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The map label for this gene is lpxA [H]

Identifier: 124026467

GI number: 124026467

Start: 1442912

End: 1443766

Strand: Reverse

Name: lpxA [H]

Synonym: NATL1_17621

Alternate gene names: 124026467

Gene position: 1443766-1442912 (Counterclockwise)

Preceding gene: 124026468

Following gene: 124026466

Centisome position: 77.42

GC content: 35.44

Gene sequence:

>855_bases
ATGATTGAACGTCAATCTTCTAAAAGCTTAATTGCAGATAACAAAGTAAATATTCATGAATTTGCGGACGTCTCTCCAAA
AGCTGAACTTGGCAGAGGTGTATCTGTTGGTTCAGGCTCTGTTATTGGTCCAGATGTGATCGTTGGTCCTAATACTTGGA
TAGGACCAAATGTAATTATCGAGGGTAAAGTGAAAATAGGATCTAATAATAAGATTTTCCCAGGAGCATGTATTGGATTA
GAACCCCAAGATTTGAAGTATGGAGGAGATTCTACTGATGTTTTAATTGGAGATGATAATACTTTTAGAGAATGTGTAAC
TATTAATAGGGCCACCTTTGAAGGGGAGAAAACTATAGTTGGGAATCAGAACTTGTTAATGGCCTATTCACATTTAGGAC
ATAATTGTGATATCGGAAACAGTGTCGTTATAGCTAATAGCGTGCAAATTGCAGGTCACGTTGTTGTTGAAGATAGAGCT
ATTATTGGAGGTTGCTTGGGGATACATCAATTTGTTCATATTGGTTATTTAGCTATGGTTGGGGGCATGACAAGAGTTGA
TAGAGATGTTCCTCCATTTTGCTTGGTGGAGGGACATCCTGGAAGAATGCGGGGACTAAATAAAGTTGGAATTAAAAGGC
AAACTTTAGATAAAGAGAATAAAGAAGAATATCTACAATTGAAAAGAATTTGGAACTTATTATTTAAATCTGAATATGTA
ATTTCTGATGGTTTAAAAAGGGCAAGACAAGAGAATTTATTACAATCTTCCGCAAGATTATGTGGATTTATAGAACTCTC
TATTGGGAAAGGTAGAAGAGGCCCAATGCCTTATTTTATTTCAACTAATAAATAA

Upstream 100 bases:

>100_bases
ATCAAAAGAAAGAGATTTGGGAAAGTTAAGGGAGAAGCAAAAGTGGATGATCAGTTGGTTTGTTCTGGAGATTTGATGTT
CTCTCTTGTGGATTGAAGTA

Downstream 100 bases:

>100_bases
TGAAGTTATTAATCAGCACTGGTGAAGTCTCTGGAGACTTGCAGGGAAGCTTATTAATAAATGCGTTAAAGACAAATGCC
GAGAAAAGGAAAATTGAATT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MIERQSSKSLIADNKVNIHEFADVSPKAELGRGVSVGSGSVIGPDVIVGPNTWIGPNVIIEGKVKIGSNNKIFPGACIGL
EPQDLKYGGDSTDVLIGDDNTFRECVTINRATFEGEKTIVGNQNLLMAYSHLGHNCDIGNSVVIANSVQIAGHVVVEDRA
IIGGCLGIHQFVHIGYLAMVGGMTRVDRDVPPFCLVEGHPGRMRGLNKVGIKRQTLDKENKEEYLQLKRIWNLLFKSEYV
ISDGLKRARQENLLQSSARLCGFIELSIGKGRRGPMPYFISTNK

Sequences:

>Translated_284_residues
MIERQSSKSLIADNKVNIHEFADVSPKAELGRGVSVGSGSVIGPDVIVGPNTWIGPNVIIEGKVKIGSNNKIFPGACIGL
EPQDLKYGGDSTDVLIGDDNTFRECVTINRATFEGEKTIVGNQNLLMAYSHLGHNCDIGNSVVIANSVQIAGHVVVEDRA
IIGGCLGIHQFVHIGYLAMVGGMTRVDRDVPPFCLVEGHPGRMRGLNKVGIKRQTLDKENKEEYLQLKRIWNLLFKSEYV
ISDGLKRARQENLLQSSARLCGFIELSIGKGRRGPMPYFISTNK
>Mature_284_residues
MIERQSSKSLIADNKVNIHEFADVSPKAELGRGVSVGSGSVIGPDVIVGPNTWIGPNVIIEGKVKIGSNNKIFPGACIGL
EPQDLKYGGDSTDVLIGDDNTFRECVTINRATFEGEKTIVGNQNLLMAYSHLGHNCDIGNSVVIANSVQIAGHVVVEDRA
IIGGCLGIHQFVHIGYLAMVGGMTRVDRDVPPFCLVEGHPGRMRGLNKVGIKRQTLDKENKEEYLQLKRIWNLLFKSEYV
ISDGLKRARQENLLQSSARLCGFIELSIGKGRRGPMPYFISTNK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=227, Percent_Identity=41.8502202643172, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1786376, Length=186, Percent_Identity=28.494623655914, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30984; Mature: 30984

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERQSSKSLIADNKVNIHEFADVSPKAELGRGVSVGSGSVIGPDVIVGPNTWIGPNVII
CCCCCCCCCEECCCCCCHHHHCCCCCHHHHCCCEECCCCCEECCEEEECCCCCCCCCEEE
EGKVKIGSNNKIFPGACIGLEPQDLKYGGDSTDVLIGDDNTFRECVTINRATFEGEKTIV
EEEEEECCCCCCCCCEEECCCHHHCCCCCCCCEEEECCCCCCCHHEEEECEEECCCEEEE
GNQNLLMAYSHLGHNCDIGNSVVIANSVQIAGHVVVEDRAIIGGCLGIHQFVHIGYLAMV
CCCCEEEEEECCCCCCCCCCEEEEEECEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
GGMTRVDRDVPPFCLVEGHPGRMRGLNKVGIKRQTLDKENKEEYLQLKRIWNLLFKSEYV
CCCHHHCCCCCCEEEEECCCHHHCCCHHHCCCHHHCCCCCHHHHHHHHHHHHHHHCCCHH
ISDGLKRARQENLLQSSARLCGFIELSIGKGRRGPMPYFISTNK
HHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEEEECCC
>Mature Secondary Structure
MIERQSSKSLIADNKVNIHEFADVSPKAELGRGVSVGSGSVIGPDVIVGPNTWIGPNVII
CCCCCCCCCEECCCCCCHHHHCCCCCHHHHCCCEECCCCCEECCEEEECCCCCCCCCEEE
EGKVKIGSNNKIFPGACIGLEPQDLKYGGDSTDVLIGDDNTFRECVTINRATFEGEKTIV
EEEEEECCCCCCCCCEEECCCHHHCCCCCCCCEEEECCCCCCCHHEEEECEEECCCEEEE
GNQNLLMAYSHLGHNCDIGNSVVIANSVQIAGHVVVEDRAIIGGCLGIHQFVHIGYLAMV
CCCCEEEEEECCCCCCCCCCEEEEEECEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
GGMTRVDRDVPPFCLVEGHPGRMRGLNKVGIKRQTLDKENKEEYLQLKRIWNLLFKSEYV
CCCHHHCCCCCCEEEEECCCHHHCCCHHHCCCHHHCCCCCHHHHHHHHHHHHHHHCCCHH
ISDGLKRARQENLLQSSARLCGFIELSIGKGRRGPMPYFISTNK
HHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]