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The map label for this gene is pepB [H]

Identifier: 124026464

GI number: 124026464

Start: 1439576

End: 1441063

Strand: Direct

Name: pepB [H]

Synonym: NATL1_17591

Alternate gene names: 124026464

Gene position: 1439576-1441063 (Clockwise)

Preceding gene: 124026463

Following gene: 124026472

Centisome position: 77.2

GC content: 38.31

Gene sequence:

>1488_bases
ATGCAAATTTCAGCAGTCCCCAAAGAAATTAACGAATGGTCAGGATCAGTGCTTATAGCTGGGATTTTGGAAGGAACAAT
CGAAAGCCAAATTAATTTATTTAAGGCAATAATAAAAGATACTTTTTTGAGCCAAAGGTTTATTGATTCAAAATTCGAAG
GCAAAAAAAATCAGAAATTATCAATTGAACTAATAGAAGGCAAAGTTAAAAAAGTAATTTTTGTAGGCTTAGGCAAGGCC
GAAACTCTTGGAATTGATGATCTGCGGAAAGCAGCTTCAATTGGTACTCGTCAAGTTTCAGGCTATGAAAGAAAGTTAGG
TATATTTTTCCCTTGGGATGCATTTGACCCTTCCTCCGCTGCATGCGCAGTTGGCGAAGCAGTTCGATTGTCATCTATTA
AAGATTTTAGATTCAAATCAGAACCAAAAGAACCTACTCCAATAGATCAAGTTGAATTAATAGGTTTGGACACCAAAACC
ACTAAATCAGCGATTGATGAAATAAATCCAATATGCGAAGGAGTTAAATTTGCAAGAGAACTTGTTTCAGCCCCTCCCAA
TTTTCTTACCCCATATCAAATGTCTAAGGAGGCTGAAAAGTTAGCCACTGACTATGATCTTGATTTGAAAGTTCTAGATA
GAAAAGAGTGCGAAAATCAAGGGATGGGAGCTTACTTAGCAGTTGCTAAAGGATCAGATCTAGATCCTAATTTTATACAT
TTAAAATATTCTCCAAAAAATGCAAAAACCAAAGTCGTCTTAATTGGCAAAGGCTTAACTTTTGACTCTGGTGGATACAA
CTTAAAAGTAGGTGCATCTCAAATTGAAAAAATGAAGTACGACATGGGAGGTAGTGCTTCTGTTCTTGGAGCAGCCAGAG
CCATCGCAGAATTAAAACCGAATAACATCGAGGTTCATTTTATTATTGCTGCTTGCGAAAATATGATCAACGGCTCTGCA
TTGCATCCTGGAGATATCATCAAAGCTTCGAATGGAAAAACCATTGAAGTAAACAATACCGATGCAGAAGGAAGGTTAAC
TTTAGCTGATGCTTTGGTTTATGCATGCAAGCTGAAGCCTGACGCCATAGTAGATCTAGCCACTCTTACTGGGGCTTGTG
TCATTGCATTAGGAGATGAAATAGCAGGTTTATGGACTGACAATGATCAGCTCTCTGAGCAATTAACGAAAGCTGCGTGT
AAAGCTGGAGAGGGTATTTGGAGAATGCCAATGCAAGATTCATATAAATCTGGAATTAAATCAACTATTGCTGATTTGCA
AAACACAGGGCCTAGGCCAGGGGGGTCAATTACTGCAGCCTTGTTTCTCAAAGAATTTGTGAACTCAAGCATTCCATGGG
CGCACATTGACATAGCAGGTACATGCTGGACAGAAAAAGATAGAGATATAACTCCAAAGGGTGCTACTGGTTATGGAGTT
AGAACGTTAATTAATTGGATCAAGGAGTTGAGTCTAAACACCAATTAA

Upstream 100 bases:

>100_bases
CACCATTTAATAAAGAGACAAGGGAAATATGGGCAACGCCATTTACTTCTCAAATCAATTAGTAAAAAATTGTTATCATG
CATACAAGTATAAAAATTAA

Downstream 100 bases:

>100_bases
TTTATTCACGCATAATCTATAGATCTAAACTATATATATTTAAGATCTATAGATTAATTATTTTGTTAATACTTATATTC
TCCCCAGACTTTTTTTAATC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MQISAVPKEINEWSGSVLIAGILEGTIESQINLFKAIIKDTFLSQRFIDSKFEGKKNQKLSIELIEGKVKKVIFVGLGKA
ETLGIDDLRKAASIGTRQVSGYERKLGIFFPWDAFDPSSAACAVGEAVRLSSIKDFRFKSEPKEPTPIDQVELIGLDTKT
TKSAIDEINPICEGVKFARELVSAPPNFLTPYQMSKEAEKLATDYDLDLKVLDRKECENQGMGAYLAVAKGSDLDPNFIH
LKYSPKNAKTKVVLIGKGLTFDSGGYNLKVGASQIEKMKYDMGGSASVLGAARAIAELKPNNIEVHFIIAACENMINGSA
LHPGDIIKASNGKTIEVNNTDAEGRLTLADALVYACKLKPDAIVDLATLTGACVIALGDEIAGLWTDNDQLSEQLTKAAC
KAGEGIWRMPMQDSYKSGIKSTIADLQNTGPRPGGSITAALFLKEFVNSSIPWAHIDIAGTCWTEKDRDITPKGATGYGV
RTLINWIKELSLNTN

Sequences:

>Translated_495_residues
MQISAVPKEINEWSGSVLIAGILEGTIESQINLFKAIIKDTFLSQRFIDSKFEGKKNQKLSIELIEGKVKKVIFVGLGKA
ETLGIDDLRKAASIGTRQVSGYERKLGIFFPWDAFDPSSAACAVGEAVRLSSIKDFRFKSEPKEPTPIDQVELIGLDTKT
TKSAIDEINPICEGVKFARELVSAPPNFLTPYQMSKEAEKLATDYDLDLKVLDRKECENQGMGAYLAVAKGSDLDPNFIH
LKYSPKNAKTKVVLIGKGLTFDSGGYNLKVGASQIEKMKYDMGGSASVLGAARAIAELKPNNIEVHFIIAACENMINGSA
LHPGDIIKASNGKTIEVNNTDAEGRLTLADALVYACKLKPDAIVDLATLTGACVIALGDEIAGLWTDNDQLSEQLTKAAC
KAGEGIWRMPMQDSYKSGIKSTIADLQNTGPRPGGSITAALFLKEFVNSSIPWAHIDIAGTCWTEKDRDITPKGATGYGV
RTLINWIKELSLNTN
>Mature_495_residues
MQISAVPKEINEWSGSVLIAGILEGTIESQINLFKAIIKDTFLSQRFIDSKFEGKKNQKLSIELIEGKVKKVIFVGLGKA
ETLGIDDLRKAASIGTRQVSGYERKLGIFFPWDAFDPSSAACAVGEAVRLSSIKDFRFKSEPKEPTPIDQVELIGLDTKT
TKSAIDEINPICEGVKFARELVSAPPNFLTPYQMSKEAEKLATDYDLDLKVLDRKECENQGMGAYLAVAKGSDLDPNFIH
LKYSPKNAKTKVVLIGKGLTFDSGGYNLKVGASQIEKMKYDMGGSASVLGAARAIAELKPNNIEVHFIIAACENMINGSA
LHPGDIIKASNGKTIEVNNTDAEGRLTLADALVYACKLKPDAIVDLATLTGACVIALGDEIAGLWTDNDQLSEQLTKAAC
KAGEGIWRMPMQDSYKSGIKSTIADLQNTGPRPGGSITAALFLKEFVNSSIPWAHIDIAGTCWTEKDRDITPKGATGYGV
RTLINWIKELSLNTN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=438, Percent_Identity=36.986301369863, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI47155554, Length=374, Percent_Identity=31.283422459893, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1790710, Length=507, Percent_Identity=33.1360946745562, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=39.375, Blast_Score=204, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17556903, Length=319, Percent_Identity=33.2288401253918, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=425, Percent_Identity=24.2352941176471, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24661038, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=35.5345911949685, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20129969, Length=325, Percent_Identity=31.6923076923077, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161077148, Length=474, Percent_Identity=29.3248945147679, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20130057, Length=474, Percent_Identity=29.3248945147679, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24662227, Length=470, Percent_Identity=27.8723404255319, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21357381, Length=334, Percent_Identity=31.7365269461078, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI221379063, Length=334, Percent_Identity=31.7365269461078, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI221379062, Length=334, Percent_Identity=31.7365269461078, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI21355645, Length=467, Percent_Identity=27.4089935760171, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24662223, Length=467, Percent_Identity=27.4089935760171, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20129963, Length=449, Percent_Identity=28.0623608017817, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922386, Length=440, Percent_Identity=27.7272727272727, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646701, Length=470, Percent_Identity=26.5957446808511, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646703, Length=470, Percent_Identity=26.5957446808511, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358201, Length=470, Percent_Identity=26.5957446808511, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53614; Mature: 53614

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISAVPKEINEWSGSVLIAGILEGTIESQINLFKAIIKDTFLSQRFIDSKFEGKKNQKL
CCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
SIELIEGKVKKVIFVGLGKAETLGIDDLRKAASIGTRQVSGYERKLGIFFPWDAFDPSSA
EEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHCCCHHCCCHHHEEEEEECCCCCCCCCC
ACAVGEAVRLSSIKDFRFKSEPKEPTPIDQVELIGLDTKTTKSAIDEINPICEGVKFARE
HHHHHHHHHHHCHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LVSAPPNFLTPYQMSKEAEKLATDYDLDLKVLDRKECENQGMGAYLAVAKGSDLDPNFIH
HHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCCEEEEEECCCCCCCCEEE
LKYSPKNAKTKVVLIGKGLTFDSGGYNLKVGASQIEKMKYDMGGSASVLGAARAIAELKP
EEECCCCCCEEEEEEECCEEECCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NNIEVHFIIAACENMINGSALHPGDIIKASNGKTIEVNNTDAEGRLTLADALVYACKLKP
CCEEEEEEHHHHHHHCCCCCCCCCCEEECCCCCEEEECCCCCCCEEEHHHHHHHHHCCCC
DAIVDLATLTGACVIALGDEIAGLWTDNDQLSEQLTKAACKAGEGIWRMPMQDSYKSGIK
HHHEEHHHHHCEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
STIADLQNTGPRPGGSITAALFLKEFVNSSIPWAHIDIAGTCWTEKDRDITPKGATGYGV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCH
RTLINWIKELSLNTN
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MQISAVPKEINEWSGSVLIAGILEGTIESQINLFKAIIKDTFLSQRFIDSKFEGKKNQKL
CCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
SIELIEGKVKKVIFVGLGKAETLGIDDLRKAASIGTRQVSGYERKLGIFFPWDAFDPSSA
EEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHCCCHHCCCHHHEEEEEECCCCCCCCCC
ACAVGEAVRLSSIKDFRFKSEPKEPTPIDQVELIGLDTKTTKSAIDEINPICEGVKFARE
HHHHHHHHHHHCHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LVSAPPNFLTPYQMSKEAEKLATDYDLDLKVLDRKECENQGMGAYLAVAKGSDLDPNFIH
HHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCCEEEEEECCCCCCCCEEE
LKYSPKNAKTKVVLIGKGLTFDSGGYNLKVGASQIEKMKYDMGGSASVLGAARAIAELKP
EEECCCCCCEEEEEEECCEEECCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NNIEVHFIIAACENMINGSALHPGDIIKASNGKTIEVNNTDAEGRLTLADALVYACKLKP
CCEEEEEEHHHHHHHCCCCCCCCCCEEECCCCCEEEECCCCCCCEEEHHHHHHHHHCCCC
DAIVDLATLTGACVIALGDEIAGLWTDNDQLSEQLTKAACKAGEGIWRMPMQDSYKSGIK
HHHEEHHHHHCEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
STIADLQNTGPRPGGSITAALFLKEFVNSSIPWAHIDIAGTCWTEKDRDITPKGATGYGV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCH
RTLINWIKELSLNTN
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]