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The map label for this gene is nei [H]

Identifier: 124026034

GI number: 124026034

Start: 1113032

End: 1113877

Strand: Direct

Name: nei [H]

Synonym: NATL1_13271

Alternate gene names: 124026034

Gene position: 1113032-1113877 (Clockwise)

Preceding gene: 124026033

Following gene: 124026041

Centisome position: 59.69

GC content: 33.81

Gene sequence:

>846_bases
ATGCCCGAAGGACCAGAGATTAAACGTGCTGCAGATAGGATTAGTAAAGTTTTAATTGGCGAAGAAATTATTGAAAGTAA
TTTTTACTATGAACGGATAAAAGAGAAAGAGGAGATAGTCAAAAACCAAAATATCAAAGACATAACAACTAGAGGAAAGG
CAATGATTATCCGTTTCAAAAATGATTGGTCAATGTATAGCCATAATCAGTTGTATGGAAGATGGACAGTAAATTTAAAT
ACAACAAAAGTCAAATCAAGAAGAGCTCTTAGAGTAGTTTTCACAACAAATAAACATGCTGTTAGATTGTGGTCAGCGAC
AGATATTGATTTAATTCCAACCAATGAAGAAAATGAACATTCATTCTTAAAAAAAATTGGGCCCGATATCCTGAATGAAT
CTTGCAGTTTAGATTTAATAGAAGAAAGATTAACGTCGAAAAGATTCCACAAAAAGAAAGCCTCAACTTTGATGCTTGAT
CAGACTGTCTTCGCTGGATTAGGTAACTATCTTCGCTCAGAAATCTTATTCGATGCAAAAATACATCCAGATGATAGACC
GTTTGATCTTGATAAAACGAGAATTACCCAATGGGCAAAATCAATAAAAAACATCTCACAGTTAGCCTATAAAACTGGAG
GTTTTACAGTCTCAAAATCATTAGCAGATAGAAACAAAGAGAATGGAGAGCCAAGAAGATCTTATAGACATGCTGTTTTC
ATGCGACACCAATATGAATGTTTAAATTGCAAAGATCGTATAGAAAGGAAATGGTATGGGAAAAGGAAAGTTGATTATTG
TCCGAGCTGTCAAGTTCAAAGAGGTAAAATCAAATCCACCAAATAA

Upstream 100 bases:

>100_bases
TAAAGAAGATCAGATTAATCTTGATAGTGATTCATGAATTTTGTATAACCTTCTATTTGGACGCATTTTAATTGAATACT
GTTTAAGATCGAAATTTTAA

Downstream 100 bases:

>100_bases
TGGTTTTTTTAGCACTTGGCGAATAACAAAAATTTAAGACAACATATGTTTTTGATGAGAACATATATAAAAGGTAGACG
TACTTAATTGTTTATAGGAT

Product: endonuclease VIII

Products: NA

Alternate protein names: DNA glycosylase/AP lyase Nei; DNA-(apurinic or apyrimidinic site) lyase Nei; Endonuclease VIII [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MPEGPEIKRAADRISKVLIGEEIIESNFYYERIKEKEEIVKNQNIKDITTRGKAMIIRFKNDWSMYSHNQLYGRWTVNLN
TTKVKSRRALRVVFTTNKHAVRLWSATDIDLIPTNEENEHSFLKKIGPDILNESCSLDLIEERLTSKRFHKKKASTLMLD
QTVFAGLGNYLRSEILFDAKIHPDDRPFDLDKTRITQWAKSIKNISQLAYKTGGFTVSKSLADRNKENGEPRRSYRHAVF
MRHQYECLNCKDRIERKWYGKRKVDYCPSCQVQRGKIKSTK

Sequences:

>Translated_281_residues
MPEGPEIKRAADRISKVLIGEEIIESNFYYERIKEKEEIVKNQNIKDITTRGKAMIIRFKNDWSMYSHNQLYGRWTVNLN
TTKVKSRRALRVVFTTNKHAVRLWSATDIDLIPTNEENEHSFLKKIGPDILNESCSLDLIEERLTSKRFHKKKASTLMLD
QTVFAGLGNYLRSEILFDAKIHPDDRPFDLDKTRITQWAKSIKNISQLAYKTGGFTVSKSLADRNKENGEPRRSYRHAVF
MRHQYECLNCKDRIERKWYGKRKVDYCPSCQVQRGKIKSTK
>Mature_280_residues
PEGPEIKRAADRISKVLIGEEIIESNFYYERIKEKEEIVKNQNIKDITTRGKAMIIRFKNDWSMYSHNQLYGRWTVNLNT
TKVKSRRALRVVFTTNKHAVRLWSATDIDLIPTNEENEHSFLKKIGPDILNESCSLDLIEERLTSKRFHKKKASTLMLDQ
TVFAGLGNYLRSEILFDAKIHPDDRPFDLDKTRITQWAKSIKNISQLAYKTGGFTVSKSLADRNKENGEPRRSYRHAVFM
RHQYECLNCKDRIERKWYGKRKVDYCPSCQVQRGKIKSTK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothy

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1786932, Length=271, Percent_Identity=35.0553505535055, Blast_Score=191, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 32995; Mature: 32864

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGPEIKRAADRISKVLIGEEIIESNFYYERIKEKEEIVKNQNIKDITTRGKAMIIRFK
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEC
NDWSMYSHNQLYGRWTVNLNTTKVKSRRALRVVFTTNKHAVRLWSATDIDLIPTNEENEH
CCCCCCCCCEEEEEEEEEEEHHEHHCCCEEEEEEECCCCEEEEECCCCEEEECCCCCHHH
SFLKKIGPDILNESCSLDLIEERLTSKRFHKKKASTLMLDQTVFAGLGNYLRSEILFDAK
HHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
IHPDDRPFDLDKTRITQWAKSIKNISQLAYKTGGFTVSKSLADRNKENGEPRRSYRHAVF
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCHHHHHHHHHH
MRHQYECLNCKDRIERKWYGKRKVDYCPSCQVQRGKIKSTK
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PEGPEIKRAADRISKVLIGEEIIESNFYYERIKEKEEIVKNQNIKDITTRGKAMIIRFK
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEC
NDWSMYSHNQLYGRWTVNLNTTKVKSRRALRVVFTTNKHAVRLWSATDIDLIPTNEENEH
CCCCCCCCCEEEEEEEEEEEHHEHHCCCEEEEEEECCCCEEEEECCCCEEEECCCCCHHH
SFLKKIGPDILNESCSLDLIEERLTSKRFHKKKASTLMLDQTVFAGLGNYLRSEILFDAK
HHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
IHPDDRPFDLDKTRITQWAKSIKNISQLAYKTGGFTVSKSLADRNKENGEPRRSYRHAVF
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCHHHHHHHHHH
MRHQYECLNCKDRIERKWYGKRKVDYCPSCQVQRGKIKSTK
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA