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The map label for this gene is serS

Identifier: 124026368

GI number: 124026368

Start: 1353713

End: 1354993

Strand: Direct

Name: serS

Synonym: NATL1_16621

Alternate gene names: 124026368

Gene position: 1353713-1354993 (Clockwise)

Preceding gene: 124026367

Following gene: 124026369

Centisome position: 72.6

GC content: 36.3

Gene sequence:

>1281_bases
GTGATAGATCAGAGACTTCTAAGAGAAAATCCTAATTTAATTTCGGAAGGGCTTAAATCAAGAGGAATGGATGTTGACTT
AGGACCTCTACAAAAATTCTGCAAAGATCTTAAAGACCTAGAAGAAAAGAGAAATTCCCTACAAGCACAAGGGAATTCAA
TCGGGAAAGAGGTTGGACAAAAAATAAAACAAGGTCTTCCTCATGATTCTGAGGAGATTTCAAATCTTCGTGTTAAGGGC
AATCAAATCAAAAAACAAGTTGGAATAATTGAAGAGGAAGAGAAATCAATTTCAAATAAATTAAATGAACAAATCCTTTG
CTTACCTAATCTTCCAGAGAAGAATTCTCTGGAAGGGAAAAACGAAAAAGATAATAAGGAACTAAGAAGATGGGGAGAAC
CTATTTCAGGAAATACTTTAAAAGAGCATTGGGAAATTGCTAATCAATTGAACCTCTGGGATAGTGAGAGATCTTCTGTA
ATAGCAAAAAGTCGATTTGTAACCCTTTTCAAGCACGCTGCAAAACTTGAGAGATCACTTATAAATTTCATGCTTGATTT
ACATATTAAAAAAGGATATTTAGAAGTTCTTCCCCCAGCTCTTGTTAACACAGCCAGTCTTACTGGTTCTGGACAGTTAC
CAAAATTTGCAGAAGAAAGTTTTCGATGTGCTGATGATGATTTATGGCTGACTCCTACTGCTGAAGTTCCAATAACATCT
CTCCATCGTGGAGAGATCATCCCTAGAGATTTGTTACCATTAAAGTACGTTGCTTATAGCCCTTGTTTCAGAAGAGAAGC
GGGAAGTTACGGAAGGGATACTAGAGGTCTAATCAGACTTCATCAATTCAATAAAGTTGAACTATATTGGTTTTCTACTC
CAGAAACATCTGAAGATGCTCTAGAACAAATCACATCTGATGCAGAGTCTGTGTTGCAAGAACTTGAACTACCGTATCGA
GTAATTCAACTTTGCACAGGCGACTTAGGTTTCTCAGCAAAAAAAACTTATGATTTGGAGGTTTGGCTTCCAGGTGCTAA
CACTTTTAGAGAAATATCTAGTTGCAGTAATTGTGGAGATTTTCAAGCTAGACGTTCATCAATACGAACAAAAGATAACA
ATAAAAAAAACATACTTTTGCATACATTAAATGGAAGTGGATTGGCTATTGGTCGCACTATGGCTGCCATTTTGGAAAAT
GGTCAACAAAGCGATGGAAGTATCAATTTGCCAAAAGCCTTAATACCTTACTTCGGTTCAAACAAATTACAGCCAGAATA
A

Upstream 100 bases:

>100_bases
TAATTAATCTAAAAAAGTCCTTGATTTAAAAGATTTTAACAAGTGTGATTATTTTAGGAACAATTAACGATTAGGCTGAA
AGTACTTCCTTATTTAGATA

Downstream 100 bases:

>100_bases
CCCAATCAAAATCTAATTAATGAACGTTCTCTTATCTATAGCTGTACTTGGCCTTCTGATTTTTTTTCATGAATCTGGTC
ATTTTTTAGCAGCAGTACTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MIDQRLLRENPNLISEGLKSRGMDVDLGPLQKFCKDLKDLEEKRNSLQAQGNSIGKEVGQKIKQGLPHDSEEISNLRVKG
NQIKKQVGIIEEEEKSISNKLNEQILCLPNLPEKNSLEGKNEKDNKELRRWGEPISGNTLKEHWEIANQLNLWDSERSSV
IAKSRFVTLFKHAAKLERSLINFMLDLHIKKGYLEVLPPALVNTASLTGSGQLPKFAEESFRCADDDLWLTPTAEVPITS
LHRGEIIPRDLLPLKYVAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFSTPETSEDALEQITSDAESVLQELELPYR
VIQLCTGDLGFSAKKTYDLEVWLPGANTFREISSCSNCGDFQARRSSIRTKDNNKKNILLHTLNGSGLAIGRTMAAILEN
GQQSDGSINLPKALIPYFGSNKLQPE

Sequences:

>Translated_426_residues
MIDQRLLRENPNLISEGLKSRGMDVDLGPLQKFCKDLKDLEEKRNSLQAQGNSIGKEVGQKIKQGLPHDSEEISNLRVKG
NQIKKQVGIIEEEEKSISNKLNEQILCLPNLPEKNSLEGKNEKDNKELRRWGEPISGNTLKEHWEIANQLNLWDSERSSV
IAKSRFVTLFKHAAKLERSLINFMLDLHIKKGYLEVLPPALVNTASLTGSGQLPKFAEESFRCADDDLWLTPTAEVPITS
LHRGEIIPRDLLPLKYVAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFSTPETSEDALEQITSDAESVLQELELPYR
VIQLCTGDLGFSAKKTYDLEVWLPGANTFREISSCSNCGDFQARRSSIRTKDNNKKNILLHTLNGSGLAIGRTMAAILEN
GQQSDGSINLPKALIPYFGSNKLQPE
>Mature_426_residues
MIDQRLLRENPNLISEGLKSRGMDVDLGPLQKFCKDLKDLEEKRNSLQAQGNSIGKEVGQKIKQGLPHDSEEISNLRVKG
NQIKKQVGIIEEEEKSISNKLNEQILCLPNLPEKNSLEGKNEKDNKELRRWGEPISGNTLKEHWEIANQLNLWDSERSSV
IAKSRFVTLFKHAAKLERSLINFMLDLHIKKGYLEVLPPALVNTASLTGSGQLPKFAEESFRCADDDLWLTPTAEVPITS
LHRGEIIPRDLLPLKYVAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFSTPETSEDALEQITSDAESVLQELELPYR
VIQLCTGDLGFSAKKTYDLEVWLPGANTFREISSCSNCGDFQARRSSIRTKDNNKKNILLHTLNGSGLAIGRTMAAILEN
GQQSDGSINLPKALIPYFGSNKLQPE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=450, Percent_Identity=32.2222222222222, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI8923421, Length=412, Percent_Identity=29.8543689320388, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI225579074, Length=416, Percent_Identity=28.8461538461538, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=46.9626168224299, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17539260, Length=459, Percent_Identity=30.9368191721133, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=332, Percent_Identity=27.710843373494, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=429, Percent_Identity=31.9347319347319, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6321799, Length=391, Percent_Identity=31.4578005115089, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24581334, Length=460, Percent_Identity=31.0869565217391, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17737985, Length=290, Percent_Identity=32.4137931034483, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24649556, Length=405, Percent_Identity=23.7037037037037, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PROM1 (A2C409)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015484.1
- ProteinModelPortal:   A2C409
- SMR:   A2C409
- STRING:   A2C409
- GeneID:   4779877
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_16621
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   PMAR167555:NATL1_16621-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48014; Mature: 48014

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQRLLRENPNLISEGLKSRGMDVDLGPLQKFCKDLKDLEEKRNSLQAQGNSIGKEVGQ
CCCHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KIKQGLPHDSEEISNLRVKGNQIKKQVGIIEEEEKSISNKLNEQILCLPNLPEKNSLEGK
HHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCC
NEKDNKELRRWGEPISGNTLKEHWEIANQLNLWDSERSSVIAKSRFVTLFKHAAKLERSL
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
INFMLDLHIKKGYLEVLPPALVNTASLTGSGQLPKFAEESFRCADDDLWLTPTAEVPITS
HHHHHHHHHCCCHHHHCCHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCCC
LHRGEIIPRDLLPLKYVAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFSTPETSEDA
CCCCCCCCCCCCCHHHHHHCCHHHHHCCCCCCCCHHHHEEECCCEEEEEEECCCCCCHHH
LEQITSDAESVLQELELPYRVIQLCTGDLGFSAKKTYDLEVWLPGANTFREISSCSNCGD
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCH
FQARRSSIRTKDNNKKNILLHTLNGSGLAIGRTMAAILENGQQSDGSINLPKALIPYFGS
HHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
NKLQPE
CCCCCC
>Mature Secondary Structure
MIDQRLLRENPNLISEGLKSRGMDVDLGPLQKFCKDLKDLEEKRNSLQAQGNSIGKEVGQ
CCCHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KIKQGLPHDSEEISNLRVKGNQIKKQVGIIEEEEKSISNKLNEQILCLPNLPEKNSLEGK
HHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCC
NEKDNKELRRWGEPISGNTLKEHWEIANQLNLWDSERSSVIAKSRFVTLFKHAAKLERSL
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
INFMLDLHIKKGYLEVLPPALVNTASLTGSGQLPKFAEESFRCADDDLWLTPTAEVPITS
HHHHHHHHHCCCHHHHCCHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCCC
LHRGEIIPRDLLPLKYVAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFSTPETSEDA
CCCCCCCCCCCCCHHHHHHCCHHHHHCCCCCCCCHHHHEEECCCEEEEEEECCCCCCHHH
LEQITSDAESVLQELELPYRVIQLCTGDLGFSAKKTYDLEVWLPGANTFREISSCSNCGD
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCH
FQARRSSIRTKDNNKKNILLHTLNGSGLAIGRTMAAILENGQQSDGSINLPKALIPYFGS
HHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
NKLQPE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA