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The map label for this gene is folP [H]

Identifier: 124025770

GI number: 124025770

Start: 982582

End: 983361

Strand: Reverse

Name: folP [H]

Synonym: NATL1_10631

Alternate gene names: 124025770

Gene position: 983361-982582 (Counterclockwise)

Preceding gene: 124025771

Following gene: 124025768

Centisome position: 52.73

GC content: 33.08

Gene sequence:

>780_bases
ATGGCAATAGTAAACATCACTGAAGATTCTTTTAGCGATGGAGGACTGTACATAGACTTACCCTCTGCGATCAATCATGC
ATCATTATGTATTAAACAAGGAGCAAATATTCTAGATATTGGAGCACAGAGCACACGACCTGGCGCCTCTGAGGTAGGTC
CTGAAACTGAGATTAAAAGATTAGTTCCATTAATAAAAGAATTAAAGTTATTACATCCAGAGATTCCGATATCTGTAGAC
ACCTTTCATCATTCTGTTGCAGAGAAAGTATTAAATATTGGTGCCGATTTGGTTAATGATGTTAGTGGTGGTCGACATGA
TCCTGAAATCTATAATGTTATCGCTAATAATGGATCTCCTTATGTTTTGACTCATAGTCGTGGAAATAGTAAGACAATGG
ATTCTTTAGCTGTATATACAAACGTTGTAAAAGATGTAAAAAATGAATTATCCAATCAAATTGATTTAGCACTATCTAAA
GGCATTAAAGACGAACAAATTATTATTGATCCTGGAATAGGCTTTGCAAAAAATGTCGATCATAACTTAACTTTGCTGCG
AAATTTAGAAGAATTCGTTTCTATGAATTATCCATTATTAATAGGTGCTTCTAGAAAAAGATTTATTGGTTCAGTTATTA
ATGAAACTGACCCAAATAAAAGAATATTTGGAATGGCTGCCGTAGCCTCTAGATGTGTGAATGCTGGTGTTGATATTCTA
AGAGTTCATGATGTTAAACAAATTTCTCAAGTTATAATAATGACTAAGTCAATTATTTAA

Upstream 100 bases:

>100_bases
GGTGGAGCCTCTCTAGATCCTACAAATTTTGCCCGAATTGCAAACTACGAAAAAATCTAATAATTTCCCGCCTAAGCATT
GGGAACGAGAAACCCAATTA

Downstream 100 bases:

>100_bases
AATATTATTAATCTTCTGTATTAACCCCTTCGATTCTATCTTCTACTTCTTGATAAAGTTCTTTTAATTGTTCAATATTT
TCATCAGATGTTTCCCAATA

Product: putative dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAIVNITEDSFSDGGLYIDLPSAINHASLCIKQGANILDIGAQSTRPGASEVGPETEIKRLVPLIKELKLLHPEIPISVD
TFHHSVAEKVLNIGADLVNDVSGGRHDPEIYNVIANNGSPYVLTHSRGNSKTMDSLAVYTNVVKDVKNELSNQIDLALSK
GIKDEQIIIDPGIGFAKNVDHNLTLLRNLEEFVSMNYPLLIGASRKRFIGSVINETDPNKRIFGMAAVASRCVNAGVDIL
RVHDVKQISQVIIMTKSII

Sequences:

>Translated_259_residues
MAIVNITEDSFSDGGLYIDLPSAINHASLCIKQGANILDIGAQSTRPGASEVGPETEIKRLVPLIKELKLLHPEIPISVD
TFHHSVAEKVLNIGADLVNDVSGGRHDPEIYNVIANNGSPYVLTHSRGNSKTMDSLAVYTNVVKDVKNELSNQIDLALSK
GIKDEQIIIDPGIGFAKNVDHNLTLLRNLEEFVSMNYPLLIGASRKRFIGSVINETDPNKRIFGMAAVASRCVNAGVDIL
RVHDVKQISQVIIMTKSII
>Mature_258_residues
AIVNITEDSFSDGGLYIDLPSAINHASLCIKQGANILDIGAQSTRPGASEVGPETEIKRLVPLIKELKLLHPEIPISVDT
FHHSVAEKVLNIGADLVNDVSGGRHDPEIYNVIANNGSPYVLTHSRGNSKTMDSLAVYTNVVKDVKNELSNQIDLALSKG
IKDEQIIIDPGIGFAKNVDHNLTLLRNLEEFVSMNYPLLIGASRKRFIGSVINETDPNKRIFGMAAVASRCVNAGVDILR
VHDVKQISQVIIMTKSII

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=39.3822393822394, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324073, Length=313, Percent_Identity=34.5047923322684, Blast_Score=175, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28154; Mature: 28023

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVNITEDSFSDGGLYIDLPSAINHASLCIKQGANILDIGAQSTRPGASEVGPETEIKR
CEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCHHHHHH
LVPLIKELKLLHPEIPISVDTFHHSVAEKVLNIGADLVNDVSGGRHDPEIYNVIANNGSP
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCC
YVLTHSRGNSKTMDSLAVYTNVVKDVKNELSNQIDLALSKGIKDEQIIIDPGIGFAKNVD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
HNLTLLRNLEEFVSMNYPLLIGASRKRFIGSVINETDPNKRIFGMAAVASRCVNAGVDIL
CHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEE
RVHDVKQISQVIIMTKSII
EHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIVNITEDSFSDGGLYIDLPSAINHASLCIKQGANILDIGAQSTRPGASEVGPETEIKR
EEEEECCCCCCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCHHHHHH
LVPLIKELKLLHPEIPISVDTFHHSVAEKVLNIGADLVNDVSGGRHDPEIYNVIANNGSP
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCC
YVLTHSRGNSKTMDSLAVYTNVVKDVKNELSNQIDLALSKGIKDEQIIIDPGIGFAKNVD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
HNLTLLRNLEEFVSMNYPLLIGASRKRFIGSVINETDPNKRIFGMAAVASRCVNAGVDIL
CHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEE
RVHDVKQISQVIIMTKSII
EHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]