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The map label for this gene is hemN [C]

Identifier: 124026436

GI number: 124026436

Start: 1417590

End: 1418822

Strand: Reverse

Name: hemN [C]

Synonym: NATL1_17311

Alternate gene names: 124026436

Gene position: 1418822-1417590 (Counterclockwise)

Preceding gene: 124026443

Following gene: 124026429

Centisome position: 76.09

GC content: 36.66

Gene sequence:

>1233_bases
ATGGTAGCCCCACCAAGAAGTGCATATTTGCATATACCCTTTTGCCATAAAAGATGTTTTTACTGCGATTTTTCGATTAT
CCCTTTAGGTGATAGCGCTCAAGCTCCAGATAGTCCAGGGATAACTTCCATTAACGCATATTTGGATTTACTTCATAGAG
AGATTTCAATTTCCCCTAAAGGTCCTGCATTATCAACAATTTATTTGGGCGGTGGAACACCTTCCTTATTAAAAAAAAAT
GAGGTGGGTGATTTGTTGCAAAATCTTCAAAGAAAATTTGGATTTCAAGATGGTGCAGAGATAACTATGGAGGTTGATCC
AGCAACATTTTTTGAAAACGACCTGCATGGATACATAGGGATTGGAATTAATAGATTTAGCTTGGGTGCGCAGGCATTTG
ATGACAGTACTTTGGCTTCAATTGGTAGAAAACATAATCGCTCACAATTAATTGAGGCTTGTGATTGGGTAAATAATTTA
TTTAAAAAAGGAATGCTAAGAAGCTGGAGTCTTGATTTGATTCAAAACCTTCCAGGATTAAATTTGTCCAAGTGGATTAA
AGAGTTGGAACAAGCGGTTCGTACGGAGGCCCCTCATTTGTCAATTTATGATTTAACTATCGAACCAGATACTGTTTTTG
GAAGACTACATAAAAAAGGAAAGTTGAATATCCCAATTGATTCTGAATCTCAAAAAATAGATTTTGAAACCACTAGATTA
CTAAAAAGTAGAGGTTTCGCTAGATACGAGATTTCAAGTTATTCATTGCCTGGTCATGCATCTAGACATAATCGCATGTA
TTGGAGTGGTTCTGGTTGGTGGGGCTTTGGGATGGGGTCAACAAGTGCTCCTTGGGGGGAAAGATTCTCTAGACCAAGAA
CAATTGCTGGTTATAAAAAATGGCTTGAACAGCAAGAGAGTCAGTCATTAGAGAAAACTTTGTCTATTGAAAAGTCAAAA
TCAATGCCATTGGATGAACTTCTGATGATTGGTCTTAGAAGACGGGAGGGTATTCATCTGGAGGAACTTGCTAAAAATGC
TGGATGGACACAAAAAAAATGTGATAAGAATTTAAAATCACTTGAGAAATTTTGGCTAAATTCTATAAATGAAGGATTTC
TATTAAGACACAATGGTAGATATTTTTTAAGTGATCCTAAGGGGTTTCAAATTAGCAATCAGATTTTGATTCAGATGTTT
TCGTGGTGGGATTCACTTGATCGAGATCAGTAG

Upstream 100 bases:

>100_bases
GTTATGCTTGCTTTTCGTTTTTTACTAAAGCTTTATTTATTTTCAAAGATTTGGTTTGTAAAAGTGACCATTTATTTGGG
TTTGTATATCTAGAGCTCAA

Downstream 100 bases:

>100_bases
AATTAATCCATTCTTTTAGGGCATTTATGCAAAGTTCTCGTCCTGCAAGTAAAGGTTTTGCAAAAGGAGGCTGCGCAATT
GAAAGGCCAAGAATATCAGC

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVAPPRSAYLHIPFCHKRCFYCDFSIIPLGDSAQAPDSPGITSINAYLDLLHREISISPKGPALSTIYLGGGTPSLLKKN
EVGDLLQNLQRKFGFQDGAEITMEVDPATFFENDLHGYIGIGINRFSLGAQAFDDSTLASIGRKHNRSQLIEACDWVNNL
FKKGMLRSWSLDLIQNLPGLNLSKWIKELEQAVRTEAPHLSIYDLTIEPDTVFGRLHKKGKLNIPIDSESQKIDFETTRL
LKSRGFARYEISSYSLPGHASRHNRMYWSGSGWWGFGMGSTSAPWGERFSRPRTIAGYKKWLEQQESQSLEKTLSIEKSK
SMPLDELLMIGLRRREGIHLEELAKNAGWTQKKCDKNLKSLEKFWLNSINEGFLLRHNGRYFLSDPKGFQISNQILIQMF
SWWDSLDRDQ

Sequences:

>Translated_410_residues
MVAPPRSAYLHIPFCHKRCFYCDFSIIPLGDSAQAPDSPGITSINAYLDLLHREISISPKGPALSTIYLGGGTPSLLKKN
EVGDLLQNLQRKFGFQDGAEITMEVDPATFFENDLHGYIGIGINRFSLGAQAFDDSTLASIGRKHNRSQLIEACDWVNNL
FKKGMLRSWSLDLIQNLPGLNLSKWIKELEQAVRTEAPHLSIYDLTIEPDTVFGRLHKKGKLNIPIDSESQKIDFETTRL
LKSRGFARYEISSYSLPGHASRHNRMYWSGSGWWGFGMGSTSAPWGERFSRPRTIAGYKKWLEQQESQSLEKTLSIEKSK
SMPLDELLMIGLRRREGIHLEELAKNAGWTQKKCDKNLKSLEKFWLNSINEGFLLRHNGRYFLSDPKGFQISNQILIQMF
SWWDSLDRDQ
>Mature_410_residues
MVAPPRSAYLHIPFCHKRCFYCDFSIIPLGDSAQAPDSPGITSINAYLDLLHREISISPKGPALSTIYLGGGTPSLLKKN
EVGDLLQNLQRKFGFQDGAEITMEVDPATFFENDLHGYIGIGINRFSLGAQAFDDSTLASIGRKHNRSQLIEACDWVNNL
FKKGMLRSWSLDLIQNLPGLNLSKWIKELEQAVRTEAPHLSIYDLTIEPDTVFGRLHKKGKLNIPIDSESQKIDFETTRL
LKSRGFARYEISSYSLPGHASRHNRMYWSGSGWWGFGMGSTSAPWGERFSRPRTIAGYKKWLEQQESQSLEKTLSIEKSK
SMPLDELLMIGLRRREGIHLEELAKNAGWTQKKCDKNLKSLEKFWLNSINEGFLLRHNGRYFLSDPKGFQISNQILIQMF
SWWDSLDRDQ

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=275, Percent_Identity=28.7272727272727, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1789325, Length=309, Percent_Identity=33.6569579288026, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082341, Length=293, Percent_Identity=28.3276450511945, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 46708; Mature: 46708

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPPRSAYLHIPFCHKRCFYCDFSIIPLGDSAQAPDSPGITSINAYLDLLHREISISPK
CCCCCCCCEEECCHHHCEEEEECEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
GPALSTIYLGGGTPSLLKKNEVGDLLQNLQRKFGFQDGAEITMEVDPATFFENDLHGYIG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCCCEEEE
IGINRFSLGAQAFDDSTLASIGRKHNRSQLIEACDWVNNLFKKGMLRSWSLDLIQNLPGL
ECEEEEECCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCC
NLSKWIKELEQAVRTEAPHLSIYDLTIEPDTVFGRLHKKGKLNIPIDSESQKIDFETTRL
CHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCCEECCCCCCCCCCCHHHHHH
LKSRGFARYEISSYSLPGHASRHNRMYWSGSGWWGFGMGSTSAPWGERFSRPRTIAGYKK
HHHCCCEEEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHCCCCHHHHHHH
WLEQQESQSLEKTLSIEKSKSMPLDELLMIGLRRREGIHLEELAKNAGWTQKKCDKNLKS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHH
LEKFWLNSINEGFLLRHNGRYFLSDPKGFQISNQILIQMFSWWDSLDRDQ
HHHHHHHCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVAPPRSAYLHIPFCHKRCFYCDFSIIPLGDSAQAPDSPGITSINAYLDLLHREISISPK
CCCCCCCCEEECCHHHCEEEEECEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
GPALSTIYLGGGTPSLLKKNEVGDLLQNLQRKFGFQDGAEITMEVDPATFFENDLHGYIG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCCCEEEE
IGINRFSLGAQAFDDSTLASIGRKHNRSQLIEACDWVNNLFKKGMLRSWSLDLIQNLPGL
ECEEEEECCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCC
NLSKWIKELEQAVRTEAPHLSIYDLTIEPDTVFGRLHKKGKLNIPIDSESQKIDFETTRL
CHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCCEECCCCCCCCCCCHHHHHH
LKSRGFARYEISSYSLPGHASRHNRMYWSGSGWWGFGMGSTSAPWGERFSRPRTIAGYKK
HHHCCCEEEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHCCCCHHHHHHH
WLEQQESQSLEKTLSIEKSKSMPLDELLMIGLRRREGIHLEELAKNAGWTQKKCDKNLKS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHH
LEKFWLNSINEGFLLRHNGRYFLSDPKGFQISNQILIQMFSWWDSLDRDQ
HHHHHHHCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]