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The map label for this gene is ppiA [C]

Identifier: 124026311

GI number: 124026311

Start: 1312416

End: 1313126

Strand: Reverse

Name: ppiA [C]

Synonym: NATL1_16051

Alternate gene names: 124026311

Gene position: 1313126-1312416 (Counterclockwise)

Preceding gene: 124026312

Following gene: 124026308

Centisome position: 70.42

GC content: 25.46

Gene sequence:

>711_bases
TTGAAGGGATTTAATAATAAAATTACTAATCTTTCAAATAATTCAATTTTATCTTATAGATTTTTTCAACCGGTTTATAT
TTTTCTATTTGTTAATTTGTTTTTGATTTCGGGATGTTCAAATATAAATAATAACGAAGATATAAATATATGCTCTACGA
CAAAACTCCCCTGCATAGATTCAAATGAATATGTCTTGTTTATTACTAATAAAGGCAATATAAAGTTAGAGTTGTATGGT
AAATTGGCCCCAATAACTGTTGGAAACTTTATAGATTTTATCGAAAAAGGTTCTTATAATAAAACAATTTTTAACAGGGT
TATTAAAAAACCTTACCCTTTTATTATTCGAGGTGGAGACAATACTTCAATAGGAAATAAAAATAAGTCTATAGATACTA
AAATAAAAGACAAAAGATATATTCCCTTGGAAATAAAATTAAAGACAAGCAATTTACCAATATATGGAAAAGAAATAGAT
GAACCTAGTCAAATAAATAATATTGAACTTAAGCATAAAAGATCATATTTATCTATGGCAAGATCTAAAGCATTAAATTC
AGCAAGTTTGCAATTTTATATTTTACTAAAATCTTTACCTGAACTTGATGGAAGGTACGCTGTTTTTGGAAAAGTGATTA
GTGGTATGAATATAGTTGATTTAATTCAAGAAGAAGATTTTATAATTGAAGCTAAAAGAGTTGACTCTTGA

Upstream 100 bases:

>100_bases
GGTAGGAAGGATTTACCTATATCTCGAGTTGGATCTCCTAAGCCATTATTGGATTTAGAGAATGAGGGGGCTGAAATTGC
GAGATTTTTAGAGGTTAACC

Downstream 100 bases:

>100_bases
AGAAAAATATTATTTTTTAGGTTTTTAACATTTCTGTATTTACTCCTGAGGCCCTCTTAAGAGCAACTTTCCCTGTCCGA
GCAATTTCTAAAATTCCATA

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKGFNNKITNLSNNSILSYRFFQPVYIFLFVNLFLISGCSNINNNEDINICSTTKLPCIDSNEYVLFITNKGNIKLELYG
KLAPITVGNFIDFIEKGSYNKTIFNRVIKKPYPFIIRGGDNTSIGNKNKSIDTKIKDKRYIPLEIKLKTSNLPIYGKEID
EPSQINNIELKHKRSYLSMARSKALNSASLQFYILLKSLPELDGRYAVFGKVISGMNIVDLIQEEDFIIEAKRVDS

Sequences:

>Translated_236_residues
MKGFNNKITNLSNNSILSYRFFQPVYIFLFVNLFLISGCSNINNNEDINICSTTKLPCIDSNEYVLFITNKGNIKLELYG
KLAPITVGNFIDFIEKGSYNKTIFNRVIKKPYPFIIRGGDNTSIGNKNKSIDTKIKDKRYIPLEIKLKTSNLPIYGKEID
EPSQINNIELKHKRSYLSMARSKALNSASLQFYILLKSLPELDGRYAVFGKVISGMNIVDLIQEEDFIIEAKRVDS
>Mature_236_residues
MKGFNNKITNLSNNSILSYRFFQPVYIFLFVNLFLISGCSNINNNEDINICSTTKLPCIDSNEYVLFITNKGNIKLELYG
KLAPITVGNFIDFIEKGSYNKTIFNRVIKKPYPFIIRGGDNTSIGNKNKSIDTKIKDKRYIPLEIKLKTSNLPIYGKEID
EPSQINNIELKHKRSYLSMARSKALNSASLQFYILLKSLPELDGRYAVFGKVISGMNIVDLIQEEDFIIEAKRVDS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=168, Percent_Identity=34.5238095238095, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1786736, Length=192, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=35.3658536585366, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17551282, Length=162, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=162, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17552784, Length=162, Percent_Identity=30.2469135802469, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=32.9192546583851, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922376, Length=182, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20130249, Length=156, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26917; Mature: 26917

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGFNNKITNLSNNSILSYRFFQPVYIFLFVNLFLISGCSNINNNEDINICSTTKLPCID
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEC
SNEYVLFITNKGNIKLELYGKLAPITVGNFIDFIEKGSYNKTIFNRVIKKPYPFIIRGGD
CCCEEEEEECCCCEEEEEECCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCC
NTSIGNKNKSIDTKIKDKRYIPLEIKLKTSNLPIYGKEIDEPSQINNIELKHKRSYLSMA
CCCCCCCCCCCCCEECCCEEEEEEEEEEECCCCEECCCCCCCCCCCCEEEHHHHHHHHHH
RSKALNSASLQFYILLKSLPELDGRYAVFGKVISGMNIVDLIQEEDFIIEAKRVDS
HHHCCCCCCEEEEEEEHHCCCCCCCEEEEHHHHCCCCHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MKGFNNKITNLSNNSILSYRFFQPVYIFLFVNLFLISGCSNINNNEDINICSTTKLPCID
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEC
SNEYVLFITNKGNIKLELYGKLAPITVGNFIDFIEKGSYNKTIFNRVIKKPYPFIIRGGD
CCCEEEEEECCCCEEEEEECCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCC
NTSIGNKNKSIDTKIKDKRYIPLEIKLKTSNLPIYGKEIDEPSQINNIELKHKRSYLSMA
CCCCCCCCCCCCCEECCCEEEEEEEEEEECCCCEECCCCCCCCCCCCEEEHHHHHHHHHH
RSKALNSASLQFYILLKSLPELDGRYAVFGKVISGMNIVDLIQEEDFIIEAKRVDS
HHHCCCCCCEEEEEEEHHCCCCCCCEEEEHHHHCCCCHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]