSLGEIVIADEISPDNCRFWDKTNSDPKGRILDKDRFRQDLGGVIDAYGEILKRIE
ECCCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RDSSNSS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA