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The map label for this gene is lpxB [H]

Identifier: 124026466

GI number: 124026466

Start: 1441740

End: 1442912

Strand: Reverse

Name: lpxB [H]

Synonym: NATL1_17611

Alternate gene names: 124026466

Gene position: 1442912-1441740 (Counterclockwise)

Preceding gene: 124026467

Following gene: 124026465

Centisome position: 77.38

GC content: 32.14

Gene sequence:

>1173_bases
ATGAAGTTATTAATCAGCACTGGTGAAGTCTCTGGAGACTTGCAGGGAAGCTTATTAATAAATGCGTTAAAGACAAATGC
CGAGAAAAGGAAAATTGAATTAGAGATAATTGCTTTAGGTGGTGAAAGGATGCAGGAAGCAGGCGCTAAATTAATATCTA
ATACTTCTTCGATAGGTGCGATTGGTTTCTTAGAAGCTCTCCCTTACGTTCTACCAACATTGAATGCGCAATCAAAAATT
GACAATTACTTAAATTCTTCCCCACCTGATGCAGTTGTTTTAATAGATTATATGGGGCCAAATATTCGACTAGGATTAAA
AGTAAAGAAAAAGTTCCCTAATATTCCAATAATCTATTATATTGCGCCTCAGGAATGGGCATGGAGATTAGGCGATTCGG
GTACAACAGATTTGATTAGTTTTACAGATAAAATATTAGCTATCTTTGAAGAGGAAGCTAAATTTTATTCAAACAAGGGA
GGAAATGTAAAATTTGTAGGTCATCCAATGTTGGATTTCTATCGAAATATTCCTACTAGAGAAGAATCTTTGAGAAGAAT
AGGATTAACTTCGGATCAGAAACTTCTTCTTATTATCCCGGCTTCTCGAAAACAAGAACTTAAATATATTTTACCCACAT
TACTAAAAGCAGCTAAGCTTCTTCAGGAAAAAGATCCTTCTATTACTGTTCTAATACCATCTGGATTAAATGAATTTAAT
GAACTTTTAAATAATTCATTAAAAGAATATGCTCTTTCTGGAAGGATTATTTTGTCTAATGAAGTTGATGATTTAAAACC
ATTTCTATTTTCAGCGGCTCATCTTGCTTTAGCTAAGTCTGGGACAATAAATATGGAATTGGCTCTAAACTCAGTTCCGC
AAATCGTGGGATATAAAGTAAGTAGAGTTACTGCTTTTTTCGCAAGATATTTATTAAGATTTAATGTTAAATATATTTCT
CCAGTTAATCTTCTTTTAAATAATATGTTGATACCAGAGTTTATACAAGAGGACTTTAAAGCTGATAAAATTTTTAATGC
AGCATTAAAAATCCTTGAAGATAATTCAACAAAAGAGGACATAAAGCTTGGTTATGAAAGATTGAAAGATAAATTAGGAA
AACCTGGAGTTACAGATAGAGCATCAAGGGATATTCTAGACTTATTAATTTAA

Upstream 100 bases:

>100_bases
ATTTATTACAATCTTCCGCAAGATTATGTGGATTTATAGAACTCTCTATTGGGAAAGGTAGAAGAGGCCCAATGCCTTAT
TTTATTTCAACTAATAAATA

Downstream 100 bases:

>100_bases
TGATTGCTATGAATAAAATCTTCAGAAGACTAATAGTATTTTCTATACTTCTGCAATTATTAATAGCTTGTCCTTTGAAA
GCATTTGCCGAATCAGAAGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKLLISTGEVSGDLQGSLLINALKTNAEKRKIELEIIALGGERMQEAGAKLISNTSSIGAIGFLEALPYVLPTLNAQSKI
DNYLNSSPPDAVVLIDYMGPNIRLGLKVKKKFPNIPIIYYIAPQEWAWRLGDSGTTDLISFTDKILAIFEEEAKFYSNKG
GNVKFVGHPMLDFYRNIPTREESLRRIGLTSDQKLLLIIPASRKQELKYILPTLLKAAKLLQEKDPSITVLIPSGLNEFN
ELLNNSLKEYALSGRIILSNEVDDLKPFLFSAAHLALAKSGTINMELALNSVPQIVGYKVSRVTAFFARYLLRFNVKYIS
PVNLLLNNMLIPEFIQEDFKADKIFNAALKILEDNSTKEDIKLGYERLKDKLGKPGVTDRASRDILDLLI

Sequences:

>Translated_390_residues
MKLLISTGEVSGDLQGSLLINALKTNAEKRKIELEIIALGGERMQEAGAKLISNTSSIGAIGFLEALPYVLPTLNAQSKI
DNYLNSSPPDAVVLIDYMGPNIRLGLKVKKKFPNIPIIYYIAPQEWAWRLGDSGTTDLISFTDKILAIFEEEAKFYSNKG
GNVKFVGHPMLDFYRNIPTREESLRRIGLTSDQKLLLIIPASRKQELKYILPTLLKAAKLLQEKDPSITVLIPSGLNEFN
ELLNNSLKEYALSGRIILSNEVDDLKPFLFSAAHLALAKSGTINMELALNSVPQIVGYKVSRVTAFFARYLLRFNVKYIS
PVNLLLNNMLIPEFIQEDFKADKIFNAALKILEDNSTKEDIKLGYERLKDKLGKPGVTDRASRDILDLLI
>Mature_390_residues
MKLLISTGEVSGDLQGSLLINALKTNAEKRKIELEIIALGGERMQEAGAKLISNTSSIGAIGFLEALPYVLPTLNAQSKI
DNYLNSSPPDAVVLIDYMGPNIRLGLKVKKKFPNIPIIYYIAPQEWAWRLGDSGTTDLISFTDKILAIFEEEAKFYSNKG
GNVKFVGHPMLDFYRNIPTREESLRRIGLTSDQKLLLIIPASRKQELKYILPTLLKAAKLLQEKDPSITVLIPSGLNEFN
ELLNNSLKEYALSGRIILSNEVDDLKPFLFSAAHLALAKSGTINMELALNSVPQIVGYKVSRVTAFFARYLLRFNVKYIS
PVNLLLNNMLIPEFIQEDFKADKIFNAALKILEDNSTKEDIKLGYERLKDKLGKPGVTDRASRDILDLLI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=388, Percent_Identity=26.5463917525773, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43543; Mature: 43543

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLISTGEVSGDLQGSLLINALKTNAEKRKIELEIIALGGERMQEAGAKLISNTSSIGA
CEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCCH
IGFLEALPYVLPTLNAQSKIDNYLNSSPPDAVVLIDYMGPNIRLGLKVKKKFPNIPIIYY
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCEEEE
IAPQEWAWRLGDSGTTDLISFTDKILAIFEEEAKFYSNKGGNVKFVGHPMLDFYRNIPTR
ECCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCH
EESLRRIGLTSDQKLLLIIPASRKQELKYILPTLLKAAKLLQEKDPSITVLIPSGLNEFN
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
ELLNNSLKEYALSGRIILSNEVDDLKPFLFSAAHLALAKSGTINMELALNSVPQIVGYKV
HHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
SRVTAFFARYLLRFNVKYISPVNLLLNNMLIPEFIQEDFKADKIFNAALKILEDNSTKED
HHHHHHHHHHHHHHCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IKLGYERLKDKLGKPGVTDRASRDILDLLI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MKLLISTGEVSGDLQGSLLINALKTNAEKRKIELEIIALGGERMQEAGAKLISNTSSIGA
CEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCCH
IGFLEALPYVLPTLNAQSKIDNYLNSSPPDAVVLIDYMGPNIRLGLKVKKKFPNIPIIYY
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCEEEE
IAPQEWAWRLGDSGTTDLISFTDKILAIFEEEAKFYSNKGGNVKFVGHPMLDFYRNIPTR
ECCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCH
EESLRRIGLTSDQKLLLIIPASRKQELKYILPTLLKAAKLLQEKDPSITVLIPSGLNEFN
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
ELLNNSLKEYALSGRIILSNEVDDLKPFLFSAAHLALAKSGTINMELALNSVPQIVGYKV
HHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
SRVTAFFARYLLRFNVKYISPVNLLLNNMLIPEFIQEDFKADKIFNAALKILEDNSTKED
HHHHHHHHHHHHHHCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IKLGYERLKDKLGKPGVTDRASRDILDLLI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA