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The map label for this gene is yggV [C]

Identifier: 124025072

GI number: 124025072

Start: 332105

End: 332695

Strand: Direct

Name: yggV [C]

Synonym: NATL1_03591

Alternate gene names: 124025072

Gene position: 332105-332695 (Clockwise)

Preceding gene: 124025071

Following gene: 124025076

Centisome position: 17.81

GC content: 36.55

Gene sequence:

>591_bases
TTGGATAATGTCCCTCTTGTAATTGCTAGTGGCAATAAGGGTAAAATTGGAGAATTTAAAAAACTTTTAGACGATTTTCC
CATTGATTTATTGACTCAACCTGTTGGTTTTGAGATTGAGGAAACAGGAAGTACATTTATGGAAAATGCAAGAATCAAGG
CCATTGCTGTCAGTCAAGCAACAGGTAATTTGTCTCTTGCTGACGACTCTGGATTAAGTGTTGAGGCTCTTGGGGGGGCT
CCAGGCATTTATTCTTCTAGGTATGCAAGTTCAGATAAGCAAAGAATTGAAAAACTGTTAGCCGAGTTAAAACCTTTTTC
AAATAGAAAAGCTAAATTTGAATGTGCATTATGTATTGCTAGTGGAGAAAAAGTGTTGATAGAAGTTTCAGGCTTTTGCG
AAGGTCTAATAACTTTTTTCCCGAAAGGGCAAAATGGGTTTGGTTATGATCCGATTTTTGAAGTTTCTGGATTAGGTGAG
ACTTATGCAGAAATGGACCACGAAAAAAAGAAGCATATTGGTCACAGGGGTAATGCATTCAAATTGCTCATACCAAAATT
AAAACAACTATTGGGTTCAATGAAAAAGTAG

Upstream 100 bases:

>100_bases
TCTGGAACAGAGCCTCTTTTAAGAATTTATTGTGAAGCGCCATCCAGTGCAGAAGTTACTTCAACTTTGTATTATGCAAA
GCAACTTATAGATAATAGTT

Downstream 100 bases:

>100_bases
TTTTTGATTTCTTGAAAACTTTTAGTTTTTAATTTTCAACCCAGCTTCCGTGTAATCCATGTGGAATTGATATTGGAACT
TCAAGAATAGCTTTTTCAGT

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MDNVPLVIASGNKGKIGEFKKLLDDFPIDLLTQPVGFEIEETGSTFMENARIKAIAVSQATGNLSLADDSGLSVEALGGA
PGIYSSRYASSDKQRIEKLLAELKPFSNRKAKFECALCIASGEKVLIEVSGFCEGLITFFPKGQNGFGYDPIFEVSGLGE
TYAEMDHEKKKHIGHRGNAFKLLIPKLKQLLGSMKK

Sequences:

>Translated_196_residues
MDNVPLVIASGNKGKIGEFKKLLDDFPIDLLTQPVGFEIEETGSTFMENARIKAIAVSQATGNLSLADDSGLSVEALGGA
PGIYSSRYASSDKQRIEKLLAELKPFSNRKAKFECALCIASGEKVLIEVSGFCEGLITFFPKGQNGFGYDPIFEVSGLGE
TYAEMDHEKKKHIGHRGNAFKLLIPKLKQLLGSMKK
>Mature_196_residues
MDNVPLVIASGNKGKIGEFKKLLDDFPIDLLTQPVGFEIEETGSTFMENARIKAIAVSQATGNLSLADDSGLSVEALGGA
PGIYSSRYASSDKQRIEKLLAELKPFSNRKAKFECALCIASGEKVLIEVSGFCEGLITFFPKGQNGFGYDPIFEVSGLGE
TYAEMDHEKKKHIGHRGNAFKLLIPKLKQLLGSMKK

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=192, Percent_Identity=30.7291666666667, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789324, Length=193, Percent_Identity=44.0414507772021, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17556833, Length=177, Percent_Identity=31.638418079096, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322529, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19920712, Length=182, Percent_Identity=30.2197802197802, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_PROM1 (A2C0B3)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014188.1
- ProteinModelPortal:   A2C0B3
- SMR:   A2C0B3
- STRING:   A2C0B3
- GeneID:   4779820
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_03591
- eggNOG:   COG0127
- HOGENOM:   HBG697237
- OMA:   VYTADWA
- ProtClustDB:   PRK00120
- BioCyc:   PMAR167555:NATL1_03591-MONOMER
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 21276; Mature: 21276

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNVPLVIASGNKGKIGEFKKLLDDFPIDLLTQPVGFEIEETGSTFMENARIKAIAVSQA
CCCCCEEEECCCCCCHHHHHHHHHHCCHHHHCCCCCCEECCCCHHHHHCCEEEEEEEEEC
TGNLSLADDSGLSVEALGGAPGIYSSRYASSDKQRIEKLLAELKPFSNRKAKFECALCIA
CCCEEECCCCCCEEEECCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEE
SGEKVLIEVSGFCEGLITFFPKGQNGFGYDPIFEVSGLGETYAEMDHEKKKHIGHRGNAF
CCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEE
KLLIPKLKQLLGSMKK
EEHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNVPLVIASGNKGKIGEFKKLLDDFPIDLLTQPVGFEIEETGSTFMENARIKAIAVSQA
CCCCCEEEECCCCCCHHHHHHHHHHCCHHHHCCCCCCEECCCCHHHHHCCEEEEEEEEEC
TGNLSLADDSGLSVEALGGAPGIYSSRYASSDKQRIEKLLAELKPFSNRKAKFECALCIA
CCCEEECCCCCCEEEECCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEE
SGEKVLIEVSGFCEGLITFFPKGQNGFGYDPIFEVSGLGETYAEMDHEKKKHIGHRGNAF
CCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEE
KLLIPKLKQLLGSMKK
EEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA