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The map label for this gene is ffh [H]

Identifier: 124026411

GI number: 124026411

Start: 1389431

End: 1390894

Strand: Reverse

Name: ffh [H]

Synonym: NATL1_17061

Alternate gene names: 124026411

Gene position: 1390894-1389431 (Counterclockwise)

Preceding gene: 124026412

Following gene: 124026410

Centisome position: 74.59

GC content: 40.98

Gene sequence:

>1464_bases
ATGTTTGATGCACTAACTAATCAATTTGAAGATGCTGTAAAGGCATTTAAAGGTGAAGCTAAAATTTCAGAGGAGAATGT
TGATGAAGCACTTAAGCAGGTCAGACGAGCTTTATTAGATGCAGATGTCAGTTTGTCTGTAGTAAAAGAATTTATTGATG
AAGTAAGAGTAAAGGCAGTTGGAACAGAAGTTGTAAGAGGTATAGACCCTGGACAGAAATTCATTCAAGTAGTTCATGAA
GAACTTGTGAATGTTATGGGAGGAGAGAATGACCCCTTAGCAAATTCAGAGGAACAGCCAACAGTCATTTTGATGGCTGG
ACTTCAGGGAGCTGGAAAGACAACCGCTACAGCAAAACTTGGATTGCTTCTTAAAGAAAAAAATAAAAAGCCATTACTTG
TGGCTGCCGATACTTACAGACCAGCAGCTATTGATCAATTAGTAACTTTGGGAAAACAAATTGATGTAGAGGTTTTTAAT
TTAAGTTCTAATTTAAAGCCGGAGGAGATTGCTAAAAAAGGCTTGGAAAAAGCTAAAAAAGAAGGTTTTGACACTGTTCT
TGTAGATACTGCTGGGCGGCTCCAAATTGATACCGACATGATGGGAGAGATGGTTCGAATTAAAGAGGCCGTTCAACCAG
ATGAAGTTTTATTGGTAGTTGATTCAATGATTGGCCAAGAGGCCGCAGACATCACCAGAAGTTTTCATGAAAAAGTAGGA
ATAACAGGCGCTGTGCTCACGAAGCTAGATGGAGATTCGAGAGGTGGAGCTGCTCTTTCTATTAGAAAAATCAGTGGAAA
ACCAATCAAATTTATAGGTACTGGAGAAAAGGTTGAGGCATTGCAACCTTTTTATCCCGAGAGGATGGCTAGCAGAATTT
TAGGGATGGGCGATGTTTTAACTCTTGTCGAAAAAGCACAGAAAGAAGTTGAAATTGCTGATGCAGAAATCATGCAAAAG
AAGCTTCAAGAAGCAACTTTTGATTTTTCAGATTTCGTAAAACAGATGAGGATGATAAAGCGAATGGGCTCGTTAGGGGG
GCTGCTGAAAATGATTCCTGGGATGAATAAAATTGATGATGGAATGATTAAAAGTGGAGAAGATCAACTTAAAAAAATCG
AGGCAATGATTGGTTCAATGTCAGTAGAGGAGAGGAATAAACCTGAATTGTTGGCAGCGCAACCATCAAGACGTCGAAGG
GTTGCAAGTGGCAGTGGACATAAGCCAGCAGACGTTGATAAGGTTCTCGCGGATTTTCAAAGGATGCGAGGCTTGATGAA
GCAGATGTCTACAGGAGGAGGTCTTCCCGGTATGGATGGAGGTCTCCCTGGTATGGGTGGACTACCTAGTATGCCTTCAT
CTGGTGCTAATCCATATCAGTCAAGGAAAGGAAAAGGAGGTCCAGGTTTGCCCCCCCGAAGACAGCGACCAATTAAGAAA
AAGAAAGGTTTTGGTGATCTTTAG

Upstream 100 bases:

>100_bases
AATATATAATAGGTAAGAATAAAAAAAACTGGCTAATAGTTGACTATATTAGTGGAAATTAAAAAATAATTTTTTAAATT
ATTTCTGTAACTCTAAGAAA

Downstream 100 bases:

>100_bases
AGATATCAAAAGGCTAAATTAATCATCCGTGGAGTATTATCAAGATGAAGAACCTTTGAGTTCAATCCACTTACAAATAA
ATCGAAGATGATCAAGCTCC

Product: signal recognition particle protein (SRP54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MFDALTNQFEDAVKAFKGEAKISEENVDEALKQVRRALLDADVSLSVVKEFIDEVRVKAVGTEVVRGIDPGQKFIQVVHE
ELVNVMGGENDPLANSEEQPTVILMAGLQGAGKTTATAKLGLLLKEKNKKPLLVAADTYRPAAIDQLVTLGKQIDVEVFN
LSSNLKPEEIAKKGLEKAKKEGFDTVLVDTAGRLQIDTDMMGEMVRIKEAVQPDEVLLVVDSMIGQEAADITRSFHEKVG
ITGAVLTKLDGDSRGGAALSIRKISGKPIKFIGTGEKVEALQPFYPERMASRILGMGDVLTLVEKAQKEVEIADAEIMQK
KLQEATFDFSDFVKQMRMIKRMGSLGGLLKMIPGMNKIDDGMIKSGEDQLKKIEAMIGSMSVEERNKPELLAAQPSRRRR
VASGSGHKPADVDKVLADFQRMRGLMKQMSTGGGLPGMDGGLPGMGGLPSMPSSGANPYQSRKGKGGPGLPPRRQRPIKK
KKGFGDL

Sequences:

>Translated_487_residues
MFDALTNQFEDAVKAFKGEAKISEENVDEALKQVRRALLDADVSLSVVKEFIDEVRVKAVGTEVVRGIDPGQKFIQVVHE
ELVNVMGGENDPLANSEEQPTVILMAGLQGAGKTTATAKLGLLLKEKNKKPLLVAADTYRPAAIDQLVTLGKQIDVEVFN
LSSNLKPEEIAKKGLEKAKKEGFDTVLVDTAGRLQIDTDMMGEMVRIKEAVQPDEVLLVVDSMIGQEAADITRSFHEKVG
ITGAVLTKLDGDSRGGAALSIRKISGKPIKFIGTGEKVEALQPFYPERMASRILGMGDVLTLVEKAQKEVEIADAEIMQK
KLQEATFDFSDFVKQMRMIKRMGSLGGLLKMIPGMNKIDDGMIKSGEDQLKKIEAMIGSMSVEERNKPELLAAQPSRRRR
VASGSGHKPADVDKVLADFQRMRGLMKQMSTGGGLPGMDGGLPGMGGLPSMPSSGANPYQSRKGKGGPGLPPRRQRPIKK
KKGFGDL
>Mature_487_residues
MFDALTNQFEDAVKAFKGEAKISEENVDEALKQVRRALLDADVSLSVVKEFIDEVRVKAVGTEVVRGIDPGQKFIQVVHE
ELVNVMGGENDPLANSEEQPTVILMAGLQGAGKTTATAKLGLLLKEKNKKPLLVAADTYRPAAIDQLVTLGKQIDVEVFN
LSSNLKPEEIAKKGLEKAKKEGFDTVLVDTAGRLQIDTDMMGEMVRIKEAVQPDEVLLVVDSMIGQEAADITRSFHEKVG
ITGAVLTKLDGDSRGGAALSIRKISGKPIKFIGTGEKVEALQPFYPERMASRILGMGDVLTLVEKAQKEVEIADAEIMQK
KLQEATFDFSDFVKQMRMIKRMGSLGGLLKMIPGMNKIDDGMIKSGEDQLKKIEAMIGSMSVEERNKPELLAAQPSRRRR
VASGSGHKPADVDKVLADFQRMRGLMKQMSTGGGLPGMDGGLPGMGGLPSMPSSGANPYQSRKGKGGPGLPPRRQRPIKK
KKGFGDL

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=444, Percent_Identity=32.8828828828829, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI226371618, Length=386, Percent_Identity=33.419689119171, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI89061728, Length=162, Percent_Identity=37.6543209876543, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI295424842, Length=295, Percent_Identity=29.1525423728814, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI23308697, Length=295, Percent_Identity=29.1525423728814, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=49.0610328638498, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1789874, Length=214, Percent_Identity=35.981308411215, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=422, Percent_Identity=32.9383886255924, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI193206261, Length=295, Percent_Identity=30.8474576271186, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6325345, Length=473, Percent_Identity=32.76955602537, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17647949, Length=434, Percent_Identity=32.7188940092166, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24641198, Length=300, Percent_Identity=27.3333333333333, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 52751; Mature: 52751

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDALTNQFEDAVKAFKGEAKISEENVDEALKQVRRALLDADVSLSVVKEFIDEVRVKAV
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GTEVVRGIDPGQKFIQVVHEELVNVMGGENDPLANSEEQPTVILMAGLQGAGKTTATAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
GLLLKEKNKKPLLVAADTYRPAAIDQLVTLGKQIDVEVFNLSSNLKPEEIAKKGLEKAKK
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
EGFDTVLVDTAGRLQIDTDMMGEMVRIKEAVQPDEVLLVVDSMIGQEAADITRSFHEKVG
CCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEHHHHHHCHHHHHHHHHHHHHHC
ITGAVLTKLDGDSRGGAALSIRKISGKPIKFIGTGEKVEALQPFYPERMASRILGMGDVL
CCHHHHEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHHHH
TLVEKAQKEVEIADAEIMQKKLQEATFDFSDFVKQMRMIKRMGSLGGLLKMIPGMNKIDD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GMIKSGEDQLKKIEAMIGSMSVEERNKPELLAAQPSRRRRVASGSGHKPADVDKVLADFQ
HHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHCCCCCCCCCCHHHHHHHHHH
RMRGLMKQMSTGGGLPGMDGGLPGMGGLPSMPSSGANPYQSRKGKGGPGLPPRRQRPIKK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHH
KKGFGDL
CCCCCCC
>Mature Secondary Structure
MFDALTNQFEDAVKAFKGEAKISEENVDEALKQVRRALLDADVSLSVVKEFIDEVRVKAV
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GTEVVRGIDPGQKFIQVVHEELVNVMGGENDPLANSEEQPTVILMAGLQGAGKTTATAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
GLLLKEKNKKPLLVAADTYRPAAIDQLVTLGKQIDVEVFNLSSNLKPEEIAKKGLEKAKK
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
EGFDTVLVDTAGRLQIDTDMMGEMVRIKEAVQPDEVLLVVDSMIGQEAADITRSFHEKVG
CCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEHHHHHHCHHHHHHHHHHHHHHC
ITGAVLTKLDGDSRGGAALSIRKISGKPIKFIGTGEKVEALQPFYPERMASRILGMGDVL
CCHHHHEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHHHH
TLVEKAQKEVEIADAEIMQKKLQEATFDFSDFVKQMRMIKRMGSLGGLLKMIPGMNKIDD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GMIKSGEDQLKKIEAMIGSMSVEERNKPELLAAQPSRRRRVASGSGHKPADVDKVLADFQ
HHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHCCCCCCCCCCHHHHHHHHHH
RMRGLMKQMSTGGGLPGMDGGLPGMGGLPSMPSSGANPYQSRKGKGGPGLPPRRQRPIKK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHH
KKGFGDL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]