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The map label for this gene is era [H]

Identifier: 124026406

GI number: 124026406

Start: 1385634

End: 1386575

Strand: Reverse

Name: era [H]

Synonym: NATL1_17011

Alternate gene names: 124026406

Gene position: 1386575-1385634 (Counterclockwise)

Preceding gene: 124026408

Following gene: 124026405

Centisome position: 74.36

GC content: 34.39

Gene sequence:

>942_bases
ATGTCTTTGGGAGATTTGAGTCAAGAGGATTTTAAATCAGGGTTTATTGCATTAATCGGCAGACCCAATGTAGGCAAATC
AACTTTCATAAACAAATTTATCGGTGAGAAAATAGCAATTACATCTCCAATTGCTCAAACCACCAGAAATCGATTGAAAG
TAATACTCACGAATGAAAAGTCTCAGATTATTTTTGTAGATACTCCTGGTATTCATAAACCACATCATTTATTAGGTGAA
AGACTTGTTCAGAGTGCTAAGAGATCTATTGGAGATGTTGATGCAGTCTTAGTTATTTTTGAAGCCAGCCATTCTCCAGG
GAGGGGGGACGCATTTATTTTGAATTTGATCAGGAATTTAAAAATCCCTGTCATTGTTGCCTTGAATAAATGGGATCTTT
TAGCATTGAGTCAAATTAAAGAAAGAAAGAAAGAATATTTAGAATTTTTAGAGGGTACTAATTGGCCAGTCTTTTGTTGT
AGCGCTCTTACAGGTCAGGGATGTATTGAATTAATTAGTGAAATAGAAGAAACACTACCTTTTGGACCTCAGCTATATCC
AAGTGATATGAATTGTGACCATCCTGAGAAGTTTTTGATAGCTGAATTTATAAGAGAACAAGTTTTAATATATACACGCG
AAGAAGTACCTCATAGTGTGGCAGTCTCTATTGATAAAATAGAAGACATAACCTCGAAAAAAAAATCTGAACAGAAATCA
AGAACTGGAATTCTTGCAACTATTTGTGTTGAGAAAAAAAGTCAGAAAGGAATTTTAATAGGTAAAGGGGGAAGCATGTT
GAAGAAAATTGGCCAGGAATCAAGAATGCAAATTCAAACTTTAATTAATGGAAATGTCTATCTAGAACTGTTTGTTAAAG
TTGTGCCTGACTGGAGAAGTAAATCTTCTCGGCTTAATGAGTTTGGTTATGAAGGTAGCTAA

Upstream 100 bases:

>100_bases
TCATTGTTGCTTCCATTGCTTCTTTAAAAGTTGGTTTCTGCTCATTCATGGTTTTATTGCACTTTTATAGTAAGGCTATA
GATAATCGTAGAGAAAGGAA

Downstream 100 bases:

>100_bases
TTTATATGACTAAATTAAGATTCGATGTCGTAAGCCTTTTTCCAGAAGCTTTTAAAAATTTTTTTAATCATGGACTAATA
AAAAAAGCATTTGAAGAGAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSLGDLSQEDFKSGFIALIGRPNVGKSTFINKFIGEKIAITSPIAQTTRNRLKVILTNEKSQIIFVDTPGIHKPHHLLGE
RLVQSAKRSIGDVDAVLVIFEASHSPGRGDAFILNLIRNLKIPVIVALNKWDLLALSQIKERKKEYLEFLEGTNWPVFCC
SALTGQGCIELISEIEETLPFGPQLYPSDMNCDHPEKFLIAEFIREQVLIYTREEVPHSVAVSIDKIEDITSKKKSEQKS
RTGILATICVEKKSQKGILIGKGGSMLKKIGQESRMQIQTLINGNVYLELFVKVVPDWRSKSSRLNEFGYEGS

Sequences:

>Translated_313_residues
MSLGDLSQEDFKSGFIALIGRPNVGKSTFINKFIGEKIAITSPIAQTTRNRLKVILTNEKSQIIFVDTPGIHKPHHLLGE
RLVQSAKRSIGDVDAVLVIFEASHSPGRGDAFILNLIRNLKIPVIVALNKWDLLALSQIKERKKEYLEFLEGTNWPVFCC
SALTGQGCIELISEIEETLPFGPQLYPSDMNCDHPEKFLIAEFIREQVLIYTREEVPHSVAVSIDKIEDITSKKKSEQKS
RTGILATICVEKKSQKGILIGKGGSMLKKIGQESRMQIQTLINGNVYLELFVKVVPDWRSKSSRLNEFGYEGS
>Mature_312_residues
SLGDLSQEDFKSGFIALIGRPNVGKSTFINKFIGEKIAITSPIAQTTRNRLKVILTNEKSQIIFVDTPGIHKPHHLLGER
LVQSAKRSIGDVDAVLVIFEASHSPGRGDAFILNLIRNLKIPVIVALNKWDLLALSQIKERKKEYLEFLEGTNWPVFCCS
ALTGQGCIELISEIEETLPFGPQLYPSDMNCDHPEKFLIAEFIREQVLIYTREEVPHSVAVSIDKIEDITSKKKSEQKSR
TGILATICVEKKSQKGILIGKGGSMLKKIGQESRMQIQTLINGNVYLELFVKVVPDWRSKSSRLNEFGYEGS

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=328, Percent_Identity=24.0853658536585, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788919, Length=301, Percent_Identity=37.5415282392027, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI87082120, Length=168, Percent_Identity=29.7619047619048, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646434, Length=256, Percent_Identity=28.125, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 35025; Mature: 34894

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGDLSQEDFKSGFIALIGRPNVGKSTFINKFIGEKIAITSPIAQTTRNRLKVILTNEK
CCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEECCHHHHHHHCCEEEEEECCC
SQIIFVDTPGIHKPHHLLGERLVQSAKRSIGDVDAVLVIFEASHSPGRGDAFILNLIRNL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHC
KIPVIVALNKWDLLALSQIKERKKEYLEFLEGTNWPVFCCSALTGQGCIELISEIEETLP
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCHHHHHHHHHHHHHCC
FGPQLYPSDMNCDHPEKFLIAEFIREQVLIYTREEVPHSVAVSIDKIEDITSKKKSEQKS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHH
RTGILATICVEKKSQKGILIGKGGSMLKKIGQESRMQIQTLINGNVYLELFVKVVPDWRS
HCCEEEEEEECCCCCCCEEEECCHHHHHHHCHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
KSSRLNEFGYEGS
HHHHHHHCCCCCC
>Mature Secondary Structure 
SLGDLSQEDFKSGFIALIGRPNVGKSTFINKFIGEKIAITSPIAQTTRNRLKVILTNEK
CCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEECCHHHHHHHCCEEEEEECCC
SQIIFVDTPGIHKPHHLLGERLVQSAKRSIGDVDAVLVIFEASHSPGRGDAFILNLIRNL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHC
KIPVIVALNKWDLLALSQIKERKKEYLEFLEGTNWPVFCCSALTGQGCIELISEIEETLP
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCHHHHHHHHHHHHHCC
FGPQLYPSDMNCDHPEKFLIAEFIREQVLIYTREEVPHSVAVSIDKIEDITSKKKSEQKS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHH
RTGILATICVEKKSQKGILIGKGGSMLKKIGQESRMQIQTLINGNVYLELFVKVVPDWRS
HCCEEEEEEECCCCCCCEEEECCHHHHHHHCHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
KSSRLNEFGYEGS
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]