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The map label for this gene is uppS [H]

Identifier: 124026194

GI number: 124026194

Start: 1198468

End: 1199238

Strand: Reverse

Name: uppS [H]

Synonym: NATL1_14881

Alternate gene names: 124026194

Gene position: 1199238-1198468 (Counterclockwise)

Preceding gene: 124026195

Following gene: 124026193

Centisome position: 64.31

GC content: 37.09

Gene sequence:

>771_bases
TTGACTTACCCTTCTGTAATAAGCACTGATAATTCTAGAAAGGTATCGCCATTACCTAAAGATTTGGACAGTCTTCGTAT
GCCTGAGCATATTGCGGTAATCATGGATGGAAATGGTAGATGGGCAAAAGAAAAGGGTTTACCAAGGACTATTGGACATA
CCGCTGGGGTTGAGGCTTTAAAAACTACCTTGCACTTATGTAGTAATTGGGGAATAGGCGCATTAACTGTTTATGCCTTC
TCAACTGAAAATTGGTCCAGACCTAGTGAAGAAGTGAATTTCTTAATGACACTTTTTGAAAGTGTTCTCAAGCGTGAATT
GACTAATTTAAAACTCGAAGAAGTAAAAATTAATTTCATGGGTGATCTTGACCCCTTGCCTATTGGCTTAAAGGACTTAA
TCAAAGAGTCTGTTGAATCAACTTCTAATAGTAAAGGTATTCATTTTAATGTTTGCACAAATTATGGAGGAAGACGAGAA
TTAGTACGAGCTGCTCAAAAGTTGGCAGAACGTTCGGTAAAAGGCGAATTAGATCCTTCATTGATAGATGAAAATGTATT
TGCTTCTGAGTTGTTTACAGCTAGTGAGGTTGATCCAGACTTACTTATTAGAACTAGTGGAGAAAAAAGGATAAGTAATT
TTCTTTTGTGGCAATTAGCTTATGCTGAAATCCATATCACAGACGTATTATGGCCAGATTTTAACGCCGATACTCTTACC
AAGGCACTACTTGACTATCAATCTAGAAGAAGGAGATTTGGTGGTGTATAA

Upstream 100 bases:

>100_bases
TTAATTCTTCAATGAAAACAACTTCCTCTAATATTGAAACTAAAGTTGCTCAATCCAGAGTTAATCTTGTGAAAAATAAT
GACAGCAAGGAGTCTTTGAA

Downstream 100 bases:

>100_bases
CTAAATTAATTGAATATTTTGAGTTGTATGATTTTTTATAGATTATCGGCTAAAACTAAATAGCAATTAAATTTCTTATA
TTCAAATTCTTTTATGACTC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTYPSVISTDNSRKVSPLPKDLDSLRMPEHIAVIMDGNGRWAKEKGLPRTIGHTAGVEALKTTLHLCSNWGIGALTVYAF
STENWSRPSEEVNFLMTLFESVLKRELTNLKLEEVKINFMGDLDPLPIGLKDLIKESVESTSNSKGIHFNVCTNYGGRRE
LVRAAQKLAERSVKGELDPSLIDENVFASELFTASEVDPDLLIRTSGEKRISNFLLWQLAYAEIHITDVLWPDFNADTLT
KALLDYQSRRRRFGGV

Sequences:

>Translated_256_residues
MTYPSVISTDNSRKVSPLPKDLDSLRMPEHIAVIMDGNGRWAKEKGLPRTIGHTAGVEALKTTLHLCSNWGIGALTVYAF
STENWSRPSEEVNFLMTLFESVLKRELTNLKLEEVKINFMGDLDPLPIGLKDLIKESVESTSNSKGIHFNVCTNYGGRRE
LVRAAQKLAERSVKGELDPSLIDENVFASELFTASEVDPDLLIRTSGEKRISNFLLWQLAYAEIHITDVLWPDFNADTLT
KALLDYQSRRRRFGGV
>Mature_255_residues
TYPSVISTDNSRKVSPLPKDLDSLRMPEHIAVIMDGNGRWAKEKGLPRTIGHTAGVEALKTTLHLCSNWGIGALTVYAFS
TENWSRPSEEVNFLMTLFESVLKRELTNLKLEEVKINFMGDLDPLPIGLKDLIKESVESTSNSKGIHFNVCTNYGGRREL
VRAAQKLAERSVKGELDPSLIDENVFASELFTASEVDPDLLIRTSGEKRISNFLLWQLAYAEIHITDVLWPDFNADTLTK
ALLDYQSRRRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=42.4107142857143, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=42.4107142857143, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=45.1327433628319, Blast_Score=215, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=38.8646288209607, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=225, Percent_Identity=37.7777777777778, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=33.4801762114537, Blast_Score=118, Evalue=9e-28,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=32.5991189427313, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28769; Mature: 28638

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYPSVISTDNSRKVSPLPKDLDSLRMPEHIAVIMDGNGRWAKEKGLPRTIGHTAGVEAL
CCCCCCEECCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCHHHCCCCHHHCHHHHHHHH
KTTLHLCSNWGIGALTVYAFSTENWSRPSEEVNFLMTLFESVLKRELTNLKLEEVKINFM
HHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEE
GDLDPLPIGLKDLIKESVESTSNSKGIHFNVCTNYGGRRELVRAAQKLAERSVKGELDPS
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHH
LIDENVFASELFTASEVDPDLLIRTSGEKRISNFLLWQLAYAEIHITDVLWPDFNADTLT
HHCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHH
KALLDYQSRRRRFGGV
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TYPSVISTDNSRKVSPLPKDLDSLRMPEHIAVIMDGNGRWAKEKGLPRTIGHTAGVEAL
CCCCCEECCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCHHHCCCCHHHCHHHHHHHH
KTTLHLCSNWGIGALTVYAFSTENWSRPSEEVNFLMTLFESVLKRELTNLKLEEVKINFM
HHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEE
GDLDPLPIGLKDLIKESVESTSNSKGIHFNVCTNYGGRRELVRAAQKLAERSVKGELDPS
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHH
LIDENVFASELFTASEVDPDLLIRTSGEKRISNFLLWQLAYAEIHITDVLWPDFNADTLT
HHCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHH
KALLDYQSRRRRFGGV
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]