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The map label for this gene is ubiE [H]

Identifier: 124025197

GI number: 124025197

Start: 440578

End: 441276

Strand: Direct

Name: ubiE [H]

Synonym: NATL1_04841

Alternate gene names: 124025197

Gene position: 440578-441276 (Clockwise)

Preceding gene: 124025196

Following gene: 124025199

Centisome position: 23.63

GC content: 33.05

Gene sequence:

>699_bases
ATGAGGCCTGGTAATACAAAAGCTATAGAAGAAATGTTTAATTCAATTTCTTCAAAATATGATTTTTTAAATGATATATT
TAGCTTTGGATTGCATAGGTTTTGGAAAACAAAATTATTGGATATTCTTAATCCAACTTTTGGAGAAAAATGGATAGATC
TTTGTTGTGGAACAGGAGATATGTCAATGCTTTTGGCTAGATATATAAAGAGTTCTAAAAATATTACTGGAATAGACTCA
GCTTCTCAAGCATTATTAGTTGCGAGAGAAAGATCTAAACAAAACTATTCTTCAATTGAATGGATAAATGGTGATGCTCT
AGAGACAAGGCTCACATCTCATCAATTCGATGGCCTTTTAATGGCCTATGGCTTAAGGAATCTTTCCAGCCCTTATGAAG
GTCTGAAAGAGGCTTTTAGGATTTTGAAACCAGGTGGAAGGGCTGGGATCTTAGATTTTAGATCTTTTGAAGGGACCTCC
ATCCAAGGGCTATTTCAAAAAATATATTTAAGTTGTTATGTTGTTCCAATTTCATCTCTTTTCGGTTTAGGAAAAGAATA
TTCATACATAAAAAAAAGTTTAGTTAACTTCCCTTCTGGTGAAAAACAAATTCATTTGGCACTTTCTGCGGGTTTCAAAA
AAGCAAAATACCAAACATTAGCAATGGGACAAATGGGGATTTTATTACTTGAAGCCTAA

Upstream 100 bases:

>100_bases
ATAAGACCAATTGAATGATAAATATTCTCATGAAAAGATGTAAAATCGATTTTTTTCACCTTAAAATTTTTTTGCTATCT
AAATTTTTTTCTGTATTTAC

Downstream 100 bases:

>100_bases
ATCAAAATCGTTCAATCTATTCTCAATTCTTTTCTTCTACAAAAACTACATTTACCCCATAATTTAACTTCTCCCTTGGG
AGATGGGACTTTACAAAAAG

Product: ubiquinone/menaquinone biosynthesis methyltransferases

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MRPGNTKAIEEMFNSISSKYDFLNDIFSFGLHRFWKTKLLDILNPTFGEKWIDLCCGTGDMSMLLARYIKSSKNITGIDS
ASQALLVARERSKQNYSSIEWINGDALETRLTSHQFDGLLMAYGLRNLSSPYEGLKEAFRILKPGGRAGILDFRSFEGTS
IQGLFQKIYLSCYVVPISSLFGLGKEYSYIKKSLVNFPSGEKQIHLALSAGFKKAKYQTLAMGQMGILLLEA

Sequences:

>Translated_232_residues
MRPGNTKAIEEMFNSISSKYDFLNDIFSFGLHRFWKTKLLDILNPTFGEKWIDLCCGTGDMSMLLARYIKSSKNITGIDS
ASQALLVARERSKQNYSSIEWINGDALETRLTSHQFDGLLMAYGLRNLSSPYEGLKEAFRILKPGGRAGILDFRSFEGTS
IQGLFQKIYLSCYVVPISSLFGLGKEYSYIKKSLVNFPSGEKQIHLALSAGFKKAKYQTLAMGQMGILLLEA
>Mature_232_residues
MRPGNTKAIEEMFNSISSKYDFLNDIFSFGLHRFWKTKLLDILNPTFGEKWIDLCCGTGDMSMLLARYIKSSKNITGIDS
ASQALLVARERSKQNYSSIEWINGDALETRLTSHQFDGLLMAYGLRNLSSPYEGLKEAFRILKPGGRAGILDFRSFEGTS
IQGLFQKIYLSCYVVPISSLFGLGKEYSYIKKSLVNFPSGEKQIHLALSAGFKKAKYQTLAMGQMGILLLEA

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=256, Percent_Identity=29.296875, Blast_Score=114, Evalue=7e-26,
Organism=Escherichia coli, GI48994983, Length=225, Percent_Identity=28.8888888888889, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17557039, Length=229, Percent_Identity=28.82096069869, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323526, Length=247, Percent_Identity=26.3157894736842, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641702, Length=237, Percent_Identity=29.1139240506329, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 26018; Mature: 26018

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGNTKAIEEMFNSISSKYDFLNDIFSFGLHRFWKTKLLDILNPTFGEKWIDLCCGTGD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
MSMLLARYIKSSKNITGIDSASQALLVARERSKQNYSSIEWINGDALETRLTSHQFDGLL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHH
MAYGLRNLSSPYEGLKEAFRILKPGGRAGILDFRSFEGTSIQGLFQKIYLSCYVVPISSL
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FGLGKEYSYIKKSLVNFPSGEKQIHLALSAGFKKAKYQTLAMGQMGILLLEA
HCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRPGNTKAIEEMFNSISSKYDFLNDIFSFGLHRFWKTKLLDILNPTFGEKWIDLCCGTGD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
MSMLLARYIKSSKNITGIDSASQALLVARERSKQNYSSIEWINGDALETRLTSHQFDGLL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHH
MAYGLRNLSSPYEGLKEAFRILKPGGRAGILDFRSFEGTSIQGLFQKIYLSCYVVPISSL
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FGLGKEYSYIKKSLVNFPSGEKQIHLALSAGFKKAKYQTLAMGQMGILLLEA
HCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA