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The map label for this gene is pntB [H]

Identifier: 124026299

GI number: 124026299

Start: 1303502

End: 1304938

Strand: Reverse

Name: pntB [H]

Synonym: NATL1_15931

Alternate gene names: 124026299

Gene position: 1304938-1303502 (Counterclockwise)

Preceding gene: 124026300

Following gene: 124026298

Centisome position: 69.98

GC content: 42.94

Gene sequence:

>1437_bases
ATGACTTTTATTGCTCCCATTAAGTTTGCTATTGATCTACTGGCAGTTTTATTGCTTGCTTTAGGCATTAAAGGCCTTTC
AAAAGTTAGATCAGCAAGAGAGGCAAATAGGCTTGCCGGTATTGCGATGATGTTGGCTGCTTTTGGAGTGTTGCTTAACT
CTCAAGGCACCATAGGGATTTCTATTAACTCTTGGATTTGGATAATTTGTGGAACTTTAATTGGAGGGCTTTTAGGAGCT
TTAACGGCTAAAAGGGTTCCAATGACTGCAATGCCTGAGATAGTTGCTTTGTTTAACGGTTGTGGAGGGATGTCATCGTT
ATTGGTCGCACTTGGCGTGGCTTTGTTCCCATCCTCAGACGCCTCTGATGGCGTTGTGGGTGAACTTATTAGGAATTTTT
CAATAGTCGTTTCACTATTTGTAGGAGCTATTACATTCTCCGGATCAATAGTTGCAATGGCTAAGCTTCAGGGCTGGTTG
TCTACTCCTTCTTGGACCCAAAGTAAGGCTAGGCATTTTTTCAATATTTTTTGCGCTGTTCTTGCTTTGATCGGTGGAAT
CTATCTTTCAATCGATGGACAAAATGGTCTTTTTCTTATTGTAATTGCCTCGTCTTTACTTGGTATAGGAGTAACTCTTC
CCATTGGTGGGGCAGATATGCCAGTAGTCATATCTCTACTGAACAGCTACTCAGGGGTTGCAGCAGCAGCTGCTGGATTC
GTCGTTGGTAGTCAACTTTTGATTGTTGCTGGTGCAATGGTTGGAGCTGCTGGGCTAATACTTACACAGGTGATGTGCGA
TGGGATGAATAGATCTTTAGTTTCGGTCTTGTTTGGCGGTGCACTTGGTTCTAGTTCAGTTGCTTCAGGAGGAGGTGGAG
AGTATACAAACATCACTAGTTGCAGCCCAGAAGAATGTGCACTGTCTCTCGAGGCTGCAGAGAGAGTTGTAATTGTGCCA
GGCTATGGCCTTGCCGTTGCTCAGGCTCAGCACACTCTTAGGGAAGTCACCAGAGTTTTAGAAAATGCCGAAATTGAAGT
CACCTATGCCATTCATCCTGTCGCTGGAAGGATGCCCGGTCATATGAATGTTCTTTTGGCAGAAGCAGATGTACCTTATG
AGCAACTAAAAGAAATGGATGTAATTAATCCTGAATTCCCTGCTACAGATGTTGTATTGGTTCTAGGAGCAAATGATGTG
GTTAATCCACAGGCTAAGACTGATCAGTCTTCCCCTCTGTATGGAATGCCGGTTTTAGATGTTCAAGAAGCGAGAACTGT
TTTTGTTGTTAAAAGAGGAATGAGCGCTGGATATTCAGGTATAAAAAACGATCTTTTTGACCTGCCTAATACTTCTATGG
TCTTTGGAGATGCAAAAAAAGTTCTTGGCGATCTTTTGTTGGAACTAAAGGATCTTGGAGTTGGTAGCAAAGGATAA

Upstream 100 bases:

>100_bases
TTGGATTCGCTTTGTTTAATGTGATTGGTGGCTTTCTGGTTACAGACAGGATGCTTGCAATGTTTAGTCGTAAAAAAACT
CGTAAATAGGATTATCTCTT

Downstream 100 bases:

>100_bases
TTTGAAAAGAGAGGAGTTACTTTCAGACTTAGGACTACAACCATTTAAGGAGCGCATTCCATGGATTGGTCCTGATCTTC
AGACACTTAGAGATACCTTC

Product: putative nicotinamide nucleotide transhydrogenase, subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTFIAPIKFAIDLLAVLLLALGIKGLSKVRSAREANRLAGIAMMLAAFGVLLNSQGTIGISINSWIWIICGTLIGGLLGA
LTAKRVPMTAMPEIVALFNGCGGMSSLLVALGVALFPSSDASDGVVGELIRNFSIVVSLFVGAITFSGSIVAMAKLQGWL
STPSWTQSKARHFFNIFCAVLALIGGIYLSIDGQNGLFLIVIASSLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAAGF
VVGSQLLIVAGAMVGAAGLILTQVMCDGMNRSLVSVLFGGALGSSSVASGGGGEYTNITSCSPEECALSLEAAERVVIVP
GYGLAVAQAQHTLREVTRVLENAEIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDV
VNPQAKTDQSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFDLPNTSMVFGDAKKVLGDLLLELKDLGVGSKG

Sequences:

>Translated_478_residues
MTFIAPIKFAIDLLAVLLLALGIKGLSKVRSAREANRLAGIAMMLAAFGVLLNSQGTIGISINSWIWIICGTLIGGLLGA
LTAKRVPMTAMPEIVALFNGCGGMSSLLVALGVALFPSSDASDGVVGELIRNFSIVVSLFVGAITFSGSIVAMAKLQGWL
STPSWTQSKARHFFNIFCAVLALIGGIYLSIDGQNGLFLIVIASSLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAAGF
VVGSQLLIVAGAMVGAAGLILTQVMCDGMNRSLVSVLFGGALGSSSVASGGGGEYTNITSCSPEECALSLEAAERVVIVP
GYGLAVAQAQHTLREVTRVLENAEIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDV
VNPQAKTDQSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFDLPNTSMVFGDAKKVLGDLLLELKDLGVGSKG
>Mature_477_residues
TFIAPIKFAIDLLAVLLLALGIKGLSKVRSAREANRLAGIAMMLAAFGVLLNSQGTIGISINSWIWIICGTLIGGLLGAL
TAKRVPMTAMPEIVALFNGCGGMSSLLVALGVALFPSSDASDGVVGELIRNFSIVVSLFVGAITFSGSIVAMAKLQGWLS
TPSWTQSKARHFFNIFCAVLALIGGIYLSIDGQNGLFLIVIASSLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAAGFV
VGSQLLIVAGAMVGAAGLILTQVMCDGMNRSLVSVLFGGALGSSSVASGGGGEYTNITSCSPEECALSLEAAERVVIVPG
YGLAVAQAQHTLREVTRVLENAEIEVTYAIHPVAGRMPGHMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVV
NPQAKTDQSSPLYGMPVLDVQEARTVFVVKRGMSAGYSGIKNDLFDLPNTSMVFGDAKKVLGDLLLELKDLGVGSKG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=406, Percent_Identity=39.4088669950739, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI122939153, Length=406, Percent_Identity=39.4088669950739, Blast_Score=276, Evalue=3e-74,
Organism=Escherichia coli, GI1787886, Length=456, Percent_Identity=44.2982456140351, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17550456, Length=477, Percent_Identity=37.9454926624738, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49475; Mature: 49344

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFIAPIKFAIDLLAVLLLALGIKGLSKVRSAREANRLAGIAMMLAAFGVLLNSQGTIGI
CCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SINSWIWIICGTLIGGLLGALTAKRVPMTAMPEIVALFNGCGGMSSLLVALGVALFPSSD
EECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
ASDGVVGELIRNFSIVVSLFVGAITFSGSIVAMAKLQGWLSTPSWTQSKARHFFNIFCAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LALIGGIYLSIDGQNGLFLIVIASSLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAAGF
HHHHCCEEEEEECCCCEEEEEEHHHHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
VVGSQLLIVAGAMVGAAGLILTQVMCDGMNRSLVSVLFGGALGSSSVASGGGGEYTNITS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
CSPEECALSLEAAERVVIVPGYGLAVAQAQHTLREVTRVLENAEIEVTYAIHPVAGRMPG
CCHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
HMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVVNPQAKTDQSSPLYGMPVLD
CCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
VQEARTVFVVKRGMSAGYSGIKNDLFDLPNTSMVFGDAKKVLGDLLLELKDLGVGSKG
HHHCCEEEEEECCCCCCCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TFIAPIKFAIDLLAVLLLALGIKGLSKVRSAREANRLAGIAMMLAAFGVLLNSQGTIGI
CEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SINSWIWIICGTLIGGLLGALTAKRVPMTAMPEIVALFNGCGGMSSLLVALGVALFPSSD
EECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
ASDGVVGELIRNFSIVVSLFVGAITFSGSIVAMAKLQGWLSTPSWTQSKARHFFNIFCAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LALIGGIYLSIDGQNGLFLIVIASSLLGIGVTLPIGGADMPVVISLLNSYSGVAAAAAGF
HHHHCCEEEEEECCCCEEEEEEHHHHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
VVGSQLLIVAGAMVGAAGLILTQVMCDGMNRSLVSVLFGGALGSSSVASGGGGEYTNITS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
CSPEECALSLEAAERVVIVPGYGLAVAQAQHTLREVTRVLENAEIEVTYAIHPVAGRMPG
CCHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
HMNVLLAEADVPYEQLKEMDVINPEFPATDVVLVLGANDVVNPQAKTDQSSPLYGMPVLD
CCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
VQEARTVFVVKRGMSAGYSGIKNDLFDLPNTSMVFGDAKKVLGDLLLELKDLGVGSKG
HHHCCEEEEEECCCCCCCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]